8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

다형성 교모세포종에서 광범위 전적출술후 단기 재발된 치험 1예

박호권,강중식,조준,문창택,장상근,임정애 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Glioblasty/ma Multiforme(GBM) is the one of the most common malignant tumors in central nervous system(CNS). The incidence of the tumor is about 12% of all CNS tumors and about 50% of all intracranial tumors. Though the development of the microsurgical technique, radiosurgical technique, and chemotherapy works effectively, complete cure of the GBM has not been achieved. It has been known that the prognosis of GBM depends on the extent of surgical tumor removal, remained tumor volume, radiation dose, and chemotherapy. Not only patient's age but also tumor characteristics such as MRI enhancement, angiogenesis and necrosis are also very important prognostic factors. Authors experienced very aggressive GBM in aged woman, who received gross total tumor removal, but refused other therapeutic motalities postoperatively. Very rapid recurrence of GBM and global cerebral edema in aged woman should be considered fatal. This case demonstrates the effectiveness of aggressive removal and the limited usefulness of neurosurgical tools in GBM recurrence. Authors would suggest that the early diagnostic effort and the verified neurosurgical therapy for malignant tumor are still strongly requested to make better prognosis.

폴리비닐 알코올-아조벤젠 유도체의 광 안정성에 관한 연구

朴泰坤,朴根浩 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

The Synthesis of long chain fatty acid containing azobenzene(Cn-Azo-PVA) was optimized, starting from Cn-Azo(C14, C16, C18) compounds and the product of reaction containing azobenzene chromophores was investigated by ultraviolet spectro-photometery in chloroform solvent at the various temperature. In addition, Reversibility and stability of azo compounds have been measured by means of Ultraviolet and the structure of these compounds were ascertained by means of FT-IR and NMR. Long chain azobenzene derivatives in chloroform solution are induced phtoisomerization by u.v. and visible light irradiation. The solution of long chain fatty acids containing azobenzene(Cn-Azo-PVA) are possible of being applied to functional molecular devices such as photomemory and light switching.

觀光動機 및 觀光誘引에 關한 考察

朴瑾浩 동국대학교 행정대학원 1975 행정논집 Vol.6 No.-

社會淨化運動과 意識改革敎育의 發展方向

朴瑾浩 동국대학교 행정대학원 1984 행정논집 Vol.14 No.-

地方公企業의 組織行態에 관한 調査硏究

朴瑾浩 동국대학교 행정대학원 1983 행정논집 Vol.13 No.-

3관능성 BPA-3MA를 기질로한 광중합형 치면열구전색재의 물성 연구

박경준,김경남,안광덕,김광만,한동근,전호욱 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The BPA-3MA(bisphenol-A trimethacrylate) in which one of two hydroxy group was substituted by methacrylate was synthesized by reaction of Bis-GMA with methacryloyl chloride. To investigate the possibility to apply BPA-3MA as matrix of composite resin or pit and fissure sealant, BPA-3MA(3MA) or Bis-GMA(GMA) as matrix, TEGDMA as diluent, CQ as photosensitizer, EDMAB as photoinitiator and 5㎛ pyrogenic silica as filler were used for making experimental sealants. In addition, these experimental sealants were compared to a commercial Concise L/C White sealant(CLW, 3M Co, U.S.A.) for flexural strength, diametral tensile strength, amount of abrasion, surface hardness, water sorption and solubility, and degree of conversion. The flexural strength of CLW was the highest value but there was not significant difference with 3MA. Diametral tensile strength of all 3 groups were similar(p>0.05) and the amounts of abrasion of 3MA and GMA were less than that of CLW(p<0.05). The surface hardness of 3MA was higher than that of GMA(p<0.05) but similar to that of CLW. The water sorption of 3MA was less than that of GMA and CLW(p<0.05) and the solubilities of 3MA and CLW were than that of GMA(p<0.05). GMA and CLW were relatively polymerized well as compared to 3MA. From these results, pit and fissure sealant using trifunctional BPA-3MA as matrix had superior physical and mechanical properties to existing Bis-GMA sealant. Furthermore, it will be possible to develop composite resin having superior properties to existing composite resin.

최대/최소 경계 스키마 추출 기법을 이용한 XML 문서의 DTD 추출

박경현,최은선,이종연,박정석,류근호 충북대학교 컴퓨터정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.2

XML이 인터넷상의 데이터 교환의 표준으로 대두되면서 데이터 모델이나 플랫폼에 관계없이 데이터의 전송이 가능하게 되었다. 특히 데이터 중심의 XML 문서의 경우 전송시의 부하를 줄이기 위해 DTD없이 전송되는 경우가 일반적이다. 그러한 이유로 전송받은 XML 데이터의 저장 효율을 높이고 질의를 최적화하며 사용자에게 편의성을 제공해주기 위해서는 XML 데이터로부터 DTD 추출이 필수적으로 요구된다. 이 논문에서는 이러한 DTD를 추출하기 위해 반구조적 데이터의 스키마 추출 기법을 적용한다. 특히, 반구조적 데이터의 최소 경계 스키마를 추출하는데 데이터로그를 이용하는 기존의 방법보다 효율적인 방법인 시뮬레이션을 적용함으로써 보다 향상된 DTD 추출 기법을 제시한다. XML makes it possible for data to be exchanged regardless of the data model in which it is represented or the platform on which it is stored, serving as a standard for data exchange format on the internet. Especially, It is natural to send XML data without DTD on the internet when XML is data-centric XML. Therefore it is needed to extract DTD to store XML data efficiently, to optimize queries, and to help users browse XML data. In this paper, Techniques for upper/lower bound schema extraction are applied to extract DTD from XML data. Especially we propose an efficient technique for extracting DTD by using simulation which is better than datalog as a lower bound schema extraction method.