생체공여콩팥적출술 후 혈중 요산치의 변화와 의의

이소리,김인곤,이정오,한보현 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.11

Purpose: The aim of this study was to investigate the changes in and implications of preoperative and postoperative serum uric acid levels in patients with living donor nephrectomy. Materials and Methods: We studied 207 patients between 1998 and 2007 at our hospital undergoing living-donor nephrectomy for kidney transplantation. The serum uric acid level and estimated glomerular filtration rate (eGFR) were measured preoperatively and at 1 year postoperatively. We also analyzed multiple independent variables such as age, sex, blood pressure, body mass index (BMI), serum total cholesterol, hemoglobin, hematocrit, total protein, albumin, calcium, and phosphorus. Results: The mean age of the study patients was 38.3±10.8 years. The mean serum uric acid concentration at 1 year after kidney donation was higher than preoperatively (5.05±1.39 mg/dl preoperatively vs. 5.85±1.14 mg/dl postoperatively) and was significantly greater in patients with hyperuricemia (uric acid≥6.8 mg/dl) than in patients without hyperuricemia (uric acid<6.8 mg/dl): 1.63±0.75 mg/dl vs. 0.69±0.66 mg/dl, respectively. The multivariate analysis showed that preoperative serum uric acid was the primary predictive factor of postoperative serum uric acid (r=1.136, p=0.001), and preoperative GFR was an independent secondary predictive factor (r=−0.004, p=0.047). The receiver operator characteristics (ROC) curves for the preoperative serum uric acid cutoff of 5.7 mg/dl showed the highest sensitivity and specificity of 96% and 86%, respectively. Conclusions: These results suggest that preoperative serum uric acid and GFR were important predictive factors of postoperative serum uric acid after living-donor nephrectomy. Therefore, in the selection and management of kidney donors, not only patients with a low GFR but also those with high uric acid (serum uric acid≥5.7 mg/dl) require careful observation before and after living-donor nephrectomy. Purpose: The aim of this study was to investigate the changes in and implications of preoperative and postoperative serum uric acid levels in patients with living donor nephrectomy. Materials and Methods: We studied 207 patients between 1998 and 2007 at our hospital undergoing living-donor nephrectomy for kidney transplantation. The serum uric acid level and estimated glomerular filtration rate (eGFR) were measured preoperatively and at 1 year postoperatively. We also analyzed multiple independent variables such as age, sex, blood pressure, body mass index (BMI), serum total cholesterol, hemoglobin, hematocrit, total protein, albumin, calcium, and phosphorus. Results: The mean age of the study patients was 38.3±10.8 years. The mean serum uric acid concentration at 1 year after kidney donation was higher than preoperatively (5.05±1.39 mg/dl preoperatively vs. 5.85±1.14 mg/dl postoperatively) and was significantly greater in patients with hyperuricemia (uric acid≥6.8 mg/dl) than in patients without hyperuricemia (uric acid<6.8 mg/dl): 1.63±0.75 mg/dl vs. 0.69±0.66 mg/dl, respectively. The multivariate analysis showed that preoperative serum uric acid was the primary predictive factor of postoperative serum uric acid (r=1.136, p=0.001), and preoperative GFR was an independent secondary predictive factor (r=−0.004, p=0.047). The receiver operator characteristics (ROC) curves for the preoperative serum uric acid cutoff of 5.7 mg/dl showed the highest sensitivity and specificity of 96% and 86%, respectively. Conclusions: These results suggest that preoperative serum uric acid and GFR were important predictive factors of postoperative serum uric acid after living-donor nephrectomy. Therefore, in the selection and management of kidney donors, not only patients with a low GFR but also those with high uric acid (serum uric acid≥5.7 mg/dl) require careful observation before and after living-donor nephrectomy.

