Doxycycline으로 치료한 피부 반흔 유육종증 1예

고주연,이창우 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.12

Scar sarcoidosis is a rarely encountering variant of cutaneous sarcoidosis and its pathogenesis is still unknown. When inactive scars that have been quiescent for years develop a red or purple hue with induration, we should doubt whether they become infi1trated with sarcoid granuloma or not. We report herein a 45-year-old patient with recurrent scar sarcoid, who shows indurated plaques on the right chin and raised serum level of angiotensin converting enzyme, although there was no evidence of systemic involvement. She was treated with oral doxycycline of moderate doses and skin lesions were cleared after 9 months of treatment. (Korean J Dermatol 2002;40(12) : 1573∼1575)

Identification of phospholipase C β downstream effect on transient receptor potential canonical 1/4, transient receptor potential canonical 1/5 channels

고주연,명종윤,곽미선,전주홍,서인석 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5

Gαq-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate (PI(4,5)P2) depletion. When PI(4,5)P2 depletion was induced by muscarinic stimulation or inositol polyphosphate 5-phosphatase (Inp54p), however, the inactivation by muscarinic stimulation was greater compared to that by Inp54p. The aim of this study was to investigate the complete inactivation mechanism of the heteromeric channels upon Gαq-phospholipase C β (Gαq-PLCβ) activation. We evaluated the activity of heteromeric channels with electrophysiological recording in HEK293 cells expressing TRPC channels. TRPC1/4 and TRPC1/5 heteromers undergo further inhibition in PLCβ activation and calcium/protein kinase C (PKC) signaling. Nevertheless, the key factors differ. For TRPC1/4, the inactivation process was facilitated by Ca2+ release from the endoplasmic reticulum, and for TRPC1/5, activation of PKC was concerned mostly. We conclude that the subsequent increase in cytoplasmic Ca2+ due to Ca2+ release from the endoplasmic reticulum and activation of PKC resulted in a second phase of channel inhibition following PI(4,5)P2 depletion.

지방자치단체의 전략적 도시경영에 의한 재정자립도 활성화 방안 : 도시축소시대의 일본 입지적정화계획과 취락지구 정비사례를 중심으로

고주연,김대일,염춘호 한국전문경영인학회 2020 專門經營人硏究 Vol.23 No.1

The deterioration of Regional Economic Status caused by population reduction and aging will result in the form of various Urban Shrinkage in the long term, forming a vicious circle between the economy, population, and cities. Analysis of the link between population, Urban Expansion Intensity, and GRDP to diagnose Urban Shrinkage in Korea shows that if the population trend line(PTL) is lower than the Urban Expansion Intensity trend line(UEITL), the GRDP trend line(GTL) is downturn, Even if the PTL was higher, GRDP in the area has decreased where the PTL becomes lower after two trend lines intersect. The continued decline of the GRDP will lead to Urban Shrinkage, and efforts by Strategic Management of Local Governments should be made to turn the tide so that the PTL intersects with the UEITL. The increase in the rate of the financial burden is reduced in cities that implement the readjustment of residential and infrastructure by Japan's Location Optimization Plan. To enhance the effectiveness of the Location Optimization Plan, improving the existing development permit system linked to the designation of residence instruction area, an integrated review of land-use regulation guidance measures in small-scale strongholds, establishing a residential adjustment zone, to facilitate the institutionalization of land-use planning for regional regeneration was proposed.

Hypoglycemia in Nesidioblastosis

고주연,정창희,서동완 대한내과학회 2023 대한내과학회 추계학술대회 Vol.2023 No.2

일본의 지속가능 도시재생 계획에 관한 사례 연구 - 입지적정화계획의 도시기능유도구역 설정을 중심으로 -

고주연,이승일 대한국토·도시계획학회 2017 國土計劃 Vol.52 No.6

우리나라의 도시재생 여건이나 실행방침은다르지만 일본의 도시재생 관련계획 체계나 법체계는 「도시재생 활성화 및 지원에 관한 특별법(이하 도시재생특별법)」(2013.6.4. 제정) 의 위상이나 구조적인 면에서 매우 유사하다. 일본은 2014년 8월에 「도시재생특별조치법(都市再生特別措置法)」의 개정을 통하여 '입지적정화계획(立地適正化計画)'을 창설하고 지속가능한 도시경영을 위해 집약적 도시개발을 지향하고 있다. 본 연구의 목적은 지속가능 도시재생 계획의수립과 시행을 위해 도시재생 계획의 방향성을재정립하고 있는 일본의 입지적정화계획을 검토하여 국내 도시재생 관련계획체계의 정비방안과 계획수립에 있어서의 개선방안을 제안하고자 한다.

Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s

고주연,명종윤,양동기,서인석 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.1

Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether the current-voltage (I-V) curve has a doubly rectifying shape or inward rectifying shape. To investigate the calcium permeability of TRPC4 channels, we attached GCaMP6s to TRPC4 and simultaneously measured the current and calcium signals. A TRPC4 specific activator, (–)-englerin A, induced both current and calcium fluorescence with the similar time course. Muscarinic receptor stimulator, carbachol, also induced both current and calcium fluorescence with the similar time course. By forming heteromers with TRPC4, TRPC1 significantly reduced the inward current with outward rectifying I-V curve, which also caused the decrease of calcium fluorescence intensity. These results suggest that GCaMP6s attached to TRPC4 can detect slight calcium changes near TRPC4 channels. Consequently, TRPC4- GCaMP6s can be a useful tool for testing the calcium permeability of TRPC4 channels.

