개와 쥐 心室의 β-Adrenergic 및 Muscarinic receptor의 性質에 關한 硏究

손승아 嶺南大學校 大學院 1986 국내석사

첫 어머니됨의 체험 연구

손승아 서울여자대학교 대학원 2000 국내박사

본 연구의 목적은 첫 어머니됨의 체험을 간접 체험함으로써 그들이 겪은 체험의 의미와 본질이 무엇인지를 이해하는데 있다. 본 연구에서는 첫 임신과 출산과정을 겪고 영아를 키우고 있는 어머니들의 첫 어머니됨 체험의 의미를 이해하기 위해 van Manen의 해석학적 현상학의 연구방법을 적용하여 체험의 본질에 집중, 실존적 조사, 해석학적 현상학의 반성, 해석학적 현상학의 글쓰기로 구성된 총 10단계를 밟아 연구를 수행하였다. 본 연구의 참여자는 첫 출산 후 만 1년 이내 된 자녀를 키우고 있는 14명의 어머니들로 그들에게서 1999년 10월부터 2000년 2월까지 심층면담과 그림, 일기를 수집하였으며 면담자료는 자료가 포화될 때까지 얻어내었다. 연구 참여자로붙의 자료수집 뿐 아니라 문학 및 예술 작품도 분석 시 참조하기 위해 수집하였다. 연구 참여자들의 진술을 분석한 결과 여러개의 주제들이 도출되었으며, 어머니가 되는 과정을 자연스런 시간의 흐름에 따라 <설레이는 기다림>, <숨통이 끊어질 것 같은 고통스러움>, <삶의 중심으로 들어온 내 자식>의 3가지 대주제 아래 각각 하위주제들로 본질적 주제를 범주화하였다. 수집된 자료를 분석한 결과 참여자들의 첫 어머니됨 체험의 본질적 주제는 다음과 같다. <설레이는 기다림> - 새 생명이 자라는 경이로움 - 설레이는 기다림 - 달라지는 몸에 대한 신기함과 당황스러움 - 태교를 위해 몸가짐을 달리함 - 뱃속의 아기와 통해있음을 실감함 - 뱃속의 아기가 안전한지 끊임없이 불안함 <숨통이 끊어질 것 같은 고통스러움> - 산실에 혼자 남겨진 외로움과 두려움 - 숨통이 끊어질 것 같은 고통스러움 - 무사히 끝냈다는 안도감과 시원함 - 첫 만남의 감격스러움 "바로 너로구나!" - 아들 낳은 홀가분함과 딸 낳은 섭섭함 <삶의 중심으로 들오온 내 자식> - 진정한 한 가족으로 자리 매김 "한 배를 탄 운명공동체" - 삶의 중심으로 들어온 내 자식 - '어머니'라는 호칭에 대한 어색함과 낯설음 - 벗어나고 싶은 아기 돌봄의 고달픔 - 무거운 책임감과 부담감 - 몸매에 대한 아쉬움 "아! 옛날이여" - 여성으로서 완성되어감 - 나와 세상을 바라보는 눈이 달라짐 위와 같이 도출해낸 본질적 주제를 통해 첫째, 첫 어머니됨 체험은 어머니에게 참 자아를 찾아가는 정체성 재확립의 체험이고, 둘째, 첫 어머니됨 체험은 어머니로 하여금 창조적 존재로서의 여성이라는 자긍심과 완성감을 느끼며 여성성의 극대화 경험을 하게 하는 체험이며, 셋째, 첫 어머니됨 체험은 어머니로 하여금 성숙한 인간되어감을 느끼게 하는 체험이고, 넷째 첫 어머니됨 체험은 어머니로 하여금 관계맺음의 재인식을 통해 사회적 조직망을 재구축하는 계기를 갖게하는 체험임을 알 수 있었다. 마지막으로 본 연구의 의의와 제한점 및 제언을 제시하였다. This qualitative research used a hermeneutic phenomenological approach to discover meaning in the first women's experience of motherhood. The goal of this study was to discover the essence of the first lived experience of motherhood and promote understanding. The study was guided by van Manen's method for doing research. The method of inquiry included : turning to phenomenon of interest ; inquiring and investigating experience as it was lived rather than as conceptualized ; reflecting and analyzing essential themes which characterize phenomenon ; and describing phenomenon through art of writing and rewriting. Multiple strategies for data collecting were needed : in depth face to face interview ; analysis of women's writings and drawing ; artistic works ; and analysis of examples of phenomenon in art and literature. Although the experience was different for all of the women interviewed, essential themes of experience emerged ; <waiting with a leap of heart> - wondering at the fact that a new life is growing - wating with a leap of heart - marveling and surprising at the changing the body - being upright demeanor for practicing prenatal education - actual feeling well each other - continuation with a feeling of anxiety about safety of new life, <feeling a pain like gasping for breath> - loneliness and fear of being left alone in a delivery room - feeling a pain like gasping for breath - feeling of relief and astonishment - deep emotion of the first facing "that's you!" - feeling lighthearted about son and regretful about daughter <my baby in the main of my life> - settle down to a family in the true sense of the world "shared the fate of t he vessel" - my baby in the main of my life - an awkward unfamiliarity to labeling as a mother - wish to run away from worning out caring a baby - a heavy responsibility and burden - unsatisfied with the changing body image "ah! my full swing day" - becoming completion as a woman - changing of a view of the me and world. Findings of this study made possible to be deeply understanding on the first lived experience of motherhood of the women.

