화학요법제가 마우스의 비특이 세포성면역에 미치는 영향

김경원,윤정구 대한미생물학회 1988 大韓微生物學會誌 Vol.23 No.1

Non-specific cellular immunity may play an important role in the immune defense mechanism against tumors and has recently become of great interest to many researchers. Among the effector cells involved in non-specific cellular immune reactions, natural killer(NK) cells and antibody dependent cell-mediated cytotoxicity(ADCC) effector cells are the principal targets in many of the investigations studying the hosts immune defense aginst tumors. In general most chemotherapeutic agents are known to depress host immune functions. However, such an effect in non-specific cellular immunity particulary on NK cell and ADCC activities has not been fully determined. In this report, the effects of 5-fluorouracil(5-FU) and adriamycin(ADM), which are widely used for the chemotherapy of human cancer, on mouse NK and ADCC activities were studied. Adult ICR mice were injected with either one of the drugs or a combination of them and then at given interval, splenocytes were collected. NK and ADCC activities were measured in vitro using a 4hr ^(51)Cr release assay employing YAC-1 and L1210 target cells respectively. The following results were obtained. 1, The administration of different doses of 5-FU or ADM either alone or in combination resulted in a dose-dependent inhibition of NK activity 48 hours post injection. In these experiments, the doses which showed the most significant inhibition were 12.0mg/ml and 1.2mg/ml or greater for 5-FU and ADM respectively. No difference in NK activity was observed between mice treated with the drugs in combination. In contrast, assays of AD- CC activity in splenocytes from the same mice showed no appreciable change in the level of cytotoxicity. 2. Kinetic studies revealed t4at splenocytes from mice treated with a single dose of 5-FU (12mg/kg) or ADM(1.2mg/kg) alone or in combination showed significantly decreased levels of NK activity 48 72 hours after treatment. Thereafter NK activity progressively increased and reacked the level of the controls at 7 days. Again, no significant changes in ADCC activity were observed in these experiments. 3. Splenocytes from mice treated 48 hours previously with the drugs significantly suppressed the NK activity of normal mice. 4. Futhermore, these splenacytes had an impaired in-vitro production of interleukin-2 as compared to those from normal controls. In conclusion, mice treated with 5-FU or ADM either alone or in combination, exhibited significantly depressed NK activities 2 3 days after treatment, but the level of ADCC activity was not effected. This suggest that NK-suppressing mechanisms which involve the appearance and activation of suppressor cells and which impair the production of interleukin-2, may de- velope following chemotherapy.

Characterization of size-resolved aerosol components using proton induced X-ray emission, inductively coupled plasma optical emission spectrometry and ion chromatography

김경원 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.7

Size-resolved aerosol monitoring for PM10, PM2.5, and PM1.0 was performed to qualify and quantify the elements and ions by using proton induced X-ray emission (PIXE), inductively coupled plasma optical emission spectrometry (ICP-OES), and ion chromatography (IC) analysis. Time-resolved aerosol samplings based on 2-hour and 14-hour intervals were carried out during daytime and nighttime, respectively. Physical and chemical properties of size-resolved aerosols were investigated to characterize air quality in the national park area of Gyeongju, Korea. The PIXE and ICPOES methods made elemental mass of Al, Si, S, K, Ca, Ti, Cr, Fe, Sr, and Pb. And ions of Na+, NH4+, Ca2+, Cl−, NO3−,and SO42− were analyzed by the IC method. The mass concentrations of Si, S, Ti, and Pb determined by PIXE showed relatively good correlation with those determined by ICP-OES. But Fe and Sr had worse correlations with an average R2 of 0.4703 and 0.4825, respectively. The PIXE method was a good alternative to measure chemical species of Al,Si, S, K, Ca, Ti, Cr, and Pb for size-resolved aerosols except Fe and Sr in this study. The average relative errors of sizeresolved elements for 2-hour and 14-hour interval collections were 10.1±5.7% (0.1-28.3%) and 9.9±7.7% (1.3-38.4%). Ammonium sulfates (AS), mineral dust (MD), and sea salt (SS) aerosols were reconstructed from the elements determined by PIXE and ICP-OES and ions obtained by IC. The mass concentration of MD was calculated with crustal elements of Al, Si, Ca, Ti, and Fe, which are associated with soil erosion. The average relative error of MD was the lowest value of 0.8% in the PM10 regime and the highest value of 10.0% in the PM1.0 regime. The average relative errors of AS for PM10, PM2.5, and PM1.0 determined by PIXE, ICP-OES, and IC showed relatively lower values of 0.8-5.7%,1.7-5.9%, and 3.3-8.3%, respectively. The average mass concentrations of AS, MD, and SS of PM10, PM2.5, and PM1.0except submicron SS determined by PIXE were comparable to those determined by ICP-OES and IC within the acceptable relative errors.

