Diode-Laser-Based Protable Thermal Lensing Spectroscopy System with Optical Fiber

김성호,Kim, Sung-Ho Korean Chemical Society 1997 Bulletin of the Korean Chemical Society Vol.18 No.1

ICR 마우스에서 방사선 조사 용량에 따른 혈액변화의 관찰

김성호,이종환,김세라,이해준,이윤실,김태환,류시윤,조성기,안미영,Kim, Sung-Ho,Lee, Jong-Hwan,Kim, Se-Ra,Lee, Hae-June,Lee, Yun-Sil,Kim, Tae-Hwan,Ryu, Si-Yun,Jo, Sung-Kee,An, Mi-Yeong 대한수의학회 2002 大韓獸醫學會誌 Vol.42 No.2

The effects of ionizing radiation on the peripheral blood elements of ICR mouse were examined after varying doses of whole-body gamma-irradiation. ICR mice (n=50) were exposed to 0, 2, 4, 6 and 8 Gy gamma-ray ($^{60}Co$) at 10 Gy/min. The animals were studied for their hematological response on days, 3, 7, 14, 21, 42 and 56 post irradiation. No significant change was noted in erythrocyte, hemoglobin and hematocrit values after irradiation with dose of 2 Gy. Decreasing erythrocyte, hemglobin and hematocrit values occured after irradiation with doses of more than 4 Gy on day 7 after irradiation followed by a sharp fall on day 14. A recovery in these values was noted after 3 weeks of irradiation. Thrombocyte counts decreased on day 3, reaching minimal values on day 7. The total number of leukocytes was reduced on day 3, mainly because of a decrease in the lymphocyte population. An evident lymphopenia and neutropenia occur almost on the day 3 and last up to the day 28 after irradiation. All of the hematological values decreased in the blood in a dose-dependent manner at the same time.

SHA-3 해쉬함수 소비전력 특성 분석 및 저전력 구조 기법

김성호,조성호,Kim, Sung-Ho,Cho, Sung-Ho 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.1

Cryptographic hash functions are also called one-way functions and they ensure the integrity of communication data and command by detecting or blocking forgery. Also hash functions can be used with other security protocols for signature, authentication, and key distribution. The SHA-1 was widely used until it was found to be cryptographically broken by Wang, et. al, 2005. For this reason, NIST launched the SHA-3 competition in November 2007 to develop new secure hash function by 2012. Many SHA-3 hash functions were proposed and currently in review process. To choose new SHA-3 hash function among the proposed hash functions, there have been many efforts to analyze the cryptographic secureness, hardware/software characteristics on each proposed one. However there are few research efforts on the SHA-3 from the point of power consumption, which is a crucial metric on hardware module. In this paper, we analyze the power consumption characteristics of the SHA-3 hash functions when they are made in the form of ASIC hardware module. Also we propose power efficient hardware architecture on Luffa, which is strong candidate as a new SHA-3 hash function. Our proposed low power architecture for Luffa achieves 10% less power consumption than previous Luffa hardware architecture. 해쉬함수는 데이터와 명령에 대한 위변조를 방지와 같은 무결성 제공하거나 서명이나 키 분배 등 다양한 보안 프로토콜에서 서명 및 인증, 키 분배 목적으로 많이 사용되는 일방향성 함수(one-way function)다. 2005년 Wang에 의해 암호학적 취약성이 발견되기까지 해쉬함수로는 SHA-1이 많이 사용 되었다. SHA-1의 안전성에 문제가 생기게 되자 NIST(National Institute of Standards and Technology)에서는 암호학적으로 안전한 새로운 해쉬함수 개발 필요성을 느껴 2007년 11월에 공개적으로 새로운 해쉬함수에 대한 공모를 시작했으며, SHA-3로 명명된 새로운 해쉬함수는 2012년 최종 선정될 예정이다. 현재 제안된 SHA-3 함수들에 대한 암호학적인 특성과 하드웨어로 구현했을 때의 하드웨어 복잡도, 소프트웨어로 구현했을 때의 성능 등에 대한 평가가 이뤄지고 있다. 하지만 하드웨어로 구현된 해쉬함수의 중요한 특성 평가 척도(metrics)인 소비 전력 특성에 대한 연구는 활발히 이뤄지지 않고 있다. 본 논문에서는 제안된 SHA-3 해쉬함수를 하드웨어로 구현했을 경우의 소비 전력 특성을 분석하고 소비전력 특성 분석 결과를 토대로 SHA-3 해쉬함수 중에서 새로운 SHA-3 해쉬함수로 선정될 확률이 높은 Luffa 함수에 대한 저전력 구조를 제안한다. 제안된 저전력 구조는 기존의 Luffa 하드웨어보다 약 10% 정도 적은 전력을 소비함을 보인다.

