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자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과
박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.
Yoon, Jung-Rag,Lee, Chang-Bae,Lee, Kyung-Min,Lee, Heun-Young,Lee, Serk-Won The Korean Institute of Electrical and Electronic 2009 Transactions on Electrical and Electronic Material Vol.10 No.5
The microstructure and the electrical properties of a ZnO varistor, which was composed of a ZnO-$Bi_2O_3$-$Sb_2O_3$-CoO- $MnO_2$ -NiO-$Nd_2O_3$ system, were investigated at various $Y_2O_3$ addition concentrations. $Y_2O_3$ played a role in the inhibition of the grain growth. As the $Y_2O_3$ content increased, the average grain size decreased from $6.8{\mu}m$ to $4{\mu}m$, and the varistor voltage($V_{1mA}$) greatly increased from 275 to 400 V/mm. The nonlinearity coefficient ($\alpha$) decreased from 72 to 65 with increasing $Y_2O_3$ amount. On the other hand, the leakage current ($I_L$) increased from 0.2 to 0.9 ${\mu}A$. These results confirmed that doping the varistors with $Y_2O_3$ is a promising production route for production of a higher fine-grained varistor voltage ($V_{1mA}$) which can dramatically reduce the size of the varistors.
( Yoon Serk Lee ),( Jeong Han Kim ),( Hyeon Young Yoon ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.3
Radio-frequency ablation (RFA) is a curative treatment for hepatocellular carcinoma (HCC). Percutaneous RFA has been shown to be beneficial for patients with small renal cell carcinoma (RCC) lacking indications for resection. We experienced the case of a 53-year-old male who had conditions that suggested HCC, RCC, and alcoholic liver cirrhosis. Abdominal contrast-enhanced computed tomography (CT) and magnetic resonance image showed liver cirrhosis with 2.8 cm ill-defined mass in segment 2 of the liver and 1.9 cm hypervascular mass in the left kidney. These findings were compatible with the double primary cancers of HCC and RCC. Transarterial chemoembolization (TACE) was performed to treat the HCC. After the TACE, a focal lipiodol uptake defect was noticed on a follow up CT images and loco-regional treatment was recommended. Therefore, we performed RFAs to treat HCC and RCC. There was no evidence of recurrence in the follow up image after 1 month. (Clin Mol Hepatol 2014;20:306-309)
Yoon, Jung-Rag,Lee, Chang-Bae,Lee, Kyung-Min,Lee, Heun-Young,Lee, Serk-Won The Korean Institute of Electrical and Electronic 2010 Transactions on Electrical and Electronic Material Vol.11 No.3
(1-X) $(Na_{0.5}K_{0.5})NbO_3-X$ $K_4CuNb_8O_{23}$ (NKN-X KCN) ceramics were produced using the conventional solid state sintering method, and their sinterability and electric properties were investigated. The density, dielectric constant (${\varepsilon}_r$), piezoelectric constant $d_{33}$, electromechanical coupling factor $k_p$ and mechanical quality factor $Q_m$ value of the NKN ceramics depended upon the KCN content and the sintering temperature. In particular, the KCN addition to the NKN greatly improved the mechanical quality factor $Q_m$ value. The ceramic with X = 2.0 mol% sintered at $1,150^{\circ}C$ possesses the optimum properties (${\varepsilon}_r=241$, $d_{33}=78$, $k_p=0.34$ and $Q_m=1,121$). These results indicate that the ceramic is a promising candidate material for applications in lead free piezoelectric transformer and filter materials.
( Yoon Serk Lee ),( Jeong Han Kim ),( Hyeon Young Yoon ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Radio-frequency ablation (RFA) is curative treatment for hepatocellular carcinoma (HCC). Recently, RFA is also known to be an effective treatment option for renal cell carcinoma (RCC) less than 4 cm. Case: We experienced a case of 53-year-old male who was referred to konkuk university hospital because of suggestive HCC, RCC, and alcoholic liver cirrhosis (Child-Pugh score 9, stage B). Contrast-enhanced abdomen CT and MRI images showed liver cirrhosis with 2.8 cm ill-defined mass in segment 2 of the liver and 2.4 cm hypervascular mass in left kidney. These findings were compatible with double primary cancers of HCC and RCC. There was no evidence of lymph node or distant metastasis. Serum AFP was 6.93 ng/mL (<7.0 ng/mL). HBsAg, Anti-HBs, Anti-HCV were all negative. Transarterial chemoembolization (TACE) was performed to treat the HCC. After TACE, focal lipiodol uptake defect was noticed on follow up CT images and loco-regional treatment was recommended. Therefore, we performed RFAs to treat HCC and RCC. There was no significant complication after the procedure. One month later, follow-up CT images were taken. There was no evidence of recurrence. Conclusions: We report a case of synchronous HCC and RCC treated with RFA.
