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김동천 ( Dong Cheon Kim ),조준 ( Joon Cho ),조요한 ( Yo Han Cho ),노홍기 ( Hong Gee Roh ),임소덕 ( So Dug Lim ),고영초 ( Young Cho Koh ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2
Malignant fibrous histiocytoma(MFH) is a soft tissue sarcoma arising from the extremities and retroperitoneum in older adults. Primary intracranial MFH is extremely rare. A 29-year-old woman presented with headache showing three large masses on brain magnetic resonance image(MRI). She had undergone extended total gastrectomy with splenectomy under the diagnosis of advanced gastric cancer three years previously. Systemic positron extension tomography(PET) computed tomography(CT) scan on routine follow-up study before the first brain surgery revealed no hot spots. Three masses were totally removed at a single session. The pathology was confirmed to be typical MFH. Two months after the first brain surgery, she underwent tonsillectomy due to a rapidly growing tonsillar mass and the pathology was found out to be MFH. Postoperative neck CT with angiography for the evaluation of hypotension showed no significant finding. Except for the tonsillar mass, she had been symptom free during 10 months after the first brain surgery. Between 11th and 18th months postoperatively, multiple intracranial recurrences including metastatic lesions of the mediastinum and the spine were noticed. She died of pneumonia 20 months after the first brain surgery during salvage chemotherapy. We report a rare case of primary MFH of the brain with a past medical history of advanced gastric cancer.
산지별 더덕 추출물의 폐암 및 난소암에 대한 항암 효능
조영락 ( Young Rak Cho ),김수현 ( Soo Hyeon Kim ),윤현재 ( Hyun Jae Yoon ),홍삼열 ( Sam Yeol Hong ),고희영 ( Hee Young Ko ),박은희 ( Eun Hee Park ),김명동 ( Myoung Dong Kim ),서동완 ( Dong Wan Seo ) 한국산업식품공학회 2011 산업 식품공학 Vol.15 No.1
Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.
김도성 ( Do Sung Kim ),박성준 ( Seong Joon Park ),김동순 ( Dong Soon Kim ),조영복 ( Young Bok Cho ),이영돈 ( Yeong Don Lee ),안능호 ( Nung Ho Ahn ),김기경 ( Ki Gyoung Kim ),서홍렬 ( Hong Yul Seo ),차진열 ( Jin Yeol Cha ) 한국환경생태학회 2014 한국환경생태학회지 Vol.28 No.6
제주도 한라산은 나비 학자들로부터 주요 관심의 대상지로 남방계와 북방계의 나비가 서식하고 있는 것으로 알려져 있다. 본 연구는 2013년 5월부터 9월까지 월별로 선조사법으로 모니터링하여 각 구간별 나비군집과 유사도를 분석하고 과거 기록과 비교하여 고도분포의 변화를 살펴보았다. 그 결과 총 5과 26종 3,397개체의 나비류가 조사되었다. 이중 상위 4종(가락지나비, 산굴뚝나비, 먹그늘나비, 조흰뱀눈나비)가 2,578개체(75.9%)로 높은 비율을 차지하여 한라산의 나비는 초지대에서 서식하는 특정종의 비율이 매우 높은 것으로 나타났다. 한라산 나비 유사도는 교목층의 수관부와 열린 초지대와 같은 단일경관지역보다는 수관부와 열린 초지 공간이 함께 있는 지역에서 유사도가 높게 나타나고 있다. 고도별 나비분포는 해발 1,665∼1,700m에서 가장 많은 종수와 개체수가 관찰되어 한라산 백록담 아래에 형성된 열린 초지공간이 주요 서식지로 나타났다. 또한 아고산대에 서식하던 종들은 고도가 좀 더 높은 쪽으로 이동하고 낮은 지역에 서식하던 종들이 새롭게 아고산대에서 관찰되는 것으로 나타났다. Mt. Hallasan in Jejudo has been well known as a habitat for both northern and southern limited butterflies and attracts the interests of many lepidopterists. In this study, the line transect method was used to monitor the community and similarity of butterflies monthly monitoring from May to September 2013, and the results were compared with the previous data. Through monitoring, 3,397 individuals in 26 species of 5 families were found in the present study. The monitored individuals belonging to 4 species (Aphantopus hyperantus, Eumenis autono, Lethe diana and Melanargia epimede) was 2,578 (75.9%), showing the prevalent species among the butterflies observed in the grassy area of the Mt. Hallasan. The butterflies inhabiting Mt. Hallasan showed higher similarity in the area where the open grassy space and the crowns of tree layer coexist than in landscape consisting of solely the tree layer or open grassy space. The habitation of butterflies by heights showed the altitudes between 1,665 to 1,700 m, located beneath the Baekrokdam (the crater) of Mt. Hallasan, possessed the most species and individuals. And it was also observed that the species that previously inhabited the subalpine zone moved to the area of higher altitudes together with the species that previously inhabited rather lower altitudes than the subalpine zone.
