Inorganic-organic hybrid nanoporous materials as adsorbent to remove VOCs

Jae Hoon Kim,Jin Hee An,Young Soo La,Jin Su Jung,Suck Man Kim,Nam Gu Moon,Byung Wha Lee,Young Ho Yoon,Young Il Choi,정한모 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.2

Inorganic–organic hybrid nanoporous materials were prepared by the co-condensation of 1,2-bis(triethoxysilyl)ethane (BTSE) with 1,3- bis(triethoxysilyl)benzene (BTSB) or 4,4'-bis(triethoxysilyl)-1,1'-biphenyl (BTSP). The nanoporous materials had broad pore-size distribution in the range of mesopore and macropore. The nanoporous materials prepared by co-condensation of BTSE with more than 30 wt% of BTSP showed an enhanced removal capability of volatile organic compounds (VOCs) from air compared to that prepared with BTSE only, probably due to the affirmative interaction between VOCs and aromatic ring in the nanoporous materials. The VOC generation from polypropylene/talc composite (PPF) was reduced to around half when three part of these inorganic–organic hybrid nanoporous material was added per 100 part of PPF during the melt compounding process as an additive, which suggests a new application of nanoporous material.

Clinical Characteristics and Treatment Outcomes of Pulmonary Diseases Caused by Coinfections With Multiple Nontuberculous Mycobacterial Species

Kim Sol,Woo A La,Yong Seung Hyun,Leem Ah Young,Lee Su Hwan,Lee Sang Hoon,Kim Song Yee,Chung Kyungsoo,Kim Eun Young,Jung Ji Ye,Kang Young Ae,Park Moo Suk,Kim Young Sam,Park Youngmok 대한의학회 2024 Journal of Korean medical science Vol.39 No.20

Background: Coinfections with multiple nontuberculous mycobacterial (NTM) species have not been widely studied. We aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-pulmonary disease (PD) caused by coinfection with multiple NTM species. Methods: We retrospectively reviewed patients with NTM-PD at a tertiary referral hospital in Korea between March 2012 and December 2018. Coinfection was defined as two or more species of NTM pathogens isolated from the same respiratory specimen or different specimens within three months. Results: Among 1,009 patients with NTM-PD, 147 (14.6%) NTM coinfections were observed (average age 64.7 years, 69.4% women). NTM species were identified more frequently (median 6 vs. 3 times, P < 0.001) in the coinfection group than in the single species group, and follow-up duration was also longer in the coinfection group (median 44.9 vs. 27.1 months, P < 0.001). Mycobacterium avium complex (MAC) and M. abscessus and M. massiliense (MAB) were the dominant combinations (n = 71, 48.3%). For patients treated for over six months in the MAC plus MAB group (n = 31), sputum culture conversion and microbiological cure were achieved in 67.7% and 41.9% of patients, respectively. We divided the MAC plus MAB coinfection group into three subgroups according to the target mycobacteria; however, no statistical differences were found in the treatment outcomes. Conclusion: In NTM-PD cases, a significant number of multiple NTM species coinfections occurred. Proper identification of all cultured NTM species through follow-up is necessary to detect multispecies coinfections. Further research is needed to understand the nature of NTM-PD in such cases.

Development of the Composite Biologic Scoring as a Predictor of Longterm Prognosis of Lung Transplantation

( Ji Yeon Choi ),( Song Lee Kim ),( Sang Hoon Lee ),( A La Woo ),( Young Mok Park ),( Seung Hyun Young ),( Ah Young Leem ),( Su Hwan Lee ),( Eun Young Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Survival after lung transplantation (LT) has steadily improved but its prognosis is still lower than other solid organ transplantation. It is important to predict prognosis in patients who underwent LT but currently there is no specific tool for prediction. Methods In the single-center retrospective study, we reviewed data from patients who underwent LT at Severance Hospital in South Korea from October 2012 to September 2020. Patients who underwent multi-organ transplantation (n=5), re-transplantation (n=5), age ≤18 years old (n=4) and early acute-phase patients within 3 months after LT (n=31) were excluded. A total of 249 LT patients were included for constructing the prediction model for prognosis called the Composite Biologic Scoring (CBS), using the numeric biologic markers around 3 months as a reference which were highest among observation period. Cox proportional hazards model was used to calculate the weight of each criterion included in the CBS, and the predictive accuracy and discriminative ability were measured by concordance index (C-index) and Kaplan Meier survival curve. Results Among 249 patients, mean age was 54.5±11.6 years, and 161 (64.7%) were men. Eight independent prognostic factors were identified and points were assigned to each variable based on Cox proportional hazards regression analysis including white blood cells, hemoglobin, platelet, ferritin, fibrinogen, aspartate aminotransferase, triglyceride, and lactate dehydrogenase (Fig. 1). The C-index for cox proportional hazards model was 0.809 and the calibration curves for the probability of 2, 3, and 5-year overall survival showed close approximation between nomogram prediction and actual observation. Three stratified risk groups according to CBS in post LT patients demonstrated significant distinction between Kaplan-Meier survival curves (Fig. 2 & 3; p-value<0.001). Conclusion The CBS is a useful prediction model for long-term prognosis of LT patients. Further validation study is needed to confirm.

