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Adiponectin Concentrations: A Genome-wide Association Study
Jee, Sun Ha,Sull, Jae Woong,Lee, Jong-Eun,Shin, Chol,Park, Jongkeun,Kimm, Heejin,Cho, Eun-Young,Shin, Eun-Soon,Yun, Ji Eun,Park, Ji Wan,Kim, Sang Yeun,Lee, Sun Ju,Jee, Eun Jung,Baik, Inkyung,Kao, Lind Elsevier 2010 American journal of human genetics Vol.87 No.4
<P>Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in <I>CDH13</I> on chromosome 16 (p = 1.69 × 10<SUP>−15</SUP> in the initial sample, p = 6.58 × 10<SUP>−39</SUP> in the second genome-wide sample, and p = 2.12 × 10<SUP>−32</SUP> in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10<SUP>−83</SUP>. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10<SUP>−58</SUP>) was even stronger in the third sample. A reporter assay that evaluated the effects of a <I>CDH13</I> promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in <I>CDH13</I> influence adiponectin levels in Korean adults.</P>
Nosocomial Outbreak of COVID-19 in a Hematologic Ward
Jung Jiwon,Jungmin Lee,Seongmin Jo,Bae Seongman,Ji Yeun Kim,Cha Hye Hee,Lim Young-Ju,Kwak Sun Hee,Hong Min Jee,Kim Eun Ok,Bae Joon-Yong,Kang Changmin,Sung Minki,Park Man-Seong,Kim Sung-Han 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.2
Background: Coronavirus disease 2019 (COVID-19) outbreaks occur in hospitals in many parts of the world. In hospital settings, the possibility of airborne transmission needs to be investigated thoroughly. Materials and Methods: There was a nosocomial outbreak of COVID-19 in a hematologic ward in a tertiary hospital, Seoul, Korea. We found 11 patients and guardians with COVID-19 through vigorous contact tracing and closed-circuit television monitoring. We found one patient who probably had acquired COVID-19 through airborne-transmission. We performed airflow investigation with simulation software, whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results: Of the nine individuals with COVID-19 who had been in the hematologic ward, six stayed in one multi-patient room (Room 36), and other three stayed in different rooms (Room 1, 34, 35). Guardian in room 35 was close contact to cases in room 36, and patient in room 34 used the shared bathroom for teeth brushing 40 minutes after index used. Airflow simulation revealed that air was spread from the bathroom to the adjacent room 1 while patient in room 1 did not used the shared bathroom. Airflow was associated with poor ventilation in shared bathroom due to dysfunctioning air-exhaust, grill on the door of shared bathroom and the unintended negative pressure of adjacent room. Conclusion: Transmission of SARS-CoV-2 in the hematologic ward occurred rapidly in the multi-patient room and shared bathroom settings. In addition, there was a case of possible airborne transmission due to unexpected airflow.
The Relationship between Heart Rate Variability and Aortic Knob Width
Si-Yeun Sung,Jee-Hye Han,Jung-Hwan Kim,Kil-Young Kwon,Seong-Wook Park 대한가정의학회 2019 Korean Journal of Family Medicine Vol.40 No.1
Background: The aortic knob width (AKW) and the heart rate variability (HRV) were suggested to be related to development of cardiovascular diseases. However, the relationship between them has not been investigated; thus, this study aimed to determine this relationship. Methods: This study included 587 Koreans aged 18–79 years. Their physical measurements, medical and social histories, blood test findings, and chest radiographs were obtained. The HRV parameters included the standard deviation of the N-N interval (SDNN), root mean square of successive differences (RMSSD), approximate entropy (ApEn), total power (TP), very low frequency (VLF), low frequency (LF), high frequency (HF), and LF/HF ratio, which were measured for 5 minutes. The AKW was measured on chest radiographs by a single reviewer. Results: The AKW was significantly correlated with the HRV parameters, except for the LF/HF ratio. However, RMSSD and ApEn were not significantly related to the AKW in women. After dividing the participants into quartile groups, the AKW was significantly related to the SDNN, RMSSD, TP, VLF, LF, and HF. The HRV parameter values decreased in the higher AKW quartile groups, the HRV parameter values decreased. After adjusting for sex, drinking status, exercise habits, smoking status, waist circumference, and triglyceride, low-density lipoprotein cholesterol, fasting blood sugar, and glycated hemoglobin levels, the AKW showed significant negative associations with the HRV parameters, except for the LF/HF ratio. Conclusion: The AKW is significantly associated with the HRV parameters of SDNN, RMSSD, ApEn, TP, VLF, LF, and HF.
