2007년 서울 지역에서 판매되고 있는 반찬류의 세균 오염과 항생제 내성실태

김미진,이도경,장석,양환진,안향미,백은혜,하남주,Kim, Mi-Jin,Lee, Do-Kyung,Jang, Seok,Yang, Hwan-Jin,An, Hyang-Mi,Baek, Eun-Hye,Ha, Nam-Joo 대한약학회 2008 약학회지 Vol.52 No.6

The purpose of this research was to investigate the microbiological quality and antimicrobial susceptibilities of the ready-to-eat side dishes, which are were collected from the grocery stores, big markets, and department stores in Seoul throughout November, 2007. Of total 124 samples, presence of staphylococci and enteric bacilli was observed in 38 samples (31%) and 53 samples (43%), respectively. And 30 samples (24%) were shown to be of unsatisfactory quality for total bacterial count (>$10^5$). Antimicrobial susceptibilities of the staphylococci isolated from the side dishes were tested for six different antimicrobial agents, which are in widespread clinical use in Korea, as well as four new antimicrobials, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline. As a result, the staphylococcal isolates were found to be resistant to oxacillin (${MIC}_{90}$, >128 ${\mu}g$/ml), teicoplanin (${MIC}_{90}$, >128 ${\mu}g$/ml), mupirocin (${MIC}_{90}$, >128 ${\mu}g$/ml), linezolid (${MIC}_{90}$, 128 ${\mu}g$/ ml) and quinupristin/dalfopristin (${MIC}_{90}$, 32 ${\mu}g$/ml). Especially, some of the staphylococcal isolates exhibited high level and multi-drug resistance. Moreover, these bacteria were also resistant to new antimicrobials, except tigecycline.

성격 강점에 기반한 유아교사의 행복 증진 프로그램 적용 및 효과

김미진 ( Mi Jin Kim ),황해익 ( Hae Ik Hwang ) 한국유아교육학회 2015 유아교육연구 Vol.35 No.5

본 연구는 성격 강점에 기반한 유아교사의 행복 증진 프로그램을 유아교사에게 적용하여 그 효과를 검증하고 추후 효과적인 적용을 위한 시사점을 제안하는 데 목적이 있다. 본 연구의 대상은 유아교사 40명으로 실험집단 20명, 통제집단 20명으로 구성되었다. 실험집단에는 주 1회, 2시간씩 13회기의 프로그램을 제공하였으며, 통제집단에는 아무런 처치도 가하지 않았다. 본 연구에서 사용된 측정도구는 다차원적행복척도, 긍정심리치료척도, 영유아교사의 행복측정척도였다. 연구 결과, 모든 종속측정치에서 실험집단과 통제집단 간 유의미한 사후검사 평균 차이가 나타났으며, 집단 간 차이는 4주 후인 추후검사까지 지속되었다. 이를 통해본 연구에서 개발된 성격 강점에 기반한 유아교사의 행복 증진 프로그램이 유아교사들의 행복 증진에 실질적인 기여를 하고, 그 효과가 프로그램 종료 후에도 지속적으로 유지된다는것을 알 수 있었다. The purpose of this study is to apply Kim Mi-jin(2015)’s Character Strengths- Based Happiness Enhancement Program for Early Childhood Teachers to participating early childhood teachers to examine its effect and ultimately to give some suggestions on the effective application of the program. The subjects of this study were 40 early childhood teachers who were 20 teachers in an experimental group and 20 in a control group. The experimental group participated in this program for 13 weeks, once a week and two hour at a time, and the control group did not participate in this program at all. The scales for this study were Multidimensional Measure of Flourishing, Positive Psychotherapy Inventory and Happiness Measurement Scale for Early Childhood Teachers. As a result of this study, there were significant differences in all dependent measures for the post test between the experimental group and the control group and these differences between groups lasted to the retention test which was conducted 4 weeks later after the program application. It confirms that the Character Strengths-Based Happiness Enhancement Program for Early Childhood Teachers, which was developed in this study, is an effective way to enhance early childhood teachers’ happiness and the program remained steadily effective even after completing the program.