멸치액젓잔사를 활용한 조미소재 및 수용성 칼슘 제조기술 개발

손승아 국립부경대학교 대학원 2024 국내석사

For the acid-hydrolyzed fish sauce produced using the optimal conditions derived from preliminary research, a quality evaluation was conducted using fish sauce, seasoned fish sauce, and acid-hydrolyzed soy sauce as control with the similar raw materials and manufacturing methods. It has been confirmed that the ingredients vary depending on whether the fish sauce by-product is reused by the company. First, the contents of amino acid nitrogen was analyzed as 443.80 ± 5.44 mg/100 g for not reused fish sauce by-product whether it was 257.96 ± 5.11 mg/100 g for reused fish sauce by-product. The amino acid nitrogen contents of the not reused fish sauce by-product was at a level that met the standards for anchovy seasoned fish sauce in the Korean Industrial Standard, and in the case of free amino acids, the free amino acids that affected taste were at the level of (82.70%-82.83%) of the total free amino acids. It could be anticipated that it might be used as a rice polishing ingredient. The Content of histamine, the most important and problematic biogenic amine, was found to be 2.16 ± 0.10 mg/kg for unreused fish sauce by-product and 149.34 ± 5.71 mg/kg for reused fish sauce by-product. Both the not reused fish sauce by-product and the acid-decomposed fish sauce made from the reused fish sauce by-product did not exceed the histamine contents and were found to meet the standard. Neither unreused nor reused fish sauce by-product was detected 3-MCPD. Therefore, it was found that it did not exceed 0.02 mg/kg, which is the standard for 3-MCPD for acid-decomposed soy sauce, and the safety of acid-decomposed fish sauce was confirmed. Lastly, in the case of minerals, the significantly checked item was Ca. The contents of Ca in not reused fish sauce by-product was 519.15±41.96 mg/kg, and the reused fish sauce by-product was 806.59±21.75 mg/kg. It was confirmed that the Ca of acid-decomposed fish sauce manufactured using fish sauce by-product was at least 2.5 to as much as 4 times higher. Therefore, it is possible to prepare rice polishing ingredients with enhanced Ca, and it is believed that this may have a special advantage of acid-decomposed fish sauce using fish sauce by-product. Thus, it is judged that the rice polishing ingredients extracted from each fish sauce by-product will have commercial value in itself if standards and specifications are established. It is believed that it can be used as an additional ingredient to overcome the limitations of price and cost. In addition, as the fish sauce by-product is decomposed with acid, the calcium contained in the by-product is dissolved and precipitated again as calcium phosphate upon neutralization. The precipitated calcium phosphate is affected by pH. Thus, the supernatant of the fish sauce by-product was used as a seasoning materials ingredient, and the precipitate was developed into a calcium phosphate material to study ways to fully utilize the fish sauce by-product. The precipitated calcium phosphate was washed with water to reduce the high salt concentration, and was incinerated in a furnace to remove organic matter and developed into calcium material. At this time, 800℃ and 1,000℃ were compared and analyzed to derive the appropriate temperature. Through mineral analysis, it was found that washing with water increased the purity of phosphorus and calcium, however decrese sodium. It was found that temperature did not significantly affect the mineral contents when washing with water. However, in X-ray diffraction analysis, it was found that as the temperature increased, crystallinity increased and the purity of the crystals increased, and it was found that incineration at 1,000℃ was appropriate. As a result of X-ray diffraction analysis, the crystal was analyzed to be Whitlockite, a form of Mg combined with calcium phosphate, and some Trimagnesium bis(phosphate(V))-Ⅲ was also found to be present. Through SEM and STEM analysis, it was analyzed that the majority of Ca and P were distributed in the elemental composition, and the particle size was analyzed to be around 10 ㎛. Therefore, it was possible to develop calcium phosphate material simply by incinerating the sediment. To increase its absorption rate, it was attempted to manufacture water-soluble calcium. Including chelating calcium with an organic acid, an attempt was made to dissolve calcium by lowering its pH using vitamin C, however only 0.22% was dissolved at the maximum. So, additional research is believed to be necessary to prepare water-soluble calcium material.

