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김성환,임정현,박나형,문창종,박수현,강성수,배춘식,김성호,신동호,김종춘,Kim, Sung-Hwan,Lim, Jeong-Hyeon,Park, Na-Hyeong,Moon, Changjong,Park, Soo-Hyun,Kang, Seong-Soo,Bae, Chun-Sik,Kim, Sung-Ho,Shin, Dong-Ho,Kim, Jong-Choon 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.2
This study investigated the potential effects of amitraz on the pre- and postnatal development, behavior, and reproductive performance of offspring of parent rats given amitraz during pre-mating, gestation, and lactation. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and lactation up to weaning. Based on fluid consumption, the male rats received an average of $0,\;5.7{\pm}1.33,\;13.2{\pm}2.08,$ and $35.8{\pm}3.42$ mg/kg/day amitraz, and the female rats received an average of $0,8.7{\pm}4.42,\;20.1{\pm}9.60,\;and\;47.6{\pm}22.38$ mg/kg/day amitraz, respectively. At 360 ppm, an increase in the incidence of abnormal clinical signs, a suppression in the body weight gain, a decrease in the food consumption and litter size, an increase in the post-implantation loss, and a decrease in the seminal vesicle weight were observed in the parent animals. In addition, a suppression in the body weight gain, a decrease in the grip strength, a delay in the negative geotaxis, an increase in the pre- and post-implantation loss, and a decrease in the number of live embryos were observed in the offspring. At 120 ppm, suppressed body weight gain and reduced food consumption were observed in the parent rats. Suppressed body weight gain and decreased grip strength were also observed in the offspring. There were no signs of either reproductive or developmental toxicity at 40 ppm. Under these experimental conditions, the no-observed-adverse-effect level of amitraz for parent rats and their offspring was estimated to be 40 ppm in rats.
알루미노 실리케이트계 내화보드와 C-STUD를 이용한 고강도 콘크리트의 내화성능
김성환,박지선,이세현,Kim, Seong-Hwan,Park, Ji-Sun,Lee, Sea-Hyun 대한건축학회 2011 대한건축학회논문집 Vol.27 No.11
As high-rise buildings are increasingly constructed on recent days, high-strength concrete is also increasingly used. However, since high-strength concrete happens to have a spalling phenomenon, it is currently required to ensure the fire safety of high-strength concrete as soonest as possible. Therefore, a number of research and development projects are in progress for developing a construction method to ensure the fire-proofing performance of high-strength concrete. In this study, discussion has been done on the fire-proofing performance of the member which was constructed by dry-covering high-strength concrete with alumino-silicate fire resistant board and C-STUD.
김성환,반태원,정방철,Kim, Seong Hwan,Ban, Tae Won,Jung, Bang Chul 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.7
최근 다수의 노드가 하나의 접속점 (AP) 혹은 기지국에 접속하는 시나리오에서 주파수 효율 및 신뢰도를 증가시켜야 할 필요성이 높아지고 있다. 본 논문은 두 개의 노드가 하나의 수신자에게 접속하는 다중 접속 (Multiple access) 시나리오를 고려한다. 기존의 할당된 자원 전체에 다수의 송신 노드의 신호를 전송하는 방식 대신, 본 논문에서는, 할당된 자원 중에서 일부의 자원만을 두 송신 노드가 공유하는 부분 다중화 방식을 고려한다. 각 노드가 할당 받은 자원 중에서 다른 노드와 공유하는 자원의 비율을 $R_s$라 하고, $R_s$에 대한 성능 분석 및 최적화를 수행한다. 근사된 BER 식을 통하여, 수율을 계산하고, 수율을 최대화 하는 $R_s$는 1 혹은 0의 값만을 갖음을 보인다. 또한 프레임 에러율 (FER) 값에 제한을 둘 때, $R_s$는 0과 1 사이의 값을 가질 수 있음을 보이고, 그것을 만족하는 $R_s$의 근사값을 닫힌 형태로 구한다. 부분 다중화는 새로운 다중 접속 방식이 될 수 있다. Recently, spectral efficiency or reliability is required to be improved in the scenario of multiple access. In this paper, we consider a scenario where two source nodes access one destination node. Different with conventional multiple access studies, in our research, a part of the allocated resource is shared by two source nodes and this scheme is called partial multiplexing. Let $R_s$ denote the ratio of the amount of the shared resource to that of the resource allocated to each user. We analyze and optimize the performance of the partial multiplexing in term of $R_s$. We show that the optimal $R_s$ to maximize the throughput is 1 or 0 based on approximated bit error rate (BER). In addition, if we set a constraint on frame error rate (FER), $R_s$ can have a value between 0 and 1. We also find the approximated $R_s$ to meet the constraint as a closed form. Partial multiplexing can be a novel multiple access scheme.
인체 혈구암세포에 대한 단선탕(丹仙湯) 추출물의 증식억제 및 세포사멸 유도에 관한 연구
김성환,박상은,홍상훈,Kim, Seong-Hwan,Park, Sang-Eun,Hong, Sang-Hoon 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.4
Objectives : This study investigated the biochemical mechanisms of anti-proliferative and pro-apoptotic effects of the water extract of Dan-Seon-Tang (DST) in human leukemia U937 cells. Methods : U937 cells were exposed to DST and growth inhibition was measured by MTT assay. Results : Exposure of U937 cells to DST resulted in the growth inhibition in a concentration-dependent manner. This inhibitory effect was associated with morphological changes and apoptotic cell death such as formation of apoptotic bodies, increased populations of apoptotic-sub G1 phase and induction of DNA fragmentation. The induction of apoptotic cell death in U937 cells by DST was associated with up-regulation of death receptor 4 (DR4) and down-regulation of Bid, surviving and cellular inhibition of apoptosis protein-2 (cIAP-2) expression. DST treatment also induced the proteolytic activation of caspase-3, caspase-8 and caspase-9, and a concomitant degradation of caspase-3 substrate proteins such as poly (ADP-ribose) polymerase (PARP), phospholipase (PLC)-${\gamma}1$, ${\beta}$-catenin and DNA fragmentation factor 45/inhibotor of caspase activated DNAse (DFF45/ICAD). Furthermore, apoptotic cell death by DST was significantly inhibited by caspase-3 specific inhibitor z-DEVD-fmk, demonstrating the important role of caspase-3. Conclusions : These findings suggest that herb prescription DST may be a potential chemotherapeutic agent for the control of human leukemia U937 cells; further study is needed to identify the active compounds.