총정맥영양법의 간담도 합병증에 대한 Ursodeoxycholic Acid 조기투여의 이중맹검 위약대조군 연구

최연호,백남선,김지희,이숙향,박태성,Choe, Yon-Ho,Beck, Nam-Sun,Kim, Ji-Hee,Lee, Suk-Hyang,Park, Tae-Sung 대한소아소화기영양학회 2002 Pediatric gastroenterology, hepatology & nutrition Vol.5 No.2

목 적: 총정맥영양법의 합병증인 간담도계 장애시 ursodeoxycholic acid (UDCA) 투여는 독성이 있는 내인성 담즙의 분비를 촉진하여 간손상을 감소시키는 역할을 하는 것으로 알려져 있다. 그러나 대부분의 연구는 합병증 발생 후 치료에 관한 것이어서 본 연구자들은 UDCA를 총정맥영양법의 시작과 동시에 조기 투여할 경우 그 예방효과를 이중맹검 위약대조군 연구로써 알아보고자 하였다. 방 법: 2000년 5월부터 2002년 5월까지 10일 이상의 총정맥영양을 받은 13명의 환아를 대상으로 하였다. 총정맥영양 시작과 동시에 UDCA를 투여받는 시험군 7명, 위약을 투여받는 대조군 6명을 이중맹검법으로 구분하였다. 연령은 생후 1일부터 13세까지이고 환아들의 진단은 경관영양이 불가능한 미숙아와 뇌성마비아, 만성설사, 거식증, 췌장염, 주기성 구토증 등이었다. 총정맥영양의 기간은 10일에서 70일까지였다. 주기적으로 간기능을 비롯한 검사항목등을 측정하였으며 총정맥영양의 기간, 조성, 투여속도, 열량 등이 조사 기록되었고 total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase에 대하여 군간 비교하였다. 결 과: Mixed procedure model을 이용한 분석에서 시험군을 reference로 하였을 때 대조군의 autoregressive coefficient 값은 total bilirubin의 경우 0.4419 (p=0.0651), AST는 -0.0431 (p=0.7923), ALT는 0.2398 (p=0.2416), 그리고 alkaline phosphatase는 0.2459 (p=0.1922)였다. 결 론: 총정맥영양과 UDCA를 초기부터 동시 투여하였을 때 total bilirubin은 대조군에 비하여 상승하지 않는 것으로 나타났으나 통계적으로 유의하지는 않았다. Purpose: Ursodeoxycholic acid (UDCA) is known to decrease hepatic injury by promoting the biliary secretion of retained toxic endogenous bile acids in hepatobiliary diseases complicated by total parenteral nutrition (TPN). However, most studies have focused on treatment for complications after TPN. We investigated the preventive role of early administration of UDCA in TPN-induced hepatobiliary complications by a randomized, double-blind, placebo-controlled trial. Methods: Between May 2000 and May 2002, thirteen patients, who were given TPN more than 10 days in the hospital, were assigned randomly to two groups. One was the case group (7 patients) who were given UDCA simultaneously with TPN regimen, and the other, the control group (6 patients) who were given placebo. Their age ranged from 1 day to 13 years. They were affected with diseases impossible for enteral nutrition, such as prematurity, cerebral palsy, chronic diarrhea, anorexia nervosa, pancreatitis, and cyclic vomiting. The duration of TPN ranged from 10 to 70 days. Hematologic parameters including liver function test were measured at regular intervals, and the duration, composition, administration rate, total calorie of TPN were recorded. The serum levels of total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase were compared between groups after cessation of the study. Results: The autoregressive coefficient of the control group was 0.4419 (p=0.0651) in bilirubin, -0.0431 (p=0.7923) in AST, 0.2398 (p=0.2416) in ALT, and 0.2459 (p=0.1922) in alkaline phosphatase by mixed procedure model when the parameters were referred to the case group. Conclusion: The serum level of total bilirubin did not increase in comparison with that of the control group, but statistically insignificant, when both TPN and UDCA were administered simultaneously from the beginning.

Helicobacter pylori 관련 철분 결핍 빈혈

최연호,Choe, Yon Ho 대한소아소화기영양학회 2006 Pediatric gastroenterology, hepatology & nutrition Vol.9 No.2

Lots of cases relating Helicobacter pylori infection to iron-deficiency anemia have been described in the literature and H. pylori infection has emerged as a cause of refractory iron-deficiency anemia which is unresponsive to oral iron therapy. H. pylori-associated iron-deficiency anemia can be treated by H. pylori eradication. It is not thought to be attributable to gastrointestinal blood loss, such as duodenal ulcer. The mechanism by which H. pylori infection contributes to iron-deficiency anemia remains unclear. However, four possible explanations can be posited for this relationship; occult blood loss secondary to chronic gastritis, reduced iron absorption due to hypo- or achlorhydria, increased iron consumption by H. pylori, and iron sequestration in gastric mucosa. H. pylori-associated iron-deficiency anemia seems to develop in populations at increased risk for iron depletion. When pubescent girls, including athletes, are found to have iron-deficiency anemia refractory to iron administration, they should be evaluated for H. pylori infection.