Factors Related to Diagnostic Yield of Lung Biopsy Using both Radial EBUS and Fluoroscopy

( Seung Hyun Yong ),( Soojoung Yu ),( Young Mok Park ),( A La Woo ),( Ah Young Leem ),( Su Hwan Lee ),( Sang Hoon Lee ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Transbronchial lung biopsy (TBLB) is a key modality in the diagnosis of peripheral lung lesions. Radial EBUS is new diagnostic technology which can apply to enhance the accuracy of peripheral lung biopsy during bronchoscopy. The purpose of this study was to investigate factors related to diagnostic yield of TBLB with radial EBUS Method A retrospective analysis on the diagnostic yield of TBLB under fluoroscopy consist with radial EBUS, with or without guide sheath (GS) was conducted. Data included TBB that was performed from 2020 to 2021 at a single center by a single operator Results 294 patients with confirmed final diagnoses were included in this study. Definitive diagnosis was established by TBLB in 117/155 (75.48%) patients using radial EBUS without GS, 55/69 (79.71%) patients using EBUS with GS, and 54/70 (77.14%) patients whose tissues were obtained partly without GS and partly with GS. We compared diagnostic yield by type pulmonary lesion which was inconsistent between the diagnostic modalities, but overall, solid lesions had highest diagnostic yield (77.05%) compared to pure ground glass opacities (75%) and part-solid lesions (76.09%). Lung cancer patients that underwent rebiopsy were analyzed in this study which showed diagnostic yield of 68.29%. Diagnostic yield showed improvement over time in radial EBUS assisted TBLB cases that did not use GS with yield of 59.62% in 2020 and 83.5% in 2021. Conclusion For many decades there has not been another diagnostic method to enhance the TBLB in diagnosis of peripheral pulmonary lesions until radial EBUS is introduced. This investigation reviewed current diagnostic usage of TBLB accompanied by radial EBUS and compared diagnostic yields not only by size and targeting, but solid components and exam period as well. Further studies on re-biopsy by TBLB will be needed to learn more about its significance in clinical application.

Clinical Implication of Candida Score in Multidrug-Resistant Pneumonia with Airway Candida Colonization

La Yeonju,Kwon Da Eun,Jeon Soyoung,Lee Sujee,Lee Kyoung Hwa,Han Sang Hoon,Song Young Goo 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2

