Does Post-traumatic Stress Disorder Impact Treatment Outcomes within a Randomised Controlled Trial of Mitochondrial Agents for Bipolar Depression?

Samantha E. Russell,Anna L. Wrobel,Melanie M. Ashton,Alyna Turner,Mohammadreza Mohebbi,MIchael Berk,Sue Cotton,Seetal Dodd,Chee H. Ng,Gin S. Malhi,Olivia M. Dean 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.3

Objective: Bipolar disorder often co-occurs with post-traumatic stress disorder, yet few studies have investigated the impact of post-traumatic stress disorder in bipolar disorder on treatment outcomes. The aim of this sub-analysis was to explore symptoms and functioning outcomes between those with bipolar disorder alone and those with comorbid bipolar disorder and post-traumatic stress disorder. Methods: Participants (n = 148) with bipolar depression were randomised to: (i) N-acetylcysteine alone; (ii) a combination of nutraceuticals; (iii) or placebo (in addition to treatment as usual) for 16 weeks (+4 weeks discontinuation). Differences between bipolar disorder and comorbid bipolar disorder and post-traumatic stress disorder on symptoms and functioning at five timepoints, as well as on the rate of change from baseline to week 16 and baseline to week 20, were examined. Results: There were no baseline differences between bipolar disorder alone and comorbid bipolar disorder and post-traumatic stress disorder apart from the bipolar disorder alone group being significantly more likely to be married (p = 0.01). There were also no significant differences between bipolar disorder alone and comorbid bipolar disorder and post-traumatic stress disorder on symptoms and functioning. Conclusion: There were no differences in clinical outcomes over time within the context of an adjunctive randomised controlled trial between those with bipolar disorder alone compared to those with comorbid bipolar disorder and post-traumatic stress disorder. However, differences in psychosocial factors may provide targets for areas of specific support for people with comorbid bipolar disorder and post-traumatic stress disorder.

위기상황 스트레스 해소 교육 프로그램 제작을 위한 소방공무원의 외상 후 스트레스 장애 분석

최혜경,김지희 한국자료분석학회 2009 Journal of the Korean Data Analysis Society Vol.11 No.4

The purpose of this study was focused on the posttraumatic stress disorder analysis in Korea fire officers for the critical incident stress debriefing program development. In order to obtain the purpose, following variables were used; 3 independent variables(work burden, stress, stress response), 1 intermediating variable(on-scene stress), and 1 dependent variable (physical symptoms). The respondents were 970 fire officers in Korea from March to December in 2007 by using questionnaires developed by the researchers. Data was analyzed by SPSS 14.0 and AMOS 7.0 programs. Data cleaning was done for the exact data input. For the reliability and validity, exploratory factor analysis and Cronbach's alpha were analyzed. The general peculiarity of the respondents was shown by frequency analysis and descriptive analysis. In order to fulfill this study, the researchers proposed the hypothesis as follows : Work burden and stress will influence upon on-scene stress. Work burden, stress, on-scene stress and stress response will influence upon physical symptoms. Through the structured equation model analysis, the lower the level of work burden, stress and on-scene stress was, the lower the level of physical symptoms became. On the other hand, the higher the stress response was, the lower the level of physical symptoms became. 본 연구의 목적은 소방공무원이 현장에서 겪는 충격 스트레스로 발생하는 외상 후 스트레스장애 분석을 통해 위기상황 스트레스 해소 교육 프로그램 기초 자료를 제시하고자 하는 데 있다. 연구 목적을 달성하기 위하여 독립변인(업무부담감, 스트레스, 스트레스 대응) 3개, 매개변인(현장충격 스트레스) 1개, 종속변인(신체적 증상)으로 구성하여 영향력을 파악하였다. 본 연구 대상자는 전국 970명 소방공무원으로 2007년 3월부터 12월까지 구조화된 설문지를 이용하여 조사하였다. 자료분석은 SPSS 14.0과 AMOS 7.0 통계패키지를 사용하였으며, 정확한 코딩데이터의 입력확인을 위해 데이터클리닝(data cleaning) 작업을 실시하였다. 신뢰도와 타당도를 검정하기 위하여 탐색적 요인분석(exploratory factor analysis)과 Cronbach's 검증을 하였다. 연구대상의 일반적인 특성을 파악하기 위하여 빈도분석(frequency analysis)을 실시하였고, 각 요인에 대한 기술통계분석(descriptive analysis)을 실시하였다. 이 연구의 목적을 달성하기 위하여 설계한 연구가설은 선행 연구의 이론적 근거를 토대로 다음과 같이 설정하였다. 업무 부담감과 스트레스는 현장충격 스트레스에, 업무부담감, 스트레스, 현장충격스트레스, 스트레스대응은 신체적 증상에 영향을 줄 것이다. 가설검증을 위하여 구조방정식 모형분석을 실시한 결과, 업무부담감, 스트레스, 현장충격 스트레스가 낮고, 스트레스 대응이 높을 때 신체적 증상이 낮아지는 것으로 나타났다.

