내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

물질주의가 과시소비, 충동구매와 삶의 만족 및 부정적 감정에 미치는 영향

윤성욱(Yoon, Sung-wook),강아롱(Kang, A-rong) 한국경영교육학회 2021 경영교육연구 Vol.36 No.1

[연구목적] 물질주의의 부정적인 영향에 대한 선행연구들은 이루어져 왔지만, 물질주의가 과시소비 및 충동구매에 영향을 미치고 이러한 비합리적인 소비가 삶의 만족 및 부정적 감정에 미치는 전체 변수들 간의 연구는 전무했기에 본 연구에서 이러한 관계들이 동시에 미치는 영향을 살펴보고자 한다. [연구방법] 본 연구는 자료 분석을 위해 신뢰도분석, 탐색적 요인분석, 확인적 요인분석을 실시한 후 측정모델의 적합도를 평가하였고, 이를 바탕으로 측정모형과 구조모델을 동시에 측정하는 구조방정식 검증을 실시하였다. [연구결과] 본 연구를 통한 결과는 다음과 같다. 물질주의가 높을수록 과시소비와 충동구매를 더 하는 것으로 나타났다. 그리고 과시소비 성향이 높을수록 삶의 만족도는 낮아지며, 부정적 감정은 높았다. 마지막으로 충동구매 성향이 높을수록 부정적 감정은 높았지만, 삶의 만족도에는 영향을 미치지 않는 것으로 나타났다. [연구의 시사점] 본 연구의 결과를 토대로 청소년들의 올바른 가치관과 소비 형태를 정립할 수 있는 교육 자료로 활용할 수 있을 것이라 본다. 그리고 물질주의를 통한 올바르지 못한 구매들이 부정적인 감정을 높이고 삶의 만족을 떨어뜨릴 수 있음을 공익광고를 통해 건전한 인식 전환을 시도해 볼 수 있을 것이며, 구매 후에 느낄 수 있는 부정적 감정들에 대해서는 과시를 통한 우월감, 만족감으로 대신하거나, 실용적인 측면들을 내세워 소비에 대한 정당성을 확보하여 부정적 감정들을 완화 시킬 수 있을 것으로 본다. [Purpose] Previous studies on the negative effects of materialism have been carried out, there has been no study of materialism’s effects on conspicuous consumption and impulse buying nor the study of entire variables between the effects of irrational consumption and satisfaction with life and negative emotions. In this context, this study examines the simultaneous effects of the relationships. [Methodology] This study evaluated the measuring model’s fitness after performing a reliability analysis, an exploratory factor analysis, and a confirmatory factor analysis. Based on this, the verification of the structural equation model simultaneously measuring the measuring model and the structural model was performed. [Findings] The results of this study are as follows: As materialism was higher, conspicuous consumption and impulse buying were higher. As conspicuous consumption was higher, satisfaction with life became lower but negative emotions were higher. Lastly, as the impulse buying disposition was higher, negative emotions were higher, but it did not affect satisfaction with life. [Implications] The result of this study can be used for educational data to establish adolescents’ proper values and behavioral patterns. A sound awareness shift that improper buying can elevate negative emotions and lower satisfaction with life can be attempted through public service advertisement. Negative emotions can be eased by securing legitimacy on consumption by replacing negative emotions with sense of superiority and satisfaction or by presenting the practical aspect.

두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과

이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.