아동성폭력 예방을 위한 행동기술훈련의 효과에 관한 연구

손승아 서울여자대학교 1992 국내석사

대학생의 ADHD 성향과 학업지연의 관계: 자기통제력의 매개효과

손승아 국립부경대학교 대학원 2024 국내석사

본 연구는 국내 대학생들을 대상으로 성인 ADHD 성향이 학업지연에 미치는 영향을 확인하고, 성인 ADHD 성향과 학업지연의 관계에서 자기통제력의 매개효 과를 검증하는데 목적이 있다. 이를 위해 전국에 소재한 4년제 대학교에 재학 및 휴학 중인 남녀 대학생 515명을 대상으로 온라인 설문업체를 통하여 성인 ADHD 성향, 학업지연, 자기통제력에 관한 설문조사를 실시하였고, 그 중 497부 의 설문지가 분석에 사용되었다. 설문조사에 수집된 자료를 SPSS 25.0를 사용하 여 각 변인 간의 상관관계를 살펴보기 위해 Pearson의 상관분석을 실시한 후 Baron 과 Kenny의 중다회귀분석을 실시하고, 부트스트래핑으로 통계적 유의성을 검증하여 매개효과를 확인하였다. 연구 결과 첫째, 대학생의 ADHD 성향은 학업지연에 유의한 정적 영향을 미치 는 것으로 나타났다. 둘째, 대학생의 ADHD 성향은 자기통제력에 유의한 부적 영향을 미치는 것으로 나타났다. 셋째, 대학생의 ADHD 성향과 학업지연의 관계 에서 자기통제력이 부분매개 하는 것으로 나타났다. 이 연구의 결과로, 대학생의 성인 ADHD 성향이 학업지연에 영향을 미치고, 성 인 ADHD 성향과 학업지연의 관계에서 자기통제력의 중요성에 대해 알 수 있었 다. 이러한 결과는 성인 ADHD 성향이 높은 대학생들은 자기통제력이 낮고, 학 업지연 문제를 보일 가능성이 높음을 의미한다. 따라서 본 연구는 성인 ADHD 성향이 높은 대학생의 학업지연에 대한 상담시, 성인 ADHD 성향에 대한 직접적 인 약물 개입뿐만 아니라 자기통제력 수준을 향상시키기 위한 구체적인 개입 방 안이 함께 모색되어야 함을 확인하였다는 점에 의의가 있다. 마지막으로 본 연구결과의 후속연구에 대한 제언을 논의하였다. The purpose of this study is to examine the effects of adult ADHD tendencies on academic procrastination among Korean college students and to test the mediating effect of self-control on the relationship between adult ADHD tendencies and academic procrastination. For this purpose, a survey was conducted among 515 male and female college students enrolled in a four-year university located in Korea, and 497 questionnaires were used for analysis. The collected data were analyzed using SPSS 25.0 to examine the correlation between each variable using Pearson's correlation analysis, followed by Baron and Kenny's multiple regression analysis, and statistical significance was verified with the bootstrapping method to confirm the mediating effect. The results of the study showed that, first, college students' ADHD tendencies affects academic procrastination and is positively related to each other. Second, college students' ADHD tendencies affects self-control and is negatively related to each other. Third, self-control was found to mediate the relationship between ADHD tendencies and academic procrastination in college students. The results of this study confirmed that adult ADHD tendencies influence academic procrastination in college students and the importance of self-control in the relationship between adult ADHD tendencies and academic procrastination. These findings suggest that college students with high adult ADHD tendencies are more likely to have low self-regulation and exhibit academic procrastination problems. Therefore, this result suggest that in order to effectively reduce academic procrastination among college students with high adult ADHD tendencies, further research on self-control as well as adult ADHD needs to be conducted, and specific interventions to improve self-control levels as well as direct medication interventions for adult ADHD tendencies need to be proposed and applied. Finally, suggestions and implications for further research are discussed.