Background The growth of Candida in respiratory secretions is usually considered colonization, and antifungal therapy is rarely required. The role of Candida colonization in the progression of bacterial pneumonia remains controversial. The aim of this study was to identify the clinical implication of Candida score by analyzinge the relationship with multidrug-resistant (MDR) pneumonia and prognosis in patients with airway Candida colonization. Materials and Methods This study was a retrospective review of patients with airway Candida colonization by bronchial washing or bronchoalveolar lavage. The Candida score was calculated according to the four factors (severe sepsis, surgery at baseline, total parenteral nutrition, and multifocal Candida colonization). Pneumonia related mortality or hopeless discharge expecting death was defined as a poor outcome. Results A total of 148 patients were enrolled in the study. In a multivariate analysis model, Candida score was identified as an independent predictor of poor outcomes (odds ratio 2.23; 95% confidential interval 1.57 – 3.17; P <0.001) in pneumonia patients with airway Candida colonization. With a Candida score of three or higher compared with low score group, it was associated with bacterial pneumonia, especially methicillin-resistant Staphylococcus aureus (MRSA) infection (0.0% vs. 15.2%, P = 0.004). In addition, patients with a high Candida score had a longer hospital stay (13 vs. 38 days, P <0.001), longer duration of intensive care (7 vs. 18 days, P <0.001), and higher pneumonia-related mortality (0.0% vs. 45.5%, P <0.001) as compared to the low Candida score group. The Candida score showed a positive correlation with other pneumonia severity scales such as CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, and age ≥65 years) (r = 0.461, P <0.001), Pneumonia Severity Index (r = 0.397, P <0.001), and predisposition, insult, response, and organ dysfunction (PIRO) score (r = 0.425, P <0.001). Conclusion This study revealed that Candida is no longer a bystander of airway colonization, and that it affects the progression of bacterial pneumonia, including multidrug-resistant pathogens, particularly MRSA infection. Also Candida score can be used to predict the prognosis of patients with pneumonia. Background The growth of Candida in respiratory secretions is usually considered colonization, and antifungal therapy is rarely required. The role of Candida colonization in the progression of bacterial pneumonia remains controversial. The aim of this study was to identify the clinical implication of Candida score by analyzinge the relationship with multidrug-resistant (MDR) pneumonia and prognosis in patients with airway Candida colonization. Materials and Methods This study was a retrospective review of patients with airway Candida colonization by bronchial washing or bronchoalveolar lavage. The Candida score was calculated according to the four factors (severe sepsis, surgery at baseline, total parenteral nutrition, and multifocal Candida colonization). Pneumonia related mortality or hopeless discharge expecting death was defined as a poor outcome. Results A total of 148 patients were enrolled in the study. In a multivariate analysis model, Candida score was identified as an independent predictor of poor outcomes (odds ratio 2.23; 95% confidential interval 1.57 – 3.17; P <0.001) in pneumonia patients with airway Candida colonization. With a Candida score of three or higher compared with low score group, it was associated with bacterial pneumonia, especially methicillin-resistant Staphylococcus aureus (MRSA) infection (0.0% vs. 15.2%, P = 0.004). In addition, patients with a high Candida score had a longer hospital stay (13 vs. 38 days, P <0.001), longer duration of intensive care (7 vs. 18 days, P <0.001), and higher pneumonia-related mortality (0.0% vs. 45.5%, P <0.001) as compared to the low Candida score group. The Candida score showed a positive correlation with other pneumonia severity scales such as CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, and age ≥65 years) (r = 0.461, P <0.001), Pneumonia Severity Index (r = 0.397, P <0.001), and predisposition, insult, response, and organ dysfunction (PIRO) score (r = 0.425, P <0.001). Conclusion This study revealed that Candida is no longer a bystander of airway colonization, and that it affects the progression of bacterial pneumonia, including multidrug-resistant pathogens, particularly MRSA infection. Also Candida score can be used to predict the prognosis of patients with pneumonia.

Antimicrobial Activity of Siegesbeckia pubescens Extracts against the Fish Pathogens

Bo la Choi,Eun ji Cho,Seung hyun Lee,Myeong jin Lee,Chae eun Kim,Se young Oh,Tae Hoon Kim,Eun-Woo Lee 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.10

Synthesis and Evaluation of Multifunctional Fluorescent Inhibitors with Synergistic Interaction of Prostate-Specific Membrane Antigen and Hypoxia for Prostate Cancer

Kwon, Young-Do,Oh, Jung-Mi,La, Minh Thanh,Chung, Hea-Jong,Lee, Sun Joo,Chun, Sungkun,Lee, Sun-Hwa,Jeong, Byung-Hoon,Kim, Hee-Kwon American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.1

<P>Prostate cancer is one of the most common cancers in the world. It is widely known that prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and hypoxia is a common characteristic of many solid tumors, including prostate cancer. In this study, we designed multifunctional fluorescent inhibitors to target PSMA and tumor hypoxia in order to increase the tumor uptake of inhibitors. Novel PSMA inhibitors were prepared using lysine as the backbone to connect three different functional groups: the glutamate-urea-lysine (GUL) structure for inhibiting PSMA, 2-nitroimidazole for the hypoxia-sensitive moiety, and a near-infrared fluorophore (sulfo-Cyanine 5.5). According to the <I>in vitro</I> PSMA binding assay, novel fluorescent inhibitors were demonstrated to have nanomolar binding affinities. Multifunctional inhibitor <B>2</B> with one 2-nitroimidazole had a similar inhibitory activity to inhibitor <B>1</B> that did not contain the hypoxia targeting moiety, but multifunctional inhibitor <B>3</B> with two 2-nitroimidazoles showed lower inhibitory activity than inhibitor <B>1</B> due to the bulky structure of the hypoxia-sensitive group. However, <I>in vivo</I> optical imaging and <I>ex vivo</I> biodistribution studies indicated that both multifunctional inhibitors <B>2</B> and <B>3</B> had higher accumulation in tumors than inhibitor <B>1</B> due to a synergistic combination of PSMA and hypoxia targeting moieties. These observations suggest that this novel multifunctional strategy might be a promising approach to improve the diagnosis and therapy of prostate cancer.</P> [FIG OMISSION]</BR>

