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Predisposing Factors Associated With Chronic and Recurrent Rhinosinusitis in Childhood
최선희,한만용,안영민,박용민,김창근,김현희,고영률,나영호 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.2
Purpose: There is currently no information regarding predisposing factors for chronic and recurrent rhinosinusitis (RS), although these are considered to be multifactorial in origin, and allergic diseases contribute to their pathogenesis. We evaluated the predisposing factors that may be associated with chronic and recurrent RS. Methods: In this prospective study, we examined patients with RS younger than 13 years of age, diagnosed with RS at six tertiary referral hospitals in Korea between October and December, 2006. Demographic and clinical data related to RS were recorded and analyzed. Results: In total, 296 patients were recruited. Acute RS was the most frequent type: 56.4% of the patients had acute RS. The prevalences of other types of RS, in descending order, were chronic RS (18.9%), subacute RS (13.2%), and recurrent RS (11.5%). Factors associated with recurrent RS were similar to those of chronic RS. Patients with chronic and recurrent RS were significantly older than those with acute and subacute RS. The prevalences of allergic rhinitis, atopy, and asthma were significantly higher in patients with chronic and recurrent RS than those with acute and subacute RS. Conclusions: An association between atopy and chronic/recurrent RS, compared to acute and subacute RS, suggests a possible causal link.
이흥만 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.6
Chronic rhinosinusitis is characterized by chronic inflammation of the nasal and paranasal mucosae and is currently classified into two major subgroups on the basis of the absence or presence of nasal polyps. A distinct set of inflammatory and remodeling factors has been found elevated in chronic rhinosinusitis. Transforming growth factor-β and matrix metalloproteinases are critical factors involved in the remodeling process. Transforming growth factor-β has been implicated as an important factor in remodeling processes involved in chronic rhinosinusitis, and serves as a main switch for different remodeling patterns in chronic rhinosinusitis.
비용 및 만성 비,부비동염 환자에서 잠재된 아스피린 과민성 천식의 유병률
박지원 ( Ji Won Park ),정덕희 ( Duk Hee Chung ),김석화 ( Seok Hwa Kim ),서범석 ( Beom Seok Seo ),민선양 ( Sun Yang Min ),최정희 ( Jeong Hee Choi ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3
Background & Objective: Aspirin-intolerant asthma (AIA) is a distinct clinical syndrome characterized by aspirin sensitivity, asthma, and nasal polyposis (NP). The incidence of AIA in adult asthmatics is 8∼20%, and the prevalence of AIA among adult asthmatics with NP and/or chronic rhinosinusitis further increases to 30∼40%. However, the prevalence of subclinical AIA in patients with NP and/or chronic rhinosinusitis has rarely been investigated. Method: A total of 36 patients with NP and chronic rhinosinusitis who was scheduled for polypectomy were enrolled. All had no previous history of AIA. Lysine-aspirin bronchoprovocation tests were performed on all subjects before operation. Positive response was defined as a >15% fall in FEV1 from baseline. Result: Five of 36 patients (13.8%) showed positive responses to lysine-aspirin provocation tests (4 subject with NP+asthma and 1 with NP alone, P<0.05). There was a significant difference in the PC20 to methacholine between AIA+NP and NP+asthma groups (0.22±0.37 vs. 3.13±2.70 mg/mg, P<0.05), and peripheral blood eosinophil counts tended to increase from NP alone through NP+asthma to AIA+NP group (P<0.01). Conclusion: The prevalence of subclinical AIA in patients with NP and chronic rhinosinusitis was 13.8%, and AIA was especially more prevalent in the asthmatics with NP and chronic rhinosinusitis. (Korean J Asthma Allergy Clin Immunol 2007;27:176-180)
최종철,김민욱,조민정,윤정희,김종엽 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.3
Background and Objectives:Many studies report changes in the expressions of nasal secretory proteins which play important roles in the evaluation of sinonasal mucosal status. The biomarkers in nasal secretions provide valuable information on patho-physiological status of the rhinosinusitis. We have monitored the level and ratio of nasal secretion markers, especially secretory IgA (sIgA) and lactoferrin as markers of sinonasal submucosal glands to evaluate mucosal status for chronic sinonasal diseases and allergic rhinitis. Subjects and Method:Samples were obtained with the filter paper absorption method from 20 normal healthy controls (Group I), 20 patients with chronic rhinosinusitis (Group II), 20 patients with allergic rhinitis (Group III), 20 normalized persons of chronic rhinosinusitis patients treated with antibiotics, previously (Group IV). We estimated concentrations of sIgA and lactoferrin determined by enzyme-linked immunosorbent assay method. Results:The concentration of sIgA and lactoferrin in nasal secretion showed a significant difference between the control group and other groups (p<0.05). The sIgA/ lactoferrin ratio was more highly significant in the normal group and normalized in chronic rhinosinusitis patients treated with antibiotics (Group IV) than other groups (p<0.05). Conclusion:In this study, sIgA and lactoferrin are useful secretion markers oring and assessing the conditions of the sinonasal mucosal diseases. (Korean J Otolaryngol 2007 ;50 :229-34)
만성 비부비동염에서 Biofilm이 수술 후 경과에 미치는 영향
최진웅,서성태,김선귀,김용민,나기상 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.6
Background and ObjectivesZZBacterial biofilm is thought to contribute to the progression and persistence of chronic rhinosinusitis. There are many studies which demonstrate these structures on chronic rhinosinusitis (CRS), but the majority of the studies just focus on the documentation of their presence and the method for identification. There are also a few researches that show the impact of biofilm on postoperative surgical outcomes. In this study, we demonstrated bacterial biofilm in CRS patients and determined whether they affect clinical courses and outcomes after surgery. Subjects and MethodZZThe mucosa of ethmoid bulla was obtained during endoscopic sinus surgery from 21 CRS patients. Fluorescent microscope and scanning electron microscopy (SEM)were used for the determination of biofilm. The outcomes of the surgery were evaluated by endoscope every two weeks for 6 months. Preoperative symptom scores, CT scores, and the post operative results were compared between patients with biofilm and patients without biofilm. ResultsZZBacterial biofilm were seen in 13 (62%) of the 21 CRS patients. A statistical association existed between the presence of biofilm and the worsened preoperative symptom scores,but the preoperative CT scores were not related to the presence of biofilm. Patients with biofilm had long-lasting postoperative mucosal inflammation and a prolonged healing time, and these differences have statistical significance. ConclusionZZThis study showed that the presence of bacterial biofilm were significantly correlated with worsening preoperative symptom scores and the prolonged postoperative recovery time. Therefore, bacterial biofilm may play an important role in the recalcitrant and resistant nature of CRS. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:349-53
Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells
Kong, Il Gyu,Kim, Dae Woo 한국조명·전기설비학회 2018 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.</P>
Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells
공일규,김대우 대한면역학회 2018 Immune Network Vol.18 No.2
Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.