폐사한우에서 검출된 Buxtonella sulcata 섬모충 감염예

김성호,김태환,이차수,정시식,Kim Sung Ho,Kim Tae Hwan,Lee Cha Soo,Jyeong Jong Sik 대한수의사회 1993 대한수의사회지 Vol.29 No.12

As three years old Korean Cattle was examined pathologically to elucidate the case of acute death, Buxtonella sulcata, ciliated parasites, were present and the results are followed, This cow had anemia, ulcer and appearance of parasites in colon accompani

치주질환 심도와 치은 열구액 내 Arylsulfatase에 관한 연구

김성호,김형섭,Kim, Sung-Ho,Kim, Hyung-Sob 대한치주과학회 1990 Journal of Periodontal & Implant Science Vol.20 No.1

대표적 근류 생약의 방사선 방호효과

김성호,오헌,김세라,조성기,변명우,김길수,이종환,신동호,Kim, Sung-ho,Oh, Heon,Kim, Se-ra,Jo, Sung-kee,Byun, Myung-woo,Kim, Kil-soo,Lee, Jong-hwan,Shin, Dong-ho 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.1

We performed this study to determine the effect of Jiegeng(Platycodon grandiflorum), Danggui(Angelica sinensis), Gancao(Glycyrrhiza glabla), Chaihu(Bupleurum falcatnosa), Shoudehuang(Rehmannia glutinosa), Huangqi(Satragalus membranaceus), Muxiang(Saussurea lappa), Yuanzhi(Polygala tenuifolia), Rensen(Panax ginseng) and Baishaoyao(Paeonia lactiflolia), as Oriental radices herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}-radiation$. Jiegeng(p<0.005), Danggui(p<0.0005), Gancao(p<0.005), Chaihu(p<0.05), Muxiang(p<0.05), Rensen(p<0.005) and Baishaoyao(p<0.005) were effective in intestinal crypt survival. Danggui(p<0.05), Chaihu(p<0.05), Shoudehuang(p<0.05), Huangqi(p<0.05), Rensan(p<0.005) and Baishaoyao(p<0.05) increased the formation of endogenous spleen colony. The frequency of radiation induced apoptosis was also reduced by pretreatment with Chaihu(p<0.05), Muxiang(p<0.005), Yuanzhi(p<0.05), Rensan(p<0.05) and Baishaoyao(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Danggui, Chaihu, Muxiang, Rensan and Baishaiyao might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

트리아졸로피리미딘계 유도체에 의한 보리 Acetolactate Synthase의 저해

김성호,남궁성건,신정휴,장수익,최정도,Kim, Sung Ho,NamGoong, Sung Keon,Shin, Jung Hyu,Chang, Soo Ik,Choi, Jung Do 대한화학회 1999 대한화학회지 Vol.43 No.4

Acetolactate synthase (ALS)는 가지를 가진 필수아미노산 Val, Leu, Ile의 생합성 과정에서 공통적으로 작용하는 효소이다. ALS는 서로 구조적 유사성이 없는triazolopyrimidine, imidazolinone,sulfonylurea, 그리고 pyrimidyl-oxy-benzoate 제초제들의 공통적인 작용 표적이다. 보리로부터 부분 정제한 ALS를 이용하여 새로이 합성한 triazolopyrimidine sulfonamide 유도체들의 저해 활성을 측정하였다. 활성을 가진 유도체들의 $IC_{50}$ 값은 0.5nM∼8${\mu}M$ 범위였으며, 그 중에서 탁월한 저해 활성을 갖는 것은 TP1과TP2 유도체로 $IC_{50}$ 값은 각각 0.5 nM과 1.6 nM이였다. 이 저해제들은 기존의 상품화된 제초제인 Metosulam ($IC_{50}$;3.6 nM), Flumetsulam ($IC_{50}$;126 nM), 그리고 Cadre ($IC_{50};4 {\mu}M$)에 비해 보리 ALS에 대한 저해 활성이 보다 우수하였다. 보리 ALS에 대한 TP2의 저해 활성은 반응시간이 증가함에 따라 증가하였고, 혼합형 저해 유형을 보였다. TP2와 imidazolinone 계열의 제초제인 Cadre, 그리고 되먹임(feedback) 저해제인 Leu에 대한 이중저해 (dual inhibition) 실험 결과 TP2와 Cadre의 경우는 평행한 반응속도론적 형태가 그러나 TP2와 Leu의 경우는 한 점에서 만나는 반응속도론적 헝태가 얻어졌다. 이는 TP2와 Cadre의 결합 부위가 최소한 부분적으로 중복되고 있음을 시사한다. Cys 잔기에 대한 화학적 변형은 TP2와 Cadre의 결합에는 영향을 미치지 않으나, Leu의 결합에는 영향을 미쳤다. Acetolactate synthase (ALS) catalyzes the first common reaction in the biosynthesis of branched-chain amino acids, valine, leucine, and isoleucine. ALS is the common target of several classes of structurally diverse herbicides, the triazolopyrimidines, the imidazolinones, the sulfonylureas, and pyrimidyl-oxy-benzoates. We examined ihibitory activities of newly synthesized triazolopyrimidine sulfonamide derivatives using partially purified ALS from barley. $IC_{50}$ values for the active derivatives are 0.5nM∼8$\mu$M. Among them TP1 and TP2 are the most potent ALS inhibitors with $IC_{50}$ values of 0.5nM and 1.6nM, respectively. These inhibitors are more potent in the inhibition of barley ALS than commercial herbicides, Metosulam ($IC_{50}$;3.6 nM), Flumetsulam ($IC_{50}$;126 nM), and Cadre ($IC_{50};4 {\mu}M$). The progress curves for inhibition of ALS by TP2 showed that the amount of inhibition increases with time. The inhibition of ALS by TP2 was mixed-type inhibition with respect to pyruvate. Dual inhibition analyses of TP2 versus an imidazolinone, Cadre, and Leu showed parallel and intercepting kinetic pattern, respectively. The results suggest that TP2 binds to ALS competively with Cadre but not with Leu. Chemical modification of cysteinly residues in ALS decreased the sensitivity of ALS to Leu, while the modification did not affect the sensitivity of ALS to TP2 and Cadre.

