뇌 혈관의 아급성 색전증을 동반한 중증 난소과자극 증후군 1례

김승현,강경화,양윤석,황인택,박준숙,김정현,김진섭,Kim, Seung-Hyun,Kang, Kyoung-Hwa,Yang, Yun-Seok,Hwang, In-Taek,Park, Jun-Suk,Kim, Jeong-Hyun,Kim, Jin-Sub 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.2

난소과자극 증후군 (Ovarian Hyperstimulation, OHSS)은 배란 유도의 가장 심각한 합병증 중의 하나로서 난소 비대, 복수, 흉수, 심막 삼출액, 혈액 농축, 전해질 이상 및 혈전증 등의 증상을 초래하는 것으로 알려져 있다. 특히 난소과자극 증후군 환자에서 혈전 색전증의 발생은 적절한 치료에도 불구하고 발생하고 예측이 어렵고 환자를 사망에 이르게 할 수도 있기에 가장 위험한 합병증 중의 하나로 인식되고 있다. 저자들은 체외수정 시술 후 중증 난소과자극 증후군 환자에서 본원 입원 치료 중 합병된 색전증에 대한 증례를 경험하였기에 보고하는 바이다. Ovarian hyperstimuation syndrome (OHSS) is the most serious complication of controlled ovarian stimulation. It causes symptoms such as, ovarian enlargement, ascites, pleural effusion, pericardial effusion, hemoconcentration, electrolyte imbalance, and thromboembolism. Although proper management is done, thromboembolism could occur and is difficult to predict. Moreover it can cause death. Consequently thromboembolism is the most dangerous complication of OHSS. We experienced a OHSS patient with thromboembolism of the brain after having IVF-ET.

언양-밀양 간 국도24호선 석남고개 주변부 절토사면 지반특성

김승현,구호본,이종현,김승희,Kim. Seung-Hyun,Koo. Ho-Bon,Rhee. Jong-Hyun,Kim. Seung-Hee,Kim. Jin-Hwan,Son. Young-Jin 한국방재학회 2008 한국방재학회 학술발표대회논문집 Vol.2008 No.1

울산광역시 울주군 상북면에서 경상남도 밀양시 산내면을 잇는 국도 24호선은 왕복 2차선으로 기존 도로의 선형이 매우 불량하고, 위험절토사면이 집중적으로 분포되어 있다. 2002년에는 관련기관과의 연계로 울주-밀양 간 국도 24호선의 도로절토사면에 대한 현황조사가 실시되었으며, 그 중 57개소 현장은 위험절토사면으로 분류하여 추가적인 상세 현장조사가 실시되었으며, 불연속면의 방향에 관한 다양한 정보들이 취득되었다. 2002년에는 관련기관과의 연계로 울주-밀양 간 국도 24호선의 도로절토사면에 대한 현황조사가 실시되었으며, 그 중 57개소 현장은 위험절토사면으로 분류하여 추가적인 상세 현장조사가 실시되었으며, 불연속면의 방향에 관한 다양한 정보들이 되었으며, 이에 대한 길이별, 경사별 분포현황, 불연속면 발달상태 등 여러제반 특성을 살펴 보았다. National Road No.24 connects Ulju-gun in Ulsan Metropolitan City and Milyang city in south Gyongsang Province. The width of the road is small and narrow and many of the dangerous cut slopes are distributed along the way. In 2002, the government officer carried on the brief exploration about road cut slopes, and KICT conduct a detailed additionally investigations 57 dangerous cut slope sites of them. We gained a variety of information of the each slope such as length, slope, discontinuites et al.

