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강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myoung Moon),이상인(Sang In Lee),전재윤(Chae Yoon Chon),김원호(Won Ho Kim),박찬일(Chan Il Park),이강석(Kang Suk Lee),이광길(Kwang Kill Lee) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
Benign tumors of esophagus arising either from mucosa or submucosa are rare pathological entities. Of the benign esophageal tumor, squamous papilloma is a distinct rare pathological peculiarity recently reported with increased frequency, giving no symptoms during life and discovered unusually and in cidentally during autopsy. Morphologically, squamous papilloma of the esophagus was benign sessile lesions of surface epithelium characteristically composed of finger-like projections of tissue lined by increased numbers of squamous cells and having cores of fibrovascular tissue. Although the etiology of squamous papilloma of esophagus remains uncertain, the most convincing etiology of humans remains chronic irritation from gastric acid reflux. Squamous papilloma of the esophagus have not been shown to be premalignant. They should be removed completely so that coexisting malignant conditions are not overlooked. Recently we had the opportunity to observe two cases of histologically demonstrated squamous papilloma of the esophagus. Our purpose here is to report these patients and to review the literatures.
해상상태를 고려한 수중예인체 진회수시스템 설계 및 실험
강진일,서주노,정성훈,최형식,김준영,김명경,유용준,Kang, Jin-il,Sur, Joo-no,Jeong, Seong-hoon,Choi, Hyeung-sik,Kim, Joon-young,Kim, Myung-gyung,Kim, Jung-hoon 한국항행학회 2017 韓國航行學會論文誌 Vol.21 No.4
Launch and recovery system(LARS) is required to perform an USV-based underwater exploration. Through the analysis of the requirements according to the scenario of underwater exploration, the mechanism of LARS and the conceptual design of the mechanical parts of LARS are carried out. In addition, a USV motion can be induced due to environmental disturbances such as waves, so the detailed design of LARS for recovering the underwater tow-fish stably in consideration of the USV motion is performed. To verify the performance of launch and recovery operations, LARS and test bed were developed. The results show that the proposed LARS can stably launch and recovery an underwater tow-fish. 무인수상정에서 수중탐색임무를 수행하기 위해서는 자동으로 수중탐색장비 진수 및 회수를 할 수 있는 진회수시스템(LARS; launch and recovery system)이 필수적이다. 수중탐색 운용시나리오에 따른 LARS 요구사항 분석을 통하여 기본적인 구동 메커니즘 및 기구부 개념설계를 수행하였다. 또한 해상에서 무인수상정은 파도와 같은 환경적인 외란에 의해 동요하게 되므로, 이러한 해상상태에 의한 외란을 고려하여 안정적으로 수중탐색장비를 회수하기 위한 상세설계와 제작을 수행하였고, 설계된 LARS에 대하여 수조시험을 통해 진회수 성능을 검증하였다.
간장 및 담도 : Ketoconazole 에 의한 독성간염 4예
강진경(Jin Kyung Kang),박찬일(Chan Il Park),김경희(Kyung Hee Kim),민희원(Hee Won Min),오광제(koyang Jae Oh),김형중(Hyung Jung Kim),전재윤(Jae Youn Jun),정재복(Jae Bock Jung),정우희(Woo Hee Jung) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Ketoconazole is the broad-spectrum antifungal ageht as an imidazole-dioxolane compound which is metabolized chiefly in the liver. It is used in onychomycosis, chronic mucocutaneous candidiasis, systemic fungal infection, and vaginal candidiasis that is chronic or not healed with topical treatment. Side reactions of ketoconazole are seen in 5%~10% of all the patients medicated but most of them are mild and transient. Nausea and vomiting are the most frequent side reactions. In addition, there are abdominal pain, headache, dizziness, itching sensation, fever, photophobia, diarrhea and transient elevation of serum hepatic enzyme level. However, symptoms of hepatitis develop rarely. In 1984, Lewis and co-workers reported 33 cases of ketoconazole- induced hepatitis and this kind of hepatitis has already been reported twice in Korea. In recent time we experienced 4 cases of hepatitis which had seemed as acute or chronic hepatitis clinically, but had confirmed with peritoneoscopic liver biopsy as toxic hepatitis developed after longterm use of ketoconazole.
