http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
CASE REPORT : A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer
( Chaiho Jeong ),( Jinhee Lee ),( Seongyul Ryu ),( Hwa Young Lee ),( Ah Young Shin ),( Ju Sang Kim ),( Joong Hyun Ahn ),( Hye Seon Kang ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
Sweet's syndrome: a cutaneous harbinger of ovarian carcinoma
Amanda Nickles Fader,Abigail Duncan Winder,Samith Sandadi,Robert DeBernardo 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.4
Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a condition characterized by fever, neutrophilia, erythematous skin lesions, and a dermal infiltrate consisting predominantly of mature neutrophils on histology. Sweet's syndrome is a reactive phenomenon and should be considered a cutaneous marker of systemic disease, including underlying malignancy. We present a case of a 56-year-old woman who presented with vague abdominal symptoms and a tender, erythematous rash on her extremities. Biopsy of her skin lesions revealed Sweet's syndrome. A work-up for malignancy eventually demonstrated a pelvic mass and carcinomatosis, and a diagnosis of advanced-stage papillary serous ovarian carcinoma was subsequently made. In postmenopausal women who present with Sweet's syndrome, a comprehensive evaluation for malignancy is indicated. In women with a known diagnosis of cancer, Sweet's syndrome may manifest in the detection of persistent or recurrent disease.
A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer
Jeong, Chaiho,Lee, Jinhee,Ryu, Seongyul,Lee, Hwa Young,Shin, Ah Young,Kim, Ju Sang,Ahn, Joong Hyun,Kang, Hye Seon The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer
정채호,이진희,류승열,이화영,심아영,김주상,안중현,강혜선 대한결핵및호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
안진검사에서 안구간대경련을 보인 혈청 음성 신생물딸림신경증후군 2예
배성훈,이전미,김성헌 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.6
The dizziness associated with paraneoplastic neurologic syndrome is hard to diagnose clinicallybecause the prevalence of disease is rare, and radiologic and serologic examination resultmay come out normal. Opsoclonus-myoclonus symdrome is a representative of classical paraneoplasticneurologic syndromes. In this paper, we report 2 cases of paraneoplastic neurologicsyndromes with negative serologic auto-antibody test and no brain lesion on MRI. Both caseswere eventually diagnosed through PET. Patients with opsoclonus-myoclonus type nystagmusshould be evaluated for paraneoplastic neurologic syndrome even if their radiologic and serologicfindings are normal.
Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin's lymphoma
Son, Hyoshin,Choi, Jongsuk,Kim, Sung Un,Park, Kyung Seok The Korean Society of Clinical Neurophysiology 2019 Annals of Clinical Neurophysiology Vol.21 No.2
Non-Hodgkin's lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
( Jeffrey M Cohen ),( Carol E Cheng ),( Aieska Desouza ),( Tina R Nandi ),( Elizabeth A Buzney ),( Allison Larson ),( Winston Y Lee ),( Arash Mostaghimi ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.2
Cutaneous paraneoplastic syndromes comprise a broad spectrum of cutaneous reactions to an underlying malignancy. These dermatoses are not the result of metastatic spread to the skin, but rather a reaction to the presence of malignancy. Cutaneous paraneoplastic syndromes often precede the identification of a malignancy. We describe the case of a 79-year-old man with a six-month history of recalcitrant treatment- resistant dermatitis. A complete blood count test performed at the time of initial presentation was normal. The patient ultimately presented with erythroderma and was diagnosed with acute myeloid leukemia (AML). The evolution of the dermatitis to erythroderma coincided with the clinical presentation of AML, and was therefore considered to be a paraneoplastic syndrome. The patient decided against therapy and died seven weeks after diagnosis. Physicians should consider a cutaneous paraneoplastic syndrome when faced with dynamic recalcitrant dermatoses that are difficult to treat and decide on laboratory testing accordingly. Patients should be evaluated regularly for two to three years after initial diagnosis with a physical exam and review of systems to monitor for signs and symptoms of malignancy.(Ann Dermatol 27(2) 190∼193, 2015)
( Jeffrey M Cohen ),( Carol E Cheng ),( Aieska Desouza ),( Tina R Nandi ),( Elizabeth A Buzney ),( Allison Larson ),( Winston Y Lee ),( Arash Mostaghimi ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Cutaneous paraneoplastic syndromes comprise a broad spectrum of cutaneous reactions to an underlying malignancy. These dermatoses are not the result of metastatic spread to the skin, but rather a reaction to the presence of malignancy. Cutaneous paraneoplastic syndromes often precede the identification of a malignancy. We describe the case of a 79-year-old man with a six-month history of recalcitrant treatment- resistant dermatitis. A complete blood count test performed at the time of initial presentation was normal. The patient ultimately presented with erythroderma and was diagnosed with acute myeloid leukemia (AML). The evolution of the dermatitis to erythroderma coincided with the clinical presentation of AML, and was therefore considered to be a paraneoplastic syndrome. The patient decided against therapy and died seven weeks after diagnosis. Physicians should consider a cutaneous paraneoplastic syndrome when faced with dynamic recalcitrant dermatoses that are difficult to treat and decide on laboratory testing accordingly. Patients should be evaluated regularly for two to three years after initial diagnosis with a physical exam and review of systems to monitor for signs and symptoms of malignancy. (Ann Dermatol 27(2) 190∼193, 2015)
Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin’s lymphoma
Hyoshin Son,Jongsuk Choi,Sung Un Kim,Kyung Seok Park 대한임상신경생리학회 2019 Annals of Clinical Neurophysiology Vol.21 No.2
Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
항 GD1b IgG 단일 항체와 관련된 길랭-바레 증후군으로 발현된 편평상피세포 폐암 증례
김예신,김성헌 대한임상신경생리학회 2015 Annals of Clinical Neurophysiology Vol.17 No.1
We report a case with squamous cell lung cancer with concomitant Guillain-Barre syndrome (GBS) as a paraneoplastic syndrome. A 67-year-old patient who was previously diagnosed as metastatic squamous cell lung cancer developed mild symmetrical weakness, paresthesia and sensory ataxia. Nerve conduction study showed sensorimotor polyneuropathy. Analysis of cerebrospinal fluid showed high tilter for monospecific anti-GD1b IgG antibody without onconeuronal antibodies. After treatment with intravenous immunoglobulin, the patient’s symptoms improved. (Korean J Clin Neurophysiol 2015;17:31-34)