김수(Su Kim),김기택(Ki-Taek Kim),김동휘(Dong-Hwi Kim),양은영(Eun-Young Yang),조명철(Myeong-Cheoul Cho),Arshad Jamal,채영(Young Chae),배도함(Do-Ham Pae),오대근(Dae-Geun Oh),황주광(Ju-Kwang Hwang) 한국원예학회 2010 원예과학기술지 Vol.28 No.6
고추 탄저병은 국내외에서 고추 생산에 있어 많은 피해를 주는 병중의 하나로서, Colletotrichum spp.에 의해 발생하며 현재 가장 많은 빈도를 나타내는 종은 C. acutatum으로 보고되고 있다. 살균제에 대한 내성이 있는 것으로 보고되어 저항성 품종의 육성이 요구되어지고 있다. 본 연구의 목적은 Capsicum baccatum 종내 교잡을 통해 고추 탄저병 저항성 육종을 위한 MAS(marker assisted selection) 체계를 개발하는 기초연구로서 저항성과 관련한 QTL분석을 수행하였다. 저항성 검정결과 고추 탄저병저항성은 85%의 높은 광의의 유전력을 보였다. 양적형질 유전자좌 분석 결과 신뢰수준 이상의 LOD 수준을 보인 2개의 QTL(An8.1, An9.1)이 탐색되었고, R²가 2.04%와 14.36%이었다. 유전적인 효과는 An8.1은 상가적 효과가 0.46으로, An9.1은 상가적 효과가 -4.52로 나타났다. An8.1과 An9.1은 상처접종에 의해 나타나는 저항성 반응과 관련이 있는 것으로 생각되었다. 포장검정(08NR)과 관련한 QTL들은 신뢰수준이상의 LOD 수준을 보이는 QTL은 탐색할 수 없었으나, R2가 19.9%인 An3.1와 30.8%인 An3.1을 포함한 5개 QTL의 전체 R²가 60.73%로 나타나 고추 탄저병저항성 유전과 관련한 인자가 다수 존재하는 것을 확인하였다. 따라서 이들 QTL은 더욱 정밀한 집단과 종간교잡 후대에서 적용성을 검정하여 고추 탄저병저항성 품종육성을 위한 MAS체계를 확립할 것이다. Pepper (Capsicum spp.) anthracnose caused by Colletotrichum acutatum is a destructive disease susceptible to areas where chili peppers are grown. Capsicum baccatum var. pendulum (Cbp) is resistant to anthracnose and has actively been used for interspecific hybridization for the introgression of resistance gene(s) into cultivated chili peppers. The goals of this study were to determine the inheritance of resistance to anthracnose within Capsicum baccatum and to map quantitative trait loci (QTLs) for the anthracnose resistance. A genetic mapping population consisting of 126 F₂ plants derived from a cross between Capsicum baccatum var. pendulum (resistant) and Capsicum baccatum ‘Golden-aji’ (susceptible) was used for linkage mapping. The linkage map was constructed with 52 SSRs, 175 AFLPs, and 100 SRAPs covering 1,896cM, with an average interval marker distance of 4.0cM. Based on this map, the number, location, and effect of QTLs for anthracnose resistance were studied using plants inoculated in the laboratory and field. A total of 19 quantitative trait loci (2 major QTLs and 16 minor QTLs) were detected. Two QTLs (An8.1, An9.1) showed 16.4% phenotypic variations for anthracnose resistance after wounding inoculation. In addition, five minor QTL loci (An7.3, An7.4, An4.1, An3.1, An3.2) showed a total of 60.73% phenotypic variations of anthracnose resistance in the field test. Several significant QTLs were also detected and their reproducibility was confirmed under different inoculation conditions. These QTLs are now being confirmed with different breeding populations. Markers tightly linked to the QTLs that are reliable under different environmental conditions will help to determine the success of marker-assisted selection for anthracnose -resistant breeding programs in chili pepper.