공군 조종사 선발시 굴절교정술 조건부 합격 기준 검토

김경원 한국항공우주의학협회 2023 항공우주의학 학술대회 Vol.2023 No.11

중국 기업의 해외상장 연구

김경원,최준환 한국전문경영인학회 2008 專門經營人硏究 Vol.11 No.2

This article analysis the state and the characteristics of Chinese firms overseas listing. Chinese firms overseas listing have begun since 1992, especially it was year 2000 when it had been in full swing. Chinese firms overseas listing has reportedly taken place in Hong Kong, Singapore and the Unites States. Most of state-owned firms are listed in Hong Kong Exchanges, and small and medium sized private ones listed in Singapore. In the meanwhile, IT related firms listed in the U.S Stock Exchanges. The reasons for the listing are as follows: Most of all it is to secure a long-term capital in an efficient and fast way. Second, they try to increase competitiveness by improving corporate governance and system under the industry leading management and surveillance. Third, as a strategic motivation, it is a good way to improve its brand image, awareness and credibility as a whole. In terms of the way to list stocks, direct listing for Hong Kong 'H' Stocks, Singapore 'S' Stocks, and the U.S 'N' Stocks. On the other hand, they list their stocks at Hong Kong and Singapore with the use of Red-chip. For the US stock market, they do it thru tax-free countries. Privatized companies make the use of "disposal by sale" in order to fast list their stocks abroad. Finally, there is another way so called "multiple listing" that enables a company to list its stocks at multiple stock exchanges.

주식의 해외교차 상장에 대한 연구-미국증권시장과 영국증권시장을 중심으로 -

김경원 한국기업경영학회 2005 기업경영연구 Vol.12 No.2

The literatures on the effect of overseas listings on the stock price show both positive and negative empirical results. The arguments are very controversial. In the previous findings, when the firms from the more developed markets list their stocks on the less developed market exchanges, overseas listing has a negative effect on the stock price. This implies that listing may be accompanied by increase of risk and cost of capital in that case. In contrast, when the firms from the less developed markets list their stocks on the more developed market exchanges, overseas listing has a positive effect on the stock price. This implies that firms can benefit from listing their stocks on the more developed exchange markets by reducing their risk and cost of capital. Thus, this study focuses on the U.S.A. and U.K. stock market exchanges since both of two countries have the most developed market exchanges of the international stock market exchanges. The effects of both stock exchange markets listing on the stock price are investigated and compared. The major empirical results of this study are as follows. Generally, overseas listing on the both U.S.A. and U.K. stock exchanges has a positive effect on the stock price. If the two exchanges are investigated further more, the U.S.A. stock exchange listing has a more positive effect on the stock price than the U.K. stock exchange listing. This study also investigates stock return volatility during in the pre- and post- listing periods. The impact of the overseas listings on the standard deviation of stock return is not significant. These findings suggest that firms planning to overseas listing might list their stocks in the U.S.A. markets rather than the U.K. markets. 증권의 해외상장효과는 주가에 긍정적 측면과 부정적인 측면 등에 대한 여러 연구결과가 있어 그 동안 논란이 되어왔다. 그리고 기존의 연구에서 주식의 해외상장효과가 비교적 선진화되고 비교적 불확실성이 적은 시장으로 상장할 경우 주가에 더 긍정적으로 영향을 미치는 연구결과가 있었다. 그리하여 본고에서는 대표적인 선진시장인 미국의 증권시장과 영국의 증권시장의 상장효과를 집중적으로 비교할 필요가 있었다. 또한 상장효과에서 주가반응뿐만 아니라 상장에 따른 변동성의 변화요인도 분석하였다. 주가반응분석에서 영국시장이나 미국시장 모두 비교적 선진화된 시장이므로, 이러한 양 선진시장에 상장된 상장효과는 긍정적임을 알 수 있었다. 미국과 영국 양 시장의 정확한 비교를 위해 구간을 나누어 분석한 결과 영국시장보다는 미국시장으로의 해외상장효과가 기업에 더 긍정적일 수 있다는 연구결과를 보여 주었다. 또한 주식의 해외상장이 주가의 변동성에 미치는 영향을 분석한 결과 상장 전과 후의 표준편차의 차이가 크게 통계적으로 유의하지 않은 결과를 보여 주었다. 이는 주식의 해외상장과 다각화를 통한 주식의 위험 분산으로 주가의 변동성을 낮추는 유동성가설이 크게 설명력이 없음을 의미한다. 위의 두 가지 분석을 통해 영국시장과 미국시장 모두 선진시장이지만, 영국시장보다는 미국시장으로의 상장이 주주의 부에 조금 더 유리할 것으로 사료된다. 이는 최근 유럽시장보다는 미국시장으로의 상장이 증가하고 있으며, 미국시장증권의 유럽시장으로의 상장은 감소하는 추세와 일치한다(핵심 주제어: 해외교차상장, 상장효과, 유동성가설, 주가의 변동성).*본 논문은 2004년도 경기대학교 교내연구비 지원에 의해 작성되었음.

