Skyrme-Type Nuclear Force for the KIDS Energy Density Functional

길하나,오용석,현창호,Panagiota PAPAKONSTANTINOU 한국물리학회 2017 New Physics: Sae Mulli Vol.67 No.4

We construct an effective nucleon-nucleon potential for describing the interactions of nucleons in nuclei or in nuclear matter. Starting from the KIDS (Korea: IBS-Daegu-Sungkyunkwan) nuclear energy density functional systematically expanded in powers of the Fermi momentum, or cubic root of the density, we fit the parameters of the model to a well-known theoretical equation of state of nuclear matter and the empirical data for symmetric nuclear matter. We then determine an effective potential that reproduces the given energy density functional in the mean-field approximation. The potential thus obtained is applied to calculate the binding energies and the sizes of the closed-shell nuclei, namely, $^{16}$O, $^{28}$O, $^{40}$Ca, and $^{60}$Ca. This process introduces one additional parameter, and calculations were made by varying the value of this parameter. We found that the model reasonably reproduced the observed data for the closed-shell nuclei to very good accuracy. Predictions on unobserved physical quantities are presented as well.

Convergence Behavior of the Nuclear Energy Density Functional for Nuclei

길하나,Chang Ho HYUN 한국물리학회 2018 New Physics: Sae Mulli Vol.68 No.3

We investigate the feasibility of a systematic expansion scheme for the study of nuclear structure. We employ a new nuclear energy density functional (EDF) proposed by P. Papakonstantinou et al. [Phys. Rev. C 97, 014312 (2018)], where the EDF is expanded in powers of the Fermi momentum $k_F$. First, we consider the two lowest-order terms proportional to $k^3_F$ and $k^4_F$ in the interaction part and calculate the properties of several spherical magic nuclei. We repeat the calculation by adding higher-order terms proportional to $k^5_F$ and $k^6_F$ and investigate the resulting predictions for the nuclear properties. The prediction is significantly improved when three interaction terms, $k^3_F$, $k^4_F$ and $k^5_F$, are considered. The fourth term proportional to $k^6_F$ corrects the preceding results in a limited range and improves the result marginally. This investigation sheds light on the possibility for accessing a perturbative understanding of nuclear structure.

상인최고경영자과정 교육서비스품질 및 참여동기가 교육만족과 긍정적 행동의도에 미치는 영향

길하나,심성민,장흥섭 한국경영교육학회 2011 경영교육연구 Vol.26 No.4

This study investigates the effect of service quality of Advanced Mercantile Management Program and the motivation of participating in education on the satisfaction of education, and the effect of satisfaction of education on positive behavioral intention. As a result of empirical analysis, among the components of quality of education service of Advanced Mercantile Management Program, all the factors except reactivity are proved to have significant effects on satisfaction of education. Concerning relative effect, conviction, trust, sympathy, and typicality are proved to have a relative effect (specified according to the order of effect). Concerning the motivation of participating in education, activity-oriented type and learning-oriented type, except aim-oriented type, are proved to have significant effects on the satisfaction of education, and activity-oriented type is proved to have more relative effect than learning-oriented type. Finally, the satisfaction of education is proved to have a significant effect on behavioral change. 본 연구는 상인최고경영자과정 교육서비스품질과 상인의 교육참여동기가 교육만족에 미치는 영향과 교육만족이 교육생의 긍정적 행동의도에 미치는 영향을 살펴보는데 목적이 있다. 이러한 연구목적을 달성키 위해 현재 상인최고경영자과정이 개설, 운영되고 있는 5개 대학 중 3개 대학(경북대, 동의대, 숭실대) 소속의 교육생들을 대상으로 2011년 6월 30일부터 7월 15일까지 설문조사를 실시하였고 총 200부의 설문지를 배포하여 174부를 분석 자료로 삼았다. 실증분석결과를 살펴보면, 상인최고경영자과정 교육서비스품질 구성요소 중 반응성을 제외한 나머지 요소들이 교육만족에 유의한 영향을 미치며, 상대적 영향력은 확신성, 신뢰성, 공감성, 유형성의 순으로 크게 나타났다. 또한 교육참여동기 중 목표지향을 제외한 활동지향과 학습지향이 교육만족에 유의한 영향을 미치고, 상대적 영향력은 활동지향형이 학습지향형보다 큰 것으로 분석되었다. 마지막으로 상인최고경영자과정의 교육만족은 긍정적 행동의도에 유의한 영향을 미치는 것으로 나타났다.