Effects of Increased Uric Acid Intake on the Abundance of Urate-anion Exchanger and Organic Anion Transporter Proteins in the Rat Kidney

( Sua Kim ),( Chang Hwa Lee ),( Chong Myung Kang ),( Gheun Ho Kim ) 대한전해질학회 2007 Electrolytes & Blood Pressure Vol.5 No.2

Renal handling of uric acid mainly occurs in the proximal tubule, and bidirectional transport of urate may involve apical absorption via the urate-anion exchanger (URAT1) and basolateral uptake via organic anion transporters (OAT1 and OAT3). In rat kidneys, we investigated whether the protein abundance of URAT1, OAT1, and OAT3 is affected by the increase in uric acid intake. Male Sprague-Dawley rats were randomly divided into control and uric acid-supplemented groups, and uric acid-supplemented rats were given 1.75 g of uric acid per 180 g body weight per day for 8 days. After the animal experiment, kidneys were harvested and semi-quantitative immunoblotting was carried out from cortical homogenates using polyclonal peptide-derived antibodies to URAT1, OAT1, and OAT3. Serum uric acid level showed an increasing tendency in the uric acid-supplemented rats compared with control rats, whereas urinary uric acid excretion was not significantly different between the uric acid-supplemented rats and control rats. URAT1 protein abundance in cortical homogenates was not significantly different between the uric acid-supplemented rats and control rats. However, OAT1 protein abundance was significantly increased in the uric acid-supplemented rats compared with the control rats. OAT3 protein abundance was not significantly different between the uric acid-supplemented rats and control rats. In conclusion, OAT1 may have a regulatory role in response to the increase in uric acid intake in the rat kidney. The up-regulation of OAT1 would exert stimulation of urinary uric acid excretion and might contribute to protection from hyperuricemia.

대한민국 성인에서 비만과 Uric acid의 관련성

박선영(Park, Sun-Young),윤현(Yun, Hyun) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.2

본 연구는 일부 종합검진 수검자들을 대상으로 비만수준이 혈 중 uric acid에 미치는 영향을 검토하고자 2011년 1월부 터 12월까지 광주광역시의 일개 종합병원 건강검진센터에서 종합건강검진을 받았던 20세 이상의 지역주민 1,118명(남자 636, 여자 482)을 분석대상으로 하였다. 우리는 혈청 uric acid, 요소 질소, creatinine 뿐만 아니라 신체계측 (SBP, DBP 및 BMI)에 대해 평가하고, 분석에 포함 하였다. Model Ⅰ에서, 연령, 성별, SBP, DBP, TC, TG, HDL-C, FBG를 보정하였을 때, 남성(p<0.001)과 여성(p=0.036)에서 uric acid의 평균값은 비만수준이 증가할수록 증가하였다. Model Ⅱ에서, BUN과 creatinine을 추가로 보정하였을 때, 남성에서는 uric acid의 평균값이 정상 체중군은 4.89±0.07 mg/dl, 과체중군은 5.01±0.09 mg/dl, 비만군은 5.35±0.08mg/dl로 비만수준이 증가할수록 증가하였다(p<0.001).그러나 여성에서는 uric acid의 평균값이 정상 체중군은 5.03±0.08 mg/dl, 과체중군은 5.19±0.11 mg/dl, 비만군은 5.27±0.09 mg/dl로 유의한 차이가 없었다(p=0.191).결론적 으로, 남성에서 비만수준의 증가는 혈 중 uric acid의 증가와 관련이 있지만, 여성에서는 관련이 없었다. The aim of this study was to examine the impact of the obesity status on serum uric acid in health check-up examinees. The study subjects were 1,118 adults, 20 years and over (636 males, 482 females), the health package check-up at the general hospital in Gwang-Ju from January to December, 2011. This study assessed the serum uric acid, blood urea nitrogen, and creatinine levels, as well as the anthropometric variables (SBP, DBP, and BMI). In a model Ⅰ, after adjusting for the variables, such as age, SBP, DBP, TC, TG, HDL-C, and FBG, the mean uric acid level (M±SE) increased with increasing obesity status in males (p<0.001) or females (p=0.036). In model Ⅱ, after adjusting for BUN and creatinine, the mean uric acid (M±SE) in males increased with increasing obesity status (Normal weight [BMI <23.0 kg/m2], 4.89±0.07 mg/dl; overweight [BMI 23.0-24.9 kg/m2], 5.01±0.09 mg/dl; obesity [BMI ≥ 25.0 kg/m2], 5.35±0.08 mg/dl) (p<0.001). In the females, however, the mean uric acid (M±SE) did not increase with increasing obesity status (Normal weight, 5.03±0.08 mg/dl; overweight, 5.19±0.11 mg/dl; obesity, 5.27±0.09 mg/dl) (p=0.191). In conclusion, these results suggest that an increase in obesity status is associated with an increase in the serum uric acid levels in males, but not in females.