강변여과에서 파일럿규모 수평집수관의 수두분포 연구

정재민(Jae Min Jeong),박재영(Jae Young Park),이종진(Jong Jin Lee),김용운(Yong Woon Kim),김승현(Seung Hyun Kim) 大韓環境工學會 2013 대한환경공학회지 Vol.35 No.5

강변여과용 수평집수관을 모사하는 파일럿 규모의 모래통 실험을 수행하였으며, 다양한 출구유속에 대한 수평집수관에서의 수두분포를 구하였다. Kim24)이 수행한 실험실 규모의 수평집수관에서의 손실수두에 Kim25)이 개발한 이론 즉, 작은 규모의 수평집수관에서의 손실수두로부터 큰 집수관의 손실수두를 계산하는 방법을 적용하여 본 연구의 관측치와 비교함으로써 Kim25)의 이론이 타당함을 알 수 있었다. 또한, 이들의 이론을 적용하여 본 연구에서의 관측치로부터 실규모 집수관에서의 수두분포를 구하는 방안을 예를 들어 설명함으로써 강변여과의 수평집수관 설계방법을 제시하였다. A pilot-scale sand-box experiment simulating a lateral of collector well used in riverbank filtration was performed, and hydraulic head distributions along the lateral were measured according to the various drawdowns at the well. The results of this experiment were compared to the predicted values obtained using a theory previously developed by Kim25) in order for its validation. This theory predicts the head loss in a large-scale lateral given the loss in a small-scale one, and to have actual values for comparison, the results from a lab-scale experiment previously performed by Kim24) were employed. Comparing the experimental values to the extrapolated value indeed confirmed the validity of the theory. A procedure to determine the hydraulic head distribution of a practical-scale lateral was also presented applying the theory to the experimental result of this study in an effort to show the process of lateral design for riverbank filtration.

천골 및 골반골에 발생한 거대세포종에 대한 동맥 색전술 치료의 효용성 분석

김승현,윤길성,조용진,신규호,서진석,양우익,Kim, Seung Hyun,Yoon, Gil Sung,Cho, Yong Jin,Shin, Kyoo-Ho,Suh, Jin-Suck,Yang, Woo-Ick 대한근골격종양학회 2013 대한골관절종양학회지 Vol.19 No.2

목적: 천골 및 골반골에 발생한 거대세포종에 대한 동맥 색전술의 효용성을 규명하고자 하였다. 대상 및 방법: 1996년 12월부터 2008년 5월까지 연속적 동맥 색전술을 시행한 9예를 대상으로 그 임상 결과 및 동맥 색전술에 대한 거대세포종의 치료 반응성을 후향적으로 분석하였다. 결과: 9예 중 6예에서 거대세포종이 진행되어 연속적 동맥 색전술은 천골 및 골반골 거대세포종 치료에 있어서 효과적인 치료 방법은 아닌 것으로 나타났다. 5예의 경우에서는 수술, 방사선 치료 등의 추가적인 치료를 시행 했음에도 불구하고 거대세포종이 진행되었다. 9예 중 3예에서 거대세포종의 호전 및 완치 소견을 보여, 카이제곱 검정을 통해 이와 관련된 인자들에 대해 분석하였다. 첫 혈관조영술 시행 시 거대세포 종양의 영양 혈관수가 6개 미만인 경우(p=0.048), 측부 순환의 개수가 3개 미만인 경우(p=0.048) 만이 동맥 색전술에 대한 치료 반응성과 연관이 있는 것으로 나타났으며, 첫 동맥 색전술 시행 후 잔존 종양 염색 유무와 반복 시행 횟수는 연관이 없었다. 결론: 천골 및 골반골 거대세포종의 치료에 있어서 연속적 동맥 색전술은 일반적으로 사용될 수 있는 효과적인 치료 방법은 아니나, 첫 혈관 조영술 시행 시 종양의 혈관 분포가 적은 경우에 한해서 시행한 다면 좋은 치료 결과를 기대할 수 있다. Purpose: The purpose of this study is to determine the usefulness of arterial embolization on sacral and pelvic giant cell tumor (GCT). Materials and Methods: We retrospectively reviewed the medical records of 9 patients who had undergone serial arterial embolization between December 1996 and May 2008. We analyzed the clinical outcomes and therapeutic responsiveness of arterial embolization on sacral and pelvic GCT. Results: Six of 9 cases showed progression of disease (PD) status, even if 5 cases showed PD status despite of additional treatments including surgery and radiation, implying that serial arterial embolization on sacral and pelvic GCT is not effective. Three of 9 cases showed stable disease (SD) or continuous disease free (CDF) status and we analyzed associated factors with these good responses for embolization by ${\chi}^2$ test. The number of feeding vessels under six (p=0.048) and the number of collateral arterial supply under three (p=0.048) in the first angiogram showed significant relationships with good response for embolization, while remaining tumor staining by contrast after the first embolization and repeated embolization times were not significant. Conclusion: Although serial arterial embolization is not an effective modality on sacral and pelvic giant cell tumors, it may be a pilot modality under narrow indication of tumors with poor vascularity at first angiogram.