한국 폐경여성에서 저밀도 지단백 수용체 관계 단백 5 유전자의 단일염기유전자다형성과 골량 사이의 연관성에 관한 연구
김자연 ( Ja Yeun Kim ),이동옥 ( Dong Ock Lee ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ),김정구 ( Jung Gu Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.1
연구목적: 한국 폐경여성에서 저밀도 지단백 수용체 관계 단백 5 (low density lipoprotein receptor-related proteins 5; LRP5) 유전자 다형성양상과 골밀도사이에 연관성이 있는가를 알아보고자 하였다. 연구재료 및 방법: 자연폐경여성 261명에서 LRP5 유전자 내 A314G, T2268C, GInv17-30A 다형성 양상을 제한절편길이다형성 (restriction fragment length polymorphism; RFLP)으로 분석하고 혈청 CrossLaps (CTX), osteocalcin, bone alkaline phosphatase (BAP), calcitonin, 부갑상선호르몬 (parathyroid hormone; PTH), 칼슘, 인 농도를 각각 효소면역법, 면역측정법, 원자흡광법으로, 요추 및 대퇴 근위부에서의 골밀도를 이중에너지 엑스레이 흡수계측기 (DXA)로 측정하였다. 결 과: LRP 유전자 내 A314G, T2268C 다형성양상에 의한 유전자형은 AA 83.1%, AG 14.9%, GG 1.9%, CC 50.2%, CT 43.3%, TT 6.5%이었으며, GInv17-30A의 경우 GG 76.2%, GA 20.7%, AA 3.1%이었다. 이러한 다형성양상에 의한 단일 유전자형 또는 haplotype 유전자형에 따른 요추 및 근위 대퇴부에서의 골밀도에서는 차이가 없었다. 혈청 PTH 농도가 A314G 다형성의 GG 유전자형에서 AA 유전자형 또는 AG 유전자형 보다 높다는 것 이외에 다른 단일 유전자형 또는 haplotype 유전자형과 골의 생화학적 인자 농도사이에는 연관성이 없었다. 결 론: 한국 자연폐경 여성에서 LRP5 유전자 내 A314G, T2268C 및 GInv17-30A 다형성양상은 골밀도에 영향을 주지 않는다. Objectives: To investigate the relationship between low density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women. Methods: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were analyzed by restriction fragment length polymorphism in 261 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone (PTH), calcitonin, calcium, and phosphorus levels were measured by enzyme linked immunosorbent assay, immunoassay and by atomic absorptiometry respectively. The BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. Results: The distributions of A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were as follows; AA 83.1%, AG 14.9%, GG 1.9%, CC 50.2%, CT 43.3%, TT 6.5%, GG 76.2%, GA 20.7%, and AA 3.1%. No significant differences in adjusted BMD of lumbar spine and femoral neck were noted among single or haplotype genotypes of LRP5 gene polymorphisms. No statistical significances in associations between serum levels of bone biochemical markers except PTH and single or haplotype genotypes were observed. Serum PTH levels in women with GG genotype of A314G polymorphism was significantly higher than those in women with AA or AG genotype. Conclusion: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene do not affect BMD at the lumbar spine and proximal femur in postmenopausal Korean women.
한국인의 혈청 아디포넥틴과 당뇨병 진단기준 설정에 관한 연구
지선하(Sun Ha Jee),이희연(Hee Yeon Lee),이선주(Sun Ju Lee),윤지은(Ji Eun Yun),지은정(Eun Jung Jee),송혜윤(Hye Yun Song),김상연(Sang Yeun Kim),박정용(Jungyong Park),김현숙(Hyon-Suk Kim) 한국역학회 2007 Epidemiology and Health Vol.29 No.2
Background: As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well known risk factor for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. Methods: The WC, BMI, and serum adiponectin were measured in 6,505 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126㎎/dL or taking medication. Results: Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high density lipoprotein cholesterol (HDL) cholesterol (P<0.001). After adjusting for age, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in both men and women. The best cut-off value of adiponectin in terms of identifying the presence of diabetes was 5.5㎍/㎖ with a sensitivity and specificity of 46.7% and 63.9% for men and 9.5㎍/㎖ with a sensitivity and specificity of 68.2% and 55.2 for women. Conclusions: These results suggest that adiponectin was associated with diabetes. The association was independent of WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC on diabetes.