Desferrioxamine이 사람 간암 세포주의 DNA 합성에 미치는 영향
강진경(Jin Kyung Kang),김원호(Won Ho Kim),송시영(Si Young Song),김도영(Doe Young Kim),문일환(Il Hwan Moon),윤견일(Kyun Il Yoon) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Desferrioxamine (DFO), an iron chelator, has been sbown to have antiproliferative activity in a variety of malignant cells including hepatocellular carcinoma. The antiproliferative effect of DFO's known to be caused by decreased activity of ribonucleotide reductase, a key enzyme in DNA synthesis. This study was conducted to investigate the effect Of DFO on the DNA synthesis of cultured hepatoma cells. The proliferation of hepatocellular carcinoma (Hep 3B) as well as hepatoblastoma (Hep G2) cells was measured by trypan blue dye exclusion method and the DNA synthesis was measured by [3H] thymidine incorporation. The results obtained were as follows: The proliferation of hepatoma cells was slightly inhibited by 2 ug/ml and markedly inhibited by 6 ug/ml of DFO. This antiproliferative effect was not enhanced any more by higher dose of DFO. The percent viability of Hep 3B and Hep G2 cells was above 90%. after 96 hours of incubation with 60 ug/ml of DFO and that of Hep 3B and Hep G2 cells was 88.0% and 89.6% respectively after l6 hours of culture with 120 ug/ml of DFO. DNA synthesis of hepatoma ceils was decreased by DFO in a dose dependent manner up to 20 ug/ ml. The decrease of DNA synthesis was not enhanced any more by higher dose of DFO. In conclusion, the antiproliferative effect of DFO on cultured human hepatoma cell lines was caused by the inhibition of DNA synthesis rather than by direct cytocidal effect.
강진일(Jin-il Kang),최형식(Hyeung-sik Choi),홍성율(Sung-yul Hong),서주노(Joo-no Seo),김문환(Moon-hwan Kim),권경엽(Kyeong-yeop Gwon) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In this paper, a 3-D simulator was developed to estimate visually the performance of propelling and integrated control system of the underwater cleaning robot. Based on the dynamics analysis of the UCR, the 3-D model of the UCR was used in the simulator including position and velocity. Also, a joystick was developed. It was an input and control device for the simulator. Moreover, integrated navigation control system was designed, and its performance was validated by a way-point simulator including the control law.
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),정재복(Jae Bock Chung),한광협(Kwang Hyub Han),김원호(Won Ho Kim),박찬일(Chan Il Park),유형식(Hyung Sik Yoo),김중영(Joong Young Kim),한은경(Eun Kyung Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A Focal fatty infiltration of the liver, a poorly characterized entity, was discovered incidentally at postmortem examination in the past, After both ultrasound and computed tomography (CT) have been extensively used over the past few years for imaging the hepatic parenchyma, it was possible to demonstrate focal fatty infiltration of the liver. Focal fatty infiltration of the liver may simulate mass lesions, so it is important to distinguish from space occupying lesions of the liver. Recently we encountered a case of focal fatty infiltration of the liver, which mimicked a liver tumor. It was detected by ultrasound and we performed abdominal CT, RBC liver scan, angiography and ultrasound guided needle biopsy. The diagnosis of focal fatty infiltration of the liver was established histologically.
각종 간질환 환자에서 혈청 Type IV Collagen 측정
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myung Moon),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),박찬일(Chan Il Park),박영년(Young Nyun Park),정진이(Jin Yi Chung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A Serum type IV collagen levels determined with one-step sandwich enzyme immunoassay using monoclonal antibodies were compared with histologic changes in the liver biopsy specimens from 95 patients with various liver diseases. Although serum type IV collagen levels were not significantly increased in patients with fatty liver and chronic persistent hepatitis compared to normal controls .serum type IV collagen levels were significantly increased in patients with chronic liver disease such as chronic active hepatitis or liver rirrhosis compared to normal controls and patients with fatty liver and chronic persistent hepatitis. According to the progression of liver disease, serum type IV collager levels wen significantly increased. In addition, all the 31 patients with chronic active hepatitis with early cirrhosis and liver cirrhosis showed elevated serum type IV collagen levels higher than mear plus one standard deviation level of controls. Serurn type. IV collagen levels did not correlate with serum transaminase levels in patients with chronic liver disease, A significant positive correlation was found between the serum type IV collagen level and the degree of fibrosis, piecemeal necrosis and portal and/or periportal inflamniation in patients with chronic active hepatitis. the results suggest that the serum type IV collagen levels correlate well with the degree of hepatir fibrosis. Therefore the measurement. of serum type IV collagen level is relatively simple and useful method to reflect the progress of hepatic fibrosis.
