마발(馬勃)의 독성(毒性)과 부작용에 관한 문헌적 고찰

서부일 ( Bu Il Seo ),노성수 ( Seong Soo Roh ),구진숙 ( Jin Suk Koo ) 한약응용학회 2017 한약응용학회지 Vol.17 No.1

Lasiosphaera Seu Calvatia is in use in the Korean medicine. The Korean medical doctors use Lasiosphaera Seu Calvatia for clearing away heat and eliminating toxin(淸熱解毒), clearing away the lung-fire(淸肺), relieving sore-throat(利咽), etc. We investigated toxicity, poisoning symptoms, side effects, poisoning treatment and prevention against poisoning of Lasiosphaera Seu Calvatia. The results were summarized as follows: 1. The possibility of serious side effects and poisoning symptoms of Lasiosphaera Seu Calvatia are almost non-existent, but this Lasiosphaera Seu Calvatia can cause hypersensitive reaction. 2. The medical doctors should treat drug poisoning by normal treatment rule for drug poisoning. And The medical doctors can use symptomatic treatment or antianaphylactic treatment according to various situations. 3. In order to prevent against poisoning of Lasiosphaera Seu Calvatia, the patients should keep usage, dosage and notes.

향가피(香加皮)의 독성(毒性)과 부작용에 관한 문헌적 고찰

이지혜 ( Ji Hye Lee ),노성수 ( Seong Soo Roh ),김정자 ( Jeong Ja Kim ),서부일 ( Bu Il Seo ) 한약응용학회 2015 한약응용학회지 Vol.15 No.1

Periplocae Radicis Cortex is in use in the Korean medicine. The Korean medical doctors use Periplocae Radicis Cortex for eliminating wind and dampness(祛風濕), strengthening tendons and bones(强筋骨), eliminating hidropesia(消水腫), etc. We investigated toxicity, poisoning symptoms, side effects, poisoning treatment and prevention against poisoning of Periplocae Radicis Cortex. The results were summarized as follows: 1. The main ingredients of poisoning are periplocin, etc. The ingredients of poisoning from Periplocae Radicis Cortex mainly can cause stimulating symptoms on digestive system in the case of slight poisoning, and mainly cause stimulating symptoms on nervous system, cardiovascular system in the case of severe poisoning. 2. The representative methods of poisoning treatment in the Korean medicine take advantage of herbs, such as Glycyrrhizae Radix(甘草), Phaseoli Radiati Semen(綠豆), etc. And Korean medical doctors should meet symptoms as patients call for attention. 3. The representative methods of poisoning treatment in the western medicine are promotion of vomiting, washing out the stomach, causing diarrhea, supplies of grape sugar and symptomatic treatment, etc. 4. In order to prevent against poisoning of Periplocae Radicis Cortex, the patients should keep usage, dosage and notes.

종설(綜說) : 하고초(夏枯草)의 독성과 부작용에 관한 문헌적 고찰

김용현 ( Yong Hyun Kim ),서부일 ( Bu Il Seo ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.4

Prunellae Spica is in use in Korean medicine. Korean medical doctors use Prunellae Spica for removing heat and fire(淸熱瀉火), etc. We investigated toxicity, poisoning symptoms, poisoning treatment, side effects and prevention against poisoning of Prunellae Spica. The results were summarized as follows: 1. Prunellae Spica did not show the special toxicity in the toxicity experiment. But side effects and hypersensitivities of Prunellae Spica have been reported by clinical experience report. The medication of Prunellae Spica can cause eruption, itching, nausea, rapid pulse, dizzy, stomachache, diarrhea, etc by side effects. And the medication of Prunellae Spica can cause eruption on the skin and stimulation on mucous membrane of the throat by hypersensitivity. 2. In the case of occurrence of side effects and poisoning. The representative treatment methods are stopping medication, and symptomatic treatment, etc. 3. In order to prevent against poisoning of Prunellae Spica, the patients should keep usage, dosage and notes.

