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- 주제어 : titanium surface reforming (검색결과 3 건)
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김은혜,박신혜,지소윤,우희동,허윤,Yoshihiro Ito,한동근,나재운,손태일 한국고분자학회 2016 Macromolecular Research Vol.24 No.2
For improving cell adhesion on titanium surface, phosphonated low-molecular-weight chitosan (P-LMC) was prepared by introducing a phosphonate group of 4-phosphonobutyric acid to low-molecular-weight chitosan (3,000<MW<10,000). The phosphonate group of P-LMC was identified by 31P NMR. At about 30 ppm from external standard, there was a specific peak derived from phosphonate group. X-Ray Photoelectron Spectroscopy (XPS) and water contact angle were carried out for characterization of titanium surface treated with P-LMC. From these results, P-LMC coated on titanium surface was remained on that in spite of washing and P-LMC made titanium surface more hydrophilic. The biocompatibility of P-LMC was demonstrated through a cytotoxicity test using the C2C12 cell line because P-LMC should have no cytotoxicity for applying to dental implant materials. As a result, P-LMC was biocompatible to use as coating material of titanium. Improvement of cell adhesion on titanium surface treated with P-LMC was observed by microscopy, and the number of attached cells was counted using a hemocytometer. Titanium surface coated with P-LMC showed improved cell adhesion for 12 h. These results demonstrate that P-LMC is biocompatible and titanium surface treated with P-LMC has positive effects on cell adhesion. Therefore, P-LMC is a useful material that can be applied for titanium coating to enhance cell adhesion and osseointegration.
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김은혜,정진홍,한가득,손태일 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Phosphonated low-molecular-weight chitosan (P-LMC) was prepared for improving cell adhesion on titanium surfaces. P-LMC was prepared by introducing a phosphonate group from 4-phosphonobutyric acid to low-molecular-weight chitosan. Introduction of the phosphonate group was confirmed by 31P-NMR. Characterization of titanium surfaces treated with P-LMC was by XPS and water contact angle. Prepared P-LMC should have no toxicity for medical applications. Cytotoxicity was tested in WST-8 assays using the C2C12 cell line. Improvements in cell adhesion on treated titanium surfaces were observed by microscopy and the number of attached cells was counted using a hemocytometer. Titanium surfaces with P-LMC had positive effects on cell adhesion. In conclusion, it is considered that P-LMC could be applied as titanium coating material.
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Preparation of dual functional low-molecular-weight chitosan derivatives for medical application
김은혜,정진홍,한가득,손태일 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Dual functional low molecular chitosan derivative (LMC) was prepared by introducing phosphate and azido group to LMC (Az-P-LMC). Az-PLMC has two properties, which are adherable to titanium and photocurable. The titanium-adherable property of Az-P-LMC promote cell adhesion to titanium surface. Also, Az-P-LMC could immobilize the protein because of the photo-curable property by azido group. The phosphate and azido group of Az-P-LMC was confirmed using 31P-,1HNMR. Adherable and photo-curable properties were evaluated by cell attachment test and photo-curing test. Also, for medical application, cytotoxicity test was proceeded by WST assay. And for checking the capacity of drugs immobilization, the protein releasing test was carried out.
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