여대생의 비만스트레스가 섭식장애, 사회적 체형불안 및 다차원적 완벽주의에 미치는 영향

서영환(Seo, Young-Hwan),이현정(Lee, Hyun-Jung) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.2

This In this study, physical and mental stress according to an obesity level of female university students and female students preparing for employment could affect eating disorders, social physique anxiety, and multidimensional perfectionism were analyzed and these conclusions were followed. First, it was verified that female university student’s desire of diet in relations between obesity stress and eating disorder was shown to affecting physical, self-improvement and mental stress. Physical and self-improvement stress factor in relations between obesity stress and eating disorder was shown to affecting dissatisfaction of their physique by eating disorder. Physical and self-improvement stress factor was shown to affecting gluttony. Second, physical stress in relations between obesity stress and social physique anxiety was shown to affecting satisfaction of physical expression by social physique anxiety. Physical, self-improvement and mental stress factors were shown to affecting negative physique by social physique anxiety. Third, physical and mental stress factors in relations between obesity stress and multidimensional perfectionism were shown to affecting concern about mistake by multidimensional perfectionism. Self-improvement stress factor was affect private standard by multidimensional perfectionism. Mental stress factor was affect condemnation to parents and doubt about fulfill by multidimensional perfectionism. Self-improvement and mental stress factors were shown to affecting multidimensional perfectionism group.

대학생들의 학업스트레스와 수면장애의 상관관계

김강토,남주희,박규병,방희정,임지훈,김지혁 한국지역사회건강관리협회 대한건강과학학회 2021 대한건강과학학회지 Vol.18 No.1

PURPOSE : The purpose of this study is to find out the correlation between academic stress and sleep disorders among college students, and list the factors that reduce academic stress. METHOD : This study was conducted with 316 college students in the 1st, 2nd, and 3rd grades enrolled in the Gyeongnam region. The study period is from October 12, 2020 to October 23, 2020, and there were a total of 316 questionnaires distributed to the study, aimed at those who explained the purpose and purpose of this study to the subject and expressed their intention to participate in it. Implemented. RESULT : The level of stress according to academic stress was 14.56%(46 people) in the health group, 63.60%(201 people) in the latent group, and 21.83%(69 people) in the high-risk stress group. Most of the subjects belonged to the latent group. Normal 0%(0 persons), moderate sleep disorder 92.72(293 persons), severe sleep disorder 7.28%(23 persons). None of the subjects were normal, and most of them had moderate sleep difficulties. CONCLUSION : In the sub-factors of academic stress, study stress was the highest, and in the correlation with sleep disorders, class stress was the highest, and all sub-factors of academic stress showed positive correlations with sleep disorders. If the causes of academic stress, measures to reduce academic stress, and measures to improve sleep quality suggested in this study are developed, it is expected that the academic stress and sleep quality of college students can be improved and improved.

