산전 진단된 수신증의 임상 경과 - 단일 기관의 경험 -

김연희,김병주,박문성,양정인,김행수,김병길,배기수,Kim Yeun-Hee,Kim Byoung-Ju,Park Moon-Sung,Yang Jung-In,Kim Haeng-Soo,Kim Pyung-Kil,Pai Ki-Soo 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

목적: 산전 초음파가 널리 이용되면서 태아기의 선천성 요로계의 이상이 발견되는 경우가 점차 증가하고 있다. 수신증의 대부분은 출생 후 1년 내에 자연스럽게 없어지는 생리적 수신증이지만 수술적 교정을 요하는 병적 수신증과의 감별이 쉽지 않다. 본 연구에서는 산전 수신증이 의심되는 환아에서 출생 후 수신증을 확진하여 산전 진단과의 연관성을 비교 분석하고, 산전 수신증의 원인과 자연경과를 이해하여 출생 후 수신증에 대한 대처에 도움을 주고자 본 연구를 시행하였다. 방법: 1994년 9월부터 2001년 8월까지 아주대학교 병원 산과에 등록되어 산전 초음파 검사상 태아 수신증이 의심되었던 환아 119명 중 출생후 실시한 신 초음파 검사에서 수신증이 확진된 91명(121 신단위)을 대상으로 수신증의 원인과 자연경과를 신 초음파 검사와 배설성 신주사 검사로 추적 관찰하였다. 결과: 산전 초음파 검사에서 수신증이 의심되었던 119명의 신생아 중 출생 후 수신증이 확진 되었던 환아는 91명으로 76%였다. 수신증의 원인으로 요관 신우 이행부 협착이 57례(47%)로 가장 많았으며 그 다음으로는 다낭성 이형성신이 12례(10%), 요관 방광 이행부 협착 5례(4%), 방광 요관 역류 5례(4%), 후부요도 판막 2례(2%)등의 눈이었으며 원인을 찾을 수 없었던 경우도 38례(31%)였다. 추적검사에서 47%가 수신증의 완전소식 혹은 호전소견을 보였으며 총 121개의 신 단위 중 10단위가 수술을 받았으며 진단에서 수술까지는 평균 7.2개원이 걸렸다. 결론: 산전 초음파로 발견된 수신증의 대부분은 출생후 수신증으로 확진되었으나 정상인 경우도 있었다. 산전 수신증의 원인으로 요관 신우 이행부 폐쇄가 가장 많았으며 대부분은 비폐색성 수신증이었고, 추적 검사에서 호전되는 경우가 많았다. 그러나 아직까지 신생아 수신증은 정확한 감별진단이 어렵기 때문에 신장기능의 보전을 위해서는 수신증의 정도에 따라 적절한 간격으로 지속적인 관찰을 하는 것이 필요할 것으로 사료된다. Purpose : The detection of hydronephrosis(HN) with antenatal ultrasonography was first reported in the 1970s. Prenatal HN is diagnosed with an incidence of 1:100 to 1:500 on antenatal screening. Recently, the purpose of antenatal screening has changed from simple detection to selection for specific diagnosis-based management. this study is to evaluate the usefulness of antenatal sonography for HN and to investigate the differential causes of HN and their clinical outcomes. Patients and methods : 11,783 live neonates with prenatal ultrasonographic examination at Ajou University School of Medicine, from Sep. 1994 to Aug. 2001 were analyzed. Results and conclusion : Hydronephrosis (>10 mm) was detected in 119 (1.0%) cases antenatally and among these, 91 were proved to have HN postnatally Males were three times more affected than females. Additional imaging studies revealed that ureteropelvic junction obstruction was the most common postnatal diagnosis (47%), followed by multicystic dysplastic kidney, vesicoureteral junction obstruction and vesicoureteral reflux. During 20 months' follow-up(3 to 72 months), 58(48%) renal units showed spontaneous resolution and surgical interventions were necessary in 10 (7.4%) of postnatally confirmed hydronephrotic renal units.

