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        Helicobacter pylori 감염의 진단을 위한 혈청 IgG 항체가의 유용성

        이정호(Jeong Ho Lee),박성진(Seong Jin Park),구정완(Jung Wan Ku),김도헌(Do Heon Kim),양창헌(Chang Heon Yang),김성철(Sung Chul Kim),이창우(Chang Woo Lee),하경임(Gyoung Im Ha) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1

        N/A Helicobacter pylori are gram-negative spiral bacteria that are associated with gastritis, pep- tic ulcer and gastric cancer. To assess the serodiagnosis of H. pylori infection and the signifi- cance of serum antibody to H. pylori, we have studied 132 patients with upper gastrointestinal disorders. The detection rate of H. Pylori by Gram stain and culture was 75% in gastric ulcer, 72k in duodenal ulcer, 68% in gastritis and 59% in gastric cancer, but there was no difference among these groups. The mean serum IgG antibody titers were significantly higher in H. pylori-de- tected groups than H. pylori-not detected groups (p<0.01). If the antibody titer greater than 300 units as a positive reaction, the sensitivity of the serologic test for IgG antibody to H. py- Lori infection was 74.5% and the specificity was 98.1%. There was no difference of serum level of IgG antibody among the various age groups. In conclusion, there was a strong association between the detection of H. pylori and presence of gastritis, peptic ulcer and gastric cancer, and it was expected that serologic tests for IgG antibody to H. Pylori could be of clinical irnportance in detecting infection of H Pylori in the gastric mucosa.(Korean J. Gastroenterol 1994; 26: 39 46)

      • KCI등재후보

        실험적으로 일이킨 백서에서의 바이러스성 심근염에 대한 연구

        박언휘(Eun Hwi Park),김흥주(Heung Joo Kim),김성진(Sung Jin Kim),방인숙(In Sook Bang),박성진(Seong Jin Park),구정완(Jung Wan Ku),윤성철(Sung Chul Yun),한동선(Dong Sun Han),정준호(Joon Ho Jung),김성숙(Sung Sook Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.1

        N/A Background: The authors injected EMC virus (Encephalomyocarditis virus) to induce viral myocarditis in ICR mice in order to study the survival rate and serial histopathologic change of viral myocarditis according to duration. Methods: Seventy adult male ICR mice of 8 to 10 weeks were used for experiment. Among 70 mice, 40 mice (Group I) were used to observe survival and 30 mice (Group II) were used to see serial histopathologic change (Each 5 mice were killed before and 5, 10, 20 days after virus injection). The hearts of animals were fixed in 10% buffered formalin and routinely processed. Hematoxylin & Eosin stain and Masson trichrome stain were done to observe inflammation and fibrosis. Results: 1) In Group I, 1 mouse died at each 2, 4, 5, 6 day after virus injection, and 4 mice died at 7 day and 2 mice died at 10 and 11 day. Total 10 animals among 40 died (mortality: 25%), and showed peak death period at 4-7 days, 2) In Group II, at 5th, 10th, 20th day after virus injection, average inflammatory grade in the myocardium were 1.8, 3.4, 2.0, respectively. 3) Histologic findings revealed monouclear cells infiltration, myofiber necrosis & degeneration. These changes occur multifocally rather than diffusely. Inflammation was most severe at 10 days. 4) Fibrosis was increased at 20 days after virus injection compared to early phase of myocarditis. Distribution of fibrosis is relatively parallel with the area of inflammation, but not with the degree of inflammation. 5) In some cases, dilation of both atriums and ventricles and thrombosis accompaning severe pulmonary congestion and edema were observed, indicating possible transition to dilated cardiomyopathy. Conclusions: It is considered that this experimental animal model may be useful not only to study the pathogenetic mechanisms of viral myocarditis but also to observe clinical course and evaluate the effect of possible drugs to treat myocarditis.

      • 신아밀로이드증 1예

        이정호,구정완,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

        A case of 52-year-old woman who was found to have isolated renal amyloidosis is reported. The patient suffered from generalized edema for 1 month and was presented with nephrotic syndrome. Renal biopsy was performed after admission. The light microscopic fidings showed massive infitration of the glomerular tuft with formation of large nodules and disappearance of most nuclei. Some glomeruli are completely obliterated by amyloid fibrils. Amyloid deposits also involve interstitium and vessels of all sizes. Congo-red stain in polarized light showed apple green birefringence of amyloid. On immunohistochemical stain, antibodies to amyloid A component, Lambda and Kappa light chain are not stained.

      • KCI등재후보

        과인슐린혈증을 보인 Nesidioblastosis 1 예

        박성진,이정호,정민영,김정란,이예봉,김성숙,윤형진,구정완,김종목,김탁관,서정욱 대한내과학회 1994 대한내과학회지 Vol.47 No.5

        Nesidioblastosis, a condition characterized by diffuse islet cell hyperplasia arising from the ductal epithelium, is often associated with hyperinsulinemic hypoglycemia. This is the most common cause of persistent neonatal hypoglycemia and is extremely rare in adults. A 38-year-old man had suffered from intermittent hypolycemic symptoms for 5 years, and had been relieved by carbohydrate ingestion. Plasma immunoreactive insulin levels and I/G ratio were inappropriately high during prolonged fast. Abdominal CT scan, angiography, and frozen section provided no evidence of a tumor. Pathologic examination of the resected pancreas revealed irregularly sized islets and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex and distinct islet cell hypertrophy are present.

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