증폭(蒸曝)에 의한 지황(地黃)의 성분 변화에 대한 고찰

정재우 ( Jae Woo Jung ),김한영 ( Han Young Kim ),류지효 ( Ji Hyo Lyu ),김정훈 ( Jung-hoon Kim ) 대한본초학회 2021 大韓本草學會誌 Vol.36 No.6

Objectives : ‘Steaming and drying’ is a traditional processing method that has been used to produce Suk-ji-hwang (熟地黃; Rehmanniae Radix Preparata) from Ji-hwang (地黃, the fresh root of Rehmannia glutinosa Liboschitz ex Steudel; Rehmanniae Radix). The steaming and drying process, which is proceeded in heating and moisturizing conditions, plays a crucial role in the change of therapeutic effect of Ji-hwang, presumably due to the modification of its chemical constituents. In this article, the chemical influence of the ‘Steaming and drying’ process was investigated for understanding the underlying mechanism of chemical modification of Ji-hwang. Methods : The articles regarding the modifications of chemical constituents of Ji-hwang during the ‘Steaming and drying’ process were collected and analyzed to investigate the influence of the processing to Ji-hwang. Results : The results indicated that iridoid glycosides were degraded to their aglycones and sugars, and such degradations occurred faster at a high pressure than at an atmospheric pressure during the process. The contents of catalpol, ajugol, and acteoside were decreased, while those of rehmannioside A and D were slightly increased during the repeated processing. The contents of oligosaccharides, namely sucrose, maltose, raffinose, and stachyose (except for manninotriose), were decreased, while those of monosaccharides, glucose and fructose, were increased by the repeated processing. Conclusions : These results demonstrate that the ‘Steaming and drying’ process influenced the chemical constituents of Ji-hwang and provide probable basis for the therapeutic modification of Suk-ji-hwang after the processing of Ji-hwang.

Ethnopharmacology, bioactivities and chemical constituents of some anti-cancer plants in Malaysia

Ong Hean Chooi 한국자원식물학회 2000 Plant Resources Vol.3 No.1

Many plant species are used in Malaysia in folk medicine for the treatment of cancer. This paper presents some of these species with details on other ethnopharmacological uses, the known bioactivities and some chemical constituents of each of the species given. It is normal practice in traditional medicine that one species of plant is used to treat various ailments. Thus the plant species listed are all used to treat cancer but have various other ethnophrmacological uses as well, some with few other uses and rest with many other uses. Information on bioactivities of each species resulting from tests on human and experimental animals are also given. Proven bioactivities give strength to ethnopharmacological claims on the efficacies of plant resources in the treatment of cancer and various other ailments but will but will not necessarily lead to the production of new pharmaceutical drugs. Many of the known chemical constituents of each species are given. This shows the richness and variety of chemicals containes in each of the species listed. The chemicals listed may or may not prove to be important in the pharmaceutical sciences but is an indication of what each species contatin in thrms of plant chemicals. It is a well known fact that many of the pharmaceutical prescriptions in present day use are of plant origin and semi-synthetic or fully synthetic chemicals produced using knowledge gained from studies of phytochemicals. Thus the paper presented will give useful information and also shows the richness of plant species that have high potentials for the development of anti-cancer resources from plants in Malaysia.

Chemical constituents, pharmacological activities, and uses of common ayurvedic medicinal plants: a future source of new drugs

Parul Kaushik,Priyanka Ahlawat,Kuldeep Singh,Raman Singh 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3

Natural products, especially plants and herbs, have always been a common medicament source, either as pure active principles or traditional preparations. Traditional medicine has been used in developing and developed countries for centuries, and still, 80% of the population uses plant-based medicines for their health care needs. The present review discusses all the possible pharmacological activity reported in various literature and active chemical constituents of herbs. A list of various herbs/plants used by Ayurvedacharya Ratiram Sharma (93-year-old and practicing since 1952) and mentioned in Ayurvedic texts. The curated list was prepared by their general availability in the household and local market. This study comprehensively documented the medicinal value of sixty-six dominant plant species used in Ayurveda and local people. In the present review, each herb is discussed with its scientifc and common names, geographical distribution, traditional medicinal uses, benefcial plant parts, and active chemical constituents. For each plant, pharmacological activities of diferent parts of plants are displayed with their chemical constituents and structure. Toxicologists, phytologists, medicinal chemists, and other researchers who are interested in the various therapeutic and related applications of plant materials will be benefted from present review. This information will open new horizons of application for the many novel drugs and drug candidates.