경상대학교 사회봉사활동 활성화 방안

강욱모 경상대학교 1997 學生生活硏究所報 Vol.23 No.-

The purpose of this study is to identify the problems of the voluntary activities and to develop strategies encoraging more voluntary activities in the Gyeongsang National Unversity. For this purpose, a survey interview for the students was conducted to identify their characteristics, duration and continuation of action, motivation, and attitudes. The survey found that volunteers are not reliable work sources yet, because only 37.9 percent of students were experienced in voluntary action, and their participations are not on the regular bases and do not last long enough. This finding suggests that if systematic supporting body is established in the university, many students may better participate in the voluntary activities Based on these findings, some policy recommendations are suggested as follows; 1)The volunteer support regulation should be legislated as soon as possible. The regulation should include such regulations as establishment of volunteer center, curriculum, and supporting systems such as insurance, incentives, and approval of career. 2) The centralized supporting organization, so-called "Gyeongsang Voluntary Center" should be established. In order to establish effective center that provide organized, coordinated and well-managed service efforts, a broad and sustainable foundation of support is necessary. Most importantly, it requires the building of genuine relationship across the student body, academic discipines, community boundaries, administrative departments. 3) Voluntary coordinators should be trained so that they can play a variety of professional roles in managing volunteer programs. 4) Various voluntary action programmes should be developed. 5) In order to increase the efficiency in voluntary activities, database and computerization should be developed. 7) Against accidents during voluntary activities, a social insurance system should

경북 유학산, 천생산과 성암산 일대의 식물군락유형 분석

박강민,김종현,정현아,강치욱,이종운 嶺南大學校基礎科學硏究所 2002 基礎科學硏究 Vol.22 No.-

At the area of Yuhak, Cheonsaeng and Seongam mountains in Kyeongbuk, we studied the vegetation patterns with 75 plots on the base of Braun-Blanquet methods from March to October 2002. For the analysis of community patterns with 75 plots we used interspecies Affinity analysis method, DECORANA and TWINSPAN. The investigated area was divided into 17 communities with 177 species, and 20∼100% of treelayer, 10∼95% of shrublayer and 20∼100% of herblayer. By toe method of affinity analysis, it showed a big community with 86 species, but divided into 6 small groups by ordination and classification methods. Although it appeared as one group by the affinity test, the area divided into two groups by classification method at second level with eigenvalue of 0.320 and 0.430. It shows that the area of Yuhak, Cheonsaeng and Seongam mountains have own properties and in the process of succession.

乳牛乳房炎 原因菌 및 藥物感受性에 關한 硏究

李康郁 건국대학교 1976 學術誌 Vol.20 No.2

A total of 142 quarter milk samples from 7 herds were examined for mastitis and the results obtained as follows : 1.Staphylococcus (39.06%) and streptococcus (34.90%) were two main causative organisms of mastitis. Pseudomonas Spp (5.83%), escherichia coli (2.60%), proteus (2.60%), klebsiella aerobacter (1.04%), corynebacterium (0.52%) and fungi (0.52%) were also isolated from the infected quarters. 2.The isolated were more sensitive to chloramphenicol (91.46%), leukomycin (76.83%), tetracyclin (75.61%) kanamycin (69.51%) and oreandomycin (62.80%). On the other hand, they were less senstive to colistin (7.93%), penicillin (34.76%), sulfisoxazole (39.63%), streptomycin (53.05%) and erythromycin (56.71%). Especially the straine of pseudomonas Spp. isolated from the infected quarters were resistant to almost all the drugs examined.

간암과 간세포이형성 부위의 철침착 저항성에 대한 조직학적 연구

조욱행,강대영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Liver cell dysplasia(LCD) is commonly associated with some liver diseases such as liver cirrhosis or hepatocellular carcinoma and has been regarded as a premaligant condition. In order to clarify the question of whether or not LCD is a premalignant liver lesion, iron special staining, Prussian blue, was done. The specimens were collected at the department of pathology, Chungnam National University College of Medicine from January 1983 to September 1992. The results were as follows: 1. Of observed 48 cases, 34 were hepatocellular carcinoma(70.8%), 11 were metastatic carcinoma(22.9%), and 3 were hepatoblastoma(6.3%). 2. LCD was present in 26 of 34 cases(76.5%) of hepatocellular carcinoma, 5 of 11 cases(45.5%) of metastatic carcinoma, and 1 of 3 case(33.3%) of hepatoblastoma. 3. The carcinoma cells were free of iron deposition(iron excluding foci) in contrast to the neighboring dysplastic or nonneoplastic normal hepatocytes. 4. The presence of iron deposition in LCD cases was similar to or more severe than that of normal hepatocytes. In summary, the results obtained from the present study indicate that LCD reflects neither a regenerating condition nor a premalignant lesion but suggests a reactive change or accompaning lession.