無機 藥劑에 依한 아세테이트 織物의 防焰加工에 關한 硏究

손승인 (孫承仁) 慶熙大學校 大學院 1980 국내석사

60대와 20대 여성의 의자높이에 따른 Sit-to-stand의 운동역학적 분석

손승 부산대학교 대학원 2010 국내박사

The purpose of this study was to investigate the chair heights affects the burden on the lower limbs and dynamic balance control in preventing falls and identify the motor strategies adopted for the execution of the sit-to-stand (STS) movement, at self-selected speed, in a sample of 10 healthy elderly women(68.78±3.29 years) and 10 young women(20.90±0.74 years). Sit-to-stand movement of twenty healthy women were analyzed by the three-dimensional video and the ground reaction force system. Findings were as follows: 1. SPPB test of 60s women were showed significant decreased than physical performance of 20s women. 2. The 60s women stood from the chair longer the 20s women and lift-off from the chair occurred at 31% of STS movement regardless of chair height in 60s and 20s women. 3. The maximum horizontal velocity of the COM was nearly the same for 60s women and 20s women, the maximum vertical velocity of the COM in 60s women was slower than 20s women. 4. The contribution of each joint about velocity of COM was shown in order that hip, knee, ankle joint in 60s women and knee, hip, ankle joint in 20s women. 5. The maximum moment was occurred after lift-off, and that in 60s women was larger than in the 20s women. 6. The rate of rise in force in 60s women was smaller than that in 20s women. 7. The center of pressure in mediolateral and anteroposterior displacement in 60s women were large than that in 20s women. In conclusion, keeping the COM to approximate to the COP and enable the COM sway around the COP during STS movement, the COM sway therefore facilitate control. If does not occur, then more joint moment would be necessary. To maintain stability, increasing the rate of rise in force and rise time will be decreased and that will reduce the COM sway. But the COP must oscillate around the COM to control body sway.

남자 대학농구선수와 비선수들의 점프슛 동작에 관한 운동학적 비교분석

손승 부산대학교 2007 국내석사

The purpose of this study was to investigate jump shoot motion in basketball and to develop generally acceptable principles of jump shoot motion. The subjects of this study were six healthy male basketball player and college student. They were divided into two group, skilled and unskilled respectively. Jump shoot motions were analyzed by the three-dimensional video. Findings were as follows: 1. Duration of skilled group showed longer than unskilled group from take off to release, and skilled group showed smaller than unskilled group from release to top. 2. Unskilled group's migration distance of skilled elbow joint was longer than skilled group's on front-rear and left-right direction, but skilled group's was longer than unskilled group's on up-down direction from take off to release. 3. Angular displacement of wrist of skilled group were larger than unskilled group's, but Angular displacement of elbow of skilled group were smaller than unskilled group from lowest position to take off; and angular displacement of wrist, elbow, shoulder angle of skilled group were larger than unskilled group from take off to release. 4. Skilled group showed upper arm alignment angle to x-axis smaller than unskilled from take off to release. 5. Release Velocity, release angle and the release height of skilled group were larger than unskilled group's.