The Utility of the Random Urine Uric Acid-to-Creatinine Ratio for Patients with Gout Who Need Uricosuric Agents: Retrospective Cross-Sectional Study

최상태,Jung Soo Song,Seung Jun Kim,Chan Ho Kim,문성진 대한의학회 2020 Journal of Korean medical science Vol.35 No.13

Background: The 24-hour uric acid excretion measurement is important in assessing disease status and helping to select the appropriate uric acid-lowering agent for patients with gout, however, it is inconvenient. The authors investigated the efficacy of the random urine uric acid- to-creatinine (UA/CR) ratio to screen the patients who under-secreted 24-hour urine uric acid. Methods: This was a retrospective cross-sectional study. Ninety patients with gout, without undergoing uric acid-lowering treatment were enrolled. Twenty-four-hour urine and random urine samples were obtained on the same day. Six hundred mg of uric acid in the 24-hour urine sample was used as a standard for distinguishing between over and under-excretion groups. Results: The random urinary UA/CR ratio showed positive correlation with 24-hour urine uric acid excretion (γ = 0.398, P < 0.001). All the patients with the random UA/CR less than 0.2 excreted less than 600 mg uric acid in 24-hour urine collection. When the random urine UA/CR ratio < 0.2 was regarded as a positive result, the positive predictive value, negative predictive value, sensitivity, and specificity in the uric acid under-excretion were 100% (8 of 8), 64.6% (53 of 82), 21.6% (8 of 37), and 100% (53 of 53), respectively. Conclusion: There is a moderate positive correlation between the random urinary UA/CR ratio and 24-hour urine uric acid excretion, so that UA/CR ratio may not be a good predictor of 24-hour urine uric acid excretion. However, the random urine UA/CR ratio 0.2 can be a useful predictor to screen the gouty patients who need to be treated with uricosuric drugs.

Chicken serum uric acid level is regulated by glucose transporter 9

Ding Xuedong,Peng Chenglu,Li Siting,Li Manman,Li Xinlu,Wang Zhi,Li Yu,Wang Xichun,Li Jinchun,wu Jinjie 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.4

Objective: Glucose transporter 9 (GLUT9) is a uric acid transporter that is associated with uric absorption in mice and humans; but it is unknown whether GLUT9 involves in chicken uric acid regulation. This experiment aimed to investigate the chicken GLUT9 expression and serum uric acid (SUA) level. Methods: Sixty chickens were divided into 4 groups (n = 15): a control group (NC); a sulfonamide-treated group (SD) supplemented with sulfamonomethoxine sodium via drinking water (8 mg/L); a fishmeal group (FM) supplemented with 16% fishmeal in diet; and a uric acid-injection group (IU), where uric acid (250 mg/kg) was intraperitoneally injected once a day. The serum was collected weekly to detect the SUA level. Liver, kidney, jejunum, and ileum tissues were collected to detect the GLUT9 mRNA and protein expression. Results: The results showed in the SD and IU groups, the SUA level increased and GLUT9 expression increased in the liver, but decreased in the kidney, jejunum, and ileum. In the FM group, the SUA level decreased slightly and GLUT9 expression increased in the kidney, but decreased in the liver, jejunum, and ileum. Correlation analysis revealed that liver GLUT9 expression correlated positively, and renal GLUT9 expression correlated negatively with the SUA level. Conclusion: These results demonstrate that there may be a feedback regulation of GLUT9 in the chicken liver and kidney to maintain the SUA balance; however, the underlying mechanism needs to be investigated in future studies. Objective: Glucose transporter 9 (GLUT9) is a uric acid transporter that is associated with uric absorption in mice and humans; but it is unknown whether GLUT9 involves in chicken uric acid regulation. This experiment aimed to investigate the chicken GLUT9 expression and serum uric acid (SUA) level.Methods: Sixty chickens were divided into 4 groups (n = 15): a control group (NC); a sulfonamide-treated group (SD) supplemented with sulfamonomethoxine sodium via drinking water (8 mg/L); a fishmeal group (FM) supplemented with 16% fishmeal in diet; and a uric acid-injection group (IU), where uric acid (250 mg/kg) was intraperitoneally injected once a day. The serum was collected weekly to detect the SUA level. Liver, kidney, jejunum, and ileum tissues were collected to detect the GLUT9 mRNA and protein expression.Results: The results showed in the SD and IU groups, the SUA level increased and GLUT9 expression increased in the liver, but decreased in the kidney, jejunum, and ileum. In the FM group, the SUA level decreased slightly and GLUT9 expression increased in the kidney, but decreased in the liver, jejunum, and ileum. Correlation analysis revealed that liver GLUT9 expression correlated positively, and renal GLUT9 expression correlated negatively with the SUA level.Conclusion: These results demonstrate that there may be a feedback regulation of GLUT9 in the chicken liver and kidney to maintain the SUA balance; however, the underlying mechanism needs to be investigated in future studies.

Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease

Ryu, Eun-Sun,Kim, Mi Jin,Shin, Hyun-Soo,Jang, Yang-Hee,Choi, Hack Sun,Jo, Inho,Johnson, Richard J.,Kang, Duk-Hee American Physiological Society 2013 American journal of physiology. Renal physiology Vol.304 No.5

<P>Recent experimental and clinical studies suggest a causal role of uric acid in the development of chronic kidney disease. Most studies have focused on uric acid-induced endothelial dysfunction, oxidative stress, and inflammation in the kidney. The direct effects of uric acid on tubular cells have not been studied in detail, and whether uric acid can mediate phenotypic transition of renal tubular cells such as epithelial-to-mesenchymal transition (EMT) is not known. We therefore investigated whether uric acid could alter E-cadherin expression and EMT in the kidney of hyperuricemic rats and in cultured renal tubular cells (NRK cells). Experimental hyperuricemia was associated with evidence of EMT before the development of significant tubulointerstitial fibrosis at 4 wk, as shown by decreased E-cadherin expression and an increased α-smooth muscle actin (α-SMA). Allopurinol significantly inhibited uric acid-induced changes in E-cadherin and α-SMA with an amelioration of renal fibrosis at 6 wk. In cultured NRK cells, uric acid induced EMT, which was blocked by the organic anion transport inhibitor probenecid. Uric acid increased expression of transcriptional factors associated with decreased synthesis of E-cadherin (Snail and Slug). Uric acid also increased the degradation of E-cadherin via ubiquitination, which is of importance since downregulation of E-cadherin is considered to be a triggering mechanism for EMT. In conclusion, uric acid induces EMT of renal tubular cells decreasing E-cadherin synthesis via an activation of Snail and Slug as well as increasing the degradation of E-cadherin.</P>

Clinical Usefulness of Uric Acid as a Biomarker for Knee Osteoarthritis: A Comparative Analysis With Plain Radiography and Musculoskeletal Ultrasound

( Seong-kyu Kim ),( Ui Hong Jung ),( Jung-yoon Choe ) 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.1

Objective. The aim of this study was to determine the relationships of serum and urine uric acid with severity or activity in knee osteoarthritis (OA). Methods. A total of 42 patients with knee OA was enrolled, together with 58 healthy controls. Serum uric acid and spot urine uric acid levels were assessed for all patients. The severity and activity of knee OA were assessed by musculoskeletal ultrasound (MSUS) and plain radiography of the knee joint. Ultrasonographic abnormalities in knee OA includedsynovial hypertrophy, suprapatellar effusion, cartilage degradation, and osteophyte formation. Kellgren-Lawrence (K-L) grade was used to evaluate radiological progression of knee OA. Results. Patients with K-L grade III had a higher urine uric acid/creatinine ratio compared to those with K-L grade I (p=0.043). Patients with synovial hypertrophy had higher serum uric acid level compared to those without synovial hypertrophy (p=0.016). The urine uric acid/creatinine ratio was higher in patients with cartilage degradation compared to those without cartilage degradation (p=0.022). Serum uric acid was significantly associated with synovial hypertrophy thickness (r=0.375, p=0.018) but not with cartilage thickness after adjusting for age and body mass index. Lower urine uric acid was related with knee OA compared to healthy controls (odds ratio=0.974, 95% confidence interval 0.954∼0.994, p=0.013). Conclusion. The results of our study suggest that serum and urine uric acid reflects synovial inflammation based on MSUS and radiographic progression and then is associated with the pathogenesis of knee OA. (J Rheum Dis 2020;27:51-60)

