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성인의 T - lymphoblastic Lymphoma 의 임상상과 Modified LSA2 - L2 화학요법의 치료성적
김인순(In Soon Kim),한동수(Dong Soo Han),최영춘(Young Chun Choi),이영열(Young Yiul Lee),정태준(Tae Joon Chung),최일영(Il Young Choi),고영혜(Young Hyeh Ko),이중달(Jung Dal Lee) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Adult T-lymphoblastic lymphoma was first described by Barcos and Lukes in 1974. It is famous for early systemic metastasis and should be treated systematically as soon as possible. We diagnosed 8 adult T-lymphoblasic lymphomas by means of clinical manifestation, tissue biopsy and their immunophenotyping from May 1986 to September 1988. Seven cases were treated with an aggressive regimen, the modified LSA2-L2 protocol. The results were as follows: 1) The median age in the group was 24 years (range 17 -35). 2) At diagnosis, all patients had mediastinal involvement, and 5 patients had bone marrow involvement. Three patients demonstrated malignant cells in the peripheral blood. 3) Six patients were positive for Tdt stain and 4 patients were CD7 (+). 4) Complete clinical response was attained in all patients with induction therapy including cytoxan, vincristine, and adriamycin. 5) Two complete responders who did not take the prescribed chemotherapeutic medication and CNS prophylaxis have had relapses in the CNS and testis. In summary, adult T-lymphoblastie lymphoma is a very aggressive and systemic disease. Systemic chemotherapy with CNS prophylaxis, such as the modified LSA2-L2 protocol, should be recommended.