급성 스트레스장애 및 외상후 스트레스장애의 한의학적 치료 3례

황정현 ( Jeong Hyun Hwang ),고재상 ( Jae Sang Ko ),배재익 ( Jae Ik Bae ),구병수 ( Byung Soo Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.3

Objectives: In this case report, we will present three patients diagnosed with acute stress disorder or post-traumatic stress disorder improved by application of oriental medical treatments. Methods: We treated three patients with acute stress disorder or post-traumatic stress disorder by oriental medical treatments. The effect of oriental medical treatments were evaluated by STAI and clinical symptoms such as anxiety, insomnia, palpitation, startle response. Results: As a result of oriental treatments, clinical symptoms such as anxiety, insomnia, palpitation, startle response were improved, and STAI scores also decreased. Conclusions: These results suggest that oriental treatments may have an effect on acute stress disorder and post-traumatic stress disorder.

突发公共事件中的心理障碍与应激行为 - 基于心理弹性的中国民众COVID-19应激行为调适机制研究 -

LUTANSHENG,卞青阳,陈琪钰 영남대학교 중국연구센터 2020 중국과 중국학 Vol.- No.40

본 연구는 코로나19 사태에서 중국 시민들이 갖는 스트레스를 분석하는 데 목적을 둔다. 이를 위하여, 연구자는 코로나19 스트레스를 인지적 평가, 정서적 공포 및 방위적 행동 등의 세 가지 영역으로 구분하여 중국 시민들의 불안감과 우울감 등의 심리적 장애가 회복탄력성을 매개로 하여 이들의 각 영역별 코로나19 스트레스에 어떤 영향을 미치는지를 밝혀 냄으로써 코로나19 스트레스를 완화시킬 수 있는 효과적인 방법을 모색 하고, 나아가 전세계 코로나 우려를 극복하는 데 보탬이 되고자 하였다. 자료 수집에 있어서는 중국 시민들을 대상으로 인터넷 설문조사를 실시 하였으며, 회수된 1248부를 분석자료에 대하여 내적일관성분석, 탐색적 요인분석, 기술통계와 단계적 회귀분석, 그리고 Sobel test를 실시하였다. 이를 토대로 한 연구결과는 다음과 같다. 먼저, 조사대상자의 불안감과 우울감이 회복탄력성에 유의미한 부정 적인 영향을 주는 것으로 나타났다. 다음으로, 연구대상자의 우울감은각 영역별 코로나19 스트레스을 억제시키는 반면에, 불안감이 코로나19 스트레스 중의 정서적 공포 및 방위적 행동에 유의미한 양(陽)적 영향을 주는 것으로 드러났다. 마지막으로, 코로나19 사태에서 중국 시민들의 심리적 장애(불안감과 우울감)와 각 영역별 코로나19 스트레스의 관계에 서, 회복탄력성이 부매개 역할을 하는 것을 확인하였다. 이를 통해 본 연구의 함의와 앞으로의 전망을 논의하였다. The goal of this research is to explore the relationship between psychological disorders, resilience and COVID-19 stress in order to contribute to overcoming the crisis of COVID-19 epidemic. In other words, through empirical study on COVID-19 stress, this study tried to find an effective flexible adjustment mechanism that can buffer the stress response to public emergencies. Data collected from 1,248 Chinese men and women through a network survey questionnaire were analyzed to test the research hypothesis. Also several analysis techniques, including internal reliability analysis, exploratory factor analysis, descriptive analysis, multiple regression analysis, and Sobeltest were adopted by using SPSS 23.0 version. The findings of the study are as follows: firstly, the study found out that psychological disorders (anxiety & depression) had significant influences on resilience statistically, secondly, depression was negatively correlated with all sub-categories of COVID-19 stress and anxiety had significant influences on COVID-19 stress statistically, among the sub-categories of COVID-19 stress, cognitive evaluation was negatively correlated with anxiety, but panic and defense response was positively correlated with anxiety, and thirdly, resilience had an indirect effect on the relationship between psychological disorders and all sub-categories of COVID-19 stress. Findings provide impetus for future investigation testing additional hypotheses and mechanisms of the COVID-19 stress behaviors.