차량 내 MOST Network를 이용한 지능형 Navigation 구현

김미진,백성현,장종욱,Kim, Mi-Jin,Baek, Sung-Hyun,Jang, Jong-Wook 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.11

최근 편의성, 안전성, 편리성 등의 키워드가 자동차 시장에서 새로운 화두로 등장하면서 자동차 시장에서 차량 내 전장부분의 중요성이 커지고 있다. 이에 따라 많은 전자기기의 사용이 필수적으로 요구되어지면서 전자기기들 간의 통신이 부각되어지고 있다. 차량 내부에서는 컨트롤러, 센서, 그리고 멀티미디어 기기인 오디오, 스피커, 비디오, 네비게이션 등 다양한 장치들이 CAN이나 MOST와 같은 차량 네트워크를 통해 연결되어 있다. 현재 차량 네트워크는 서로 각각의 목적에 따라 운용되고 관리되어 지고 있다. 본 논문에서는 MOST Network를 이용하여 최근의 키워드가 되고 있는 편의성, 안전성, 편리성 등을 고려한 지능형 자동차에 요구되는 Navigation을 구현하여 차량 내 CAN Network를 제어하는 시스템을 제시하고자 한다. Lately, in the automotive market appeared keywords such as convenience, safety in presentation and increase importance of pan of vehicle. Accordingly, the use of many electronic devices was required essentially and communication between electronic devices is being highlighted. Various devices such as controllers, sensors and multimedia device(audio, speakers, video, navigation) in-vehicle connected car network such as CAN, MOST. Modem in-vehicle network managed and operated as purpose of each other. In this Paper, intelligent car navigation considering convenience and safety implement on MOST Network and present system to control CAN Network in vehicle.

In vitro Screening of Jeju Island Plants for Cosmetic Ingredients

김미진,정택규,김무한,윤경섭,Kim, Mi Jin,Jung, Taek Kyu,Kim, Moo-Han,Yoon, Kyung-Sup Korean Society for Biotechnology and Bioengineerin 2018 KSBB Journal Vol.33 No.2

To identify new active cosmetic ingredients of natural origin, we screened the biological activities of 50 different kinds of plants from Jeju Island, the southernmost island of the Korean Peninsula. In this study, plant extracts were screened for inhibitory effects on elastase, nitric oxide, and melanin production, and for free radical scavenging effects. Eight plants, Viburnum erosum Thunb., Trachelospermum asiaticum var. intermedium Nakai, Sageretia theezans Brongn., Sorbus alnifolia var. hirtella T. Lee, Staphylea bumalda DC., Pourthicea villosa var. brunnea Nak., Illicium religiosum S. et Z., and Castanopsis cuspidata var. sieboldii Nakai were potent inhibitors of elastase (over 80% inhibition at 1 mg/mL). Elaeocarpus sylvestris var. Ellipticus (Thunb.) Hara ($IC_{50}$: $13.99{\mu}g/mL$), Sapium sebiferum (L.) ROXB. ($IC_{50}$: $14.27{\mu}g/mL$), and Castanopsis cuspidata var. sieboldii Nakai ($IC_{50}$: $16.46{\mu}g/mL$) showed good antioxidant effects. Eurya japonica Thunb., Quercus myrsinaefolia Bl., Caesalpinia decapetala var. japonica (S. et Z.) Ohashi, Weigela subsessilis L. H. Bailey, and Crinum asiaticum var. japonicum dose-dependently inhibited LPS-induced NO production on RAW 264.7 cells (at $50-200{\mu}g/mL$). Furthermore, Elaeocarpus sylvestris var. Ellipticus (Thunb.) Hara, Ilex integra Thunb., and Agastache rugosa (Fisch. et Meyer) O. Kuntze dose-dependently inhibited ${\alpha}-MSH$ stimulated melanin synthesis on B16 F10 cells (at $25-100{\mu}g/mL$). These results suggest that Jeju Island plants possess several biological activities and may be potent anti-aging, anti-inflammatory, skin-whitening, and anti-oxidative ingredients as functional cosmetic materials.