소아 십이지장궤양에서의 H. pylori 박멸과 궤양재발에 대한 연구

최연호,고재성,김순영,유영미,서정기,Choe, Yon-Ho,Ko, Jae-Sung,Kim, Soon-Yeong,Yoo, Young-Mee,Seo, Jeong-Kee 대한소아소화기영양학회 1998 Pediatric gastroenterology, hepatology & nutrition Vol.1 No.1

목 적: H. pylori가 만성유문부 위염의 원인으로 밝혀지면서 십이지장궤양 환자의 90%이상에서 그 위점막에 H. pylori의 존재가 확인되어 H. pylori의 박멸이 십이지장궤양 치료 및 재발에 미치는 영향에 대해 많은 연구가 이루어져 왔고 여러 보고에서 H. pylori의 박멸로 십이지장궤양의 재발율이 현저히 감소한다고 하였다. 소아에서는 성인에 비해 궤양의 빈도가 낮고 내시경적 검사의 제약으로 인하여 이에 대한 관심이 상대적으로 적었으며 소아 십이지장궤양에 대한 연구는 현재까지 거의 없는 실정이다. 이에 저자들은 내시경으로 진단한 소아 십이지장궤양에서 고식적 궤양치료와 H. pylori 병행치료후의 궤양의 재발에 대해 비교 분석해 보고자 하였다. 방 법: 1987년 7월부터 1995년 8월까지 서울대학병원 어린이 병원에 내원하여 내시경검사상 십이지장궤양으로 진단받은 105명(남:여=78:27)을 대상으로, 고식적 치료(ranitidine+antacid)를 행한 군과, H. pylori 진단을 받은 경우 고식적 치료와 함께 amoxicillin(50 mg/kg) 2주, denol(8 mg/kg) 4주의 균박멸 치료를 병행한 군으로 나누어 궤양재발율에 대하여 비교 조사하여 보았다. H. pylori 양성은 내시경생검을 통한 CLO test, Giemsa 염색과 혈청 IgG 항체검사중 둘 이상이 양성이거나 생검조직의 균배양이 양성인 것으로 하였다. 결 과: 1) 91년 5월이후 진단받은 38명(남:여=30:8) 중 원발성 십이지장궤양은 30명(78.9%)이었으며 모두 H. pylori 검사가 시행되어 이중 27명이 양성으로 H. pylori의 감염율은 90.0%였다. 2) H. pylori 양성인 27명 환아에 대해 고식적 치료와 H. pylori 치료를 병행하였는데 추적내시경검사상 23명에서 궤양치유와 함께 균의 박멸이 확인되어 H. pylori 치료성공율은 85.2%였다. 3) 6주의 치료후 추적검사상 박멸에 실패한 3명은 강화요법으로 균의 소실이 확인되었고 이중 1명(33.3%)이 치료종료 2.4년후 재발하였다. 4) 십이지장궤양 환아의 치료후 추적관찰 1년이내 궤양의 재발율은 고식적 치료만을 시행한 경우 65.3%였고 H. pylori 치료를 병행한 경우는 4.3%였다. 결 론: 십이지장궤양 환아들의 대부분이 H. pylori의 감염이 있으며 H. pylori 양성인 소아 십이지장궤양에서 H. pylori 박멸 요법은 궤양 재발의 방지를 위하여 반드시 필요하다. Purpose: It is well known that duodenal ulcer disease does not relapse if H. pylori is cleared from the gastric mucosa. Little is known about the recurrence of duodenal ulcer in children. The purpose of this study was to evaluate the effect of the eradication of H. pylori in duodenal ulcer in children upon the duodenal ulcer recurrence. Methods: 105 patients (M:F=78:27) diagnosed as duodenal ulcer by endoscopy in 1987~1995 were reviewed clinically, and were parted into two groups. The two treatment groups were ranitidine/antacid (RAN/ANT) and ranitidine/amoxicillin/denol (RAN/AMX/D). The latter was for H. pylori-positive children with duodenal ulcer who were diagnosed by serology and/or antral biopsies for histology, culture, and urease testing. The recurrence rates were compared between the two groups. Results: 1) 30 patients with primary duodenal ulcer underwent endoscopy for H. pylori and 27 (90.0%) of them were positive for H. pylori. 2) 27 of H. pylori-positive children received RAN/AMX/D. 23(85.2%) of them showed cure of duodenal ulcer and eradication of H. pylori. 3) The duodenal ulcer recurrence rate in RAN/ANT group was 65.3% and the rate in RAN/AMX/D was 4.3% by a year. Conclusions: There is a strong correlation between the duodenal ulceration and H. pylori infection in children, and the eradication of H. pylori in duodenal ulcer patients reduces the recurrence of the ulcer. Because of the low incidence of duodenal ulcers in children, a multicenter prospective study is required to determine the effect of treating H. pylori infetion on the long term natural history of duodenal ulcer disease.

