Effective Response of the Peritoneum Microenvironment to Peritoneal and Systemic Metastasis from Colorectal Carcinoma

Yu, Min,Niu, Zhi-Min,Wei, Yu-Quan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

We here document discovery of a new and simple model of tumor seeding involving the mouse peritoneum. Irradiated tumor cells administered by i.p. injection provided effective vaccination against peritoneal carcinomatosis and distal metastasis with colorectal carcinomas. In flow cytometric analysis, CD4+ and CD8+ T lymphocytes, macrophages and myeloid-derived suppressor cells (MDSCs), which are easy to obtain in the peritoneal cavity, were revealed to have significant differences between immunized and non-immunized mice and these contributed to antitumor responses. We also observed that both serum and peritoneal lavage fluid harvested from immunized mice showed the presence of CT26-specific autoantibodies. In addition, increase in level of TGF-${\beta}1$ and IL-10 in serum but a decrease of TGF-${\beta}1$ in peritoneum was found. Taken together, these findings may provide a new vaccine strategy for the prevention of peritoneal and even systemic metastasis of carcinomas through induction of an autoimmune response in the peritoneum.

원발성 복막 장액성 유두암종: 1예 보고

박원규,장재천,조재호,김시형,신명호,황미수 대한영상의학회 2001 대한영상의학회지 Vol.45 No.3

원발성 복막 장액성 유두암종은 복막에서 기인하는 드문 원발성 종양으로 병리조직학적으로는 난소에 생기는 장액성 유두암종과 감별이 되지 않으나 난소에는 종양이 없거나 미세한 표재성 침범만 있다는 것이 특징이다. 방사선학적으로 복수를 동반한 복막과 대망내에 종괴를 보이는 경우가 많아 복막 암종증과 악성 중피종과의 감별이 용이하지 않다. 저자들은 수술 후 원발성 복막 장액성 유두암종으로 화진된 1예를 경험하였기에 보고한다. Primary serous papillary carcinoma of the peritoneum is a rare neoplasm arising from the mesothelium. Histologically it is indistinguisable from ovarian serous papillary carcinoma, but it should be free of tumor or involved only superficially with the ovary. Radiologically its common findings are peritoneal and oriental masses with ascites, and it is indistinguisable from peritoneal carcinomatosis or malignant mesothelioma. We report a case of surgically proven primary serous papillary carcinoma of the peritoneum in a 63-year-old woman.

복통을 일으키는 벽측 복막 지방종 1예

방창석 ( Chang Seok Bang ),김연수 ( Yeon Soo Kim ),백광호 ( Gwang Ho Baik ),한상학 ( Sang Hak Han ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.6

Lipomas are common benign tumors of mature adipose tissue, enclosed by thin fibrous capsules. They can occur on any part of the body; however, peritoneal lipoma is extremely rare. We encountered a case of a 75-year-old man presenting with intermittent abdominal pain, who had undergone right hemicolectomy due to colon cancer. Abdominal computerized tomography showed a well-defined heterogenous fatty mass measuring 4.5×3.5 cm in size, suggesting fat necrosis located in the abdominalwall. Laparotomy showed a very large soft mass of peritoneum. Pathologically, the tumor was diagnosed as lipoma containing fat necrosis located in parietal peritoneum not fixed to any organs, but with small bowel adhesion. Due to its rare etiologic origin and obscure cause of development, we report on a case of lipoma of parietal peritoneum causing abdominal pain.(Korean J Gastroenterol 2014;63:369-372)

Complicated benign cystic mesothelioma of mesoappendix misdiagnosed as an appendiceal abscess in a postpartum period woman

Sunchul Yeom,Taeil Son,Young Ok Hong 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.3

Benign cystic mesothelioma is an uncommon tumor arising from the peritoneal mesothelium. It is characterized by multilocular grapelike, thin-, and translucent-walled cysts, or a unilocular cyst lined by benign mesothelial cells. It occurs predominantly in women of reproductive age, and shows a predilection for the surface of the pelvic peritoneum or visceral peritoneum. Patients usually present abdominal pain and palpable mass, but many cases have been found incidentally during laparotomy. Definite preoperative diagnosis is known to be difficult. Benign cystic mesothelioma has a tendency towards local recurrence, although the gross microscopic features are benign. Moreover, there is controversy over whether this disease is neoplastic or reactive. Initial complete surgical resection and cytoreductive surgery for recurred cases are standard treatments. In the following report, we describe a case of complicated benign cystic mesothelioma in a postpartum woman, involving the pelvic peritoneum and mesoappendix, which was initially misdiagnosed as a periappendiceal abscess.

