무산소 운동 없이 발생한 Patchy Renal Vasoconstriction 2예

김희성 ( Hee Sung Kim ),윤수인 ( Su In Yoon ),최경석 ( Kyung Suck Cheoi ),정기옥 ( Ki Ok Joung ),권순길 ( Soon Kil Kwon ),김혜영 ( Hye Young Kim ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5

Patchy renal vasoconstriction is one of the reversible renal vasoconstrictions, which usually occur in healthy young men following strenuous anaerobic exercise. Analgesics, viral infection, dehydration were known to be the causes of patchy renal vasoconstriction. We experienced two cases of patchy renal vasoconstriction without antecedent anaerobic exercise. The first case is a 54-year-old woman admitted to a hospital with severe loin pain. On admission, serum creatinine was elevated to 2.2 ㎎/dL. Patchy areas of delayed contrast enhancement in both kidneys were observed on immediate post-contrast CT and 14 hours delayed image. This severe loin pain was initiated without anaerobic exercise. On the 4th day, her loin pain was relieved and on the 12th day of her illness, serum creatinine was normalized with supportive care. The second case is an 18-year-old man presented with pain in the both flanks. Five days earlier, operation had been performed for treatment of gynecomastia. There had been no preceding anaerobic exercise before the flank pain occurred. On admission to the hospital, laboratory studies revealed a serum creatinine 2.3 ㎎/dL. Computed tomography showed multiple patchy areas of enhancement in the renal parenchyma. On 12 hours delayed image, there were delayed contrast enhancement. On the sixth day, serum creatinine decreased to 1.4 ㎎/dl and the loin pain was subsided. Patchy renal vasoconstriction can occur without exercise, and we suggest that patchy renal vasoconstriction should be suspected in the patients suffering from acute renal failure with severe loin pain even without strenuous exercise. (Korean J Nephrol 2006;25(5):841-846)

巴豆가 흰쥐 흉부대동맥 혈관수축에 미치는 영향

朴完洙,金亨煥,安德均,崔湖榮 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : We have examined the vasoconstriction response to the various extracts of Crotonis Fructus (CF, Seed of Croton tiglium L.), defatted CF (DCF), roasted CF (RCF), and Croton oil in rat isolated thoracic aorta. Methods : We have examined the thoracic aorta segments obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. Results : We found that the thoracic aorta segments responded to various extracts of CF with a dose-dependent vasoconstriction. In comparison to the 100 mM KCl induced contraction, it was contracted by 150% (water extract of CF), 144.5% (70% ethanol extract of CF), 80.1% (water extract of DCF) and 96.6% (ethanol extract of DCF) after addition of the 3 mg/ml each extract. The thoracic aorta segments were contracted by 118.5% (0.01 mg/ml Croton oil), 133.8% (3 mg/ml RCF for 10min), 123.1% (20min), 117.8% (30min), and 103.9% (40min). Conclusions : In the conclusion, CF, DCF, and RCF induced dose-dependent contraction in the isolated rat thoracic aorta. And it's major component, Croton oil, has potent vasoconstriction effect.

Atypical Manifestation of Zoster Meningitis Presented with Headache and Multiple Cerebral Vasoconstrictions

Jung Woo Kim,Yun Jeong Hong,Eun Jin Yang,Seung-Hee Na,Young-Do Kim,Jeong Wook Park 대한신경초음파학회 2023 대한신경초음파학회지 (JNN) Vol.15 No.2

Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by headaches and multiple transient cerebral vasoconstrictions. Central nervous system (CNS) infections related to the varicella zoster virus (VZV) can complicate various neurological disorders, including cerebral vasculopathy. We present the case of a patient who complained of a severe headache without any other symptoms or focal neurological signs. Brain magnetic resonance angiography showed multiple focal stenoses, especially in the right middle cerebral artery (MCA), and transcranial Doppler sonography revealed increased velocities in the MCA and right anterior cerebral artery. Initially, the headache was attributed to RCVS, and nimodipine infusion was initiated; however, the headache worsened. A cerebrospinal fluid study showed pleocytosis, increased protein levels, and positive polymerase chain reaction markers for VZV. No skin lesions or fever were observed during treatment. Our case emphasizes considering VZV meningitis as a cause of cerebral vasoconstriction, even in the absence of typical signs of CNS infection.