2009 개정 교육과정 미술 교과서의 영역별 참고작품 분석 연구

고주연,오재환 한국초등미술교육학회 2015 미술교육연구논총 Vol.43 No.-

This study, based on recognizing the importance of reference works presented in art textbooks, comparatively analyzes reference works presented in 3rd, 4th grade elementary school art textbooks, finds their problems and explore improvement plans so that a direction of efficient improvement that the existing art textbooks may be complemented. Its research was done in the following process. Based on understanding the year 2009 revised educational curricula and research on the meaning of reference works in the textbooks, it comparatively analyzed works presented in the 5 kinds of art textbooks for 3rd/4th grade elementary students to find out problems, based on which results the following plan to improve reference works is suggested; First, clear explanation of illustrations should be presented. Second, proper number of reference works should be presented by publisher. Third, the number of natural objects and man-made ones in the experience area should be properly regulated. Fourth, expression area should properly regulate the number of works by students and present more by foreign students. Fifth, reference books should be evenly distributed by nation and time. Sixth, it’s necessary to evenly distribute reference works of various genres in the appreciation area. The plan devised by this study to improve reference works of the 2009 revised art textbooks is expected to have meaning as foregoing data for would-be revised art textbooks and further, the current writer expects that continuos research in year ahead on reference works in art textbooks will bring about an increase in their quality. 본 연구에서는 미술 교과서에 제시된 참고작품의 중요성에 대한 인식을 바탕으로2009 개정 교육과정에 따른 초등학교 3, 4학년 미술 교과서에 제시된 참고작품을 비교․분석하고, 그에 따른 문제점과 개선 방향을 모색하여 차후에 개정되는 미술 교과서에 보완할 수 있는 보다 효율적인 교과 내용의 개선 방향을 제시하는데 그 의의를 두었다. 이에 따라 2009 개정 교육과정 미술 교과서에서 참고작품의 의미에 대한 문헌연구를 바탕으로 초등학교 3, 4학년 5종의 미술 교과서에 제시된 참고작품을 영역별로 비교․분석하여 문제점을 살펴보고 그 결과를 토대로 성취기준에 따른 영역별 참고작품 개선방안을 다음과 같이 제안하였다. 첫째, 참고작품에 대한 도판 설명을 명확하게 제시해야 한다. 둘째, 출판사별로 적정한 참고작품 수를 제시할 필요가 있다. 셋째, 체험 영역에서 자연물과 인공물에 대한 참고작품의 수를 적절하게 조정할 필요가 있다. 넷째, 표현 영역에서 학생작품의 수를 적정하게 조절하고, 국외 학생의 참고작품을 제시할 필요가 있다. 다섯째, 참고작품을 국가별, 시대별로 고르게 분배하여 수록해야 한다. 여섯째, 감상 영역에 다양한 장르의 참고작품을 고르게 제시하는 것이 필요하다. 이와 같이 본 연구를 통해 도출된 2009 개정 교육과정 미술 교과서의 참고작품 개선 방안이 추후 개정되는 미술 교과서 개발의 선행 자료로서 의의가 있을 것으로기대하며, 나아가 초등 미술 교과서에서 참고작품에 대한 연구가 지속적으로 이루어져미술 교과서의 질적 향상이 이루어지기를 기대한다.

Prick test and blood tests used in skin allergy

고주연 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

수학체험전을 운영한 중학생들의 의사소통 역량 변화

고주연,신인선,박미미 대한수학교육학회 2019 수학교육학연구 Vol.29 No.1

Recently, there is more emphasis on the importance of activities focused on experience. One of these activities is the Mathematics experience exhibition. The purpose of this study is to explore how students' communication competences change during the preparation and running of the mathematics experience exhibition. The research problem is as follows: How do students' communication competences change during the running of the mathematics experience exhibition? In order to solve the research problem, four middle school mathematics club students took part in the exercise. All of them were in charge of running booths on exploring the polyhedron compound and Latin square in the mathematics experience exhibition. The results of the exercise are summarized as follows. The students showed the changes of their communication competences. First, they could make logical and clear explanations. They also showed the use of mathematical terms properly with everyday language. Second, the students were able to concentrate on others' explanations and changed their explanations according to the level of the opponent. From the results, implications for developing communication competences of students running mathematics experience exhibitions are suggested. 최근 체험 중심의 활동이 학교 내외에서 확산되고 있다. 수학체험전은 이러한 활동의 예 중 하나이다. 본 연구는 중학교 수학동아리 학생들이 수학체험전 체험부스를 준비하고 운영하는 과정에서, 이들의 수학적 의사소통 역량이 어떻게 변화하는지를 탐색하는 것을 목적으로 한다. 연구문제는 다음과 같다. 수학체험전을 운영한 중학교 학생들의 수학적 의사소통 역량은 어떻게 변화하는가? 본 연구의 연구참여자는 중학교 수학동아리 학생 4명으로, 이들은 합성다면체와 라틴방진을 탐구하는 수학체험전 체험부스를 준비하고 운영하였다. 그 과정에서 이들의 의사소통 역량은 다음과 같은 변화를 보였다. 첫째, 수학체험전 체험부스 운영과 연습이 진행됨에 따라 일상 언어와 수학적 표현을 조화롭고 적절하게 사용하게 되었고, 상대방에게 논리적이고 명확한 설명을 하며 대화를 이끌어 나가게 되었다. 둘째, 학생들은 상대방의 얘기를 집중하여 듣고, 상대방의 이해 수준에 따라 다른 표현 방식을 사용하여 의사소통 하는 모습을 보였다. 연구 결과를 기반으로 수학체험전을 통한 의사소통 역량 함양을 위한 시사점을 제시하였다.

Multifocal Lesions of Morphea in a Patient with Systemic Lupus Erythematosus

고주연,주민숙,김용석,이창우 대한피부과학회 2008 초록집 Vol.46 No.10