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      • KCI등재

        Primary Malignant Melanoma of the Female Urethra

        조성태,송형철,조병철,최우석,이원기,이용성,이영구,김기경,박성호,김정원 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.3

        We report here on a rare case of primary malignant melanoma of the female urethra. A 69-year-old female presented at our hospital with a several month history of dysuria, poor stream, gross hematuria, intermittent blood spots, and a painful mass at the external urethral meatus. The physical examination revealed a soft, small, chestnut-sized lesion through the urethral orifice. The mass was tan colored, ulcerated, covered with necrotic tissue, and protruded from the external urethral meatus. The mass was removed by wide local excision under spinal anesthesia. The pathological diagnosis was malignant melanoma of the urethra. Computed tomography of the abdomen as well as a whole-body bone scan showed no evidence of metastasis. The patient has been free of disease for 6 months postoperatively. We discuss the clinicopathologic features and treatment of this tumor.

      • KCI등재

        비마취하 요역동학적 검사에서 PGE2로 유발한 과민성방광에서 수컷과 암컷 흰쥐의 배뇨변화

        이병연,김룡호,윤상민,이택 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.9

        Purpose: We wanted to obtain informations on the different mechanisms of awake micturitions between male and female rats by using an overactive model with intravesical PGE2 instillation. Materials and Methods: Sprague Dawley rats(6 male, 6 female) were used. A catheter was implanted into the bladder to record the intravesical pressure. Three days later, the awake cystometry was performed, and PGE2 was given intravesically to induce detrusor overactivity(DO). With using the conventional pressure and volume parameters, a new parameter of flow pressure was investigated. Results: When recorded as the flow pressure, the male rats exhibited higher urethral resistance than did the female rats in the normal state. The male rats showed higher urethral resistances after DO was induced, than those before the DO. However, the female rats did not show increased urethral resistance after DO was induced. Conclusions: An increase in urethral resistance through the outlet region was induced in male rats after intravesical PGE2 instillation, but this didn’t occur in female rats. This result indicates that overactive bladder has different mechanisms and responses in different genders. Purpose: We wanted to obtain informations on the different mechanisms of awake micturitions between male and female rats by using an overactive model with intravesical PGE2 instillation. Materials and Methods: Sprague Dawley rats(6 male, 6 female) were used. A catheter was implanted into the bladder to record the intravesical pressure. Three days later, the awake cystometry was performed, and PGE2 was given intravesically to induce detrusor overactivity(DO). With using the conventional pressure and volume parameters, a new parameter of flow pressure was investigated. Results: When recorded as the flow pressure, the male rats exhibited higher urethral resistance than did the female rats in the normal state. The male rats showed higher urethral resistances after DO was induced, than those before the DO. However, the female rats did not show increased urethral resistance after DO was induced. Conclusions: An increase in urethral resistance through the outlet region was induced in male rats after intravesical PGE2 instillation, but this didn’t occur in female rats. This result indicates that overactive bladder has different mechanisms and responses in different genders.

      • KCI등재SCOPUS
      • 원발성 여성 요도 종양의 임상특성 및 추적관찰

        정창호,류현열 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

        Background : Female urethral lesions encompass a spectrum of entities that have significance in clinical urology. With that, female urethral lesions have rarely been reported and the differential diagnosis between benign and malignant lesions has not been established. I investigate retrospectively the incidence and the clinical presentations of female urethral lesions by my experience about 20 cases of the female primary urethral tumor. I also analyze the data to determine the optimum procedure for diagnosis and therapy. Method : The study included 20 patients with female urethral tumor treated by surgical procedure at Masan Samsung hospital of Sungkyunkwan University between Jan. 1994 to Apr. 2001. We investigated the clinical aspect of the female urethral tumor by symptom of each lesion, the spread of the patient's age, the method of the diagnosis and treatment. The preoperative evaluation included a thorough clinical history, physical examination, urinalysis, urine cytology, cystourethroscopy, and the radiologic studies, including voiding cystourethrography, retrograde urethrography, pelvic ultrasonography, pelvic CT or MRI. Results : The age range of the patients, who were surveyed for the 20 cases of the primary tumor, was between 25.2 and 74.6 (mean age 46.9 years), and 8 of them were in the period of menopause. We can inspect urethral diverticulum and we can treated it through diverticulectomy only. 4 cases were necessary to use Martius interposition graft when the path between urethra and the diverticulum was large. 2 cases had the stress incontinence postoperatively and there were necessary anterior vaginal wall sling procedure. The tumor was removed under transvaginal approach in urethral leiomyoma and leiomysarcoma and had not seen a significant morbidity. Urethral transitional cell carcinoma was found that it metastasized to the inguinal lymph nodes and distant metastasis to lung and bone after radical total cystourethrectomy. After the surgical excision of the benign urethral lesions, there would be no relapse or progression to malignancy. Conclusion : Urethral masses are essentially needed radiologic or endourologic procedure and pathologic examination due to possible development of a malignant tumor even though it is rare. A large scale of the urethral tumor like the leiomyoma of urethral diverticulum could be cured and safely managed by surgical excision, but the preventive procedure of the stress incontinence was needed. Finally it is important to perform auxiliary radiotherapy or chemotherapy with radical cystourethrectomy in female urethral malignant tumor to prevent the disease progression.