에틸렌옥사이드 노출 이후 발생한 뇌경색을 동반한 가역뇌혈관수축증후군

이민오,박수현,유위선 대한신경과학회 2016 대한신경과학회지 Vol.34 No.3

Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headache and multiple reversible intracranial vasoconstrictions. Here we report a case of RCVS after exposure to ethylene oxide (EO) gas, which is a widely used sterilant. A 34-year-old woman presented with aphasia, right-arm weakness, and severe headache after inhaling EO gas. Brain imaging revealed multiple infarcts and multiple intracranial stenoses. The stenotic lesions completely regressed on follow-up CT angiography. This is the first report of RCVS after exposure to EO gas.

고농도 U-46619에 의한 혈관의 수축에 대한 Resveratrol의 억제 작용에서 MEK 활성 또는 Rho-kinase 활성의 변화 : 내피 비의존적 수축성 조절

제현동(Hyun Dong Je) 대한약학회 2011 약학회지 Vol.55 No.2

The aim of present study was to investigate the possible influence and related mechanism of resveratrol on U-46619 (high concentration)-induced vasoconstriction. Agonist-induced vascular smooth muscle contractions involve the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in resveratrol-induced relaxation in rat aortae contracted with high U-46619. We hypothesized that MEK or Rho-kinase inhibition plays a role in vascular relaxation evoked by resveratrol in rat aortae. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Resveratrol fully inhibited U-46619 in low concentration-induced contraction regardless of endothelial function. However, resveratrol partially decreased U-46619 in high concentration- induced contraction regardless of endothelial function. Interestingly, only in U-46619 (high concentration)-induced contraction, no significant decrease was observed in phospho-ERK1/2 levels and slight decrease in phospho-MYPT1 levels suggesting that additional pathways different from them or endothelial nitric oxide synthesis might be involved in the vasorelaxation. In conclusion, in high U-46619-contracted rat aortae, resveratrol showed relaxation response regardless of endothelial function significantly but slightly decreasing MYPT1 phosphorylation rather than ERK1/2 phosphorylation.

A novel blood pressure modulator C1q/TNF-α-related protein 1 (CTRP1)

( Sora Han ),( Young Yang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.12

C1q/TNF-α-Related Protein 1 (CTRP1) has recently been shown to act as a blood pressure regulator, as it induces vasoconstriction. In the aorta, CTRP1 facilitates recruitment of angiotensin II receptor 1 (AT1R) to plasma membrane, through activation of the AKT/AS160 signaling pathway. This leads to activation of the Ras homolog gene family (Rho)/Rho kinase (ROCK) signaling pathway, resulting in vasoconstriction. Accordingly, mice overexpressing Ctrp1 have hypertensive phenotype. Patients with hypertension also display higher circulating CTRP1 levels, compared to healthy individuals, indicating that excessive CTRP1 may affect development of hypertension. Conversely, CTRP1 is regarded as an ‘innate blood pressure modulator’ because CTRP1 increases blood pressure under dehydration to prevent hypotension. Mice lacking Ctrp1 fail to maintain normotension under dehydration conditions, resulting in hypotension, suggesting that CTRP1 is an essential protein for maintaining blood pressure homeostasis. In conclusion, CTRP1 is a novel, anti-hypotensive vasoconstrictor that increases blood pressure during dehydration-induced hypotension. [BMB Reports: Perspective 2018; 51(12): 611-612]

관상동맥 질환 환자에서 관상동맥내 Acetycholine 유발검사의 임상적 의의에 관한 연구

강흥선(Heung Sun Kang),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jeung Sang Song),배종화(Jong Hoa Bae) 대한내과학회 1992 대한내과학회지 Vol.43 No.2

N/A Backgroand: Coronary vasoconstriction plays an improtant role in the pathogenesis of coronary artery disease. It has been known that acetylcholine (Ach) dilate normal vessels by releasing an endothelium- derived relaxing factor (EDRF), but when the endothelium is removed or dysfunctional, the vasodilator response is replaced by vasoconstriction resulting from the direct effects of this agent on vascular smooth mulscle. Methods: To evaluate the effects of intracoronary injection of Ach, 42 patients (27 males, 15 females; age range, 32~70 years) who had a history of chest pain were studied by using biplane cineangiography. Twentytwo patients had angiographically normal coronary arteries (Group I) and 20 patients had significant coronary artery disease (Group II). Results: Coronary artery vasoconstriction was induced in 11 patients (50%) of Group I, and in 14 patients (70%) of Group II by intracoronary injection of Ach. The site of vasoconstiction induced by Ach was more frequent in right coronary artery (23 patients out of 25 patients) than in left coronary artery. The levels of plasma total cholesterol in the patients with coronary vasoconstriction (GroupIB: 191.8±23.9 mg/dl, GroupIIB: 208.6±34.2mg/dl) were higher than those who without coronary vasoconstriction (154.5±35.9 mg/ dl)(p?0.01). Conclusion: These results suggest that vasoconstriction of coronary artery are induced easily by intracoronary injection of Ach and more frequent observed in right coronary artery, Intracoronary injection of Ach may be helpful in the evaluation of the patients with atypical chest pain and in the early detection of the patients with coronary artery atherosclerosis

Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle

Lee, Moo-Yeol,Lee, Young-Ho,Lim, Kyung-Min,Chung, Seung-Min,Bae, Ok-Nam,Kim, Heon,Lee, Choong-Ryeol,Park, Jung-Duck,Chung, Jin-Ho National Institute of Environmental Health Science 2005 Environmental health perspectives Vol.113 No.10

<P>Chronic exposure to arsenic is well known as the cause of cardiovascular diseases such as hypertension. To investigate the effect of arsenic on blood vessels, we examined whether arsenic affected the contraction of aortic rings in an isolated organ bath system. Treatment with arsenite, a trivalent inorganic species, increased vasoconstriction induced by phenylephrine or serotonin in a concentration-dependent manner. Among the arsenic species tested—arsenite, pentavalent inorganic species (arsenate), monomethylarsonic acid (MMA<SUP>V</SUP>), and dimethylarsinic acid (DMA<SUP>V</SUP>)—arsenite was the most potent. Similar effects were also observed in aortic rings without endothelium, suggesting that vascular smooth muscle plays a key role in enhancing vasoconstriction induced by arsenite. This hypercontraction by arsenite was well correlated with the extent of myosin light chain (MLC) phosphorylation stimulated by phenylephrine. Direct Ca<SUP>2+</SUP> measurement using fura-2 dye in aortic strips revealed that arsenite enhanced vasoconstriction induced by high K<SUP>+</SUP> without concomitant increase in intracellular Ca<SUP>2+</SUP> elevation, suggesting that, rather than direct Ca<SUP>2+</SUP> elevation, Ca<SUP>2+</SUP> sensitization may be a major contributor to the enhanced vasoconstriction by arsenite. Consistent with these <I>in vitro</I> results, 2-hr pretreatment of 1.0 mg/kg intravenous arsenite augmented phenylephrine-induced blood pressure increase in conscious rats. All these results suggest that arsenite increases agonist-induced vasoconstriction mediated by MLC phosphorylation in smooth muscles and that calcium sensitization is one of the key mechanisms for the hypercontraction induced by arsenite in blood vessels.</P>

스테로이드치료에 반응한 가역적뇌혈관수축증후군

이만용,신동훈,이선민,이진수 대한신경과학회 2016 대한신경과학회지 Vol.34 No.1

A 50-year-old woman with thunderclap headache and transient neurologic symptoms was diagnosed with reversible cerebral vasoconstriction syndrome. Serial angiography showed multifocal arterial vasoconstrictions, and MRI revealed multiple scattered cerebral infarctions. New neurologic symptoms and vasoconstriction in other arteries occurred repeatedly despite the on-going administration of traditional treatments. However, the symptoms reduced dramatically after administering intravenous steroid pulse therapy. This case suggests that steroid therapy can be considered as an alternative treatment when reversible cerebral vasoconstriction syndrome is intractable to traditional treatment.

Reversible Cerebral Vasoconstriction Syndrome Presenting as Transient Vessel Wall Enhancement on Contrast-Enhanced Fluid-Attenuated Inversion Recovery Images: A Case Report and Literature Review

허선아,김은수,이열 대한영상의학회 2020 대한영상의학회지 Vol.81 No.5

Reversible cerebral vasoconstriction syndrome (RCVS) is a clinical and radiological syndrome with primary features that include hyperacute onset of severe headache and segmental vasoconstriction of the cerebral arteries, which resolve within 3 months. Vessel wall enhancement has been reported in some cases of RCVS; however, its pathophysiological and diagnostic implications remain unclear. We review a case of RCVS in a patient with transient vessel wall enhancement on contrast-enhanced fluid-attenuated inversion recovery images, focusing on the pathophysiological and diagnostic implications.