급성 제초제 중독의 임상 양상: Chlorophenoxy계 제초제 중심으로

송하균,최상천,정윤석,박은정,김혁훈 대한임상독성학회 2019 대한임상독성학회지 Vol.17 No.2

Purpose: Herbicide-related mortality has decreased since the complete ban of paraquat product sales in 2012, but there still have been other herbicides intoxications with relatively severe complications. Glyphosate and glufosinate herbicides are used widely, and considerable research has been conducted. Chlorophenoxy herbicide is another major herbicide that has shown poor outcomes and mortality without proper management, but research in this area is lacking. Therefore, this study compared the clinical features of chlorophenoxy herbicide with those of other herbicides. Methods: The medical records of patients exposed to herbicides at a tertiary academic university hospital in Korea from May 2014 to April 2019 were reviewed retrospectively. The demographic and clinical data of 135 patients were then analyzed to identify the recent herbicides intoxication trends after the paraquat sales ban, focusing mainly on chlorophenoxy herbicide poisoning. Results: Of the 135 patients, 13 patients (9.6%) had chlorophenoxy herbicide poisoning. No significant differences in all the variables were observed between the chlorophenoxy herbicide poisoning group and non-chlorophenoxy herbicides poisoning groups. Toxic symptoms after poisoning varied from nothing noticeable to confusion; none of the patients had severe complications after their treatments. Conclusion: Acute chlorophenoxy poisoning is relatively less severe, with lower mortality rates than glyphosate and glufosinate poisoning.

도꼬마리 열매 복용으로 발생한 중독증상(中毒症狀)의 한방치료 1례

심원석,박상은,홍상훈,Shim, Won-suk,Park, Sang-eun,Hong, Sang-hoon 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.1

This is a clinical report of one patient with mental disorientation, abnormal behavior, spasm, and other symptoms caused by poisoning with Xanthii Fructus, who recovered completely with treatment. The patient was treated with Korean medical treatments, such as herbal medicine and acupuncture. After treatment, various symptoms caused by the Xanthii Fructus poisoning disappeared completely and laboratory findings, such as liver function tests (aspartate transaminase and alanine transaminase), were also close to the normal ranges. This case shows that Korean medicine therapy can be applicable in treating various symptoms caused by Xanthii Fructus poisoning. It is considered that further research is needed to confirm the safe use of Xanthii Fructus.

조위승청탕(調胃升淸湯)등 한방치료로 호전된 급성 일산화탄소 중독의 지연성 후유증 환자

김윤용 ( Yun Yong Kim ),김지영 ( Ji Young Kim ),조혜영 ( Hye Young Cho ),조성훈 ( Seung Hun Cho ),황의완 ( Wei Wan Hwang ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3

After recovery from acute carbon monoxide poisoning, some patients suffer from neuropsychiatric problems such as cognitive impairement, movement disorder, change of personality and mental disorder after lucid interval in which the patient has no symptom. This sequela of carbon monoxide poisoning is called delayed post-anoxic encephalopathy(DPE). No neuroprotective drug has yet demonstrated ecfficacy and hyperbaric oxygen treatment`s effect have little scientific evidence in preventing and improving DPE. In such situation, korean traditional treatment may be helpful in treating the patient suffering from DPE. In this case report, we will describe the patient that has suffered from severe DPE involving cognitive impairment, gait disturbance and incontinence but has been improved successfully by korean traditional medicine treatment, especially Jowiseungchungtang. This case could present how we will study about DPE.

감귤농가 농약 살포시 착용하는 보호장비와 피해 증상분석

류갑희(Gaphee-Ryu),최칠구(Chil-koo Choi),조형욱(Hyeong-Wook Jo),문준관(Joon-Kwan Moon) 한국농약과학회 2024 농약과학회지 Vol.28 No.1

Tangerines cultivation takes place in the southern region of Korea, including the Jeju region, however, the cultivation area in the Jeju region is 21,877 ha, which is 99% of the total cultivation area. To support stable production, disease and pest control time accounts for 13.4%, the second highest proportion after harvest work. The amount of pesticide usage (kg a.i./ha) according to crop was highest for citrus at 40.0 kg a.i./ha, making it the crop with the greatest exposure to pesticides. An analysis was performed to determine the number of citrus farmers who are in compliance with the standards for safe use of pesticides as well as symptoms they may be experiencing and treating. A survey of 232 target farms was conducted, which represents 0.8% of citrus growing farms. Among citrus farmers, symptoms of pesticide poisoning were limited to 11 symptoms, including dizziness, vomiting, nausea, headache, fever, skin allergy, itching, hives, bloodshot eyes, difficulty breathing, and skin spots. Protective clothing was regarded as protective equipment for prevention of pesticide poisoning. The study was limited to hats, gloves, protective glasses, and masks. The protective equipment worn by citrus farmers when spraying pesticides was most often protective clothing + hat + gloves + mask at 62%, followed by protective clothing + hat + gloves + mask + protective glasses at 18%, and hat + gloves at 18%. Those wearing masks, protective clothing, hats, and gloves accounted for 4%, while the percentage of remaining minority responses was 12%. The various symbols of pesticide poisoning affecting citrus farmers after spraying pesticides included dizziness + skin allergy + bloodshot eyes in 18%, bloodshot eyes in 12%, itching in 10.3%, and hives in 8.6%. Of the 232 surveyed farmers, 19.0% (44 people) received treatment at a hospital, 59 (25.4%) received pharmacy prescriptions, however, 55.6% (129 people) responded that they did not receive medical treatment. In particular, 40.3% of non-medical farmers did not receive medical treatment due to asymptomatic symptoms, however, 59.7% of subjects did not receive hospital treatment or pharmacy prescriptions despite a diagnosis of pesticide poisoning. These research findings are expected to provide basic information to prevent pesticide poisoning in citrus farmers.