피로 및 응력부식균열에 의한 원전 배관의 복합누설확률 평가

김승현,나시물 고니,장윤석,장창희,Kim, Seung Hyun,Goni, Nasimul,Chang, Yoon-Suk,Jang, Changheui 한국압력기기공학회 2015 한국압력기기공학회 논문집 Vol.11 No.2

In the present study, complex leakage probabilities of nuclear pipes due to fatigue and stress corrosion cracking are evaluated by using the PINTIN(Piping INTegrity INner flaws) that is developed based on the existing PRAISE(Piping Reliability Analysis Including Seismic Events) program. With regard to the aging and crack instability, small leak and big leak probabilities are calculated for several pipes in a reactor coolant system of domestic nuclear plant. Moreover, sensitivity analysis is also performed to find out the effect of parameters for the leakage of pipes, which shows the coolant temperature is the most influencing parameter.

감정평가업에 있어서 서비스 요인과 고객만족의 관계에 대한 고찰

김승현,민규식,Kim, Seung-Hyun,Min, Gu-Sik 한국전자통신학회 2012 한국전자통신학회 논문지 Vol.7 No.3

The future of appraisal industry looks negative in the reality of change of the property market and over-competition of the field. Unless Constituent members of appraisal industry cope actively with the changing circumstances the profit structure of their company will get worse and they will finally fall behind in the competition. The best policy to survive from the changing circumstances in the limited appraisal market is to provide better service and improve its structure in order to have differential competitiveness. The purpose of this study is to describe the relation between the service factors of appraisal industry and customer satisfaction for providing more effective and high quality appraisal service. 감정평가업계도 근래 부동산 시장의 장기침체와 더불어 평가시장의 축소 및 그에 따른 과당경쟁이 심화되고 있다. 감정평가업에 있어 서비스 요인은 공정성, 객관성, 충실성, 공시업무 수행능력, 연구개발 기여도 등이 있으며 평가업계는 최상의 감정평가를 통하여 고객의 만족도를 높이고 이러한 노력은 고객의 평가를 통하여 감정평가 산업이 지속적으로 발전할 수 있게 할 것이다.

정신분열증환자에서 Haloperidol 투여에 따른 임상효과와 혈장 Homovanillic Acid의 농도 및 혈장 5-Hydroxyindoleacetic Acid 농도와의 관계

김승현,이민수,곽동일,Kim, Seung Hyun,Lee, Min Soo,Kwak, Dong Il 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

The Purposes of this study were to examine plasma homovanillic acid(pHVA) levels and 5-hydroxyindoleacetic acid(pHIAA) levels in schizophrenics during haloperidol treatment, and to assess the association of pHVA and pHIM levels with their psychopathology and treatment responses. Fourteen patients entered the study and pHVA, pHIAA levels were measured at baseline, first week, second week and fourth week during treatment. Also, plasma haloperidol levels were measured at first week, second week and fourth week. Psychopathology was evaluated with Brief Psychiatric Rating Scale(BPRS) at baseline, 1st week, 2nd week and 4th week. 1) There were significant differences on the duration of illness and total BPRS scores at baseline between higher pHVA group(baseline pHVA level >7.72ng/mL) and lower pHVA group(baseline pHVA level <7.72ng/mL). 2) There was no significant difference on the duration of illness between higher pHIM group(baseline pHIAA level >3.18ng/mL). and lower pHIAA group(baseline pHIAA level <3.18ng/mL). 3) The Means of pHVA levels at 1 st week and 2nd week after treatment decreased significantly in the higher pHVA group and did not change in the lower pHVA group. 4) In the higher pHIAA group, the mean of pHIAA levels at 4th week after treatment decreased significantly, but did not change in the lower pHIAA group. 5) Between the higher pHIVA group and lower pHVA group, the response rates(percentile improvement) after treatment were not different from each other, but there was significant difference on the response rate between the lower pHIAA group and higher pHIM group at 2nd week. 6) There was significant correlation between total BPRS scores and pHVA levels in the higher pHVA group during treatment. The results suggest that repeated measurement of pHVA levels and pHIAA levels following antipsychotic treatment have prognostic significance for response. Also, shcizophrenics whose have relatively nigh levels of pHVA, or relatively low levels of pHIAA before treatment will show a favorable early responses to antipsychotics.

