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박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.
박정란,손장원 한국디지털건축·인테리어학회 2008 한국디지털건축인테리어학회 논문집 Vol.8 No.1
This paper intends to predict characteristic of the balcony space composition in apartment that residents want by analyzing floorplans utilizing balcony that is directly described by housewives in competitions. According to change of age, Modern's lifestyle is variously changed and future housing life may undergo changes continuously. Therefore, development of apartment housing plans is reflected by grasping and collecting space residents desire. Purpose of study is 1) arrangement characteristic of balcony space housewives prefer 2) relations characteristic between balcony and room adjoining balcony 3) characteristic of balcony space composition Through this study, the public space that family use together prefer facing the front side and the kitchen is required to face the front side. Balcony adjoining bedroom is utilized according to user of the bedroom, and independent space like hobby room do not have distinctive relationships with adjacent space. Recent trend that space is reflected in various lifestyle of resident require needs that exercise room for well-being life and other room for various functions. Based upon the study, the results show the basic information and understanding how the plans are supposed to change, particularly to facilitate the usage of the balcony.
공사립 유치원 에듀케어 프로그램의 혼합연령학급 운영 실제 및 교육적 효과에 대한 교사 인식
박정란 한국영유아교원교육학회 2007 幼兒 敎育學論集 Vol.11 No.2
The Public and Private Kindergarten Teachers' Recognition of Edu-care Program Practice and Educational Effects Regarding the Mixed-aged Group