스트레스 관리 프로그램이 간호사의 스트레스 지각, 대처유형, 스트레스 반응에 미치는 효과

하나선(Na Sun Ha),최정(Jung Choi),이용미(Yong Mi Lee),임미영(Mee Young Im),이규은(Kyu Eun Lee),길숙영(Suk Young Kil),고명숙(Myung Suk Kho) 한국간호행정학회 2002 간호행정학회지 Vol.8 No.1

Lgr5와 결합하는 신규 헵타펩타이드를 이용한 인체 모낭 세포의 활성과 모낭줄기세포 분화 유도

김민웅,이응지,길하나,정용지,김은미 사단법인 대한화장품학회 2023 대한화장품학회지 Vol.49 No.1

This study was conducted to assess the effect of heptapeptide, composed of seven amino acids, on the activation of human hair cells isolated from human hair follicles. We have confirmed that the heptapeptide could bind to Lgr5 from the results of surface plasmon resonance (SPR) analysis. Heptapeptide enhanced the proliferation of human hair follicle dermal papilla cells (HHFDPCs) in a dose dependent manner. It induced the protein level of nuclear β-catenin, and the expressions of β-catenin downstream target genes, including LEF1, Cyc-D1 and c-Myc, in HHFDPCs. Heptapeptide significantly induced the phosphorylation of Akt and ERK, and the mRNA expressions of growth factors, including hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF), in HHFDPCs. In addition, heptapeptide significantly increased mRNA expression levels of differentiation-related transcription factors of human hair germinal matrix cells (HHGMCs) and differentiation markers of human hair outer root sheath cells (HHORSCs). Additionally, we investigated the effect of heptapeptide on human hair follicle stem cells (HHFSCs) differentiation and found that the heptapeptide reduced the mRNA and protein levels of stem cell markers, while it increased those levels of differentiation markers. These results have indicated that the heptapeptide promotes proliferation or differentiation of various types of hair follicle constituent cells through the induction of Wnt/β-catenin signaling. From the results, we have suggested that the heptapeptide in this study could be applied as a new functional material for the improvement of hair growth and alopecia. 본 연구에서는 7 개의 아미노산으로 이루어진 헵타펩타이드의 Lgr5 binding에 따른 인체 모낭 구성세포의 활성에 대한 영향을 확인하였다. 표면 플라즈몬 공명(surface plasmon resonance, SPR) 시스템을 이용하여 헵타펩타이드가 Lgr5에 결합하는 것을 확인하였다. 인체 모유두세포(human hair follicle dermal papilla cell, HHFDPC)에 헵타펩타이드를 처리한 결과, 농도 의존적인 세포 증식이 나타났으며 β-catenin의 세포 내핵 이동 및 하위 유전자인 LEF1, Cyclin-D1, c-Myc의 발현 증가가 관찰되었다. 그리고 세포 증식 기전 관련인자인 Akt와 ERK의 인산화 수준이 증가되었으며, 성장인자인 hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF) 발현이 유도되었다. 또한 인체 모모세포(human hair germinal matrix cell, HHGMC)의 분화 관련 전사 인자와 인체 외모근초세포(human hair outer root sheath cell, HHORSC)의 분화 표지 인자들도 헵타펩타이드 처리 시 높은 발현율을 보였다. 추가적으로우리는 헵타펩타이드의 인체 모낭줄기세포(human hair follicle stem cell, HHFSC) 분화에 대한 영향을 조사하였다. 그 결과, HHFSC 표지인자들의 mRNA와 단백질 수준이 감소하였고 반면에 분화 표지인자들은 증가하였다. 상기의 결과들은 헵타펩타이드가 인체 모낭 구성 세포에서 Wnt/β-catenin 경로를 촉진시켜 증식 또는 분화를유도할 수 있음을 보여준다. 이를 토대로 종합해 볼 때, 본 연구의 헵타펩타이드는 모발 성장을 유도하고 탈모개선에 도움을 줄 수 있는 기능성 원료로 사용될 수 있을 것으로 보인다.