Association of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels

정동혁,이용제,이혜리,이정현,심재용 대한의학회 2010 Journal of Korean medical science Vol.25 No.12

Several studies have reported that hyperuricemia is associated with the development of hypertension and cardiovascular disease. Increasing evidences also suggest that hyperuricemia may have a pathogenic role in the progression of renal disease. Paradoxically, uric acid is also widely accepted to have antioxidant activity in experimental studies. We aimed to investigate the association between glomerular filtration rate (GFR)and uric acid in healthy individuals with a normal serum level of uric acid. We examined renal function determined by GFR and uric acid in 3,376 subjects (1,896 men; 1,480women; aged 20-80 yr) who underwent medical examinations at Gangnam Severance Hospital from November 2006 to June 2007. Determinants for renal function and uric acid levels were also investigated. In both men and women, GFR was negatively correlated with systolic and diastolic blood pressures, fasting plasma glucose, total cholesterol, uric acid,log transformed C reactive protein, and log transformed triglycerides. In multivariate regression analysis, total uric acid was found to be an independent factor associated with estimated GFR in both men and women. This result suggests that uric acid appears to contribute to renal impairment in subjects with normal serum level of uric acid.

정상체중군과 체중과다군 남자에서 혈중 총항산화능과 평소 식이섭취 상태에 관한 연구

김순경,박영숙,변광의 대한지역사회영양학회 2000 대한지역사회영양학회지 Vol.5 No.4

본 연구는 체중과다나 비만에서 총항산화능의 변화를 관찰하고, 총항산화능과 평소의 식사섭취상태와는 어떤 관계가 있는가를 관찰하고져 실시하였다. 20대의 젊은 남성을 대상으로 정상체중군(n = 17, BMI 20∼25, 비만지수 90∼110% 체지방 16∼20%)과 체중과다군(n = 13, BMI > 25, 비만지수 120%이상, 체지방 25%이상)으로 분류한 후, 인체계측, 생화학적 검사(총콜레스테롤, glucose, albumin, creatinine, GOT, GPT, uric acid), 식이섭취 조사(24회상법)를 실시하였다. 총항산화능은 체중과다군에서 유의적으로(p <0.01) 높게 나타났으며 , 측정된 생화학적 지수들에서는 uric acid의 함량이 체중과다군에서 유의하게(p<0.05) 높았다 평소의 식이섭취 상태는 두 군 모두 칼슘과 비타민 B2의 섭취량이 권장량에 비해 부족한 것으로 나타났으며, 체중과다군에서 비타민 C(p <0.05)의 섭취량이 유의적으로 낮게 나타났다. U-carotene과 비타민 E 섭취량에는 두 군간 차이가 없었고, 채소와 과일의 섭취량은 체중과다군이 적게 섭취한 반면, 음주와 흡연량은 체중과다군이 더 높게 나타났다. 두 군 모두 식사의 질은 양호하였다. 총항산화능 및 uric acid 함량과 측정지표들간의 상관관계를 살펴본 결과에서는 두 군 모두에서 총항산화능 및 uric acid 함량에서 서로 다른 경향을 보였다. 체중과다군에서는 총항산화능과 음주량이 부( - )의 상관 관계를 보였으며, uric acid 함량과 BMI, 비만지수, 및 총항산화능은 유의적인 정 (+)의 상관관계를 보였다. 이상의 결과에서 체중과다군은 정상체중군에 비해 총항산화능에 유의적인 차이가 있었으며 식이섭취상태와의 관련성은 나타나지 않았다. Uric acid 함량의 측정은 총항산화능과 정 (+)의 상관관계를 보여 또 다른 항산화능을 나타내주는 좋은 지표임을 알 수 있었다. This study was conducted to measure the difference in the total antioxidant status(TAS) of overweight and normal weight adults, and to investigate the correlation between TAS and the nutrient intake. Anthropometric parameter, TAS, biochemical parameters and dietary intake were measured in the normal weight group(n=17, BMI 20-25, obesity index 90-110%, body fat 16-20%) and overweight group(n=13, BMI > 25, obesity index > 120%, body fat > 25%) among Korean young males. The TAS of the overweight group was significantly higher than that of the normal weight group(p < 0.01). Among biochemical parameters, the average uric acid concentration of the overweight group was significantly higher(p < 0.05) compared to that of the normal weight group indicating, the uric acid concentration reflects TAS. Usual dietary intake showed that the intakes of Ca and vitamin B$_2$, are below RDA. The average intake of vitamin C in the overweight group was significantly lower than that in the normal group(p < 0.05). There was no difference in the intake of carotene and vitamin E between groups. The diet quality of both groups was satisfactory. The result of the correlation analysis on TAS, the uric acid concentration, and the measured indexs are as follows : In the overweight group, TAS was negatively correlated with alchol drinking, and uric acid concentration was positively correlated with BMI, obesity index, and TAS. In conclusion, TAS was significantly higher in the overweight group than that of the normal group, although no association was found with nutrient intakes. Serum uric acid showed a positive relationship with TAS indicating, it is a possible determinant of the antioxidant capacity.

