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Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma
Ho-Chang Lee1, Seung-Myoung Son, Yong-Moon Lee, Ji Hae Koo, Song-Yi Choi, Ok-Jun Lee, Eun-Hwan Jeong 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2
Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report on a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old female. A unilocular cyst consistent with MCT was observed; however, a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. When a sarcomatous component is observed in the ovary tumor, it is important to find a squamous cell component, either benign or malignant.
이윤형(Yun-Hyung Lee),안종갑(Jong-Kap Ahn),소명옥(Myung-Ok So),이준탁(Jun-Tack Lee) 한국마린엔지니어링학회 2007 한국마린엔지니어링학회 학술대회 논문집 Vol.2007 No.-
A simple tuning methods of PI, PD and PID controller are proposed for an integrating process with time delay. This is based on matching the coefficients of corresponding powers of s in the numerator and that in the denominator of the closed-loop transfer function. For set-point tracking problem, the derived controller is found to be a PD controller which is shown by Lee's tuning rule based on minimizing the performance indexes (lSE, IAE, ITAE) using a real-coded genetic algorithm. A method can be also proposed PI, PID controllers according to tuning parameter lambda (A) similar to IMC method. Simulation example is given to illustrate the set-point tracking performance of the proposed method.
Lee, Kum Hee,Kim, Seul Ong,You, Jae Nam,Kang, Sunwoo,Lee, Jin Yong,Yook, Kyoung Soo,Jeon, Soon Ok,Lee, Jun Yeob,Yoon, Seung Soo The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.11
<P>A series of <I>tert</I>-butylated spirofluorene derivatives incorporating a diphenylaminoaryl-vinyl group was synthesized <I>via</I> the Horner–Wadsworth–Emmons olefination and a Suzuki cross-coupling reaction. To examine the electroluminescent properties of these materials, multilayered OLEDs were fabricated into the following device structure: ITO/DNTPD/NPB/MADN:blue dopant materials <B>1–14</B>/Alq<SUB>3</SUB>/Liq/Al. All devices showed efficient blue emission. In particular, one device exhibited highly efficient sky blue emission with a maximum luminance of 25 100 cd m<SUP>−2</SUP> at 8.5 V, as well as luminous, power and external quantum efficiencies of 9.5 cd A<SUP>−1</SUP>, 5.1 lm W<SUP>−1</SUP> and 6.7% at 20 mA cm<SUP>−2</SUP>, respectively. The peak wavelength of electroluminescence was 458 and 484 nm with CIE<SUB><I>x</I>,<I>y</I></SUB> coordinates of (0.14, 0.21) at 8.0 V. In addition, a deep blue device with CIE<SUB><I>x</I>,<I>y</I></SUB> coordinates of (0.15, 0.15) at 8.0 V showed a luminous efficiency and external quantum efficiency of 3.8 cd A<SUP>−1</SUP> and 3.3% at 20 mA cm<SUP>−2</SUP>, respectively.</P> <P>Graphic Abstract</P><P>A series of <I>tert</I>-butylated spirofluorene derivatives incorporating a diphenylaminoaryl-vinyl group was synthesized and their photophysical and electroluminescent properties examined. In the case of devices <B>10A</B>, using <B>10</B> as a dopant in the emitting layer, exhibited efficient blue emission with CIE coordinates of (0.15, 0.15). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm14869b'> </P>
Lee, Mee-Hyun,Huang, Zunnan,Kim, Dong Joon,Kim, Sung-Hyun,Kim, Myoung Ok,Lee, Sung-Young,Xie, Hua,Park, Si Jun,Kim, Jae Young,Kundu, Joydeb Kumar,Bode, Ann M.,Surh, Young-Joon,Dong, Zigang American Association for Cancer Research 2013 Cancer prevention research Vol.6 No.5
<P>Abnormal functioning of multiple gene products underlies the neoplastic transformation of cells. Thus, chemopreventive and/or chemotherapeutic agents with multigene targets hold promise in the development of effective anticancer drugs. Silybin, a component of milk thistle, is a natural anticancer agent. In the present study, we investigated the effect of silybin on melanoma cell growth and elucidated its molecular targets. Our study revealed that silybin attenuated the growth of melanoma xenograft tumors in nude mice. Silybin inhibited the kinase activity of mitogen-activated protein kinase (MEK)-1/2 and ribosomal S6 kinase (RSK)-2 in melanoma cells. The direct binding of silybin with MEK1/2 