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Standardized Body Size Indexes of 10 Canine Breeds Vulnerable to Intervertebral Disc Disease
권영삼 한국임상수의학회 2024 한국임상수의학회지 Vol.41 No.1
The intervertebral disc is a crucial structure located between each vertebral body, except C1 and C2 and the fused sacral vertebrae, which provides cushioning and stability. However, sometimes these discs may bulge or extrude, causing painful conditions and various neurological problems such as ataxia, paresis, motor or sensorimotor paralysis. As a result, dogs affected by intervertebral disc disease (IVDD) can suffer a significant decrease in their quality of life. The main objective of this study was to provide comprehensive data on the body size of several IVDD-susceptible dog breeds commonly bred in South Korea, which could help develop supportive devices for IVDD patients. Using standardized measurements, the study aimed to design appropriate support tools, taking into account the mobility challenges faced by IVDD patients. The findings provide valuable data to improve the quality of life of patients with IVDD. In addition, it may lay the foundation for research to establish the correlation between body size and IVDD through future research.
BMP-2와 GDF-5의 Rat 골수 유래 중간엽 줄기세포의 골 분화 효과 비교
권영삼,유정준,전흥재,김희중 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.13
Recently, it has been reported that growth and differentiation factor-5 (GDF-5) regulates and promotes osteoblastic and osteogenic differentiation. We here compared effects of GDF-5 and BMP-2 on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBM-MSCs). Cell proliferation was significantly increased in BMP-2 and GDF-5 treated group compared to those in control group. The ALP activities of osteogenic differentiation group, BMP-2 treated group, and GDF-5 treated group was higher than in control group. The ALP activity of GDF-5 group was similar with that of BMP-2 group. When the Ca activity was compared in all groups, the Ca level of GDF-5 group was highest and was similar with that of BMP-2 group. As a result of Von Kossa staining and RT-PCR, the calcium deposition and osteogenic gene expression were increased in the GDF-5 group than in the osteogenic differentiation group. In the present study, GDF-5 appears to be an effective stimulator of proliferation and osteogenic differentiation of rBM-MSCs. To this regard, GDF-5 may be a useful regulator for promoting the bone regeneration and formation by inducing rBM-MSCs proliferation and osteogenic differentiation. Recently, it has been reported that growth and differentiation factor-5 (GDF-5) regulates and promotes osteoblastic and osteogenic differentiation. We here compared effects of GDF-5 and BMP-2 on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBM-MSCs). Cell proliferation was significantly increased in BMP-2 and GDF-5 treated group compared to those in control group. The ALP activities of osteogenic differentiation group, BMP-2 treated group, and GDF-5 treated group was higher than in control group. The ALP activity of GDF-5 group was similar with that of BMP-2 group. When the Ca activity was compared in all groups, the Ca level of GDF-5 group was highest and was similar with that of BMP-2 group. As a result of Von Kossa staining and RT-PCR, the calcium deposition and osteogenic gene expression were increased in the GDF-5 group than in the osteogenic differentiation group. In the present study, GDF-5 appears to be an effective stimulator of proliferation and osteogenic differentiation of rBM-MSCs. To this regard, GDF-5 may be a useful regulator for promoting the bone regeneration and formation by inducing rBM-MSCs proliferation and osteogenic differentiation.
권영삼,장광호,김정은,채형규,임재현,이근우,장인호 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.2
The effects of continuous administration of propofol on the blood, liver and kidney of dogs were evaluated. Propofol(5mg/kg) was repeatedly administered to 8 mongrel dogs intravenously for consecutive seven days. Time to recovery, body temperature, heart rate, and respiratory rate were measured and recorded during experimental period. Hematology (WBC, RBC, PCV) and serum chemistry (AST, ALT, BUN, Creatinine) were also monitored for eight days. Time to standing significantly decreased on day 4 and 6 compared with that on day 1. Body temperature 5 minutes after injection on day 5 and 6, and respiratory rate before injection on day 2, 3, 5 and 6 were significantly increased, respectively. No significant changes were observed in total WBC counts, total RBC counts and PCV values. The AST and AIT values were decreased on day 2 compared with those on day 1, but were within clinically normal range. There were no significant changes in BUN and Creatinine levels. This study suggests that consecutive day propofol anesthesia in dogs can be used for the purpose of the treatment and restraint.
개에서 Sodium Carboxymethylcellulose와 Low Molecular Weight Heparin(Fraxiparine$^{(R)}$)의 유착방지효과
권영삼,장인호 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.1
This study was carried out to compare the efficacy of sodium carboxymethyl cellulose (SCMC) with the combination of low molecular weight heparin (LMWH) and SCMC for the prevention of postoperative adhesions in the dog. After laparotomy, abrasions were made on the surface of ileal serosa in 17 dogs. The animals were randomly divided into the control group (N = 5) which received no treatment, the SCMC-treated group (N = 6), and the SCMC & LMWH-treated group (N = 6). Hematologic values were monitored before laparotomy and 1, 4, 7, 10 and 14 days after laparotomy. The location and score of adhesion were assessed at second laparotomy 3 weeks later, Although the mean adhesion score both in the SCMC-treated group (7.17${\pm}$1.17) and in the SCMC & LMWH-treated group (4.50${\pm}$1.38) was found to be significantly lower than that in the control group (9.40${\pm}$0.89) (p<0.01 and p<0.01, respectively), more favorable adhesion prevention was achieved in the SCMC & LMWH-treated group in comparison with the SCMC-treated group without any hemor-rhagic complications (p<0.01). This study could conclude that SCMC & LMWH are highly effective in prevention against postoperative adhesion in the dog.
Rapamycin의 angiogenin 유도성 가토 각막의 혈관신생 억제
권영삼,김재찬,장광호 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.3
The purpose of this study was to determine whether immunosuppresant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate the its role by micropocket assay. The rabbit's eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the rapamycin group. We could observed that the angiogen induced corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the rapamycin group than in the angiogenin group at 7 and 10 days after pellet implantation (p0.05). Histologically, the cornea treated with rapamycin group also showed much less new vessels than the cornea treated with angiogenin. In conclusion, rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.