자화전호(紫花前胡), 백화전호(白花前胡), 아삼(峨參)의 화학 성분 비교

정승일,김정훈 한약정보연구회 2013 한약정보연구회지 Vol.1 No.-

The chemical constituents of Angelica decursiva (Miq.) Franch. & Sav., Peucedanum praeruptorum Dunn and Anthriscus sylvestris (L.) Hoffm., papers were investigated and compared. Papers were searched through electronic bibliographic databases with search terms and the chemical constituents were classified by chemical structures. Most constituents were dihydroxanthyletin structures in A. decursiva and dihydroseselin structures in P. praeruptorum which were coumarin-based structures. A. sylvestris showed lignan-based constituents in many literatures, of which dibenzyl butyrolactone structures were mostly reported. A. sylvestris must be differentiated from A. decursiva and P. praeruptorum due to its difference of chemical constituents.

Essential Oil of Marrubium vulgare: Chemical Composition and Biological Activities. A Review

Benalia Yabrir 한국생약학회 2019 Natural Product Sciences Vol.25 No.2

Marrubium vulgare, plant species belonging to Marrubium genus, is widespread in the Mediterranean areas, introduced elsewhere and also cultivated in many countries. Its oil is recognized to possess a considerable biological activities with varied chemical composition. This paper aims to overview the chemical composition and biological activities of M. vulgare essential oil’s considered as a medicinal plant, widely used in folk medicine overall the world. In essential oils of M. vulgare, germacrene D, β-caryophyllene, β-bisabolene, bicyclogermacrene and carvacrol are generally considered as either mains or minor constituents and each species presents its own composition. Sesquiterpenoids were the dominant fraction while monoterpenoids were present in appreciable or in trace amount. Oxygenated fractions dominated in monoterpenes however, hydrocarbon fraction overpowered in sesquiterpenes. These oils are biologically active, they exhibit an antioxidant and antimicrobial activities and other activities. Due to the variability of composition of essential oil, further studies are necessary, particularly regarding their chemical’s which may cause an important change in the biological activities of oils and probably defined different chemotype.

韓國 野生茶 遺傳資源의 品質 特性에 의한 品種群의 分類

천종은(J.U. Chun),임준택(J.T. Lim),최정(J. Choi),김주희(J.H. Kim),임근철(K.C. Lim) 한국차학회 2003 한국차학회지 Vol.9 No.1

The genetic relationship among Korean native tea tree germplasm based on chemical constituets is required to increase the efficiency of breeding. This work was done to classify 63 native tea tree lines by 7 chemical constituents which were analyzed by NIR system. The principal component and cluster analyses revealed 10 groups. The first group included 3lines that had the traits with lower total nitrogen contents, but higher vitamin C of leaves. The second group included 6 lines having lower free amino acid and theanine contents, but higher catechin contents of leaves. The third group included 2 lines having lower contents of free amino acid and theanine. the 5th group included 67%(42 lines) showing medium values of 7 chemical constituents. The 6th group included 2 lines that had higher caffeine and catechin contents, but lower fiber and vitamin C contents. The 7th group included higher caffeine and catechin contents, but lower theanine and vitamin C contents. The 8th group included lower catechin contents, but higher free amino acid, thenine and vitamin C contents. The 9th group included 2 lines showing lower caffeine and catechin contents, but higher theanine and fiber, and the last group included 1 lines that had lower catechin, but higher total nitrogen, free amino acid and thanine contents of leaves. The free amino acid contents that are the most important in flavor evaluation of green tea quality highly positively correlated with the contents of total nitrogen (0.848**), theanine(0.927**), but negatively with the contents of catechin (-0.501**) and fiber(-0.574**), respectively.

