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권유빈,Yulan Liao,구보경,배호정,Jiabao Zhang,한은혜,윤수민,임미경,이상호,정서윤,류종훈 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.10
The stem of Opuntia ficus-indica var. saboten is edible and has been used as a medicinal herb on Jeju Island in Korea. We previously reported that the butanolic extract of O. ficus-indica var. saboten exerts the enhancement of long-term memory in mice. However, the antiamnesic effects of O. ficus-indica var. saboten and its mode of action has not been clearly elucidated. In the present study, we explored the effects of the ethanolic extract of stems of O. ficus-indica var. saboten (EOFS) on cognitive performance in mouse and attempted to delineate its mechanism of action. We used the passive avoidance, Y-maze, and novel object recognition tests to assess its effects on cognitive functions in scopolamine-induced memory-impaired mice. We observed that EOFS (100, 200, and 400 mg/kg) ameliorated scopolamine-induced cognitive dysfunction. We also explored its mechanism of action by conducting an acetylcholinesterase (AChE) activity assay using the mouse whole brain and Western blot using the mouse hippocampal tissue. Western blot analysis and the ex vivo study revealed that EOFS increased the levels of phosphorylated extracellular signal-regulated kinase and cAMP response element-binding protein (CREB) and the levels of brain-derived neurotrophic factor (BDNF) expression in the hippocampus. It also inhibited AChE activity in the brain. Our findings suggest that EOFS would be useful for the treatment of cholinergic blockade-induced cognitive dysfunction.
Scopolamine으로 유도된 콜린성 신경계 차단 동물모델에서 포공영(Taraxacum platycarpum) 추출물의 기억력 개선효과
권유빈,박호재,신범영,류종훈 한국생약학회 2017 생약학회지 Vol.48 No.2
Taraxacum platycarpum H. Dahl. (Compositae) has been used as an anti-inflammatory or anti-cancer agent in the clinic. Although its antidepressant effect has been reported, however, its cognitive function is not investigated until yet. In the present study, we investigated whether the water extract of T. platycarpum (WETP) could improve cognitive function in cholinergic blockade-induced amnesia mouse model using the passive avoidance or Y-maze task. WETP (12.5, 25 or 50 mg/kg) significantly ameliorated the scopolamine-induced cognitive impairment both in the passive avoidance test and the Y-maze test. In addition, WETP significantly inhibited acetylcholinesterase (AChE) activity measured by an ex vivo study using the mouse whole brain. These results suggest that WETP alleviates the cognitive dysfunction caused by the cholinergic blockade, in part, via AChE inhibition, and that it may be a useful for treating cognitive dysfunction.
권유빈,이상룡,서태훈,김영관 한국고분자학회 2022 Macromolecular Research Vol.30 No.4
A strong graphene oxide (GO)-based artificial nacre is developed by using a simple and efficient interfacial chemistry. GO is simultaneously reduced and functionalized with tannic acid (TA) and the resulting TA-reduced GO (TA-RGO) exhibits a high aqueous dispersibility owing to abundant phenol groups. TA-RGO sheets are incorporated with poly(vinyl alcohol) (PVA) and then assembled into an artificial nacre-like structure by vacuum-assisted filtration to induce the formation of multidentate interfacial hydrogen bonding between TA-RGO and PVA. Based on the multidentate hydrogen bonding, the resulting TA-RGO/ PVA (1 wt%) composite film presented an overall and efficient reinforcement of tensile strength (186.1 ± 12.8 MPa), modulus (15.2 ± 1.2 GPa) and toughness (1546 ± 248 kJ/m3) compared to those of GO (83.3 ± 5.4 MPa, 8.9 ± 0.4 GPa and 1434 ± 152 kJ/m3) and TA-RGO (87.6 ± 10.6 MPa, 13.8 ± 1.4 GPa and 306 ± 51 kJ/m3), respectively. The present study demonstrates the rational design of interfacial interaction can greatly improve the performance of a structural composite material.
송라(Usnea longissima)추출물로부터 균핵병 병원균(Sclerotinia sclerotiorum)에 대한 항균 활성물질 탐색
권유빈,최용화 한국유기농업학회 2015 韓國有機農業學會誌 Vol.23 No.4
To develop environment-friendly agricultural products with anti-microbial activity against Sclerotinia sclerotiorum as a pathogen of sclerotium disease, Usnea longissima was extracted by methanol and its extract was fractionated into several solvent fractions. The chloroform fraction, which showed the highest antimicrobial activity, was separated by silica gel-column chromatography and obtained into nine group subfractions. The nine group fractions were searched the antifungal activities by bioassay. The most active No. 3 subfraction was analyzed by GC-MS. Each mass spectra, corresponding to each peak of chromatogram, was compared to database of Wiley library. As a result, Usnic acid was identified as main compounds. In conclusion, Usnic acid isolated from Usnea longissima was antimicrobial chemical against Sclerotinia sclerotiorum as a pathogen of sclerotium disease.