Effects of Caffeine and Exercise on Blood Levels of Dopamine and Serotonin in Male Humans

Jeong-Beom Lee,Young-Ki Min,Jeong-Ho Kim,Hee-Jin Lee3,Mi-Young Lee 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

2차원 및 3차원 초음파를 이용한 태아표면의 해부학적 선별 검사에 관한 연구

윤석범,이해혁,이정재,최경훈,이순곤,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Objective : Our purpose of this study was to determine the clarity and consuming time of fetal surface screening in thirty-eight fetuses from 24 to 32 weeks of gestation by use of two and three-dimensional ultrasonography. Methods : From May 1998 to July 1998, we performed the fetal surface screening of the fetal face, extremities, and spine. Thirty-eight fetuses of 24-32 weeks of gestation (thirty-seven normal fetuses and one abnormal fetus) were studied by use two-dimensional (AI 5200S, 3.5-5.0MHz; Acoustic Imaging Technologic Cooperation, U.S.A.) and three-dimensional ultrasonography (Volusion 530D, 3.5-5.0 MHz ; Kretz-Medicine, Korea). On the fetal face, we evaluated both orbits, nose, lips and brow. Both hands and feet, five digits and toes should be seen in this study. We evaluated cervical spine and lumbosacral junction of the spine. Results : The maternal average age of 38 patients was 29.9 years and the average gestational age was 29.7 weeks. The results of fetal surface screening were as follows : face (both orbits 89.5%, lips 92.1%, nose 92.1%, and brow 89.5%), extremities (both hands 68.4% and feet 73.7%), and spine (cervical spine 94.7% and lumbosacral junction 97.4%) by use of two-dimensional ultrasonography. By use of three-dimensional ultrasonography, results were as follows : face (both orbits 76.3%, lips 81.6%, nose 81.6%, and brow 78.9%), extremities (both hands 76.3% and feet 78.9%), and spine (cervical spine 71.1% and lumbosacral junction 73.7%). Consuming time for two-dimensional ultrasonography were 4.7 minutes for face, 11.6 minutes for extremities, and 5.7 minutes for spine. Using three-dimensional ultrasonography results were 12.8 minutes for face, 17.9 minutes for extremities, and 11.7 minutes for spine. Average consuming time of all fetal anatomic screening was 22.0 and 42.4 minutes by use of two and three dimensional ultrasonography. In one abnormal fetus had cleft lip and polydactyly of right foot which were detected all by three-dimensional ultrasonography, but we couldn't detect the polydactyly by two-dimensional ultrasonography. Conclusion : Three-dimensional ultrasonography was more time-consuming method, but we suggested that three-dimensional ultrasonography was superior than two-dimensional ultrasonography in fetal surface screening.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Pika의 열생리학적 특징

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Pika의 형태학상 특징과 열조절 기능은 추위와 높은 고도 환경에 생태학적으로 적응한 결과라 생각된다. 최근 보고에서 heat shock protein 70 kDa (HSP70)가 열이 열관용에 관계함으로써 유도된다고 하였다. 그래서 이번 연구에서는 세포, 심장혈관 그리고 열 생리학적 관점에서 pika의 몇 가지 특징을 조사하였다. Pika와 rat의 몸 전체에 heat shock을 준 후 HSP의 유도를 10% SDS-PAGE로 확인하였다. Rat에서는 HSP70이 확실하게 유도되었으나, pika의 liver protein에서는 HSP70의 변화를 heat shock 후에 10% SDS-PAGE로 관찰하기 어려웠다. Pika의 HSP 유도의 부족은 높은 온도의 환경의 적응에 있어 단점으로 작용하는 것으로 생각된다.

유산소 체계의 훈련이 아세티콜린에 대한 말초 발한 감도에 미치는 영향

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Higher sweating in trained, compared to sedentary men has been attributed to differences in the peripheral sweating mechanisms, although such mechanisms have not been completely investigated in comparative terms. The aim of this study is to quantitatively investingate the peripheral sudomotor adaptive mechanisms attributed for greater sweating in endurance-trained athletes as opposed to sedentary men. To do this, we compared sudomotor activities to acetylcholin (ACh) iontophoresed in the fore arm skins of trained versus untrained subjects. Changes in sking and body temperatures, sweating rate (sweat volume), sweat onset time, active sweat gland density (SGD), and single sweat gland output (SGO) were measured. Training-related differences were observed for sweat volume, onset-time, SGD, SGO and skin temperature. It was concluded that endurance trained atholetes had higher sweat outputs due to the combinations of a higher sweat output per activated sweat gland, shorter lag phase for sweating, higher number of activated sweat glands.