(번역) '개인'으로서의 생활과 '성'으로서의 생활 사이의 투쟁에 대하여 (히라츠카 라이초우)

김경원 한국여성문학학회 2005 여성문학연구 Vol.14 No.-

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상표등록출원서 작성요령

김경원 한국발명진흥회 1978 特協 Vol.3 No.5

Multiomics Approach to Acromegaly: Unveiling Translational Insights for Precision Medicine

김경원,구철룡,이은직 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.5

The clinical characteristics and prognoses of acromegaly vary among patients. Assessment of current and novel predictors can lead to multilevel categorization of patients, allowing integration into new clinical guidelines and a reduction in the increased morbidity and mortality associated with acromegaly. Despite advances in the diagnosis and treatment of acromegaly, its pathophysiology remains unclear. Recent advancements in multiomics technologies, including genomics, transcriptomics, proteomics, metabolomics, and radiomics, have offered new opportunities to unravel the complex pathophysiology of acromegaly. This review comprehensively explores the emerging role of multiomics approaches in elucidating the molecular landscape of acromegaly. We discuss the potential implications of multiomics data integration in the development of novel diagnostic tools, identification of therapeutic targets, and the prospects of precision medicine in acromegaly management. By integrating diverse omics datasets, these approaches can provide valuable insights into disease mechanisms, facilitate the identification of diagnostic biomarkers, and identify potential therapeutic targets for precision medicine in the management of acromegaly.

캄파나 형제와 브훌렉 형제의 가구디자인 비교 연구

김경원 한국가구학회 2022 한국가구학회지 Vol.33 No.4

Today, furniture is not only a tool for human daily life, but also an important medium of communication that enriches human life. It is an ideal for many designers of this era to build their own independent formative world based on in-depth thought and philosophy on human life and to communicate it with many people. There are two designer brothers who realized this ideal through continuous efforts. The Campana brothers and the Bouroullec brothers are presenting their creative capabilities not only in furniture design, but also in various media such as architecture, interior, painting, sculpture, and urban facilities. The furniture of the Campana brothers, which organically combines small pieces of various materials to complete a piece of furniture, and the furniture of the Bouroullec brothers, which form a close relationship with the user and are characterized by the variability of organic combinations, have common characteristics shows a clear difference. In particular, there is a marked difference in the selection of furniture materials and production methods. The Campana brothers, who adhere to the handicraft production techniques of skilled craftsmen, and the Bouroullec brothers, who mass-produce from professional manufacturing companies through careful planning and design, show the value of furniture. Differences appear not only in terms of granting, but also in the way they communicate with the public. As such, the two brothers, who show a stark difference in furniture expression, production method, and value giving, are making repeated efforts by converting their creative capabilities into various media to communicate with a wider audience in their own way.

A Case of Subacute Psychosis in a Patient With Germ Cell Tumor

김경원,이병대,박제민,이영민,문은수,정희정,서화규,강태욱 대한생물치료정신의학회 2023 생물치료정신의학 Vol.29 No.1

We report a case of subacute psychotic symptoms in a patient with germ cell tumor (GCT). The 32-year-old male patient showed progressive psychotic symptoms with diagnosis of GCT. His psychotic symptoms included delusions of reference and persecution. Brain magnetic resonance imaging, electroencephalography, and laboratory examinations were performed to evaluate any other causes. The clinical, neuroimaging, and laboratory review in this case suggested that the progressively developed psychotic symptoms that led to chronic deterioration were caused by the GCT. This is the case report in which subacute atypical psychotic symptoms in his thirties could develop from a GCT based on previous basic research findings showing the correlations of psychotic symptoms with GCT although it has the limitation of so early speculation.