항암화학요법을 받는 급성 백혈병 환자의 구내염 예방에 관한 연구 - 중조 생리식염수 가글링과 클로로헥시딘 가글링의 비교

김연희,전명희,최진선,Kim, Yeon-Hui,Jeon, Myeong-Hui,Choe, Jin-Seon 대한간호협회 1997 대한간호 Vol.36 No.2

COVID-19 관련 업무 경험이 간호사의 직무 스트레스에 주는 영향

김연희,주현실,이정언,이미선,Kim, Yeon Hee,Joo, Hyun Sil,Lee, Jeong Eon,Lee, Mi Sun 한국직업건강간호학회 2022 한국직업건강간호학회지 Vol.31 No.4

Purpose: This study aimed to compare and analyze the job stress of nurses with and without in COVID-19-related work. Methods: A structured self-reported questionnaire survey was conducted to assess job stress. The extent of job stress was compared between nurses with COVID-19 (COVID-19 group) and those without such experience (non-COVID-19 group). Multiple regression analysis was performed to identify the factors influencing job stress. Results: Job stress was higher in the COVID-19 group compared to the non-COVID-19 group (t=2.54, p=.12). In sub-categorical comparison, stress driven by a taxing work environment, relationship conflict, and work schedule was higher in the COVID-19 group than the non-COVID-19 group. Multiple regression analysis revealed the job stress was higher among nurses with COVID-19-related work experience than that of non-experienced nurses. The factors affecting job stress of nurses with COVID-19-related work experience included emergency room work, providing nursing assistant for COVID-patients, and caring for these patients. Conclusion: Since COVID-19-related work experience is a major factor that affects nurses' job stress, it is imperative to provide various support measures for nursing assistants such as providing a break from working in an environment with high risk of infection, adjusting work schedules, resolving conflicts between personnel, and securing support.

만성폐쇄각녹내장 환자에서 백내장 단독수술의 효과

김연희,형성민,Younhui Kim,Sungmin Hyung,Ph,D 대한안과학회 2007 대한안과학회지 Vol.48 No.4

Purpose: To investigate the effects of cataract extraction in chronic angle-closure glaucoma (CACG) patients. Methods: Sixteen eyes from 14 patients with CACG underwent phacoemulsification with posterior chamber intraocular lens (PCL) implantation (group A), and 19 eyes from 17 patients with CACG underwent cataract surgery and additional trabeculectomy (combined surgery, group B) were evaluated for visual acuity, intraocular pressure (IOP), number of glaucoma medications and surgical complications. All patients had patent peripheral iridotomy holes before cataract surgery, and a minimum 6 month follow-up period was needed. Results: The mean postoperative follow-up period was 15.6 months in group A, and 21.7 months in group B. After surgery, the IOP was significantly reduced in both groups [from 16.1 mmHg to 13.8 mmHg in group A (P=0.013), and from 16.7 mmHg to 13.2 mmHg in group B (P=0.005)], but the amount of IOP reduction was not significantly different between the two groups (P=0.401). The relative decrease in the mean number of postoperative glaucoma medications was 0.9 in group A and 1.8 in group B, but these were not significantly different (P=0.060). Conclusions: Simple cataract surgery was effective in reducing IOP as much as combined surgery in CACG patients. These results affirm that phacoemusification with PCL implantation may be considered as the first treatment in cataract and CACG patients.

