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소결조제를 달리해 상압 반응소결로 제조된 AlON의 투명도
구본경,구교헌,김지혜,정인철,이재형,Koo, Bon-Kyung,Koo, Kyeo-Hun,Kim, Ji-Hye,Jung, In-Chul,Lee, Jae-Hyung 한국세라믹학회 2009 한국세라믹학회지 Vol.46 No.4
AlON was fabricated by the pressureless reaction sintering of $Al_2O_3$-AlN powder mixtures. The ratio of AlN to $Al_2O_3$ as well as various sintering aids were the main variables for this study. The optimum ratio of AlN in the $Al_2O_3$-AlN mixture was approximately 35.0 mol%. For the sintering aids, only when a small amount of MgO was added together with $Y_2O_3$ and BN, AlON specimens could be sintered to a full density with negligible pores and high transparency. Other combinations of $Y_2O_3$, BN, CaO and MgO resulted in enough pores in the sintered specimens to have in-line transmittance only between 0% and 30%. The in-line transmittance reached over 80% after sintering at $1975^{\circ}C$ for 10 h for the specimen containing 0.15 wt% MgO, 0.08 wt% $Y_2O_3$ and 0.02 wt% BN.
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자폐스펙트럼장애 영유아를 위한 집중적 조기행동개입 프로그램의 효과성 검증:
구본경(Koo, Bon kyung),정경미(Chung, Kyong mee) 한국자폐학회 2018 자폐성 장애연구 Vol.18 No.2
본 연구는 국내의 자폐 스펙트럼 장애(Autism Spectrum Disorder: ASD)로 진단받은 영유아를 대상으로, 집중적 조기행동개입(Early Intensive Behavior Intervention: EIBI) 프로그램의 효과성을 확인하고, 프로그램 시작 시 영유아의 연령, 언어능력, 또는 문제행동이나, 부모의 양육 스트레스가 프로그램의 효과를 예측할 수 있는지 알아보았다. 연구의 참가자는 ASD진단을 받은 만 2세-5세의 영유아와 그 부모 19쌍으로, 그들은 6개월 동안 전문 치료 기관에서 응용행동분석에 근거한 EIBI 프로그램에 참여하였다. EIBI 프로그램 전후로 아동을 대상으로 교육진단검사, ABA커리큘럼평가, 적응행동검사, 바인랜드 적응행동척도, 유아행동평가척도, 그리고 소아용 삶의 질 검사를 실시하였고, 부모를 대상으로 부모양육스트레스 척도와 Beck우울척도를 실시하여 그 변화정도를 비교하였다. 통계 분석 방법은 대응표본 t검정과 중다회귀분석을 실시하였으며, 그 결과는 다음과 같다. EIBI 프로그램 후 영유아의 전반적인 발달연령, ABA커리큘럼평가점수, 그리고 삶의 질에서 유의미한 향상이 나타났다. 그러나 부모의 양육스트레스나 우울감에서는 차이가 관찰되지 않았다. 추가적으로 프로그램 시작 시 아동과 부모 변인 모두, 6개월 후 교육진단검사와 ABA커리큘럼평가에서 향상 정도를 예측하는 못하는 것으로 나타났다. 이 결과를 바탕으로 국내의 ASD 영유아를 위한 효과적인 집중적 조기행동개입(EIBI) 프로그램의 개발을 위해 향후 개입 방향을 제안하고, 본 연구의 의의와 한계점에 대해 논의하였다. The purpose of this study was to investigate the effectiveness of an Early Intensive Behavioral Intervention(EIBI) program on infants with autism spectrum disorder(ASD) and to explore the factors predicting the effectiveness of the program, focusing on the infant s age, language ability, problem behaviors, and parental stress. 19 pairs of infants aged between 2 and 5 years and diagnosed with ASD, and their parents, participated in an EIBI program at a treatment center providing evidence-based treatment based on applied behavior analysis. The measurement tools which were administered before and after the EIBI program and compared, included PEP-R, a curriculum evaluation, K-SIB-R, K-Vineland-II, K-CBCL, and PedsQL for the infants, and included PSI-SF and BDI-II for the parents. Statistical analysis was performed using a sample t-test and multiple regression analysis and the results were as follows. The EIBI program showed significant improvements in overall developmental age, curriculum assessment, and quality of life for infants. There was no difference in parenting stress or depression. Furthermore, measures for both children and parents at the start of the program predicted neither PEP-R nor the degree of improvement in curriculum evaluation measured six months later at the end of the program. Based on these results, the authors suggest future directions for developing an effective intensive early intervention (EIBI) program for infants with ASD in Korea, and discuss the implications and limitations of this study.