복막에 발생한 결합조직형성 소원형세포종양 1예

양기열 ( Ki Yeol Yang ),김영선 ( Young Sun Kim ),한지현 ( Ji Hyun Han ),박용구 ( Yong Ku Park ),정민형 ( Min Hyung Jung ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.3

Desmoplastic small round cell tumor is a rare and aggressive tumor that affects young males. It is usually an abdominopelvic malignancy that demonstrates distinct histological appearances and a unique cytogenetic profile. There have been many different approaches to the treatment of desmoplastic small round cell tumor, but unfortunately it remains incurable and has poor long-term survival rates. However, with an aggressive approach to the treatment using multiple modalities, some temporary benefit to survival can be achieved. There has not yet been a case in which treatment has led to a curative outcome. Recently, we also experienced a case of very poor outcome of 31-year-old female with small round cell tumor in peritoneum. Here, we report the case with a brief review of literatures.

결핵성 복막증과 복막내암종증의 CT소견 비교: 복막변화와 대망 침윤정도의 상관관계를 중심으로

정성기 대한영상의학회 1997 대한영상의학회지 Vol.36 No.1

Purpose: To compare the CT findings of peritoneal tuberculosis (PT) and peritoneal carcinomatosis (PC) based on the morphologic features of the peritoneum and assess the relationship between the degree of peritoneal thickness and the severity of omental infiltration in PT and PC. Materials and Methods: We retrospectively reviewed the CT findings of 15 patients with PT and 14 with PC. We checked morphologic changes of the peritoneum as seen on CT, for the following points: 1) the presence of peritoneal change: 2) the pattern of any change-diffuse thickening, plaque or nodularity, combined thickening (diffuse and plaque, or nodularity); 3) the degree of thickness on the whole peritoneum - mild (grossly definite, but not more than 3mm), moderate (more than 3mm); 4) the presence of irregularity on the peritoneal surface. We also evaluated the significance of the relationship between peritoneal thickness and omental infiltration in both disease entities. The degree of omental infiltration was described as follows: grade I (no change or focal smudge pattern); grade II (diffuse smudge), grade III (omental cake regardless extent). Results: Peritoneal change was seen in 12 of 15 PT patients and in 7 of 14 PC patients. In all 12 PT patients, the pattern of change was diffuse thickening, and among the seven PC patients, there was diffuse thickening in one, plaque or nodular thickening in four, and combined thickening in two. In PT patients, the degree of thickness on the whole peritoneum was mild in six and moderate in six, and in PC patients it was mild in two and moderate in one. An irregular peritoneum surface was seen in one patient with PT and in two with PC. The degree of omental infiltration in PT was grade I in four patients, grade II in six and grade III in five. In PC, its was grade I in six patients, grade II in two and grade III in six. Smooth diffuse thickening of the peritoneum was seen in 11 of 15 PT cases and in one of 14 PC (P<0.01). Accompanying plaque or nodularity was seen only in PC, in six of 14 patients (P<0.001). The relationship between the degree of peritoneal thickness and severity of omental infiltration was significantly proportional in PT (r=0.900, P<0.001), but not in PC (r=0.068, P>0.5). Conclusion: In PT and PC different CT findings based on peritoneal morphologic changes might be useful in differentiating these two entities. In addition, careful observation of the relationship between peritoneal change and the severity of omental infiltration is necessary.

Streptozotocin 당뇨 백서의 복막내 최종당화산물의 형성

박미옥(Mi Ok Park),김용진(Yong Jin Kim),김용림(Yong Lim Kim) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1

