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Effects of Repeated Seafood Consumption on Urinary Excretion of Arsenic Species by Volunteers
Choi, Byung-Sun,Choi, Seong-Jin,Kim, Dong-Won,Huang, Mingai,Kim, Na-Young,Park, Kyung-Su,Kim, Choong-Yong,Lee, Hyo-Min,Yum, Young-Na,Han, Eui-Sik,Kang, Tae-Seok,Yu, Il-Je,Park, Jung-Duck Springer-Verlag 2010 Archives of environmental contamination and toxico Vol.58 No.1
Choi, Jung Hoon,Chung, Jin Young,Yoo, Dae Young,Hwang, In Koo,Yoo, Ki-Yeon,Lee, Choong Hyun,Yan, Bing Chun,Ahn, Jin Ok,Youn, Hwa Young,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2011 Cellular and molecular neurobiology Vol.31 No.8
<P>Mesenchymal stem cells (MSC) have emerged as a new therapeutic tool for a number of clinical applications, because they have multipotency and paracrine effects via various factors. In the present study, we investigated the effects of adipose-derived MSC (Ad-MSC) transplantation via intrathecal injection through the cisterna magna on cell proliferation and differentiation of endogenous stem cells in the hippocampal dentate gyrus (DG) using Ki-67 (a marker for proliferating cells), and doublecortin (DCX, a marker for neuroblasts). The transplanted Ad-MSC were detected in the meninges, not in the hippocampal parenchyma. However, the number of Ki-67-immunoreactive cells was significantly increased by 83% in the DG 2 days after single Ad-MSC injection, and by 67% at 23 days after repeated Ad-MSC treatment compared with that in the vehicle-treated group after Ad-MSC transplantation. On the other hand, the number of DCX-immunoreactive cells in the DG was not changed at 2 days after single Ad-MSC injection; however, it was significantly increased by 62% 9 days after single Ad-MSC injection. At 23 days after repeated Ad-MSC application, the number of DCX-immunoreactive cells was much more increased (223% of the vehicle-treated group). At this time point, DCX protein levels were also significantly increased compared with those in the vehicle-treated group. These results suggest that the intrathecal injection of Ad-MSC could enhance endogenous cell proliferation, and the repeated Ad-MSC injection could be more efficient for an enhancement of endogenous cell proliferation and differentiation in the brain.</P>
Use of Antacid and the Incidence of Interstitial Lung Disease
( Won-il Choi ),( Jihyeon Jeong ),( Dong Yoon Lee ),( Choong Won Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose To investigate whether Antacid (proton pump inhibitor and/or histamine-2 receptor antagonist) as a preventive measure to reduce the development of interstitial lung disease (ILD) in a real-world Methods This nationwide, retrospective, cohort study used data from the Korean National Health Insurance Database, NHIS-NSC 2002-2015. Eligible participants (n = 497,262) were people aged above 40 years who had treated with either PPI +/- H-2 blocker or H-2 blocker only between 2011 and 2015 and had no history of ILD between 2002 and 2010. The duration of antacid administration between January 2006 and December 2010 was calculated for each participant. Exposure to antacid medications was defined as administration of either proton pump inhibitors or histamine H2 receptor antagonists for more than 14 days, whereas no exposure or underexposure was defined as antacid treatment administered for less than 14 days. Newly developed ILDs were counted during the 5-year observation period (1 January 2011 to 31 December 2015). Results A total of 510 (0.14%) antacid-exposed patients (n = 345,904) developed ILD. Among patients with no antacid exposure or underexposure (n = 151,358), 162 (0.10%) developed ILD. In multivariable analysis, antacid exposure before the diagnosis of ILD cancer was independently associated with reduced incidence of ILD (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.45 to 0.71; P <0.001). Conclusions Antacid use might be independently associated with a decreased risk of ILD development.
Choi, Won-Il,Kim, Min-Young,Jeon, Bu-Nam,Koh, Dong-In,Yun, Chae-Ok,Li, Yan,Lee, Choong-Eun,Oh, Jiyoung,Kim, Kunhong,Hur, Man-Wook American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.27
<P>Promyelocytic leukemia zinc finger (PLZF) is a transcription repressor that was initially isolated as a fusion protein with retinoic acid receptor α. PLZF is aberrantly overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. PLZF causes cellular transformation of NIH3T3 cells and increases cell proliferation in several cell types. PLZF also increases tumor growth in the mouse xenograft tumor model. PLZF may stimulate cell proliferation by controlling expression of the genes of the p53 pathway (<I>ARF</I>, <I>TP53</I>, and <I>CDKN1A</I>). We found that PLZF can directly repress transcription of <I>CDKN1A</I> encoding p21, a negative regulator of cell cycle progression. PLZF binds to the proximal Sp1-binding GC-box 5/6 and the distal p53-responsive elements of the <I>CDKN1A</I> promoter to repress transcription. Interestingly, PLZF interacts with Sp1 or p53 and competes with Sp1 or p53. PLZF interacts with corepressors, such as mSin3A, NCoR, and SMRT, thereby deacetylates Ac-H3 and Ac-H4 histones at the <I>CDKN1A</I> promoter, which indicated the involvement of the corepressor·HDACs complex in transcription repression by PLZF. Also, PLZF represses transcription of <I>TP53</I> and also decreases p53 protein stability by ubiquitination. PLZF may act as a potential proto-oncoprotein in various cell types.</P>