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APTT에서 경계치에 속한 정상 성인의 혈액응고인자 활성도 분석
권의훈 ( Eui Hoon Kwon ),구본경 ( Bon Kyung Koo ),방성환 ( Sung Hwan Bang ),김희진 ( Hee Jin Kim ),조영국 ( Young Kuk Cho ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.4
The coagulation factor activity compared two groups of the lower 10% (29.1∼30.9 sec) and the upper 10% (38.0∼41.9 sec) of the normal reference range of aPTT. The aim of this study was to investigate the influence of sex, age, and ABO blood type on coagulation factor activity. There was significant difference in the activity of the coagulation factor assay based on age. The VIII (p<0.0001) and IX (p=0.0050) in the lower group of samples from those over sixty years of age is higher than from those under sixty. In contrast, XII (p=0.0285) for samples over sixty was lower than for samples under sixty. While in the upper group V (p=0.0219), VIII (p=0.0005), and IX (p=0.0014) for samples from the over sixty group was higher than those under sixty. In the case of activity of coagulation factor between O and non-O blood type, VIII (p<0.001) activity of the non-O blood type was higher than that of the O blood type in the both groups. The XII (p=0.016) activity of non-O blood type was lower than that of O blood type in the upper group. According to the multiple logistic regression analysis, when other variables are under the same conditions between lower and upper groups, there is a strong possibility for the lower group when activity of V (p=0.001), VIII (p<0.001), X (p<0.001) and XII (p<0.001) is increased. Furthermore, there is also a strong possibility of upper group when activity of II (p=0.004) and IX (p=0.012) is increased. However, no significant difference in between sex, age and XI was observed.
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방영일(Young-Il Bang),구본경(Bon-Kyung Koo),허영도(Yong-Do Her),김진수(Jin-Soo Kim) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B
본 논문에서는 웹상에서 학습자의 학습능력을 진단하기 위하여 각 단계별로 질문을 제시하고 해당 질문의 응답 여부에 따라 자신의 학습 능력을 평가받고 향후 자신의 능력을 좀더 향상시킬 수 있는 지침을 제공하는 학습능력 진단시스템을 개발하였다. 본 시스템에서는 소프트웨어 프로세스를 향상시키기 위해 사용되고 있는 능력성숙 모델(CMM)을 기반으로 질문 리스트를 구성하였으며 다양한 학습자의 학습능력을 진단할 수 있도록 학습자의 직업에 따라 별도의 질문 리스트를 준비하였고 질문 리스트와 메시지 및 가산점을 조정한다면 다양한 분야에서도 활용될 수 있을 것이다.
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임상검체에서 분리된 Aspergillus Species의 연구
이장호 ( Jang Ho Lee ),구본경 ( Bon Kyung Koo ) 대한임상검사과학회 2016 대한임상검사과학회지(KJCLS) Vol.48 No.1
Aspergillus is the most common opportunistic fungus causing infection. Aspergillus is the most morphologically identified in the laboratory. Recently, molecular genetic methods have been proposed for identification of fungi that unidentified morphologically or identified genus level. Of 475 cases of Aspergillus isolated from clinical specimens, there were Aspergillus fumigatus 257 (54.1%), A. niger 101 (21.3%), A. flavus 43 (9.1%), A. terreus 29 (6.1%), Aspergillus nidulans 2 (0.4%), Aspergillus clavatus 1 (0.2%), and the Aspergillus species 42 (8.8%). Eleven cases of unidentified or identified at the genus level included Aspergillus fumigatus 5, Aspergillus falvus 1, Aspergillus terreus 1, and Aspergillus lentulus 1 was identified in the sequencing of the strain level. It was identified as Aspergillus versicolor 2, and Emericella parvathecia 1. 92.2% of Aspergillus was identified as a possible morphological, 8.8% could not be identified at the species level. Sequence-based molecular analysis using the ITS and D1D2 is considered useful for identification of the species level.
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시판용 요구르트와 Lactobacillus acidophilus 요구르트의 생화학적 활성의 비교
류재기 ( Jae Ki Ryu ),이형선 ( Hyeong Seon Lee ),구본경 ( Bon Kyung Koo ),김현경 ( Hyun Kyung Kim ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.2
Lactic acid-producing bacteria such as Lactobacillus spp. function to ferment carbohydrates and produce ATP. Such Lactobacillus spp. are used for the production of commercial yogurts. Lactobacillus spp. are beneficial to the intestinal tract, and Lactobacillus acidophilus-containing yogurts have received considerable attention because of their preventive effects against early-stage cancer of the large intestine. In this study, lactic acid-producing bacteria were cultured from three different groups: commercial solid yogurt (for eating), commercial liquid yogurt (for drinking), and Lactobacillus acidophilus-containing yogurt. We first determined the optimum culture conditions for Lactobacillus spp. and then analyzed turbidity and pH in order to compare the growth abilities and lactic acid-production capacities among the groups. Finally, high-performance liquid chromatography was used to measure the lactic acid content in the culture supernatants, and the antibacterial activities against Staphylococcus aureus and Escherichia coli were compared among the three groups. The optimum culture conditions for Lactobacillus spp. were MRS medium at 25oC, for 24 h. The highest turbidity was found in L. acidophilus-containing yogurt, followed by liquid yogurt and solid yogurt. Similarly, the highest lactic acid production ability was found in L. acidophilus-containing yogurt, followed by liquid yogurt and solid yogurt. Culture supernatants from the three groups did not show any antibacterial activity towards S. aureus; however, supernatants derived from L. acidophilus-containing yogurt resulted in a 1.8 mm inhibitory zone against E. coli in a paper disk diffusion test. These results revealed the high level of lactic acid-production capacity and antibacterial activity in L. acidophilus-containing yogurt.
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