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정신분열병 환자의 임신 전 기간 Risperdal Consta 사용 사례
선우영경,김지영,배재남,김철응 대한정신약물학회 2006 대한정신약물학회지 Vol.17 No.6
Long acting noble antipsychotic, Risperdal Consta, has been reported to be efficacious and well tolerated in treatment of schizophrenia. However there was no report about the safety in using during pregnancy. Here we present the case of female patient with schizophrenia treated with risperdal consta during the entire period of pregnancy and delivered normal child. This case report highlights the benefit/risk of risperdal consta during pregnancy.
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선우영경,이상헌,강민희,김철응,이정섭,배재남 대한정신약물학회 2007 대한정신약물학회지 Vol.18 No.3
We describe a young male patient with rhabdomyolysis associated with the use of the atypical antipsychotic medication ziprasidone. A 23-year-old male was diagnosed with psychotic disorder not otherwise specified and treated with ziprasidone 120 mg/day. On hospital day 6, the patient developed acute dystonia. On day 8, his serum creatine kinase (CK) level was markedly elevated (up to 53,880 IU/L) and the white blood cell count was 10,500 cells/L. No other diagnostic criteria for neuroleptic malignant syndrome (NMS) were present. On discontinuation of the drug, serum CK concentrations returned to normal within 10 days. Atypical NMS should be considered when patients who are treated with novel atypical antipsychotics develop isolated serum CK elevation. 상기 증례의 경우 환자가 젊은 남성이고, 항정신병약물의 빠른 용량 증가가 신경악성증후군 위험 요인으로 추론된다. 따라서 비정형 항정신병약물 치료 시작 시기에 신경악성증후군의 위험 요인을 가진 환자들에서 혈청 CK 수치를 확인하는 것이 필요하며, 조기 발견과 적극적인 치료를 하는 것이 신경악성증후군으로 진행하는 것을 막을 수 있을 것이다. 앞으로 새로운 비정형 항정신병약물의 부작용에 대한 체계적인 연구가 필요할 것으로 생각된다.
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Relationships of Mental Disorders and Weight Status in the Korean Adult Population
선우영경,배재남,함봉진,이동우,박종익,조성진,이준영,김진영,장성만,전홍진,조맹제 대한의학회 2011 Journal of Korean medical science Vol.26 No.1
The purpose of this study was to evaluate the associations between weight status and mental disorders, including depressive disorder, anxiety disorder and alcohol use disorder. A total of nationally representative 6,510 subjects aged 18-64 yr was interviewed in faceto-face household survey. Response rate was 81.7%. Mental disorders were diagnosed using the Korean version of the Composite International Diagnostic Interview (K-CIDI). The subjects reported their heights and weights. After adjusting for age and gender, the lifetime diagnosis of depressive disorder had a significant association with only the underweight group (odds ratio [OR], 1.68, 95% confidence interval [CI], 1.19-2.38). The association between underweight and depressive disorder was the strongest for subjects with a high education level (OR, 1.75, 95% CI, 1.2-2.56), subjects with a married/cohabiting status (OR, 1.94, 95% CI, 1.17-3.22) and smokers (OR, 2.58, 95% CI, 1.33-4.98). There was no significant association between obesity and depressive disorder in Korea. But there was a significant association between the underweight group and depressive disorder. The relationship between obesity and mental disorder in a Korean population was different from that in a Western population. These results suggest that the differences of traditional cultures and races might have an important effect on the associations between the weight status and mental disorders.
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