Structure, function, and cell cycle-dependent proteostasis of the transcription factor CP2c complexes

손승한 한양대학교 대학원 2023 국내박사

The protein homeostasis (proteostasis) is crucial for the regulation of cellular and tissue metabolism. Homeostasis is regulated very tightly by various regulatory proteins, including transcription factors (TFs) that play a role in regulating the expression of target genes by binding to DNA. TF CP2c is an evolutionarily conserved TF belonging to the TFCP2/grainyhead family. CP2c is expressed ubiquitously and involves in various tissue/stage cellular activities and human malignancies including cancer. Despite its importance, fundamental regulatory mechanisms of CP2c, including the underlying regulatory mechanisms for CP2c homeostasis and functionalization, are still unclear. In this dissertation, I elucidated the mechanisms about the stoichiometries, DNA binding targets, and regulation of nuclear levels of CP2c TF, and their cell-cycle-dependent proteostasis. Firstly, the structural and functional aspects of CP2c, stoichiometries, DNA binding targets, and regulation of nuclear levels of CP2c TF complexes were analyzed using DSP crosslinking and Western blot in addition to conventional methods. I found that the homotetramer of CP2c ([C4]) binds to the known CP2c binding DNA sequence (CNRGN5/ 6-CNRG), whereas a dimeric form of a CP2c, CP2b, and PIAS1 heterohexamer ([C2B2P2]2) binds to the three consecutive CP2c half-sites (CNRG-N5/6)or two staggered CP2c binding motifs, where the [C4] exerts a pioneering function for recruiting the [C2B2P2]2 to the target. CP2c exists in both the nucleus and cytoplasm, it forms the following three complexes in natural cells, [C4], [C2B2P2]2, or [C2B2P2]4. Importantly, one more cytosolic heterotetrameric CP2c and CP2a complex ([C2A2]) regulates the steady nuclear levels of CP2c complexes. Overall, the transcriptional activity of CP2c is mediated by two complexes ([C4] and [C2B2P2]2), and the extra complex components are trapped by other complexes ([C2B2P2]4, [C2A2], [CABP]x), so the number of functional complexes is tightly controlled in cells. Next, an unprecedented CP2c degradation mechanism via a novel SUMO1/PSME3/20S proteasome pathway and its biological significance were elucidated. CP2c is SUMOylated in a SUMO1-dependent way, and SUMOylated CP2c is degraded through the ubiquitinindependent PSME3/20S proteasome system. SUMOylated PSME3 could also interact with CP2c to degrade CP2c via the 20S proteasomal pathway. In addition, the delicate control of CP2c degradation through the SUMO1/PSME3/20S proteasome pathway occurred specifically in the G2/M/G1 phase, and this mechanism is needed for precise cell cycle progression. The SUMO1/PSME3/20S proteasome pathway engages in the proteostasis of not only CP2c but also other cell cycle-related factors, BRCA1, BRD4, and TP53. Collectively, these results supply unprecedented information about the stoichiometries, DNA binding targets, and regulation of nuclear levels of CP2c TF, and their cell-cycledependent proteostasis as follows. 1) tCP2c binds to DNA sequences having two consecutive CP2c half-sites, while CBP binds to sequences containing three consecutive CP2c half-sites or two staggered CP2c binding motifs. 2) CP2c always existed as complexes in cells, either as [C4] or various heteromers with other proteins, such as [C2B2P2]2 or [C2B2P2]4, and heterotetrameric [C2A2]. Since the net concentrations of nuclear CP2c complexes were not much different, whereas their net cytosolic concentrations were quite variable, I propose a model in which CP2a regulates the nuclear concentration of CP2c complexes to cope with cellular demands by squelching CP2c into [C2A2] in the cytosol at physiological conditions, or by squelching all proteins together into an aberrant heterodecameric complex at non-physiological conditions, such as ectopic overexpression of CP2c complex proteins. 3) [C4] exerts a pioneering function for recruiting [C2B2P2]2 to the CP2c binding sites with three or more CP2c half-sites, concomitantly inducing synergistic binding of [C4] to the two nearby CP2c half sites. 4) The existence of nuclear [C2B2P2]4 suggests a facilitated intersegmental transfer mechanism between two CP2c binding sites, where a DNA-bound [C2B2P2]4 interacts with another DNA target, nearby or in proximal localization within a nuclear condensate, via protein–DNA interaction, forming a DNA loop or an inter-strand joining required for efficient transcriptional activation of the specific gene. 5) The precisely timed degradation of CP2c, that is needed to ensure a correct progression of the cell cycle, occurs through the SUMO1/PSME3/20S proteasome axis. Moreover, since CP2c always existed as complexes in cells, it is also expected that a free state of CP2c, not engaged into complexes, should be also removed by this SUMO1/PSME3/20S proteasome axis. Therefore, these results will