Yoon, Jung Rag,Lee, Chang-Bae,Lee, Serk Won,Lee, Heun-Young The Korean Institute of Electrical and Electronic 2012 Transactions on Electrical and Electronic Material Vol.13 No.6
(1-X)$(Na_{0.5}K_{0.5})NbO_3-XK_{5.4}Cu_{1.3}Ta_{10}O_{29}$ (NKN-KCT) lead-free piezoelectric ceramics have been synthesized by the conventional solid state sintering method, and their sinterability and piezoelectric properties were investigated. Typically, this material is sintered between 1,025 and $1,100^{\circ}C$ for 2 hours to achieve the required densification. Crystalline structures and Microstructures were analyzed by X-ray diffraction and scanning electron microscope. The density, dielectric constant (${\varepsilon}_r$), piezoelectric constant $d_{33}$, electromechanical coupling factor $k_p$ and mechanical quality factor $Q_m$ value of the NKN ceramics depended upon the KCT content and the sintering temperature. In particular, the KCT addition to NKN greatly improved the mechanical quality factor $Q_m$ value. The ceramic with X = 1.0 mol% sintered at $1,050^{\circ}C$ exhibited optimum properties (${\varepsilon}_r$=246, $d_{33}$=95, $k_p$=0.38 and $Q_m$=1,826). These results indicate that the ceramic is a promising candidate material for applications in lead free piezoelectric transformer and filter materials.
휴먼인터페이스에 입각한 커뮤니티 시설로서의 미디어테크에 대한 연구 - 공간구문론을 이용한 센다이 미디어테크(smt)의 분석 및 기존 연구의 비판
이윤석(Lee Yoon Serk),최재필(Choi Jaepil) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The purpose of this thesis is to analyze about the Mediatheque as a community facility, especially on the point of Human Interface elements, in the world of radically changing information society. Also the research aims to discover Sendai Mediatheque plan's spatial configuration by using the Space-Syntax theory which provides quantitative analysis. This analysis allows further and better comprehension on the previous studies about Sendai Mediatheque. The following results were induced as follows;<br/> 1. Sendai Mediatheque is composed of 'silent zone' & 'gossip zone', which attracts various people in different age and class which is desirable in community facility. 2. In an open plan in Sendai Mediatheque, the privacy is a very important issue. To solve this privacy problems, Sendai Mediatheque puts the reading room in the deepest place and this is also verified with the space-syntax theory. 3. At 3rd floor, the silent zone, the olds are mostly found where integration value is high. And also the olds are mostly found in 5, 6th gallery. This fact should be considered in designing community facility. 4. By the shape of the furniture, the visitor's tension could be manipulated. The manipulation of furniture positions and shape is essential in designing.
STEAM 교사 연구회 개발 자료 분석: 융복합교육적 접근
박영석 ( Young Serk Park ),구하라 ( Ha Ra Ku ),문종은 ( Jong Eun Moon ),안성호 ( Sung Ho G Ahn ),유병규 ( Byung Gyu Yoo ),이경윤 ( Kyung Yoon Lee ),이삼형 ( Sam Hyung Lee ),이선경 ( Sun Kyung Lee ),주미경 ( Mi Kyung Ju ),차윤경 ( 한국교육과정학회 2013 교육과정연구 Vol.31 No.1
본 연구는 우리나라 교육현장에서 실행되고 있는 융복합교육의 현황을 파악하고 향후 발전적 실행을 위한 제언을 탐색하기 위해 2011년 한국과학창의재단이 지원한 STEAM 교사연구회가 개발한 교육 자료 가운데 고등학교 수준의 자료를 ‘융복합목표’, ‘융복합수준’, ‘융복합맥락’ 차원에서 다각적으로 분석하였다. 분석 결과, STEAM 교사연구회가 개발한 교육 자료들은 융복합목표, 융복합수준, 융복합맥락 차원에 포함된 다양한 구성요소들을 광범위하게 반영하고 있는 것으로 나타났다. 이는 STEAM이 학생들의 창의성과 능동성, 그리고 다양성을 지원하는 학습 환경을 조성하는데 긍정적으로 기여하고 있는 부분으로 평가할 수 있다. 그러나 대부분의 과제들이 융복합목표와 수준, 맥락 차원에 관련된 구성요소를 수업에 도입하는 데 정형화된 접근 방법을 채택하고 있는 것으로 나타나고 있다. 이러한 경향은 융복합교육에서 학생들의 창의성과 능동성의 효과적인 개발을 저해하는 요소로 작용할 수 있을 것이다. 이러한 분석 결과에 기초하여 향후 융합인재교육의 발전적 실행을 위한 시사점을 논의하였다. This study was conducted to investigate the current status of yungbokhap education in Korea and identify the remaining tasks for its future development. For this purpose, we analyzed a wide range of relevant instructional materials that had recently been developed by high school STEAM teachers with support from the Korean Ministry of Education, Science, and Technology. For the analysis, we inquired what educational objectives and key competencies were pursued, to what extent curriculum integration was achieved, and what kinds of context stood out in the instructional materials. The findings suggested the possibility that the instructional materials analyzed made a significant contribution to the improvement of the quality of education. In particular, the materials set clear educational objectives and key competencies and provided a variety of tasks to bridge students` cognitive resources to learning. However, the materials showed a tendency to patternize instructional modules, constituting a potential barrier to students` engagement in more authentic learning geared toward helping them become creative and autonomous learners. Based on the findings from this study, we discussed the implications for the future development of yungbokhap models of education.