자외선 B 조사 hairless 마우스에서 일광화상세포 발생 억제에 대한 녹차의 효과

김성호,김세라,이해준,이진희,김유진,김종춘,장종식,조성기,Kim, Sung-ho,Kim, Se-ra,Lee, Hae-june,Lee, Jin-hee,Kim, Yu-jin,Kim, Jong-choon,Jang, Jong-sik,Jo, Sung-kee 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.1

In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal cells by apoptotic sunburn cell (SBC) and the effect of green tea treatment on the inhibition of SBC formation in SKH1-hr mouse. The extent of changes following $200mJ/cm^2$ (0.5 mW/sec) was studied at 0, 3, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were recognized by 3 hours after irradiation. There was tendency to increase from 3 hours to 24 hours and decrease from then to 36 hours after irradiation. The mice that received 0, 25, 50, 100, 200, 400 or $800mJ/cm^2$ of UVB were examined 24 hours after irradiation. The SBCs were induced as the radiation dose increases from 0 to $200mJ/cm^2$. A further increase of radiation dose has little further effect. The frequency of UVB ($200mJ/cm^2$)-induced SBC formation was reduced by intraperitoneal injection of green tea extract (p<0.01).

A New Auto-Localization Scheme in Sensor Networks

김성호,장총위,Kim, Sung-Ho,Zhang, Cong Yi Institute of Control 2008 제어·로봇·시스템학회 논문지 Vol.14 No.9

Many sensor network applications require that each node's sensor data stream be annotated with its physical location in some coordinate system. Equipping GPS on every sensor node is often expensive and does not work in indoor deployments. Recently, cricket-based localization system is often used for indoor localization system. It is very important to know the exact position of beacons in cricket-based localization system for identifying moving sensor node's position. In this paper, a new method, Mobile Listener Detect Algorithm (MLD) which can automatically calculate the unknown newly installed beacons is proposed. For the verification of the feasibility of the proposed scheme, we have conducted several experiments.

The effect of caffeine on promotion step of diethylnitrosamine-initiated hepatic altered foci in a mid-term induction system

김성호,이차수,Kim, Sung-ho,Lee, Cha-soo The Korean Society of Veterinary Science 1992 大韓獸醫學會誌 Vol.32 No.4

Caffeine이 랫드의 간조직에서 diethylnitrosamine(200mg/kg B.W., DEN)에 의해 유도되는 preneoplastic altered foci형성의 promotion단계에 미치는 효과를 관찰한 바 다음과 같은 결과를 얻었다. Altered foci의 지표로 사용되는 glutathione S-transferase(GST-P)-positive foci의 수는 caffeine 음수 $m{\ell}$당 2mg 병행투여군($3.10{\pm}2.74$) 및 1mg병행 투여군($5.86{\pm}2.83$) 모두에서 DEN 단독투여 대조군($11.55{\pm}5.82$)에 비하여 현저히 낮게 나타났으며 면적 또한 caffeine 2mg 병행투여군($0.13{\pm}0.11$), 1mg 병행투여군($0.21{\pm}0.12$)에서 DEN 단독투여 대조군($0.76{\pm}0.33$)에 비하여 유의성있는 낮은 수치가 관찰되었다. 간 세포배양에서 unscheduled DNA synthesis(UDS)는 DEN($250{\mu}g/m{\ell}$ of medium)단독처리군에 비하여 caffeine($200{\mu}g/m{\ell}$ of medium) 처리시 약 70% 감소하였다. 이러한 결과는 caffeine이 간암발생의 promotion단계에 작용하여 억제효과를 나타냄을 암시하며 이는 DNA회복의 억제와 관계됨을 알 수 있었다.