간장 및 담도 : 생검으로 확진된 지방간의 임상적 고찰
강진경(Jin Kyung Kang),최흥재(Heung Jae Choi),전재윤(Chae Yoon Chon),박찬일(Chan Il Park),윤정한(Jung Han Yoon),임대순(Dae Soon Yim) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Fatty liver is caused by derangement of fat metabolism and can be reversed by removal of contributing factors. The contributing factors of fatty liver include overweight, chronic alcoholism, diabetes mellitus, malnutrition, and drug abuse such as tetracycline. In this study, age and sex distribution, contributing factors, clinical features, liver function tests, correlation of grade of fatty liver to body weight, liver function test and viral markers were reviewed. Clinical diagnosis, peritoneoscopic diagnosis, and pathologic findings were compared in 54 cases with fatty liver proven by peritoneoscopic liver biopsy who were admitted to Yonsei University Severance Hospital from January 1981 to June 1985. The following results were obtained. 1) The mean age of 54 cases was 39. 9 years and the male to female ratio was 2.9 to 1 2) Contributing factors of fatty liver were overweight in 27 cases(50.0%), chronic alcoh- olism in 23 cases(42.5%), diabetes mellitus in 8 cases(14.9%), and malnutrition in 1 case (1 .9%). Overweight was the only contributing factor in 13 cases(24.o%), chronic alcoholism only in 12 cases(22.2%) There were more than one contributing factors in 16 cases(29.7%) and no definite contributing factors in 12 cases(22.2%). 3) Easy fatigability was the most frequent symptom which was found in 28 cases(52.7%) and hepatomegaly was the most common physical finding which was found in 26 cases (48.6%). 4) The r-GTP level was increased in 43 cases(80%), SGOT in 35 cases(65.5%), SGPT in 40 cases(74.5%), and triglyceride in 37 cases(68.9%). 5) The r-GTP and SGOT level were more elevated with statistical significance in chronic alcoholic group than in overweight group. G) There were no correlations of grade of fatty liver to body weight and liver function tests. 7) Eleven cases(22.5%) of 49 cases were HBsAg positive which was significantly higher than that of normal population in Korea. 8) A clinical diagnosis prior to peritoneoscopy was chronic hepatitis in 34 cases(62.8%), alcoholic liver disease in 9 cases(16.7%), fatty liver in 5 cases(9.2%), and HBsAg carrier in 4 cases(7.5%) A peritoneoscopic diagnosis was fatty liver in 3l cases(57.4%), chronic hepatitis in 10 cases(18.5%), acute unresolved hepatitis in 5 cases(9.3%), and normal liver in 8 cases(14.8%). In summary, the clinical diagnosis of fatty liver was made only in 5 cases(9.2%), and peritoneoscopic diagnosis of fatty liver in 31 cases(57.4%). The majority of the rest was chronic hepatitis. Therefore, it is mandatory to perform liver biopsy to distinguish fatty liver from chronic hepatitis.
간외담관 낭선종 ( Extrahepatic Biliary Cystadenoma )
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),정재복(Jae Bock Chung),전재윤(Chae Yoon Chon),김원호(Won Ho Kim),박찬일(Chan Il Park),송시영(Si Young Song),박영년(Young Nyun Park),이경식(Kyoung Sik Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Cystic tumor of the intra- or extra- hepatic bile ducts is a rare but distinctive neoplasm, similar to that occurring in the pancreas or ovary. The cystadenomas of the extrahepatic biliary tree are extremely rare, and most of them are usually intrahepatic, and rarely diagnosed preoperatively. We report a 63-year-old woman admitted because of intermittent abdominal pain for 1 month. Abdominal ultrasonography revealed a 2.5 cm hypoechoic oval mass with hyperechoic rim in dilatecl common hepatic duct and common bile duct. Abdominal computerized tomography revealed a hypodense mass surrounded by a thick dense outer rim. A 2.5*1.5 cm filling defect hanging from the right hepatic duct with a stalk was noticed on endoscopic retrograde cholangiography (ERC). Under the diagnosis of benign tumor originating from extrahep:,stic bile duct, laparotomy was performed. A 2.5* 1.8 * 0.6 cm mass, clinged with stalk from the right hepatic duct was noted and could be removecl by segmcntal resection of the common bile duct and the common hepatic duct. On cut section, greenisherous fluid containing multilocular cysts surrounded by a smooth wall with 0.3 cm thickness was seen. Microscopic findings revealed a cystadenoma lined by a single layer of columnar epitheliuni containing intracellular mucin pools without evidence of cellular atypism or mitosis.