Lagomorpha (토끼)의 열생물학적 분류와 특성

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

고산지대 또는 추운 지역에서 서식하는 Pika는 높은 고도에 의한 추위에 적응되어 있다. 저 호흡, 작은 귀이개와 열이 없는 타액의 분비와 행동의 특성에 의한 고 체온, 높은 대사량과 열을 적게 잃는 능력을 가진 Pika는 땅 밑의 토굴 또는 바위 사이의 은신처에 겨우내 먹을 수 잇는 저장된 먹이와 풀이 있는 곳에서 겨울을 난다고 보고 되어져 있다. 혈액 glucose 수준은 Pika (83±5.3 mg/ml)와 rabbit 90±8.2 mg/ml)에 비하여 Rat (120±15.5 mg/ml)이 높게 나타났다. 이는 통게적으로 유의한 차이가 인정되었다. (P<0.01). 또한 Pika와 Rabbit에 있어서는 통게적으로 유의한 차이가 인정되지 않았다. Pika는 생태학적으로나 자율 행동성 체온 조절학적인 것뿐만 아니라 추위에 대한 단열적인 방어 기전에 적응한 것으로 생각된다. 앞으로의 연구들에서 밝혀지겠지만 Pika의 연속적인 체온 주기의 소실은 주기 연구 영역에서 상당히 특이하고 흥미로운 것이다.

모 주물공장 근로자의 작업공정별 분진폭로량, 자각증상 및 건강진단판정 비교

이범식,조영채,변정식,김동현,원선혜,김정윤 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-

The relationship among dust exposure dose, special health diagnosis results and subjective symptom questionaire survey for 109 casting foundry workers supervised by a local laber office has been studied from august to october 1993. Subjective symptom, dust exposure dose and health examination evaluation of respective working processes have been analized and concluded as follows; 1. Metal fume concentration in melting process measured 3.21±1.46㎎/㎥ is under threshould limit value(TLV;5.0㎎/㎥), casting sand dust measured in molding and desanding process is 5.8 ±3.41㎎/㎥ and 9.69 ±2.64㎎/㎥ which is 3-5 times higher than TLV(2.0㎎/㎥), metal fume, welding fume and metal dust in finishing process measured 9.34 ±1.32, 13.73 ±16.97 and 10.17 ±3.50㎎/㎥ respectively, which are also 2-3 times higher than TLV(5.0㎎/㎥). 2. The complain rate subjective symptoms appeal evaluated for finishing process are 35.9%, 46.2%, 27.2% and 42.2% for eye smptoms, respiractory, skin, general symptom respectively and the rates above express the highest values and the complain rates for melting process are 24.4%, 37.5% and 35.7% for eye smptoms, respiratory and mental system respectively and for molding and desanding it is 24.3%. 3. Perceived occupational disease rate is found 0.9% with are out of 109 worker surveyed who have been exposed in metal fume of finishing process. 4. 33.0% of workers surved are found to require close examination, the worker of hepatopathy suspected are 21.4% which is the highest and 3.7% for circulatory disturbance suspected. 5. The statistically significant variables in general chracteristics that affect health examination evaluation are smoking(P<0.001), respirator put-on (P<0.05) and working career(P<0.05). 6. Cough(P<0.001), "headache"(P<0.05) and "easily skin exchange by slight stimulation" (P<0.05) are statistically significant to the subjective symptom variables affect health examination evaluation.

Macrophge에서 IL-1과 heat shock protein의 상관관계

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The macrophage plays an important role in lipopolysaccharide (LPS)-induced fever. Fever formation is attributed to macrophage activity. The purpose of this study is to examine whether induced fever has the charateristics of self-restriction during the process of a fever response. The result of methy-[^(3)H]-thymidine incorporation in RAW 246.7 cells showed that the proliferation of the macrohage was suppressed by a heat load of 39℃ for 2 hr. Enzyme-linked immunosorbent assay (ELISA) showed that the activity of IL-1 secretion induced by LPS was also suppressed by heat load. Suppression of activities of the macrophage including proliferation and secretion suggest that negative feedback loops exist where the end product, heat, may act back on the macrophage and finally result in the subsiding of a fever. The induction of heat shock protein (hsp70) by heat shock in the macrophage was detected by Western blot and Northern blot analysis. In U-937 cells, the increase of hsp70 band appears to be related to the extent of inhibition of IL-1 secretion. It is assumed that IL-1 secretion from the macrophage which effects the induction of fever, has a close relationship to the induction of hsp70.

갑상선 기능 향진증과 저하증에서의 발한 반응

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

갑상선의 기능 상태와 발한 반응의 관계를 알아보기 위해서, 온도가 25℃이고 상대습도가 60%인 실험실에서, 피실험자들은 43℃의 항온수조에 30분 동안 다리를 담그고 국소 발한 속도는 통풍 캡슐 방법(ventilated capsule method)으로 측정되었다. 갑상성 기능 항진증에 있어서, 정상과 비교했을 때 발한 시작점 시간은 짧아졌고 발한량은 많아졌으며, 발한에 대한 한계 핵 온도는 상향 변화되었다. 발한 반응은 만성 갑상선 기능 저하중에서 뚜렷하게 억제되었으나 단기 갑상선 기능 저하증에서는 발한 반응이 다소 증가되는 것을 알 수 있었다. 이러한 결과는 갑상선 호르몬이 열적 발한을 증가시키고 오랫동안 지속되는 갑상성 기능 저하 상태가 발한 기작에서 어떠한 기능 장애를 유도할 수 있다는 것과 세포내 갑상선 기능이 아주 느리게 변화하고 혈청 수준이후에는 지연된다는 것을 나타낸다.