and RSK2 was explored using a computational docking model. Treatment of melanoma cells with silybin attenuated the phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 and RSK2, which are regulated by the upstream kinases MEK1/2. The blockade of MEK1/2-ERK1/2-RSK2 signaling by silybin resulted in a reduced activation of NF-κB, activator protein-1, and STAT3, which are transcriptional regulators of a variety of proliferative genes in melanomas. Silybin, by blocking the activation of these transcription factors, induced cell-cycle arrest at the G<SUB>1</SUB> phase and inhibited melanoma cell growth <I>in vitro</I> and <I>in vivo</I>. Taken together, silybin suppresses melanoma growth by directly targeting MEK- and RSK-mediated signaling pathways. <I>Cancer Prev Res; 6(5); 455–65. ©2013 AACR</I>.</P>
Local-dependency of morphological and optical properties between breast cancer cell lines
Lee, Seung Ho,Kim, Ok-Kyun,Lee, Sanghwa,Kim, Jun Ki Elsevier 2018 Spectrochimica acta. Part A, Molecular and biomole Vol.205 No.-
<P><B>Abstract</B></P> <P>Breast cancer is the most malignant type of cancer in women and is a global health problem, with mortality by metastasis being the main factor among others. Currently, detection and diagnosis of breast cancer is achieved through a variety of procedures, such as clinical examination, medical imaging, biopsy, and histopathological analysis. In contrast, spectroscopic analysis has a variety of advantages such as being noninvasive, not destroying biological materials, and not requiring additional histological analysis. In this study, various approaches using Raman spectroscopy, atomic force microscopy (AFM), and optical microscopy were used together to differentiate between and characterize normal breast cell lines (MCF-10A) and breast cancer cell lines (MDA-MB-231, MDA-MB-453). Raman spectra of normal breast cell and breast cancer cell lines confirmed visual differences in the concentrations of various compounds. These spectra were also analyzed using principle component analysis (PCA), and the PCA results showed reliable separation of the three cell lines and the cancer cell lines (MDA-MB-231, MDA-MB-453). With these results, optically synchronizing the AFM morphology, the Raman spectroscopy, and the visible RGB optical transmission intensity provided contrasts for not only conformational differences but also intracellular variation between the normal and cancer cell lines. We observed the inherent characteristic that there is no local difference in cancer cells regardless of morphology in a wide range of optical properties such as absorption, scattering and inelastic scattering.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The inherent optical properties of cancer cells separated from normal cells in terms of local variation were observed. </LI> <LI> Raman spectra and its PCA results of normal breast cell and breast cancer cell lines were confirmed to be visual differences. </LI> <LI> The RGB transmission imaging is also compared to the morphological difference obtained from AFM. </LI> <LI> In cancer cells, the conformational difference did not appear to be dependent on the intracellular location. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Young-Jun,Kim, Kui-Jin,Park, Kee-Jai,Yoon, Bo-Ra,Lim, Jeong-Ho,Lee, Ok-Hwan MDPI 2013 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.14 No.1
<P>Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demonstrate the effect of TBWE on anti-adipogenesis and pro-oxidant enzyme in 3T3-L1 adipocytes. We also evaluated the anti-oxidative activity of TBWE in adipocytes by using the nitroblue tetrazolium assay. Our data showed that TBWE markedly inhibited adipocyte differentiation and ROS production in 3T3-L1 cells compared with control groups. Moreover, TBWE has strongly shown the inhibition of adipogenic transcription factor as well as pro-oxidant enzymes. Together, we demonstrate that the MeJA treatment significantly increased the amount of phenolic compound, resulting in the suppression of adipogenesis and ROS production in the 3T3-L1 cells. These findings indicate that TBWE has the potential for anti-adipogenesis activity with anti-oxidative properties.</P>