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2-D microphase properties of novel ceramides assembled to intercellular lipid membranes
이보령,성민철,김진웅 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.1
In this study, we investigated how 1-O-acylceramide (CENP) and ceramide with ultra-long chain (C24-C32) (CULC) associate with ceramide NP (CNP), respectively. To characterize their structure, we fabricated a 2-D lipid membrane composed of ceramides/stearic acid/cholesterol, which mimics the intercellular lipid in our stratum corneum, by using Langmuir-Blodgett technology. The π-A isotherms of the lipid membranes revealed that CENP disturbed the association of lipid membranes, whereas CULC led to formation of closely packed membranes. Moreover, CENP showed a slower phase transition compared with CULC, which was confirmed by fluorescence microscopy. In addition, through the AFM analysis, we verified the CULC had the higher domains by associating between CNP and CULC more tightly than between CENP and CNP. We expect these findings of novel ceramides are able to contribute to the developed skin barrier function.