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저선량 방사선에 의한 Ikaros-Autotaxin 상호작용 조절 효과
강한아,조성준,김성진,남선영,양광희 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.1
Abstract - Ikaros, a transcription factor containing zinc-finger motif, has known as a criticalregulator of hematopoiesis in immune system. Ikaros protein modulates the transcription of targetgenes via binding to the regulatory elements of the genes promoters. However the regulatoryfunction of Ikaros in other organelle except nuclear remains to be determined. This study exploredradiation-induced modulatory function of Ikaros in cytoplasm. The results showed that Ikarosprotein lost its DNA binding ability after LDIR (low-dose ionizing radiation) exposure. Cell fractionationand Western blot analysis showed that Ikaros protein was translocated into cytoplasmfrom nuclear by LDIR. This was confirmed by immunofluorescence assay. We identified Autotaxinas a novel protein which potentially interacts with Ikaros through in vitro protein-binding screening. Co-immunoprecipitation assay revealed that Ikaros and Autotaxin are able to bind eachother. Autotaxin is a crucial enzyme generating lysophosphatidic acid (LPA), a phospholipidmediator, which has potential regulatory effects on immune cell growth and motility. Our resultsindicate that LDIR potentially regulates immune system via protein-protein interaction of Ikarosand Autotaxin. Ikaros, a transcription factor containing zinc-finger motif, has known as a criticalregulator of hematopoiesis in immune system. Ikaros protein modulates the transcription of targetgenes via binding to the regulatory elements of the genes promoters. However the regulatoryfunction of Ikaros in other organelle except nuclear remains to be determined. This study exploredradiation-induced modulatory function of Ikaros in cytoplasm. The results showed that Ikarosprotein lost its DNA binding ability after LDIR (low-dose ionizing radiation) exposure. Cell fractionationand Western blot analysis showed that Ikaros protein was translocated into cytoplasmfrom nuclear by LDIR. This was confirmed by immunofluorescence assay. We identified Autotaxinas a novel protein which potentially interacts with Ikaros through in vitro protein-binding screening. Co-immunoprecipitation assay revealed that Ikaros and Autotaxin are able to bind eachother. Autotaxin is a crucial enzyme generating lysophosphatidic acid (LPA), a phospholipidmediator, which has potential regulatory effects on immune cell growth and motility. Our resultsindicate that LDIR potentially regulates immune system via protein-protein interaction of Ikarosand Autotaxin.
사유는 저항인가? - 아도르노와 사유의 비판적 자기반성 -
강한 대한철학회 2019 哲學硏究 Vol.151 No.-
Thinking would be the love of wisdom as the etymology of philosophy, if today thinking begins with a question sparked by wonders of the world. But when thinking is already locked in coercion, thinking becomes not the love of wisdom but a resistance. In the asymmetric relationship between mind and power that cannot be separated by dichotomy today, Adorno argues that thinking is a resistance to coercion prior to particular content. This paper divides the coercive moments inherent in rationality into the non historicity of thinking, the degeneration of social progress, the facticity of Positivism, and the forgotten correlation between humans and nature. It also critically examines the nature of these moments in the contexts of epistemology, social philosophy and historical philosophy. In the critical self-reflection of aporia which is not separated by dichotomy, a model of resistive thinking is revealed. It has a contemporary significance to present a model of thinking to those who strive to find the driver of criticism and resistance. 만일 오늘날도 사유가 세계의 경이에서 촉발된 물음에서 시작한다면, 사유는 철학의 어원대로 지혜사랑의 활동일 것이다. 그러나 사유가 이미 강압 속에 놓여 있을 때, 사유는 애지적 활동이 아닌 저항적 활동이 된다. 오늘날 이분법으로 분리될 수 없는 정신과 권력의 비대칭적 관계 속에서, 아도르노는 사유가 특수한 내용에 앞서 자체로 부정이며 강압에 맞선 저항임을 주장한다. 본고는 합리성에 내재된 강압적 계기들을 사유의 비역사성‧사회적 진보의 퇴보성・실증주주의 사실성・망각된 자연연관성으로 구별한다. 그리고 이 계기들의 성격을 인식론적・사회철학적・역사철학적 맥락에서 비판적으로 검토한다. 정신과 권력, 자유와 지배, 의식과 사회가 뒤엉킨 합리성 그 자신의 비판적 자기반성 속에서, 저항으로서 사유의 모델은 드러난다. 이는 오늘날 비판과 저항의 동인을 찾는 이들에게 스스로 생각할 수 있는 사유의 모델을 제시한다는 점에서 의의가 있을 것으로 보인다.
영양 용화광산의 광미 및 침출수의 광물학적 및 지화학적 특성 연구
강한,김영훈,장윤득,김정진,Kang, Han,Kim, Young-Hun,Jang, Yun-Deug,Kim, Jeong-Jin 대한자원환경지질학회 2012 자원환경지질 Vol.45 No.3
용화광산의 광미와 침출수에 대한 분석을 실시하여 광미로부터 부과될 수 있는 성분을 예측하고, 침출수가 주변하천으로 유입될 때 오염물질의 거리에 따른 변화를 측정하였다. 하천수의 거리에 따른 변화는 갱내수와 침출수가 유출되는 지점에는 대체로 높게 나타나고 하류로 갈수록 이온의 농도는 급격히 낮아진다. 이는 침출수에 비해 훨씬 유량이 많은 비오염하천수에 의한 희석효과 때문이다. 광미는 붉은색과 노란색으로 구분되며 붉은색 광미의 주 구성광물은 석영, 일라이트, 플럼보자로사이트와 약간의 섬아연석이며 노란색 광미는 백운모, 석영, 플럼보자로사이트(Plumbojarosite) 그리고 소량의 황동석(Chalcopyrite)과 섬아연석(Sphalerite)을 포함하고 있다. 침출수에서 높은 값을 나타내는 Pb, Zn 등은 광미에 포함된 플럼보자로사이트와 섬아연석의 용해작용에 의한 것으로 하천수의 오염에 주 원인으로 작용하고 있다. Current study includes the analysis of mine tailings and leachate water and prediction of species originated from the tailings. The variation of contaminants were measured upon the distance from the tailings to the nearby stream. The ions concentration was highest at the tailings and pit mouth and it becomes lower as it goes far away from the origin. This is the reason that the leachate was diluted with the uncontaminated stream water. The tailings were mainly classified into reddish one and yellow one. The main mineral of reddish tailings were quarts, illite, plumbojarosite and a small amount of sphalerite. The main mineral of yellow tailings were muscovite, quarts, plumbojarosite, and a small amount of chalcopyrite and sphalerite. Pb and Zn were found in the leachate in high concentration and become the major contaminants. These come from the dissolution of plumbojarosite and sphalerite contained in the mine tailings.