헤지의 표준화된 평균차를 이용한 프로폴리스의 항-당뇨 효과

김미진,최기헌,Kim, Mi-Jin,Choi, Ki-Heon 한국데이터정보과학회 2010 한국데이터정보과학회지 Vol.21 No.3

The present study was carried out to summarize the effect of propolis in the diabetic rats by meta-analysis related studies. The association measure to test effect of propolis was Hedges's standardized mean difference between group of rats induced streptozotocin(STZ) or alloxan and group of rats induced STZ or alloxan treated with propolis about the considered 4 effect factors. In this particular fixed-effect model, blood glucose, Cholesterol, Triglyceride were significantly reduce. The case of heterogenous variable such as body weight, blood glucose, cholesterol, triglyceride, random-effect model was applied. In this model, blood glucose, triglyceride were decreased significantly in propolis treated group. According to the meta-regression analysis, period of injection was significant for body weight and blood glucose, cholesterol. 본 연구는 메타분석에서 헤지의 표준화된 평균차를 이용하여 당뇨에 걸린 쥐들에게 프로폴리스를 투여하여 체중, 혈당량, 콜레스테롤, 트리글리세리드의 평균비교를 통해 프로폴리스의 항-당뇨 효과에 대해 알아보았다. 고정효과모형을 적용시킨 결과 혈당량의 감소, 콜레스테롤 농도의 감소, 트리글리세리드 농도의 감소에 대해 유의한 효과를 보였고, 동질성 검정을 통해 동질성을 만족하지 않은 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 혈당량의 감소와 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈다. 또한 프로폴리스의 투여기간과 투여량에 대해 메타회귀분석을 실시한 결과, 투여기간이 체중, 혈당량, 콜레스테롤에 유의한 변수로 나타났다.

타액선 질환의 세침흡인생검에 관한 세포학적 연구

김미진,이태숙,Kim, Mi-Jin,Lee, Tae-Suk 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

Fine needle aspiration biopsy cytology is a widely recognized and useful technique which can provide diagnosis in lesions of the head and neck, enabling appropriate management plans for individual patient to be made. Fifty one fine needle aspirates from salivary gland masses were examined. Four aspirates (8%) were inadequate for examination. Of the remaning 47 samples, 42 cases (82%) were benign lesions which consist of 30 pleomorphic adenoma(58%), 7 inflammatory lesion (14%), 4 Warthin's tumor(8%) and 1 benign lesion(2%). Two cases(4%) were atypical lesions. Three cases(6%) were malignant lesions consisting of 2 adenoid cystic carcinomas(4%) and 1 mucoepidermoid carcinoma (2%). The cytologic diagnoses were compared with the subsequent histologic diagnosis of surgical resected specimen in 24 cases. 19 cases of 21 aspirates from benign tumors were correctly diagnosed by fine needle aspiration cytology, with a specificity of 90%. All 3 aspirates from the 3 patients with malignant tumor were correctly diagnosed by fine needle aspiration cytology, with a sensitivity at 100%. Overall acurracy was 88%. Diagnostic error was encountered in adenoid cystic carcinoma, mucoepidermoid carcinoma and Warthin's tumor Correct histologic diagnosis was made in 86% of benign tumors(84% for pleomorphic adenoma and 100% for Warthin's tumor) and in 100% of malignant tumors.

IP 네트워크에서 IPTV 방송 화질에 관한 연구

김미진,장종욱,Kim, Mi-Jin,Jang, Jong-Wook 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.7

최근 멀티미디어 콘텐츠가 빠르게 확산되고, 초고속 광대역 IP 네트워크 기술이 발전하면서 통신과 방송의 독자적 개별 서비스가 서로 공존하여 통합융합 서비스로 진화발전하고 있다. 대표적 방송/통신 융합 서비스인 IPTV는 통합융합서비스의 가장 강력한 응용분야이며, IPTV와 같은 서비스들이 증가함으로 인해 다양한 인터넷 서비스를 구현하기 위해서 인터넷 프로토콜을 통한 고화질의 데이터 처리에 대한관심이 통신업계의 화두로 등장하고 있다. 본 연구에서는 소규모에서 사용되는 표준 라우팅 프로토콜인, RIP 환경과 대규모 자율 네트워크에서 사용되는 링크 상태 라우팅 프로토콜인, OSPF 환경을 구현하여 IPTV 서비스 중에서 방송 화질의 PSNR값으로 성능을 측정하고 평가하여 효율적인 IPTV 서비스를 위한 네트워크 구축 방안을 제시하고자 한다. The multimedia contents are diffused rapidly. Also, the course individual service of communication and broadcasting coexists with each other and develop to the integrated fusion service with development of the high speed broadband IP network technology. The IPTV which is representative broadcasting a communication total service is the powerful application field. The communication industry has been interested in data processing of the high-definition that supports many kinds of internet service by internet protocol. In this paper, we configure the standard routing protocol use in the small scaled, on RIP environment and the link status routing protocol use the large scale autonomous network, on OSPF environment. We also measure and evaluate broadcasting quality by PSNR(Peak Signal-to-Noise Ratio). Finally, we propose the network construction plan for IPTV services which are efficient.