인간체외수정시술시 다낭성난포종 난포액이 정자의 운동성에 미치는 영향

김연희,이상훈,허민,Kim, Yeon-Hee,Lee, Sang-Hoon,Hur, Min 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.2

Objective: The purpose of this study was to evaluate the effect of polycystic ovarian follicular fluid on sperm motility in human in vitro fertilization (IVF). Methods: From May, 1998 to July, 1999, 55 patients who complained of infertility were involved in this study. We obtained ovarian follicular fluids from the patients by ultrasono-guided aspiration. Subjects were divided into two groups. 20 patients who had polycystic ovarian disease were belong to study group, and 25 patients who had normal ovarian follicular fluid were belong to control group. The follicular fluid dilution was done with Ham's fluid as 10%, 20%, 50%, 100%. The sperm motility was analyzed by CASA at 6hr and 12hr after incubation in follicular fluids. Results: The levels of average path velocity (VAP) in all concentration fluid didn't show significant difference between study and control group. The other parameters including curvilinear velocity (VCL), amplitude of lateral head displacement (ALH), and linerity (LIN) were didn't show any significant difference between both groups. Conclusion: PCOD fluid had seemed to have an adverse effect on the sperm biological function. But, this study showed that PCOD fluid had no different effect on sperm motility with normal follicular fluid.

세포막손상 유발로 인한 황련의 캔디다 바이오필름 형성 억제

김연희,Kim, Younhee 한국미생물학회 2013 미생물학회지 Vol.49 No.1

Candida 바이오필름은 숙주조직이나 인체에 삽입된 의료기구의 표면에 자라는 진균의 군락으로 전통적인 항진균제에 대한 내성을 유발한다. 황련(Coptidis chinensis)의 뿌리는 극동지방에서 의료용 목적으로 널리 사용되어 왔다. 본 연구의 목적은 임상에서 분리한 C. albicans 바이오필름 형성 균주가 형성한 바이오필름에 대한 C. chinensis 수용성 추출물의 효과와 C. albicans 바이오필름 형성을 저해하는 데 기여하는 항진균활성을 평가하는 데 있다. 바이오필름에 대한 효과는 XTT [2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide)] 환원분석법을 사용하였으며, 조사된 모든 균주에 대한 대사활성은 $98{\mu}g/ml$의 C. chinensis 수용성 추출물에 의해 현저하게 감소($57.3{\pm}14.7%$)되어 유의성 있는 항바이오필름 활성을 나타내었다. Fluorescein diacetate와 propidium iodide로 이중 염색한 결과 C. chinensis 추출물은 C. albicans의 세포막을 손상시켰다. C. chinensis 수용성 추출물은 살진균 활성을 나타냈고, C. albicans 바이오필름의 폴리스티렌 표면으로의 부착을 억제하였으며 C. albicans를 $G_o/G_1$기에 머무르게 하여 바이오필름이나 출아법에 의한 증식을 억제시켰다. 본 연구의 결과는 C. chinensis 추출물이 목표가 되는 C. albicans에 복합적으로 유해한 효과를 내어 궁극적으로는 C. albicans 바이오필름 형성을 억제함을 나타낸다. 따라서 C. chinensis 추출물은 바이오필름과 관련된 캔디다의 감염을 치료하고 제거하기 위한 천연물 기반항진균제 개발에 대한 높은 가능성을 가진다. Candida biofilms are organized microbial communities growing on the surfaces of host tissues or indwelling medical devices, and the biofilms show enhanced resistance against the conventional antifungal agents. The roots of Coptidis chinensis have been widely used for medicinal purposes in East Asia. The present study was aimed to assess the effect of C. chinensis aqueous extract upon preformed biofilms of 10 clinical Candida albicans isolates and the antifungal activities which contribute to inhibit the C. albicans biofilm formation. Its effect on preformed biofilms was judged using XTT [2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide)] reduction assay, and metabolic activity of all tested strains was reduced significantly ($57.3{\pm}14.7%$) at $98{\mu}g/ml$ of the C. chinensis extract. The extract damaged the cell membrane of C. albicans which was analyzed by fluorescein diacetate and propidium iodide staining. The anticandidal activity was fungicidal, and the extract obstructed the adhesion of C. albicans biofilms to polystyrene surfaces, arrested C. albicans cells at $G_o/G_1$ as well, and reduced the growth of biofilms or budding yeasts finally. The data suggest that C. chinensis has multiple antifungal effects on target fungi resulting in preventing the formation of biofilms. Therefore, C. chinensis holds great promise for exploring antifungal agents from natural products in treating and eliminating biofilm-associated Candida infection.

