한국인 집단에서의 혈장 단백질의 다형현상에 관한 연구

姜順子,申賢洙 이화여자대학교 사범대학 과학교육과 1993 생명과학연구논문집 Vol.4 No.-

To detect genetic polymorphisms of human plasma protein, Apolipoprotein H(APD.H), Apolipoprotein D(APO D) and Hemopexin(HPX) in Korean population, the vertical polyacrylamide slab gel isoelectric focusing method was used. The results were obtained as follows: 1. The phenotype of APO H is characterized by the most frequend APO H 2-2 and two rare phenotypes, 2-1 and 3-2 in Korean population. Other rare phenotypes, 1-1, 3-3, 3-1 and 4-2, were not detected. 2. The frequencies of the three alleles designated APO H * 1, APO H * 2, and APO H * 3 were caculated to be 0.042, 0.942, and 0.017, respectively. 3. Only APO D 1-1 type was detected in Korean population. APO D 2-1 was not found in Korean population. the gene frequency of APO D alleles was 1.00. 4. The phenotype of HPX foudn in Korean population was only HPX 1-1, and other rare phenotypes, 2-1, 3-1, and 3-3 were not found. The gene frequency of HPX alleles also was 1.00. 5. Based on the above results, APO H was polymorphic, but both of the APO D and HPX were monomorphic in Korean population.

Monosodium glutamate (MSG)와 saccharose가 노랑초파리(Drosophila melanogaster)의 발생에 미치는 영향에 대한 연구

姜順子 梨花女子大學校 韓國生活科學硏究院 1976 韓國生活科學硏究院 論叢 Vol.16 No.-

In order to see if monosodium glutamate (MSG) affects the development (emergence rates) when treated it at the various larval stages (first instar larva, second instar larva, and third instar larva) of D. melanogaster, the emergence rates of the three strains of D. melanogaster.(Oregon-R, Sinchon-4 and Chunchun). The MSG and sacchrose media were preapred by adding them at a concentration of 0.0M, 0.1M, 0.3M,0.5M, 0.7M and 1.0M to the standard media. The following conclusions were obtained: 1) The emergence rates from the MSG media is not significantlydifferevt among the three strains but strikingly different among the concentration of MSG in each of larval stages of D. melanogaster. 2) The emergence rates decrease as the concentration of MSG increase. 3) The decrease of emergence rates is found to be rather conspicuous when treated with MSG at the first instar larval stage but not when treated it at the second and thethird instar larval stages. 4) The emergence rates are not significantly different among concentrations of saccharose, impling that no effect of saccharose on the emergence rates of D. melanogaster.

韓國産 노랑초파리(Drosophila melanogaster)의 Alcohol Dehydrogenase에 대한 集團遺傳學的 硏究

姜順子 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.23 No.-

한국산 노랑초파리 (D. melanogaster)의 alchol dehydrogenase (ADH) 인자형의 분포를 조사하기 위하여 7개 지역의 노랑초파리 자연집단(창신동, 불광동, 부천, 수원, 포천, 대구 그리고 광주)과 9개 지역의 실험실집단(성북동, 여의도, 부암동, 창동, 신촌, 인천, 춘천, 대전, 그리고 전주)와 그리고 Oregon-R계통의 ADH에 대하여 agarose gel 전기영동법으로 실험한 결과는 아래와 같다. 1) 본 연구에서 다른 자연집단과 실험실집단은 ADH alleles에 대해서 모두 polymorphic하다. 2) 한국산 노랑초파리의 자연집단과 실험실집단은 ADH alleles에 대해서 FF형이 가장 많이 분포되어 있다. 3) ADH alleles의 F인자빈도는 S인자빈도 보다 훨씬 높다. The purpse of the present investigation in to exame distributiers of alcohol dehydrogenase genotypes in the Korean natural and laboratory populations of Drosophila melanogaster. The alchol dehydrogenase of D. melanogaster was Examined by the agarose gel electophoresis and frequencies of their alleles were alleles were calculated. The result obtained are presented below: 1. ADH alleles are polymorphic in the 7 natural and 9 laboratory populations od D. melanogaster in Korea. 2. The FF genotype is most frequently involved in natural and laboratory populations of D. melanogaster in Korea. 3. The F gene frequency of ADH alleles is higher than that of the S gene.