효율적인 색인어 추출을 위한 합성명사 생성 방안에 대한 연구

김미진,박미성,최재혁,이상조,Kim, Mi-Jin,Park, Mi-Seong,Choe, Jae-Hyeok,Lee, Sang-Jo 한국정보처리학회 2000 정보처리논문지 Vol.7 No.4

The efficiency of thesytem depends upon an accurate extraction capability of index terms in the system of information search or in that of automatic index. Therefore, extraction of accurate index terms is of utmost importance. This report presents the generation methods of composition noun for efficient index term extraction by using words of high frequency appearance, so that the right documents can be found during information search. For the sake of presentation of this method, index terms of composition noun shall be extracted by applying the rule of composition and disintegration to the nouns with high frequency of appearance in the documents, such as those with upper 30%∼40% of frequency ratio. In addition, for he purpose of effecting an inspection of validity in relation to a composition of high frequency nouns such as those with upper 30∼40% of frequency ratio as presented in this report, it proposes an adequate frquency ratio during noun composition. Based upon the proposed application, in this short documents with less than 300 syllables, low frequency omissions were noticed, when composed with nouns in the upper 30% of frequency ratio; whereas the documents with more than 30 syllables, when composed with nouns in he upper 40% of frequency ration, had a considerable reduction of low frequency omissions. Thus, total number of index terms has decreased to 57.7% of these existing and an accurate extraction of index terms with an 85.6% adequacy ratio became possible.

림프세포증식성 질환에서 효과를 보인 부분적 비동맥 색전술 1례

김미진,노영일,양은석,문경래,Kim, Mi Jin,Rho, Young Il,Yang, Eun Seok,Moon, Kyung Rye 대한소아소화기영양학회 2004 Pediatric gastroenterology, hepatology & nutrition Vol.7 No.1

저자들은 간 이식 후 지속적 비기능 항진에 발생된 내과적 치료에 반응하지 않는 림프세포증식성질환의 6세된 남아에서 부분적 비동맥 색전술을 치료의 한 방법으로 선택하였다. 비기능항진의 억제 효과로 면역력 증강을 통해 혈액학적 호전을 유도하고자 하였으며 치료 후 PTLD의 호전을 보인 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Posttranplantations lymphoproliferative disease (PTLD) is a common and life-threatening complication for soid organ transplantation associated with the use of chronic immunosuppression and Epstein-Barr virus. There is no standardized treatment algorithm, but numerous management strategies are vaiable. Partial splenic embolization (PSE) had been demonstrated to be an effetive alternatie to splenectomy for patients hypersplenism and portal hypertension. PSE has the advantages of non-invasive intervention and resolution of the complications of hypersplenism. We report the effect of the PSE in a 6-year old male liver transplantation recepient with PTLD who has undergone persistent hypersplenism post-transplant. We reduced immunosuppression agent, started antiviral agent. We started with interferon and IV globulin one month after admission. Hepatosplenomegaly and cervical lymphadenopathy were improved. But fever was not subside. We selectively embolized the lower pole of the spleen to achieve a 50~60% reduction in flow as determined by angiography. After embolization, fever subside and peripheral blood findings were improved. Follow up abdominal CT revealed reduced volume of spleen due to ischemic change and there was no multiple enlarged mesenteric lymphnode compared to preembolization state. We thick that PSE is a safe an effetive treatment modality of PTLD with persistent hypersplenism in patients twho failed to medical treatment.

Exposure to mercury induced early apoptotic signals in human placental BeWo cells through alteration of cell cycle regulation

김미진,김철홍,An Mi-Jin,Shin Geun-Seup,Lee Hyun-Min,김지영,Hwang Jae Yoon,이주현,Kim Jung-Woong 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.4

Backgrounds Heavy metals are environmental pollutants and their breakdown is regarded as a serious risk to human health. Despite increasing evidence that heavy metals have adverse efects in vivo and in vitro, there is no evidence of the efect of heavy metals during placental formation. Objective We determined the efect of heavy metals on cell viability of BeWo human placental cells using MTS assay and live and dead assay. We also evaluated cell proliferation, cell cycle, and apoptosis by heavy metal treatment using FACS analysis. Results Mercury chloride induces severe cell cycle arrest at the sub-G1 phase by the accumulation of cyclin B. Furthermore, we identifed that mercury chloride induces apoptosis by enhancing the activity of caspase-3. However, we were unable to confrm the deleterious efect of lead in BeWo cells. Conclusion Our results suggested that exposure to heavy metals, specifcally mercury chloride, induced cytotoxic efects in BeWo cells through cell cycle arrest and apoptosis.