장기간 복막 투석을 하는 말기 신부전증 환자에서 투석액에 포함된 고농도의 포도당은 AGEs의 생성을 증가시켜 복막의 혈관계에 침착됨으로서 당뇨병성 혈관병과 유사한 변화를 일으켜 투석의 효율을 저하시킨다고 알려져 있다. 당뇨병성 말기 신부전증의 환자들은 유지 신대체요범으로 복막투석을 받는데, 당뇨병 환자에서는 투석을 시작할 당시 이미 최종당화산물(AGEs)에 의한 당뇨병성 미세 혈관의 변화가 진행되어 있을 가능성이 많다. 이점에 착안하여 저자들은 췌장의 베타세포를 파괴시키는 streptozotocin을 투여하여 백서에서 당뇨병을 유발시키고 5주 후에 복막의 형태학적 변화와 면역조직 화학염색법으로 AGEs의 침착되는 정도를 알아보고자 본 연구를 시행하였다. 대조군에 비해 실험군에서 경도의 복막의 섬유화와 교원섬유 조직의 두께의 증가가 관찰되었으나 증피세포의 쇠퇴나 증식은 관찰되지 않았다. 복막의 증피세포하의 교원섬유조직층에서 세정맥과 모세혈관의 증식, 비후, 유리질화나 염증세포의 침윤은 관찰되지 않았다. AGEs에 대한 면역조직 화학염색에서 실험군 복막의 증피세포 기저막 아래층에 AGEs가 갈색으로 희미하게 염색이 되었으나 대조군과 비교해 볼 때 유의할만한 염색 강도의 차이는 없었다. 이상의 결과로 STZ 투여로 당뇨병이 유도되고 5주 후에 관찰된 백서의 복막에서는 AGEs의 침착 정도가 극히 적었으며, 진행된 당뇨병의 복막에서의 AGEs의 침착에 대한 연구을 위해서는 당뇨병성 실험동물 모델의 장기간의 추적관찰이 이루어져야 할 것으로 생각한다. In diabetic and diabetic renal failure patients on continuous ambulant peritoneal dialysis(CAPD) treat- ment, the peritoneal membrane and vascular beds are continuously exposed to the high glucose concentration contained in the dialysate and blood. This may lead to the local generation of advanced glycosylated end-products(AGEs), formed from nonenzymatic glycation of proteins and lipids with reducing sugars and have been implicated in many diabetic complications. AGEs is cross linked to the circulating proteins resulting in peritoneal dysfunction and vascular thickening. To elucidate the deposition of AGEs in diabetic rats(n=10) induced by streptozotocin(STZ, 75mg/kg) injection via tail vein and those of age-matched control rats(n=10), peritoneums were examined light microscopically and immunohistochemically with monoclonal antibody specific for AGEs after 5 weeks of disease. Histologically, the peritoneum of the STZ diabetic rats showed mild interstitial fibrosis and no mesothelial alteration, vascular proliferation, compared with age-matche4 nondiabetic control group. Immunohistochemical staining with AGEs demonstrated that weakly accumulation in the submesothelial layer, but it was not different from comparison with control group. We speculate that the peritoneum of the STZ-induced diabetic rat did not stain with monoclonal antibody against AGEs after 5 weeks of disease, but long-term experiments may demonstrate significant functional and morphological alterations of peritoneum

Experimental Study on Sustained-release 5-Fluorouracil Implantation in Canine Peritoneum and Para-aortic Abdominalis

Wei, Guo,Nie, Ming-Ming,Shen, Xiao-Jun,Xue, Xu-Chao,Ma, Li-Ye,Du, Cheng-Hui,Wang, Shi-Liang,Bi, Jian-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Objective: To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time. Methods: 300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood. Results: 10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever. Conclusions: Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour-inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.

복막의 악성혼합 뮬러리안종양 1 예

김수평(Soo Pyung Kim),김정자(Jeong Ja Kim),최은(Eun Choi),노승혜(Seung Hae Ro),김장흡(Jang Heub Kim),이안희(An Hee Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1

Malignant mixed miillerian tumor (MMMT) was one of the rare uterine sarcoma. This tumor is composed of sarcoma and carcinoma. Primary MMMT in the peritoneum is among the rarest sites for MMMT. MMMT is highly malignant and the prognosis is grave due to frequent recurrence and metastasis. In the world literature, only 22 cases with primary MMMT of the peritoneum have been reported and most of these were single report. We report one case of primary MMMT in the peritoneum with a brief review.

Anomalous peritoneal band connecting greater omentum to the ascending colon: a possible cause for dilation of ascending colon

Satheesha B,Nayak,K,V,Soumya 대한해부학회 2020 Anatomy & Cell Biology Vol.53 No.3

Anomalies of the peritoneum and the colon are quite common. Some of these anomalies can disturb the normal digestive and absorptive functions of the intestine and the others might result in formation of volvulus or impede the blood supply of the intestine. We report a rare, combined variation of peritoneum and ascending colon. In a 70-year-old male cadaver, the greater omentum was very small and extended only for about an inch below the transverse colon. From its lower end, a fibrous band extended to the right wall of the upper part of ascending colon. There was a deep constriction on the right wall of the ascending colon at the site of attachment of the fibrous band. The ascending colon was grossly dilated. Further, the ascending colon was mobile and presented a small ascending mesocolon along its left edge. We discuss the possible embryological basis and clinical and surgical relevance of the case.