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Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers
김경빈,최경운,박원용,김지연,설미영,신동훈,박도윤,이창훈,이정희 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.6
Background: Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis. Methods: Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC). Results: CA IX expression was significantly associated with an endometrioid and mucinous histology,nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers. Conclusions: The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.
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Cocaine 및 Methamphetamine 복합남용으로 인한 진행성 정신증 1례
김경빈 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.2
The author has experienced a patient with flashback phenomena and progressive psychotic changes during reabuse of cocaine and methamphetamine after remission from cocaine psychosis. The case reported here attest to the need for recognition for progressive disease concept of psychosis induced by psychostimalant drug abuse.
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