하이 포이드 기어 단조 공정 개발

최연호,박원규,김대원,최호준,윤덕재,이상목,임성주,이영선 한국소성가공학회 2010 단조 심포지엄 Vol.2010 No.6

Prediction of Retail Beef Yield Using Parameters Based on Korean Beef Carcass Grading Standards

최연호,이선호,최성복,전기준,김형철,정학재,이종문,박범영 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.6

Two sets of data on carcass traits and beef cut parameters were used to investigate the relationships between carcass and beef cut measurements, which can be used to make predictions of retail cut percentages. One set had a total of 1,141 measurements of Hanwoo cattle of three different sex origins, which were slaughtered in an abattoir located at the National Institute of Animal Science, RDA, Korea from 1996 to 2008. To develop prediction models for retail cut percentage with higher accuracies than the current model, another set consisting of a total of 13,389 records of carcass and beef cut traits were collected from 30 abattoirs and butcheries in Korea from 2008 to 2009. Bulls yielded heavier and leaner carcasses than steers. High correlation coefficients were estimated between amount of body fat and percent retail cut (-0.82) as well as between back fat thickness (BF)and percent retail cut (-0.62). The amount of retail cut, however, was highly correlated with body weight before slaughter (BW,0.95) or with cold carcass weight (CWT, 0.94). Relationships between percent retail cut and measurable beef yield traits, BF,loin eye area (LEA) or CWT varied by sex class, which must be considered for development of a prediction model with high accuracy. Models of data for all breeds and sexes fit the effects of breed, sex, and interaction of abattoir by butchers, whereas models of data for each breed and sex fit the effect of interaction of abattoir by butcher only. Due to possible future changes in back fat control, we performed a log transformation of BF. Our new models fit better than the currently used model.

홀스타인 젖소의 생시체중과 분만난이도와의 상관관계

최연호,원정일,윤호백,조광현,Alam Mahboob,조충일,연성흠,박병호,양보석 강원대학교 동물생명과학연구소(구 강원대학교 동물자원공동연구소) 2015 동물자원연구 Vol.26 No.2

The objective of this study was to identify the phenotypic relationships among calving difficulty, calf birth weight and gestation length of Holstein dairy cattle under the environment of Korea. A total of 1,834 calving records collected by Dairy Science Division of National Institute of Animal Science, RDA from 2000 to 2014 was analyzed. General linear multivariate models for calving difficulty scores (CD: 1=no assistance, 2=minor assistance, 3=two to three persons assisted, 4=more than three persons assisted, 5=cesarean section), calf body weight at birth (BW), and gestation length (GL) included fixed effects of year and season (spring, summer, autumn, winter) of births (YS), sex of calves, and parity. For GL and BW, all three fixed effects (YS, sex of calves, parity) were significant (p<0.05). For CD, the effects of YS and sex of calves were significant (p<0.05). Bull calves were born with heavier BW by 3.18 kg, with greater CD by 0.18 point and with longer GL by 0.6 days than heifer calves. The least squares mean of BW was the heaviest at the third parity (44.1 kg) compared to those at the first, the second and the fourth parities or later (41.3-41.9 kg). The least squares mean CD at the first parity was 1.74 point, which was higher than CD at the second and later parities (about 1.68 points). Phenotypic correlation (partial residual correlation) between GL and BW was 0.36. But those between GL and CD and between BW and CD were -0.03 and 0.04, almost zeros. To conclude, we observed higher incidence of calving difficulty in the first calving than in the later ones. Further investigation on the relationships between calf’s birth weight and calving difficulty is needed.

LAYFAMS V2.5 업그레이드판 안내

최연호 대한양계협회 1997 월간 양계 Vol.29 No.5

제트가 충돌하는 회전원판에서의 열전달 특성 ( Heat Transfer Characteristics on a Rotating Disk Subjected to Jet Impingement )

최연호,정영석,이준식,유정열 대한기계학회 1999 대한기계학회 춘추학술대회 Vol.- No.-

바다의 날 특집 / 미래의 해양산업에 대한 기대 : 한국조선산업의 경쟁력 현황과 발전 방향

최연호 한국해사문제연구소 1996 (月刊)海洋韓國 Vol.273 No.-

생체모방 공중로봇의 날개 구조 모델링

최연호,조내수,정정은,권우현,이동하,Choi, Youn-Ho,Cho, Nae-Soo,Joung, Jung-Eun,Kwon, Woo-Hyen,Lee, Dong-Ha 한국태양에너지학회 2012 한국태양에너지학회 논문집 Vol.32 No.suppl3

The research of the biological mimics robot which utilizes the operation of the organism is progressed on the ground, aerial, and underwater robot sector. In the field of flying robot, the research for implementing the wing movement structure of the bird and insect is progressed. The joint structure for the wing movement of the bird is implemented. The operation of the wing is simulated. For this purpose, by using the Matlab/Simulink, the joint structure of the wing is modelled. The joint movement of the wing is tested through the simulation.