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김건종,이남영,안용민,강웅구 대한신경정신의학회 2010 신경정신의학 Vol.49 No.5
ObjectivesZZDiminished suppression of the P50 response, a consistent finding in schizophrenia,has also been reported in patients with bipolar disorder. It is a promising endophenotype for schizophrenia, but its relationship to genetic liability in mood disorder is controversial. The present study investigated event-related brain potential (ERP) indices of auditory processing and sensory gating in mood disorder and subgroups of patients with bipolar disorder with or without a history of psychosis using the P50 dual-click procedure. MethodsZZThe P50 auditory evoked potential response to paired stimuli was measured in 77 subjects with mood disorder (58 with bipolar disorder and 19 with major depressive disorder) and 28 healthy controls. P50 parameters were compared between groups. ResultsZZP50 suppression in patients with mood disorder did not differ from that in the healthy subjects. Except for S1 latency, there were no significant differences in P50 parameters between the diagnosis groups. In patients with bipolar disorder, a history of psychosis made no difference to P50 parameters. ConclusionZZP50 was not significantly impaired in patients with mood disorder. There has been much debate on the meaning of P50, and more studies including longitudinal within-subjects studies are warranted to clarify the meaning and mechanisms of P50.
구리 나노 큐브를 전기 도금한 레이저 유도 그래핀 전극 기반의 글루코스 측정용 유연 센서 개발
김건종(Geon-Jong Kim),김태헌(Taeheon Kim),박정호(Jungho Pak) 대한전기학회 2018 전기학회논문지 Vol.67 No.3
In this paper, we describe the development of a non-enzymatic glucose sensor based on copper nanocubes(Cu NCs) electroplated laser induced graphene(LIG) electrodes which can detect a certain range of glucose concentrations. CO₂ laser equipment was used to form LIG electrodes on the PI film. This fabrication method allows easy control of the LIG electrode size and shape. The Cu NCs were electrochemically deposited on the LIG electrodes to improve electron transfer rates and thus enhancing electrocatalytic reaction with glucose. The average sheet resistances before and after electroplating were 15.6 Ω/□ and 19.6 Ω/□, respectively, which confirmed that copper nanocubes were formed on the laser induced graphene electrodes. The prepared electrode was used to measure the current according to glucose concentration using an electrochemical method. The LIG electrodes with Cu NCs demonstrated a high degree of sensitivity (1643.31 μA/mM·cm²), good stability with a linear response to glucose ranging from 0.05 mM to 1 mM concentration, and a limit of detection of 0.05 mM. In order to verify that these electrodes can be used as flexible devices, the electrodes were bent to 30°, 90°, and 180° and cyclic voltammetry measurements were taken while the electrodes were bent. The measured data showed that the peak voltage was almost constant at 0.42 V and the signal was stable even in the flexed condition. Therefore, it is concluded that these electrodes can be used in flexible sensors for detecting glucose in the physiological sample like saliva, tear or sweat.
腸嵌入을 誘發한 小腸(回腸)腺癌 1症例 : One Case Report
盧在胤,崔松林,金建鐘,朴泰成,金春圭 中央醫學社 1970 中央醫學 Vol.18 No.2
Because of its relatively infrequency, difficulty of proper preoperative diagnosis and combined intussusception, one case of adenocarcinoma of the ileum is re2ported. The patient was 46 year-old male and complained intermittent abdominal pain and a palpable mass at right lower quadrant with the duration of one year. Except for a right lower abdominal mass, physical examination was negative. Laboratory examination disclosed hemoglobin 13.3 gm. per 100ml., hematocrit 43 per cent and white blood cell count 10,100 per cu. mm. Urinalyses and stool examination disclosed within normal limit. Barium enema revealed complete filling defect below the mid portion of the ascending colon. Grossly, the specimen was partial segment of surgically resected ileum and measures 9.2 cm in length and 3 cm in diameter. On the center of the specimen, relatively well circumscribed tumor mass revealed yellowish white in color and slightly hard in consistency. The histopathology of the lesion revealed focal ulceration and moderately well differentiated adenocarcinoma spread to muscle layer. A brief review of the literature was done.
임철수,박노춘,남세종,김건종 한국공업화학회 1998 한국공업화학회 연구논문 초록집 Vol.1994 No.1
A type zeolitic crystal film was synthesized on porous supports from the reaction mixture of 1.9 SiO₂-1.5 Na₂O-Al₂O₃-40 H₂O. The zeolite film was characterized by XRD and SEM. The crystals grown on the porous matrix were very closely bound together and the thickness of membrane was about 8 - l5㎛. The densely intergrown crystals could be also synthesized by e hydrothermal treatment at 100℃ after pressing the reaction mixture without addition of water, A zeolite membrane crystallized as a thin film showed the selective permeability of water from water and methanol mixture through the molecular sieving activity of micropores.
중장년 만성 조현병 환자에서 인지행동사회기술훈련의 효과 6주, 전향적, 무작위 비교연구 : 예비연구
이도형,고석만,최용성,김건종,박한선 대한신경정신의학회 2012 신경정신의학 Vol.51 No.4
Objectives Cognitive behavioral therapy and social skills training have been proposed as a promising modality for treatment of patients with schizophrenia. The objective of this study was to evaluate the effectiveness of Cognitive Behavioral Social Skill Training (CBSST) in patients with chronic schizophrenia. Methods Twenty six middle- or older-aged hospitalized patients with schizophrenia were selected in a mental hospital. Eleven participants were randomly assigned to undergo treatment with CBSST and 15 participants were assigned to receive the usual treatment. CBSST was administered in a single group over 12 sessions for a period of weeks, and the participants were assessed by blinded raters at base line and end point, and end of treatment. Results Compared to patients who received the usual treatment, those who received treatment with CBSST showed a significant reduction of Hamilton Rating Scale for Depression score, however, scores for other psychiatric symptoms did not differ significantly. In terms of Quality of life (QoL) analysis, scores for overall quality of life showed a more significant increase in the CBSST group, compared with the group of patients who received the usual treatment. According to results of the Independent Living Skill Survey, patients receiving CBSST showed significantly greater involvement in social activities than patients receiving usual treatment group. Conclusion Psychosocial intervention for patients with chronic schizophrenia is very important, not only for management of primary psychiatric symptoms, but also for QoL and social rehabilitation. The results of this study, showing improvement of depressive mood, overall life quality, and social activities, suggest that CBSST could be an effective treatment for these patients. This study is a pilot study performed in an inpatient treatment setting. Further studies are required in order to clarify the advantage of CBSST in treatment of patients with chronic schizophrenia, esp. under outpatient settings. 본 연구는 만성 조현병 환자에서 인지행동사회기술훈련의 효과를 검증하고자 하였다. 연구 결과 인지행동사회기술훈련에 참여한 집단의 환자군이 대조군에 비해서 우울감이호전되었고 전반적 삶의 질과 사회적 관계의 향상을 보여주었다. 정신병원에 입원 중인 만성 조현병 환자들에 대해서인지행동요법과 사회기술 훈련을 병합한 본 치료프로그램의 적용을 통해서 몇 가지 유의한 임상적 이득을 가질 수 있다는 가능성을 보여 주었다. 추후 본 프로그램에 대한 보다다양하고 폭넓은 임상적 적용을 통해서 다양한 환자군에 대한 임상적 증상 개선 및 삶의 질, 사회적 기술의 향상에 대한정교한 확인뿐만 아니라, 그 외의 잠재적인 가능성에 대한추가적인 연구가 필요할 것으로 보인다.