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Drug resistance of bladder cancer cells through activation of ABCG2 by FOXM1
( Yun-gil Roh ),( Mi-hye Mun ),( Mi-so Jeong ),( Won-tae Kim ),( Se-ra Lee ),( Jin-woong Chung ),( Seung Il Kim ),( Tae Nam Kim ),( Jong Kil Nam ),( Sun-hee Leem ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.2
Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer. [BMB Reports 2018; 51(2): 98-103]
VCO를 이용한 1T 구조의 그래픽 메모리용 self-refresh 클럭 생성회로 설계
노길성(Gil-Sung Roh),김학윤(Hak-Yun Kim),이명학(Myunga-Hak Lee),최호용(Ho-Yong Choi) 한국정보기술학회 2014 한국정보기술학회논문지 Vol.12 No.6
In this paper, we design a self-refresh (SRF) clock generation circuit for 1T-based graphic memory of DDI(display driver IC) using a voltage controlled oscillator to reduce power consumption by self-refresh operation due to temperature. The SRF clock generation circuit consists of a temperature sensor which senses memory temperature, and a voltage controlled oscillator (VCO) which generates a continuous variable clock. The circuit is operated in temperature range, 0℃ ~ 85℃, and is operated with 2 times slope at temperature above 70℃ to be effective. The circuit has been designed using the TSMC 0.18㎛ CMOS process. The simulation results show that the temperature sensor generates the output voltage, 920mV ~ 2.02V, in temperature range, 0℃ and 85℃, and the VCO generates self-refresh clock with 10Hz ~ 167Hz. Also our design has about 34% ~ 67% power consumption at 0℃ ~ 85℃ compared with the previous methods.
Deletion of xylR Gene Enhances Expression of Xylose Isomerase in Streptomyces lividans TK24
( Gun Young Heo ),( Won Chan Kim ),( Gil Jae Joo ),( Yun Young Kwak ),( Jae Ho Shin ),( Dong Hyun Roh ),( Heui Dong Park ),( In Koo Rhee ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.5