Schisandra chinensis inhibiting TGFb-induced activation of hepatic stellate cells

신순영,이준호,길하나,정유정,김경란,강길학,임융호 한국응용생명화학회 2018 Applied Biological Chemistry (Appl Biol Chem) Vol.61 No.6

Hepatic fibrosis is one of the critical steps contained in the pathogenesis of liver cirrhosis. Excessive deposition of collagen contributes to the development of fibrosis in chronic liver injury. Activation of hepatic stellate cells (HSCs) plays an important role in fibrogenesis and is accountable for providing extracellular matrix components. The berry of Schisandra chinensis has been known to exert hepatoprotective properties. However, its effect on HSCs is not completely understood. Therefore, in this study, we investigated the inhibitory effect of its ethanolic extract (SBE) on hepatic fibrogenesis. We found that SBE treatment effectively reduced the serum levels of alanine aminotransferase and aspartate aminotransferase as well as collagen deposition in the hepatic parenchyma in a thioacetamide-induced hepatic fibrosis mouse model. Moreover, SBE inhibited transforming growth factor b (TGFb)-induced mRNA expression of a-smooth muscle actin (aSMA) and collagen type 1 a1 (COL1A1) in HSCs, suggesting that SBE exerts anti-fibrotic activity by attenuating TGFb-induced HSC activation. To identify the active components of SBE accountable for HSC inhibition, SBE was further partitioned based on the hydrophobicity of the solvents such as water, n-butanol, ethyl acetate, chloroform, and n-hexane. The n-hexane fraction was selected and further separated using analytical high-performance liquid chromatography. We found that six lignans contained in the n-hexane fraction strongly reduced TGFbinduced expression of both aSMA and COL1A1 mRNA. These data suggest that at least six lignans contained in SBE have the strong potential to prevent TGFb-induced HSC activation.

간호대학생의 자기표출과 임상수행능력간의 관계

이규은(Lee, Kyu Eun),하나선(Ha, Na Sun),길숙영(Kil, Suk Young) 한국간호과학회 2000 Journal of Korean Academy of Nursing Vol.30 No.3

리튬 회수용 크라운 에테르가 함침된 고분자 나노화이버 분리막 개발

로렌스 림주코,그레이스 니솔라,레이 토레호스,하나 게브리찌아버,이성풍,서정길,정욱진 한국막학회 2016 한국막학회 총회 및 학술발표회 Vol.2016 No.05

Synthesis of Li+-selective 14-crown ether (CE) having rigid and bulky subunits was reported. CE-poly(vinyl alcohol) (PVA) dope solutions were electrospun. CEs were immobilized on PVA matrix via acid-catalyzed acetalization using novel aerosol method. Structures of new compounds and their immobilization to PVA were confirmed and characterized. Adsorption experiments show superior lithium capacity and selectivity among previously reported solid-supported CEs. Dihydroxy-dibenzo-14-crown-4 ether-PVA nanofiber membrane showed superior performance. This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2015R1A2A1A15055407) and by the Ministry of Education (No. 2009-0093816).

스마트 홈의 IoT 환경 구축을 위한 이동성관리 기법

장하나 ( Jang-ha Na ),이성길 ( Lee-sung Gil ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1

무선 센서 네트워크(WSN)는 의사소통의 수단이었던 기존 네트워크와는 달리 자동화된 원격 정보 수집을 기본으로 하여 다양한 응용 개발에 활용되면서 센서의 이동성이 중요한 문제로 다루어 진다. 이를 바탕으로 본 논문에서는 센서기반 PMIPv6 네트워크에서 IoT 기술을 이용한 스마트 홈의 이동성 관리 기법을 제안한다. 시그널링 비용, 이동성 비용 등을 고려하여 성능분석을 실시하였고 [1,2], 분석결과 기존의 PMIPv6 와 SPMIPv6 에 비하여 제안하는 기법이 전체적으로 개선되었음을 알 수 있다.