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경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염
홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.
Ah Reum Lee,Yu Ock Shin,Joo Young Lee,Min Yeong Kim,Sung Ho Shin,Bu-Il Seo,Young-Bae Seo,Man Hee Rhee,TakakoYokozawa,Chan Hum Park,Seong-SooRoh 한국약용작물학회 2015 한국약용작물학술대회 발표집 Vol.2015 No.05
Purpose Rhei Rhizoma (RR) is one of the herbal medicines traditionally used to treat diverse inflammatory diseases. The present study was undertaken to elucidate the antioxidant and anti-inflammatory activities of Rhei Rhizoma on experimental reflux esophagitis (RE) in rats. Methods The antioxidant activity of RR in vitro was measured in terms of radical scavenging capacity such as DPPH and ABTS. RE was produced by ligating both the pylorus and the transitional junction between the forestomach and the corpus. Rhei Rhizoma (125 and 250 mg/kg) were administered every day for 7 days, and its effect was estimated on comparison with RE control and normal rats. Results RR scavenged DPPH and ABTS effectively and IC50ofDPPH and ABTS radical scavenging activity of RR were 4.8 μg/ml and 15.75 μg/ml. The administration of RR decreased the elevated serum ROS in RE control rats. The RE control rats exhibited the down-regulation of antioxidant-related proteins such as Nrf2 and HO-1expression levels in the esophagitis; however, the level in the RR-treated RE rats was significantly higher than that in the RE control rats. Moreover, RE control rats exhibited the up-regulation of the protein expression related to oxidative stress at the esophagitis, but RR administration significantly reduced the expression of inflammatory proteins through the MAPK-independent signaling pathways. The expression of inflammatory mediators and cytokines by NF-κB activation was modulated through blocking the degradation of IκBα. In addition, the oral administration of RR regulated the gastric mucosal damage in RE rats. Conclusion The administration of Rhei Rhizoma effectively ameliorates the inflammatory damage of esophageal mucosa through radical scavenging activity and the activation of the Nrf2/HO-1 pathway.
( Yu Jung Jo ),( Kyung Ah Kim ),( June Sung Lee ),( Nam Hoon Kim ),( Won Ki Bae ),( Tae June Song ),( Jeong Wook Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2
Background/Aims: The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV. Methods: Chronic hepatitis B patients treated with ETV (0.5 mg/day) for at least 1 year were enrolled retrospectively. PVR was defined as a decrease in hepatitis B virus (HBV) DNA titer of more than 2 log10 IU/mL, yet with residual serum HBV DNA, as determined by real time-polymerase chain reaction, at week 48 of ETV therapy. Results: A total of 202 patients (127 NA-naive and 75 NA-experienced, male 70.8%, antigen positive 53.2%, baseline serum HBV DNA 6.2 ± 1.5 log10 IU/mL) were analyzed. Twenty-eight patients demonstrated a PVR. The PVR was associated with a high serum HBV DNA titer at baseline and at week 24. Virological response (< 60 IU/mL) was achieved in 46.2%, 61.5%, 77.6%, and 85% of patients with PVR at week 72, 96, 144, and 192, respectively. Resistance to antivirals developed in two NA-experienced patients. Failure of virological response (VR) in patients with PVR was associated with high levels of serum HBV DNA at week 48. Conclusions: Patients with PVR to ETV had favorable long-term virological outcomes. The low serum level of HBV DNA (< 200 IU/mL) at week 48 was associated with subsequent development of a VR in patients with PVR to ETV.
Alpha-lipoic Acid Protects Neuronal Cells from Ethanol-induced Neurotoxicity
Yu Jeong Bae,Yoo Hun Noh,Do Hee Kim,Jiae Park,Ok Hyeon Kim,Seung-Ah Lee,Yoon Hee Chung,Seung Ho Han,Kyung Yong Kim,Won Bok Lee 중앙대학교 의과대학 의과학연구소 2014 中央醫大誌 Vol.39 No.2
Ethanol exposure has various toxic effects on the human nervous system results in various developmental and behavioral deficits. Present studies showed the protective effect of alpha-lipoic acid (LA), a potent natural anti-oxidant and anti-inflammatory molecule against various brain toxins. Since LA has attracted more attention for its anti-apoptotic properties, we investigated the neuroprotective efficacy of LA in EtOH-treated SH-SY5Y human neuroblastoma cells. The cell death was evaluated by MTT assay, morphological assessment. EtOH induced neuronal cell death in a time- and dose-dependent manner. The cell death examined was increased and the apoptotic morphological features, including retraction of neuritis, cell shrinkage, and membrane blebbing were induced by EtOH. However, in the cells treated with LA for 1h and exposed to EtOH the EtOH-induced neuronal cell death was significantly attenuated in a dose-dependent manner. The LA effectively inhibited SH-SY5Y cell death and apoptotic morphological changes in the cells induced by EtOH. Our results indicate that pretreatment with LA interrupts EtOH-induced apoptotic morphological change, and suggest that some of the protective effects of LA and other antioxidants likely involve classical antioxidant actions by EtOH-related brain damages and nerve injuries by oxidative stress which causes apoptosis.
( Yu Jung Cho ),( June Sung Lee ),( Tae Jun Song ),( Won Ki Bae ),( Nam Hoon Kim ),( Kyung Ah Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: According to current guidelines, patients showing a partial virological response (PVR) at week 24 to nucleos(t)ide analogues (NA) with a low genetic barrier should change or add a more potent drug, and patients with PVR to NA with a higher genetic barrier can continue the same drug until week 48. However, there are few studies on a PVR at week 48 to drugs with a high genetic barrier such as entecavir (ETV). The aim is to assess long-term outcomes of chronic hepatitis B patients with a PVR to ETV at week 48. Methods: Chronic hepatitis B patients treated with entecavir 0.5mg for 1 year or longer at a single center were analyzed retrospectively. Virological response (VR) was defined as undetectable serum HBV DNA by real-time PCR (<300 copies/mL). PVR was defined as a decrease in HBV DNA of more than 1 log IU/mL but detectable serum HBV DNA by PCR. Results: Total 190 patients (116 NA-naive and 74 NA- experienced, male 67.9%. cirrhosis 35.8%, eAg-positive 42.1%) were analyzed in this study. VR was achieved in 80.2%, 88.9%, and 94.6% of NA-naive patients and 72.2%, 81.3%, 91.9% of NA-experienced patients at week 24, 48, and 96 respectively. Baseline serum HBV DNA and extent of HBV DNA decline were independent predictable factors for a PVR at week 48. Patient with a PVR achieved a VR at week 96 in 57.1% (60% in NA-naive patients, 54.5% in NA-experienced patients). Serum HBV DNA at week 48 was only predictable for achieving VR at week 96 (88.9% in patients with serum HBV DNA <1000 copies/mL, 0% in patients with serum HBV DNA ≥1000 copies/mL). Two out of 11 NA-experienced patients with a PVR at week 48 developed ETV-resistance, whereas none of 13 NA-naive patients with PVR developed antiviral resistance. Conclusion: Most of NA-naive patients with a PVR to ETV and serum HBV DNA < 1000 copies/mL at week 48 achieved a VR at week 96. However, patients with NA-experience or serum HBV DNA ≥1000 copies/mL at week 48 showed poor long-term outcome to ETV.