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하지용,조영호,이지숙 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1
In order to investigate annumor and immune response effect by Hyangsapyungwisan after Sarcoma- 180 cells and methotrexate were treared each other. the extract of Hyangsapyungwisan was orally administered to ICR mice for 14 days. To evaluate the effects of the Hyangsapyungwisan, 50% inhibition concentration(IC_50), mean survival days, tumor weight for antitumor effects, hemagglutinin titer, hemolysin titer, rosette forming cells, natural killer cell and productivity of interleukin-2 for immune responses measured in ICR mice. The results were summarized as follows: 1. Mean survival time in Hyangsapyungwisan-treated group was slightly prolonged, as compared with control group(13.46%). 2. On the MTT assay, cell viability was significantly inhibited by 5ug/well, 2.5ug/well, l.25ug/well. and 0.625ug/well of Hyangsapyung-wism concentration inhibited cell viability significantly. IC_5o for cell viability was 11.59ug/well. 3. Tumor weight in Hyangsapyungwisan treated group was depressed, as compared with the control group(P<0.05). 4. Hemagglutinin titer in Hyangsapyungwisan-treated group was slightly increased with no significance, as compared with the control group. 5. Hemolysin titer in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(P<0.05). 6. Rosette forming cells in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(P<0.05). 7. Naural killer cell activity in Hyangsapyungwisan-treated group was significantly increased(P<0.05). 8. Production of interleukin-2 was significantly increased(P<0.05). According to the above results, Hyangsapygwisan had prominent antitumor, and enhance both cellular and humoral immunity in mice.
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향사평위산(香砂平胃散)이 항암(抗癌) 및 면역조절작용(免疫調節作用)에 미치는 영향(影響)
하지용,조영호,이지숙,Ha, Jee-Yong,Jo, Young-Ho,Lee, Jee-Suk 대한암한의학회 2000 大韓癌韓醫學會誌 Vol.6 No.1
In order to investigate antitumor and immune response effect by Hyangsapyungwisan after Sarcoma-180 cells and methotrexate were treatred each other, the extract of Hyangsapyungwisan was orally administered to ICR mice for 14 days. To evaluate the effects of the Hyangsapyungwisan, 50% inhibition concentration($IC_{50}$), mean survival days, tumor weight for antitumor effects, hemagglutinin titer, hemolysin titer, rosette forming cells, natural killer cell activity and productivity of interleukin-2 for immune responses measured in ICR mice. The results were summarized as follows: 1. Mean survival time in Hyangsapyungwisan-treated group was slightly prolonged, as compared with control group(13.46%). 2. On the MTT assay, cell viability was significantly inhibited by $5{\mu}g/well,\;2.5{\mu}g/well,\;1.25{\mu}g/well,\;and\;0.625{\mu}g/well$ of Hyangsapyung-wisan concentration inhibited cell viability significantly. $IC_{50}$ for cell viability was $11.59{\mu}g/well$. 3. Tumor weight in Hyangsapyungwisan treated group was depressed, as compared with the control group(p<0.05). 4. Hemagglutinin titer in Hyangsapyungwisan-treated group was slightly increased with no significance, as compared with the control group. 5. Hemolysin titer in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(p<0.05). 6. Rosette forming cells in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(p<0.05). 7. Naural killer cell activity in Hyangsapyungwisan-treated group was significantly increased(p<0.05). 8. Production of interleukin-2 was significantly increased(p<0.05). According to the above results, Hyangsapygwisan had prominent antitumor effects, and enhance both cellular and humoral immunity in mice.
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향사평위산(香砂平胃散)으로 호전된 위암으로 인한 위장절제술 후유증(後遺症) 환자의 임상증례(臨床證例) 보고
김국범,한종현,김은곤,김상욱,성기원,강병철,성경화,심윤섭,Kim, Guk-Bum,Han, Jong-Hyun,Kim, Eun-Gon,Kim, Sang-Uk,Seong, Ki-Won,Gang, Byeong-Cheol,Seong, Gyeong-Hwa,Kim, Sun-Hong,Shim, Yun-Seub 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
Gastrectomy is the most common treatment for gastric cancer, but patients often suffer from post-operative side effects. This study describes the clinical effects of HyangSaPyungWiSan on a pateint who suffered from nausea, vomitting, indigestion, headache, abdomen pain, and loss of appetite after his gastrectomy. The patient undewent a gastrectomy due to gastric cancer, and HyangSaPyungWiSan was used to treat all thses symptoms. This study suggests that treatment with HyangSaPyungWiSan is effectious for such aftereffects of gastrectomy as nausea, vomitting, indigestion, headache, abdomen pain, and loss of appetite.
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향사평위산(香砂平胃散) 약침액(藥鍼液)의 자유기 소거활성 및 혈관내피세포의 산화적 손상에 대한 보호효과
임선희 ( Sun Hee Lim ),이효승 ( Hyo Seung Yi ),문진영 ( Jin Young Moon ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.1
Objectives: Hyangsapyungwisan (HPS) has been used for treatment of cardiovascular diseases including of arthralgia, myalgia in traditional Korean medicine. However, the medical actions of HPS have not been clearly investigated. The aim of this study was to elucidate the antiradical and antioxidant activity of the extract for herb-acupuncture (HPS-HA) obtained from HPS. Methods & Results: HPS-HA exhibited a stronger inhibition rate (55.5%) on Lipid peroxidation of rat Liver homogenate induced by FeCl2-ascorbic acid. In addition, HPS-HA markedly interfered with hydroxyl radical generation through iron ions chelating action. While pro-oxidant effect of HPS-HA was nearly undetectable at concentrations of 0.5-10㎎/mL. Moerover, HPS-HA revealed a potent antiradical activities on 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals, superoxide anions, nitric oxide and peroxynitrite. Furthermore, HPS-HA inhibited copper- and AAPH-mediated oxidation of human Low-density Lipoprotein (LDL), and also suppressed the relative electrophoretic mobility of LDL. HPS-HA showed strong protective activity against oxidative damage of HUVECs induced by SIN-1. Conclusions: These results suggest that HPS-HA may be effective in protecting against oxidative diseases.
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