온실 환경에서 엽면적 지수에 의한 엽온 및 열유속 예측 모델 개발

전영광 ( Young Kwang Jeon ),조라훈 ( La Hoon Cho ),박선용 ( Sun Yong Park ),김석준 ( Seok Jun Kim ),이충건 ( Chung Geon Lee ),오광철 ( Kwang Cheol Oh ),김대현 ( Dae Hyun Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1

다층 작물의 정확한 물리적 분류 해석은 온실 환경에서 각 캐노피의 상호 작용을 이해하고, 조사, 캐노피 온도, 증산 및 엽면적 지수에 의한 열유속을 기반으로 하는 식물 모델을 설계 하는데 있어서 매우 중요하다. 본 연구에서는 실제 운영중인 온실의 측정값을 기반으로 각 엽면적 지수에 대한 작물 모델을 논의한다. 식물과 공기 사이의 열유속에 대해 엽면적 지수을 이용한 식물 모델을 통해 정확하게 예측할 수 있다면, 작물이 밀식된 다양한 가상 온실의 냉난방 부하를 예측할 수 있을 것이다. 측정 정확도를 높이기 위해 흡기 차폐가 있는 온습도 센서, 적외선 캐노피 센서 및 이산화탄소 센서를 설치했다. 작물 환경은 휴대용 일사계, 기공전도계, 엽면적지수계, 풍속계로 측정되었다. 측정값을 작물 모델식에 입력하고 캐노피 모델 온도를 계산하였다. 작물 모델의 캐노피 온도를 현장 측정값과 비교하였고, R2=0.98, RMSE=0.46으로 신뢰성이 평가 되었다. 연구 결과, 큰 잎 작물 모델은 공기 순환층이 캐노피 크기보다 클 때 적합하지만, 온실에서 작물의 물리적 특성이 엽면적 지수에 의해 영향을 받을 때, 작물 모델은 다층 해석을 통해 고려되어야 할 것이다.

Antimicrobial Activity of Siegesbeckia pubescens Extracts against the Fish Pathogens

Bo la Choi,Eun ji Cho,Seung hyun Lee,Myeong jin Lee,Chae eun Kim,Se young Oh,Tae Hoon Kim,Eun-Woo Lee 한국수산해양기술학회(구 한국어업기술학회) 2015 한국수산해양기술학회 학술발표대회 Vol.2015 No.10

BES 융합을 위한 스마트온실 복합환경제어에 관한 연구

전영광 ( Young Kwang Jeon ),조라훈 ( La Hoon Cho ),박선용 ( Sun Yong Park ),김석준 ( Seok Jun Kim ),김대현 ( Dae Hyun Kim ),( Chung Geon Lee ),( Kwang Cheol Oh ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.2

최근 스마트팜 온실 환경 제어는 IT 기술을 융합한 정밀한 제어 기술로 발전되고 있다. 온실의 복합환경 제어를 통해, 작물 재배를 위한 최적의 환경 조건을 제공해야 하고, 동시에 에너지 절감 기술은 지속 성장을 위한 중요한 요인으로 제기된다. 아울러, 온실의 복합환경 제어는 스마트 온실의 에너지 부하에 직접적인 영향을 주는 요인이다. 하지만 복합환경 제어의 알고리즘의 실체를 식별하고 이를 가상 공간의 시뮬레이션에 적용한 사례는 거의 없었다. 본 연구는 스마트 온실의 과채류를 대상으로 복합환경제어가 이루어졌던 다년간의 경험적 사례를 수집 및 분석하여 이를 모델링하였다. 향후 BES에 복합환경제어 EMS(Energy Management System) 프로그래밍 적용을 통한 온실 에너지의 예측 결과는 온실 기후 환경 시뮬레이션 사용자에게 온실 제어 목적 및 의미를 전달할 수 있을 것으로 기대된다.