소방공무원의 외상 후 스트레스 장애(PTSD)가 자살생각에 미치는 영향과 우울의 매개효과 및 회복탄력성과 사회적 지지의 조절된 매개효과

김숙영(Suk-Yeong kim),지재훈(Jae-hun Ji) 한국자료분석학회 2021 Journal of the Korean Data Analysis Society Vol.23 No.4

본 연구는 소방공무원의 외상 후 스트레스 장애가 자살생각에 미치는 영향을 규명하고 우울의 매개효과와 회복탄력성 및 사회적 지지의 조절된 매개효과를 분석함으로써 소방공무원의 자살 생각에 대한 효과적인 예방대책을 마련할 뿐만 아니라 추후 이들 분야의 기초자료를 제공하고 시사점을 도출하고자 시행되었다. 경남지역에 소속된 소방공무원을 대상으로 하였으며, 구글 설문지를 이용한 자기 기입식 설문 조사로 조사기간은 IRB승인 후 2020년 1월부터 약 1개월간 실시하였으며, 총 224부를 실증분석 자료에 이용하였다. 통계분석은 SPSS 26.0 및 SPSS PROCESS Macro, AMOS 24.0을 이용하여 분석하였다. 외상 후 스트레스 장애 요인 중 과각성, 침습, 수면장애/정서마비/해리는 우울에 유의한 정(+)의 영향을 미쳤으며 우울은 자살생각에 유의한 직접효과가 있었고 외상 후 스트레스 장애의 하위요인들은 자살생각에 직접효과가 없었다. 매개효과를 분석한 결과, 과각성과 자살생각 간의 인과관계에서 우울은 유의한 매개효과가 있었고, 수면장애/정서마비/해리와 자살생각 사이에 있어서도 우울은 유의한 매개효과가 있었다. 다만, 침습과 자살생각간의 인과관계에서는 우울이 경계역에서 유의한 매개효과가 있었다. 소방공무원의 외상 후 스트레스장애가 자살생각에 미치는 영향에 있어 우울의 매개효과가 있었으므로 외상 후 스트레스 장애가 있는 소방공무원의 경우 소방청에서 제시하고 있는 정신건강 지원 사업의 하나인 치료단계에서 건강정보 통합관리시스템, 치료비 지급 및 안심 프로그램을 적시에 적용함으로써 우울을 줄일 수 있는 것으로 생각되며 이에 따라 자살 생각을 감소시킬 수 있다고 판단될 뿐만 아니라, 본 연구로 추후 이들 분야에서 기초자료로 활용될 수 있을 것으로 생각된다. This study was conducted to provide effective prevention method of suicidal ideation in firefighters and provide the basic data (and derive implication) in this field by identifying the effect of the suicidal ideation that post-traumatic stress disorders (PTSD) influenced and by analyzing the mediation effect of depression, resilience and social support. Subjects were fire-fighting officers who worked in Kyongnam province and it was investigated with self-questionnaire Google survey from Jan 2020 for a month after IRB permission and total 224 cases were analyzed with SPSS 26.0 and SPSS PROCESS Macro, AMOS 24.0. Over-awakening, invasion, sleep disorder/emotional disturbance/dissociation affected positively to depression, depression directly affected significantly to suicide and the low level of factors of post-traumatic stress disorders(PTSD) did not affected directly to suicide. As the result of analyzing the moderated mediation effect, depression affected significant moderated mediation effect on the causal relationship with over-awakening and suicide thinking, depression affected as well moderated mediation effect significantly on disorder/emotional disturbance/dissociation. Depression affected moderated mediation effect significantly at border area on invasion and suicide thinking. In the effect of suicide thinking affected by post-traumatic stress disorders(PTSD), there was moderated mediation effect of depression. In case of the fire-fighting officer who have had post-traumatic stress disorders(PTSD), it is necessary to apply for health information integrated management system, medical expenses payment and relief system timely which were provided by the National Fire Agency to reduce the depression and it may help to reduce the suicide thinking. This study would provide the basic data in this field in the future.