정신과 치료 거부 중독 자살 시도 환자의 특성과 중재 치료로서 응급의학과 입원의 효과

임용균,정회한,박은정,민영기,최상천 대한응급의학회 2016 대한응급의학회지 Vol.27 No.1

Purpose: Discharge against medical advice (DAMA) carries a risk of increased mortality and readmissions in the emergency department (ED). The aim of the current study was to examine characteristics of suicidal attempters with acute poisoning who were discharged against psychiatric medical advice and other clinical department admission as acute intervention. Methods: We retrospectively selected a consecutive series of suicidal attempters with acute poisoning who were admitted to the emergency department between 2011 and 2012. Sex, age, admission time, psychiatric DAMA, impressions by the Psychiatrist-in-charge, and psychiatry follow-up after discharge were reviewed in the medical records. DAMA was defined as an unplanned discharge for which the psychiatrist- in-charge documented in the medical record that the patient or one’s legally authorized representatives decided to refuse hospitalization against the psychiatrist’s medical advice including closed ward admission. Results: A total of 883 patients who had attempted suicide who visited the emergency department were included. Of these, 155 patients were suicidal attempters with acute poisoning for ED ward admission. Among these patients, the rate of psychiatric DAMA was 66.5% (n=103). Psychiatric impressions were 1) adjustment disorder 51.5% (n=53), 2) major depressive disorder 28.2% (29%). The rate of DAMA was higher in the adjustment disorder group than in the major depressive disorder group (82.8% vs 58.7%, p <0.001). The rate of follow-up after hospital discharge to the psychiatric outpatient department was 26.5% (n=27). Conclusion: Admission to the emergency department may improve psychiatric outpatient department referral in suicidal attempters with acute poisoning. In addition, customized plans according to psychiatric diagnosis will be considered for effective acute intervention and continuous psychiatric referral.

Pills or Poison? Introduction of Poison Pill in Korea

( Hae Sun Park ) 고려대학교 법학연구원 2010 Korea University Law Review Vol.7 No.-

The Committee for Improvement of the Corporate Control Defense Legal Framework, instituted by the Ministry of Justice in April 2008, designed a revised draft of the Commercial Code in November 2008, which introduced a stock purchase right known as poison pill. Public hearing for Commercial Code draft was held a, at March 2010. The Draft gained approval in subsequent cabinet meeting. However, some people are concerned about introducing poison pill in Korea. Although introduction of poison pill has significant positive effect at little cost, the worry of abuse cannot completely be ruled out. Moreover, effectiveness of poison pill within the Korean business structure is also questioned, Compared to that of U.S. This paper will attempt to review the controversy over introduction of poison pill in Korea, with the cases of the U.S. and Japan, based upon the draft Commercial Code.

일개 도 지역 의도적 음독에 대한 병원전 단계 분석

안웅찬,조준휘,문중범,박찬우,신명철,김가을,이준열,박윤수,황병선,양고은,이희영,김민수,천인국,옥택근 대한응급의학회 2020 대한응급의학회지 Vol.31 No.1

Objective: This study examined the characteristics of the patients taking poison intentionally at the pre-hospital stage to prevent it at the community level. Methods: We retrospectively reviewed the data that had been reported to fire stations from January 2017 to December 2018. This data included sex, age, occupation, the season of the year, time, place, methods, alcohol ingestion, transferred to the hospital or not, and we examined how taking poison had an effect on the suicide success rate. Results: The subjects were a total of 1,356 patients who had been reported to fire stations due to intentionally taking poison. Forty-five point five percent of them were male, and 54.5% were female. The most common method of intentional taking poison was sedatives (58.3%), followed by pesticides (24.6%), antidepressants (19.0%), and other methods (12.6%). The home place was preferred more than any other places. The suicide success rate was 2.1% in males and 1.4% in females. For the age groups, those patients 40-64 years old tried taking poison much more than the other age groups. In the aspect of the season of the year, summer was the highest season for taking poison, at 30.3%. The daytime was more preferred than the night time. Conclusion: In this study, we analyzed the characteristics of the pre-hospital intentional poisoning cases according to gender, age, occupation, season of the year, time, and between the transferred and the untransferred groups. Efforts should be made in cooperation with the community to prevent suicide attempts by intentionally taking poison.