관상동맥질환에서 Tc-99m Methoxyisobutyl Isonitrile (MIBI) Myocardial SPECT의 이용 : Dipyridamole 심근부하 SPECT와 관상동맥조영술과의 비교 A Comparison between Coronary Angiography and Tc-99m-MIBI Myocardial SPECT

이강욱,전은석,박종훈,신영태,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

In order to evaluate clinical utilities of Tc-99m MIBI dipyridamole stress myocardial SPECT in patients with coronary artery disease (CAD), we compaired tomographic and polar map images of Tc-99m MIBI myocardial SPECT with the results of coronary angiography in 25 patients with CAD (myocardial infarction 13,angina pectoris 12) in Chungnam National University Hospital from Oct. 1991 to Oct 1993. Percutaneous transcoronary angioplasty (PTCA) was done in three patients of 25 CAD patients and follow up SPECT studies were done in same three patients within 2 months after PTCA. The results were as follows : 1. Mean age of patients was 57.4 years. Man was 2.7 times more than woman. 2. Sensitivity and specificity of Tc-99m MIBI myocardial SPECT for the detection of coronary artery stenosis in patients with myocardial infarction were 92.7 % anf 85 %, respectively. 3. Sensitivity and specificity of Tc-99m MIBI myocardial SPECT for the detection of coronary artery stenosis in patients with angina pectoris were 100 % and 67 %, respectively. 4. After PTCA size of perfusion defects in stress SPELT images was decreased in all three patients . With the results above,we thought that Tc-99m MIBI myocardial SPECT is useful noninvasive method to detect stenosed coronary artery in patients with CAD and it can be used as a method to evaluate the result of PTCA.

경북 천생산, 유학산, 숲데미산지역의 식물군락유형

박강민,김종현,강치욱,이종운 嶺南大學校基礎科學硏究所 2001 基礎科學硏究 Vol.21 No.-

From April to October 2001, we studied on vegetation of 60 plots through the methods of Braun-Blanquet at Cheonsaengsan, Yuhaksan and Supdemisan in Gyeongbuk. Through the methods of interspecific affinity analysis, DECORANA and TWINSPAN the patterns of plant communities of 60 were analysed. It showed 6 communities at Cheonsaengsan, 5 communities at Yuhaksan, 6 communities at Supdemisan and total appearance of 128 species and covered with 50∼95% of tree layer, 20∼90% of shrub layer, 20∼90% of herb layer. As the result of interspecific affinity analysis it showed one big specific complex composed with 52 species and the 60 plots were divided into 4 groups by classification and ordination. One big species complex as a result of affinity analysis and eigenvalue of 0.303 at first step by classification indicate that Cheonsaengsan, Yuhaksan and Supdemisan are in developing stage of succession.

사람의 혈관 내피세포에 대한 Rickettsia typhi의 감염

안욱수,이강순,송호연 순천향대학교 1994 논문집 Vol.17 No.4

R. typhi, the etiologic agent of murine typhus, has known to cause fever, headache, maculopapular rash and vasculitis of small blood vessel. The skin rash and vasculitis are thought to be the results of endothelial cell injury from the infection with R. typhi in vivo. R. typhi showed ability to cause cellular injury of cultured human endothelial cells. The endothelial cells used in this experiment wee obtained by collagenase treatment of human umbilical cord veins. These cells were conformed to be endothelial cell by the presence of von Willebrand factor through the immunofluorescent antibody technique and Weibel-Palade bodies under the electron microscopy. Ultrastructural study revealed that there were no evidences of entry and/or escape from endothelial cells of R. typhi in 24 hours through 48 hours after infection. On the contrary, numerous particles implicating R. typhi were observed in large vacuole within endothelial cells at 48 hours after inoculations. Estimating the severe injury of endothelial cells by infection of R. typhi, the endothelial cells seems to be the primary target cells in human disease caused by R. typhi infection.