중환자실 환자의 환경적 스트레스 요인이 외상후 스트레스장애 위험도와 삶의 질에 미치는 영향

차효정,안숙희 한국중환자간호학회 2019 중환자간호학회지 Vol.12 No.1

Purpose : This study was to determine the levels of environmental stressor, posttraumatic stress disorder, and quality of life in intensive care units (ICU) survivors after intensive care, and to explore the factors affecting posttraumatic stress disorder and quality of life. Methods: With a longitudinal survey design, data were collected from 116 patients who were discharged from the ICU of a university hospital. The environmental stressor, posttraumatic stress disorder, and quality of life were measured immediately following and 1 month after the ICU discharge. Results: Of all the subjects, 16.4% experienced posttraumatic stress disorder after discharge. Multiple regression analysis revealed that ICU environmental stressors, experience of ICU readmission, using psychotropic drugs and narcotic analgesics, and ICU admission after surgery or cardiac intervention accounted for 22.2% of posttraumatic stress disorder. Posttraumatic stress disorder and sedation status when entering ICU accounted for 28.3% of the quality of life 1 month after ICU discharge. Conclusion: Nursing interventions focused on ICU environmental stressors would not only reduce environmental stress but also contribute to the reduction of posttraumatic stress disorder and later improvement of quality of life.

자동차 정비 작업이 근골격계질환과 스트레스에 미치는 영향

길여진 ( Yo-chin Kil ),송영웅 ( Young-woong Song ) 대구가톨릭대학교 자연과학연구소 2023 자연과학연구논문집 Vol.21 No.1

This study tried to survey the prevalence of musculoskeletal disorders(MSD) and psychosocial stress among the automobile maintenance workers, and assessed the correlation between MSD symptoms and psychosocial stress. A structured self-reported questionnaire was distributed to 117 auto mechanics from wheel mobile equipment located in Daegu city and Gyeongsangbuk-do. The questionnaire was composed of three parts: (1) demographic and work related characteristics (age, martial status, smoking, physical load level ets.) (2) MSD symptoms (3) psychosocial stress. Psychosocial stress was measured using a PWI-SF(Psychosocial Well-being Index-Short Form). The prevalence of musculoskeletal disorders during last year preceding data collection was reported as about 31.4%. Marital status, exercise, phsical workload, job satisfaction, psychological stress were significantly associated with MSDs. Single, no exercise, high physical workload, low job satisfaction, high psychosocial stress showed high percentage of MSD symptoms. Of the 117 subjects, 8(8.2%) were in the normal group of psychosocial stress, 87(88.8%) were in the latent stress group of psychosocial stress and 3(3.1%) were in high risk stress group of psychosocial stress. Job satisfaction, MSD symptoms were found to be significantly associated with psychsocial stress. No exercise, high psychosocial stress were found to be significantly associated with possibility of MSD symptoms.

화상에 의한 급성 스트레스 장애 환자의 임상적 특성

민경준,유태혁 중앙대학교 의과대학 의과학연구소 1996 中央醫大誌 Vol.21 No.2

Recently acute stress disorder was classified in DSM-Ⅳ. This study was performed to investigate the clinical characteristics of patients with acute stress disorder after burn injury. The symptoms were reported at 10.7 days after burn injury, and the patients were referred to psychiatric department 5.5days after the symptoms reported. Two of 17 patients were diagnosed as posttraumatic stress disorder later. The patients with acute stress disorder were not different from the patient without acute stress disorder in age, sex, educational level. But the percentage of burn area and the degree of burn were higher in acute stress disorder patients. There were no differences in duration of admission, duration of ICU care, number of dressing, and number of operation between the acute stress disorder group and the control group. The results support that the objective severity of stress is related with the occurrence of acute stress disorder.