      • 원발성 여성 요도 종양의 임상특성 및 추적관찰

        정창호,류현열 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1

        Background : Female urethral lesions encompass a spectrum of entities that have significance in clinical urology. With that, female urethral lesions have rarely been reported and the differential diagnosis between benign and malignant lesions has not been established. I investigate retrospectively the incidence and the clinical presentations of female urethral lesions by my experience about 20 cases of the female primary urethral tumor. I also analyze the data to determine the optimum procedure for diagnosis and therapy. Method : The study included 20 patients with female urethral tumor treated by surgical procedure at Masan Samsung Hospital of Sungkyunkwan University between Jan. 1994 to Apr. 2001. We investigated the clinical aspect of the female urethral tumor by clinical symptom of each lesion, the spread of the patient's age, the method of the diagnosis and treatment. The preoperative evaluation included a thorough clinical history, physical examination, urinalysis, urine cytology, cystourethroscopy, and the radiologic studies, including voiding cystourethrography, retrograde urthrography, pelvic ultrasonography, pelvic CT or MRI. Results : The age range of the patients, who were surveyed for the 20 cases of the primary tumor, was between 25.2 and 74.6 (mean age 46.9 years), and 8 of them were in the period of menopause. We can inspect urethral diverticulum and we can treated it through diverticulectomy only. 4 cases were necessary to use Martius interposition graft when the path between urethra and the diverticulum large. 2 cases had the stress incontinence postoperatively and there were necessary anterior vaginal wall sling procedure. The tumor was removed under transvaginal approach in urethral leiomyoma and leiomyosarcoma and had not seen a significant morbidity. Urethral transition cell carcinoma was found that it metastasized to the inguinal lymph nodes and distant metastasis to lung and bone after radical total cystourethrectomy. After the surgical excision of the benign urethral lesions, there would be no relapse or progression to malignancy. Conclusion : Urethral masses are essentially needed radiologic or endourologic procedure and pathologic examination due to posibble development of a malignant tumor even though it tis rare. A large scale of the urethral examination due to possible development of a malignant tumor even thoguh it is rare. A large scale of the urethral tumor like the leiomyoma or urethral diverticulum could be cured and safely managed by surgical excision, but the preventive procedure of the stress incontinence was needed. Finally it is important to perform auxiliary radiotherapy or chemotherapy with radical cystourethrectomy in female urethral malignant tumor to prevent the disease progression.

      • 여성 요도에 발생한 평활근종 1예

        김도리,강동일,임주학,최준호,최창훈,정재일,최성협 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

        Leiomyoma of the female urethra is a very rare condition. There are only 13 documented cases of Leiomyoma of the female periurethral tissue in the literature in Korea. It is a benign mesenchymal tumor that commonly present with palpable periurethral mass or recurrent urinary tract infection. A case of the leiomyoma arised from paraurethral area between the urethra and anterior vaginal wall in nineteen year old female is presented that mass enucleated surgically and confirmed as a leiomyoma histologically. This patient has no problem so far during its 3 months follow up.

      • KCI등재SCOPUS
      • SCISCIESCOPUSKCI등재
      • KCI등재후보
      • KCI등재SCOPUS

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