투자권유규제의 실효성 제고 및 개선에 관한 연구

손승인 고려대학교 법무대학원 2015 국내석사

‘투자권유’는 자본시장법상 투자권유규제의 출발점이자 그 적용여부를 결정하는 중요한 개념이다. 자본시장법 시행으로 투자권유규제가 정비되었고 내용이 크게 강화되어 시행되고 있음에도 금융상품 판매현장에서는 투자권유 개념의 포괄적?추상적 개념정의로 인해 규제의 출발점에서부터 혼선이 발생하고 있고, 이후 순차적으로 적용되어야 할 적합성원칙과 설명의무 등 투자자보호를 위한 조치들이 적법하게 이행되지 않는 문제점이 여전히 발생하고 있는 것으로 보인다. 이는 2013년 동양증권의 사례에서와 같이 대규모의 불완전판매를 초래한 원인중의 하나로도 판단된다. 이에 본 연구는 자본시장법상 투자권유규제의 효과적인 작동을 위해 다음과 같은 실효성 있는 개선방안을 제시하였다. 우선, 투자권유의 개념 분석을 통해 투자권유 해당여부를 판단할 수 있는 구체적인 기준을 검토하였다. 이와 함께 투자권유의 개념을 보다 명확히 하고 실무적으로 발생하고 있는 단순 상담과의 혼선을 제거하기 위해 투자권유에서 제외되는 단순 상담의 범위를 자본시장법시행령이나 금융투자업규정 등을 통해 구체적으로 명시하는 방안을 제시하였다. 또한, 금융투자업자의 적정하고 합리적인 적합성 판단을 유도하기 위해 투자권유 전 적합성 확인절차를 거치지 않은 행위에 대한 과태료 부과와 부적합 확인서 등을 통한 판매유인 차단방안을 검토하였고 적합성원칙을 현저히 위반한 행위에 대해서는 자본시장법 제48조를 적용하여 투자자의 입증책임을 경감하는 방안 등을 제시하였다. 이와 함께 투자위험 고지강화 등 금융당국의 투자자보호를 위한 설명의무 이행방식의 개선대책 등에 대해서도 살펴보았다. Investment recommendation is one of the key concepts in Korea's Financial Investment Services and Capital Markets Act (FISCMA) that is critical to the application of investment recommendation rules stipulated in the FISCMA. The FISCMA has contributed greatly to fine-tuning and tightening investment recommendation rules, but the broad and abstract nature of the definition of investment recommendation still causes some degree of confusion at the point of distribution of investment products. There also remains a room for improvement in compliance with suitability and duty-to-explain requirements. This partly contributed to a large number of mis-selling cases revealed in 2013 in connection with Tong Yang Securities. Against this backdrop, this study proposes several measures to make investment recommendation rules function in a more effective fashion. First of all, based on the concept analysis of investment recommendation, it comes up with a set of detailed criteria that would help determine the application of investment recommendation rules. It also examines the idea of excluding "simply providing advice or consultation" from the scope of investment recommendation and explicitly stipulating what constitutes such advice or consultation in the Enforcement Decree of the FISCMA or the Regulations on Financial Investment Business. In addition, in order to make financial investment companies assess the suitability of investment products in a more adequate and reasonable manner, this study reviews the ideas of imposing fines on the failure to assess the suitability of investment products before recommending them to investors and discouraging the practice of seeking confirmation from investors in an effort to evade suitability requirements that they are investing in high-risk products at their own will. The study also proposes an idea of applying Article 48 of the FISCMA to mitigate the burden of proof on investors in case of financial investment companies' failure to comply with suitability requirements. This study also looks at measures to help investors make more informed choices and better protect them, such as reinforcing the effectiveness of duty-to-explain requirements.