혈중 요산 농도가 IgA 신병증의 진행에 미치는 연구

진호준 ( Ho Jun Chin ),나기영 ( Ki Young Na ),정해일 ( Hae Il Cheong ),김연수 ( Yon Su Kim ),김성권 ( Suhng Gwon Kim ),채동완 ( Dong Wan Chae ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.2

목적: 요산은 고혈압의 발병원인으로 거론되고 있으며 신질환에서 고혈압과 신 동맥 병변을 유발하여 신기능 악화에 관여하는 것으로 보고되고 있다. 본 연구에서는 IgA 신병증에서 가능한 교란 변수 효과를 배제하여 요산의 신기능 악화인자 역할을 조사하고 그 병리 기전으로 요산과 고혈압 및 신동맥 병변과의 관련성을 조사하였다. 방법: 신조직 검사에서 확진을 받은 서울대학교 병원의 IgA 신병증 환자 172명을 대상으로 하였다. 신기능 악화 기준은 추적 도중 혈청 크레아티닌이 신 조직 검사 당시 혈청 크레아티닌의 2배 이상 증가하는 경우로 정하였다. 고요산군은 정상인 혈청 요산 수치의 4사분위에 해당되는 요산 수치를 가진 환자군으로 정하였다. 결과: IgA 신병증에서 혈중 요산 수치는 간질 섬유화, 세뇨관 위축, 세동맥 경화의 존재와 관련이 있었고, 추적 전후 혈압의 변동과는 무관하였다. 고요산군은 다변량 분석에서 IgA 신병증의 신기능 악화에 대한 위험인자 이었다. 고혈압, 사구체 여과율, 병리 소견으로 세분하여 분석한 결과 고요산군은 고혈압 유무와 세동맥 경화 유무에 관련없이 신병증의 예후를 결정하는 독립적인 인자이었고, 사구체 여과율이 60mL/min/1.73m2 이상인 환자군에서도 예후 인자로 분석되었다. 결론: IgA 신병증에서 고요산혈증은 신 동맥 병변과 신기능 악화와 관련이 있었다. Purpose: Many evidences about hyperuricemia as a risk factor to hypertension and renal progression in kidney diseases have been reported. We have analyzed the impact of uric acid on renal progression of IgA nephropathy while getting rid of possible confounding variables and revealed the possible pathophysiology of uric acid in terms of hypertension or renal vasculopathy provoked by uric acid. Methods: We selected 172 patients with IgA nephropathy diagnosed by renal biopsy at Seoul National University Hospital. We adapted the criteria of renal progression as the final value of serum creatinine increased more then twice compared to the value at renal biopsy. Results: Serum uric acid was correlated with the severity of interstitial fibrosis and tubular atrophy and the presence of artherosclerosis. The incidence of hypertension during follow-up period was not different between low uric acid group and high uric acid group. The high uric acid level was an independent risk factor to renal progression in IgA nephropathy with multivariate analysis regardless of the presence of hypertension or artherosclerosis of renal pathologic finding. The high uric acid level was also a risk factor to renal progression in patients with estimated GFR more than 60 mL/min/1.73m2. Conclusion: Serum uric acid was related to the presence of artherosclerosis and the renal progression of IgA nephropathy.