정신과약물의 혈중농도 측정방법 및 임상적 적용 : 항우울제를 중심으로

김승현,이민수,Kim, Seung Hyun,Lee, Min Soo 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

Therapeutic montitoring of drugs is a well established clinical 1001. However, the state of art is somewhat less advanced for psychotrpoic agents than it is for other classes of drugs, for several reasons. Most psychotropics have large volumes of distribution and achieve relatively low plasma concentrations following therapeutic doses. Many have one or more active metabolites. As a consequene, the analytical methodologies are often complex and not always reliable; well-controlled clinical studies are difficult to perform; and therapeutic ranges have been difficult to establish. Despite these limitations, prudent and selective monitoring of serum drug concentrations, particularly of the tricyclic antidepressants can be helpful in clinical management. This paper presents an overview of clinical and mothodological issues surrounding the utility of blood level measurement.

가림치료에 반응하지 않는 난치성 약시에서 도파민 약물치료의 효과

김승현,신형호,고성범,조윤애,Seung Hyun Kim,Hyoung Ho Shin,Seong Bum Koh,Yoonae A,Cho 대한안과학회 2006 대한안과학회지 Vol.47 No.3

Purpose: This study was undertaken to evaluate the effect of L-dopa in amblyopic children for whom occlusion treatment failed. Methods: We studied nine amblyopic children (11 eyes) for whom part-time occlusion (4~8 hours/day) treatment for a minimum period of 6 months had failed. The types of amblyopia included: anisometropic (1 patient, 1 eye), stimulus deprivation (4 patients, 6 eyes) and mixed (anisometropic and strabismic: 2 patients, 2 eyes; anisometropic and organic: 2 patients, 2 eyes). Best corrected visual acuity before treatment was between 0.05 and 0.5. They received, with full informed consent of the parent, levodopa (2~4 mg/kg) for 8 weeks combined with part-time occlusion. Results: The children were between 4 and 11 years old (mean 5.8±2.05). Of the subjects, 45.5% (4 patients, 5 eyes) had improved visual acuity after 8 weeks of treatment. In one patient with anisometropic, two patients with mixed (anisometropic and strabismic), and one patient with stimulus deprivation (ametropic) amblyopia, visual acuity improved by one to five lines. Conclusions: In anisometropic, strabismic amblyopes and mild deprivational amblyopes for whom occlusion treatment failed, L-dopa improved visual acuity. L-dopa may be an additional option for treatment of amblyopic patients with a guarded visual prognosis.

학습과 기억에서 NMDA 수용체의 역할

김승현,신경호,Kim, Seung-Hyun,Shin, Kyung-Ho 대한수면의학회 2000 수면·정신생리 Vol.7 No.1

To investigate the neurobiological bases of learning and memory is one of the ambitious goals of modern neuroscience. The progress in this field of recent years has not only brought us closer to understanding the molecular mechanism underlying long-lasting changes in synaptic strength, but it has also provided further evidence that these mechanisms are required for memory formation. Since twenty years ago, several studies for the tests of the hypothesis that NMDA-dependent hippocampal long-term potentiation(LTP) underlies learning have been reported. Also, in the recent year, data from mutant mice showed that a potential role for NMDA-dependent LTP in hippocampal CA1 and spatial learning. Although the current evidence for the role of NMDA receptor in learning and memory is not still obvious, NMDA receptor seems to act as a critical switch for activation of a cascade of events that underlie synaptic plasticity.