Chemical constituents and their acetyl cholinesterase inhibitory and antioxidant activities from leaves of Acanthopanax henryi: potential complementary source against Alzheimer's disease

Zhang, Xiao Dan,Liu, Xiang Qian,Kim, Yang Hee,Whang, Wan Kyunn 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5

The aim of this study was to investigate chemical constituents of the leaves of Acanthopanax henryi, and their antioxidant, acetyl cholinesterase inhibitory activities. Caffeoyl quinic acid derivates and flavonoids were obtained from A. henry, through column chromatography technologies, and the content of major constituents was determined by the HPLC-UV method. Anti-oxidant activity of the isolated metabolites was evaluated by free radical scavenging (DPPH, ABTS radicals) and superoxide anion scavenging. The results showed that di-caffeoyl quinic acid derivates had stronger antioxidant activity than positive controls (ascorbic acid, trolox and allopurinol). Acetyl cholinesterase inhibitory activity was estimated on the constituents, among which, quercetin, 4-caffeoyl-quinic acid and 4,5-caffeoyl quinic acid were found to have strong acetyl cholinesterase inhibitory activity with $IC_{50}$ values ranging from 62.6 to $121.9{\mu}M$. The present study showed that some of the tested constituents from the leaves of A. henryi exhibit strong antioxidant and acetyl cholinesterase inhibitory effects. This suggest that the leaves of A. henryi can be used as a new natural complementary source of acetyl cholinesterase inhibitors and anti-oxidant agents, thus being a promising potential complementary source against Alzheimer's disease.

Chemical Constituents and Pharmacological Activities of Hedyotis diffusa

Bao-Jun Xu,성창근 한국생약학회 2005 Natural Product Sciences Vol.11 No.1

The chemical constituents from Hedyotis difusa Wild and their pharmacological activities weresummarized. It has been known data that this herb contains anthraquinones, terpenoids, steroids, flavonoids,organic acid, and polysaccharides. The studies of pharmacology have shown that Hedyotis difusa Wild possessvarious levels of activities such as anticancer, anti-inflammatory, immunostimulatory, antioxidative, neuroprotective,and hepatoprotective activities. Keywords Hedyotis difusa, chemical constituents, pharmacological activities

Chemical Constituents and Biological Activities of Cichorium intybus L.

Abdalla M. El-Lakany,Maha A. Aboul-Ela,Mohamed M. Abdul-Ghani,Hattem Mekky 한국생약학회 2004 Natural Product Sciences Vol.10 No.2

Continuation of a phytochemical study of Cichorium intybus L. (Astraceae) growing in Egypt, resulted in the isolation and identification of a new sesquiterpene lactone 3, 4-dihydrolactucin, in addition to the eight known compounds; kaempferol, isoscutellarin, cichoriin, umbelliferone, lupeol, lupeol acetate, β-sitosterol, and β-sitosterol-3-O-glucoside. Chemical structures of the isolated compounds were assigned based on different physical, chemical, and spectroscopic techniques including IR, UV, MS, 1D- and 2D-NMR spectra. Furthermore, the antimicrobial, and spasmogenic activities of some fractions and isolates were also assessed.

Chemical Constituents of the Culture Broth of Panus rudis

( Ja-gyeong Song ),( Lee Su Ha ),( Dae-won Ki ),( Dae-cheol Choi ),( In-kyoung Lee ),( Bong-sik Yun ) 한국균학회 2021 Mycobiology Vol.49 No.6

In our ongoing search for new secondary metabolites from fungal strains, one novel compound (1) and nine known compounds (2-10) were isolated from the EtOAc-soluble layer of the culture broth of Panus rudis. The culture broth of P. rudis was extracted in acetone and fractionated by solvent partition; column chromatography using silica gel, Sephadex LH-20, and Sephadex G-10; MPLC; and HPLC. The structures of isolated compounds were elucidated by one- and two-dimensional NMR and LC-ESI-mass measurements. One new compound, panepoxydiol (1), and nine known compounds, (E)-3-(3-hydroxy-3-methylbut-1-en-1-yl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol (2), isopanepoxydone (3), neopanepoxydone (4), panepoxydone (5), panepophenanthrin (6), 4-hydroxy-2,2-dimethyl-6-methoxychromane (7), 6-hydroxy-2,2-dimethyl-3-chromen (8), 2,2-dimethyl-6-methoxychroman-4-one (9), 3,4-dihydroxy-2,2-dimethyl-6-methoxychromane (10), were isolated from the culture broth of P. rudis. This is the first report of isolation of a new compound panepoxydiol (1) and nine other chemical constituents (2-5, 7-10) from the culture broth of P. rudis.