Monosodium glutamate(MSG)와 Sucrose가 먹초파리(Drosophila virilis)의 發生에 미치는 影響에 關하여

姜順子 梨花女子大學校 韓國生活科學硏究院 1974 韓國生活科學硏究院 論叢 Vol.13 No.-

In order to see if monosodium glutamate (MSG), a widely used food additive, affects the development of Drosophila virilis, an experiment was undertaken by examining the numbers of F_1 individuals emerged from the medium containing various concentrations of monosodium glutamate and sucrose. The results obtained are presented below: 1) The numbers of F_1 flies decrease as the concentration of monosodium glutamate increase. This suggests that monosodium glutamate has inhibitory effect on the development of Drosophila virilis. 2) Sucrose also shows an inhibitory effect on the development of Dosorphila virilis, but it is not so conspicuous as the effect of monosodium glutamate is.

Dietary Carbohydrate 가 노랑초파리의 GPDH Isozyme 발현에 미치는 영향

강순자,박광숙,박지연 한국유전학회 1999 Genes & Genomics Vol.21 No.1

We have examined the relative effects of dietary carbohydrates on GPDH isozymes in both larvae and adults of Drosophila. In larvae, GPDH tissue activities and cross-reacting materials (CRMs) were significantly increased in proportion to the dietary carbohydrate concentration. These observations indicate that the diet-induced change in GPDH activity is due to the modulation of GPDH CRM. The carbohydrate-stimulated increase of GPDH in larvae appears to be involved with the function of larval isozyme, GPDH-3, which plays a role in the diversion of carbohydrate into lipid. GPDH activities and CRMs in adult flies were a little increased with increasing carbohydrate concentration, but the staining activity in CRMs was reduced by high concentration of carbohydrate. In the case of adults, the exact modulating effects on functionally distinct GPDH isozymes are hard to discern in the protein level, because all the isozymes are present at the adult stage. With respect to transcript abundance, Northern analysis showed that Gpdh-411 transcript, encoding adult-limited GPDH-1, was repressed in high-carbohydrate diet. The change in GPDH-1 appears, in part, to be a stressful response to a high-carbohydrate diet. As a result, these findings suggest that GPDH isozymes can respond to dietary carbohydrates to varying degrees, and the regulation of isozymes by the diet is possibly involved with tissue-specific functions.

편지 II

강순자 대구대학교 국어교육과 1988 나랏말쌈 Vol.3 No.-

수학영재교육에서의 도전적 과제

강순자 全南大學校 師範大學 科學敎育硏究所 2004 科學敎育硏究誌 Vol.28 No.1

In this paper, we survey the nature of the differentiated curriculum for the gifted students of mathematics, the teaching strategy and the role of teacher for the gifted. From this point of view we analyze the some tasks which were carried out to the mathematics gifted students in the CNU Science Education Center for the Gifted and then suggest the patterns of desirable challenging tasks for the mathematics gifted.

오늘에 살자

강순자 대구대학교 국어교육과 1988 나랏말쌈 Vol.3 No.-

수학 및 과학 교과내용의 연계성 분석을 위한 준거모형 설정과 예시적 분석

강순자,이영하,박종윤,김규한,이종록,김성원,송순희,강순희,유계화 한국과학교육학회 1991 한국과학교육학회지 Vol.11 No.2

A taxonomy which can be used conveniently for analyzing the vertical articulation of mathematics and science textbooks has been developed. It includes two types analysis criterion: one is based on the detail of description and the other is based on the depth of contents in terms of their sequence. These two criterion elements are combined to form groups of 'overlap', 'development' and 'gap' to represent the extent of articulation. Examples of applying the taxonomy are illustrated for the concepts of gemetrical area in mathematics and potential energy in science.

한국인 집단에서 형광검출에 의한 STR(short tandem repeat)마커의 DNA 형 분석

강순자,최상규,선문숙 한국유전학회 1995 Genes & Genomics Vol.17 No.1

The short tandem repeat (STR) markers display considerable polymorphisms and provide the complementary information. This paper represented the analysis of a multilocus genotype using fluorescently tagged primers for eleven dimeric STR markers with (CA)n repeats (D5S416, D18S66, D18S70, D20S100, D20S106, D20S115, D20S119, D21S265, D21S266, D22S274, and D22S283). The number of alleles observed, ranging from 6 to 14 and the most common allele frequency was generally low showing below 0.5 excluding D20S115. Although deviations from Hardy-Weinberg equilibrium were noted at four markers (D5S416, D18S70, D20S106, and D22S274), genotype data from the others were overall consistent with Hardy-Weinberg equilibrium. The heterozygosities of the markers showed ranging from 0.547 to 0.816 and ten markers excluding D20S115 showed heterozygosities above 0.7. These STR markers were highly polymorphic, with the polymorphism information content (PIC) values ranging from 0.494 to 0.791 and nine STR markers showing PIC above 0.7. Consequently, the STR genotyping by the automated analysis of fluorescently amplified products will provide the high informativeness and the useful information for the genetic linkage mapping.