Oxidative Synthesis of Benzoylpteridines from Benzylpteridines by Potassium Permanganate

김연희,강용한,백대진,Kim, Yeon Hui,Gang, Yong Han,Baek, Dae Jin Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.2

6- and 7-Benzylpteridine derivatives have been converted to the corresponding 6- and 7-benzoylpteridines by the oxidation reaction with KMnO4. The newly synthesized compounds have been characterized by pKa determinations, UV, and 1H-NMR spectra.

콘텐츠라인-게임넷2005

김연희,Kim, Yeon-Hui 한국데이터베이스진흥원 2005 디지털콘텐츠 Vol.5 No.-

올해로 52회째를 맞는 NCTA(National Cable & Telecommunications Association)의‘내셔널 쇼’가 미국 샌프란시스코 모스코니 센터(Moscone Center)에서 세계 각지에서 몰려든 참관자들로 북적거리는 가운데 지난 지난달 5일까지 3일 동안 개최됐다.

종합병원 간호사의 요통과 직무스트레스

김연희,김영신,안양희,Kim, Yeon-Hee,Kim, Young-Sin,Ahn, Yang-Heui 대한근관절건강학회 2007 근관절건강학회지 Vol.14 No.1

Purpose: The purpose of the study was to identify the relationship between low back pain and job stress in hospital nurses. Method: A descriptive correlation research design was employed. The participants were 355 nurses who worked in a general hospital in W city Kangwon-do and consented to participate in this study. The Visual Analog Scale and job stress scale were used in this study. Analysis included descriptive statistics, t-test, ANOVA, and partial correlation coefficients. Results: Experience of low back pain for nurse in the past was 86.5% and in the present was 67.5% for low back pain which measured an average of 4.4 points for the level of low back pain. The mean score for job stress was relatively low(M=47.2). Job demand, organization system, job instability and conflict in relationships contributed to high stress scores, instead inappropriate compensation, job culture, and job autonomy contributed to low stress. There was a significant relationship between low back pain and job stress. Conclusion: These results suggest that further research is needed to develop programs to prevention and management of low back pain for nurses.

약시에서 간헐적 아트로핀 처벌치료와 부분 가림치료 효과의 전향적 비교

김연희,최미영,Youn Hui Kim,Mi Young Choi 대한안과학회 2008 대한안과학회지 Vol.49 No.6

Purpose: The objective of this study was to compare prospectively the efficacy between intermittent atropine penalization and part-time occlusion therapy for amblyopia in patients younger than 10 years old. Methods: The patients with newly diagnosed amblyopia were randomly assigned to either atropine penalization (Group A) or occlusion therapy (Group O). One drop of atropine was instilled into the sound eyes of patients in group A twice per week, while each patient in group O underwent daily patching for 6 hours in their sound eyes. The minimum follow-up time was 3 months after treatment. Best corrected visual acuity and compliance were compared for both groups. Results: A total of 43 patients were enrolled in this study, with 18 assigned to group A and 25 to group O. The follow-up period was not significantly different between group A and group O (6.3 and 7.0 months, respectively; p=0.437). The final corrected visual acuity (LogMAR) scores of amblyopic eyes in both groups showed significant improvement in the visual acuity of amblyopic eyes compared with that at baseline (0.28 in group A and 0.19 in group O). Group A had a higher level of compliance than group O (97.0 and 91.5%, respectively; p=0.007). There was no difference in the groups with regard to visual acuity in amblyopic eyes, which showed similar improvement (3.5:3.4 lines, respectively; p=0.867). Conclusions: This study shows that for treating amblyopia in children younger than 10 years old, intermittent atropine penalization seems to be as effective as part-time occlusion. J Korean Ophthalmol Soc 49(6):958-966, 2008