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Chung, Sung-Kun,Lee, Ja-Young,Joo, Choun-Ki,Kim, Jae-Ho 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Farnesyl transferase inhibitors (FTI) disrupt fanesylation of ras protein and thus, suppress tumor growth in vivo, To determine whether FTI extracted from Cinnamomum Cassia Blume (CB2'-ph) interferes with angiogenesis, we studied the effect of CB2'-ph on rabbit corneal angiogenesis induced by basic fibroblast growth factor (bFGF). A hydrogel disk containing 1000ng of bFGF was implanted intrastromally in the superior cornea of 12 NZW rabbit eyes. All eyes received a second intrastromal disk, randomized to contain either 40㎍ of CB2'-ph(n=6) or phosphate-buffered saline (PBS) (n=6). Both disks were positioned side-by-side, 1.2mm from the superior limbus. Each eye was examined daily by two masked of new blood vessels. At 3, 5, and 7 days postimplantation of bFGF disks, eyes treated with CB2'-ph showed mean angiogenesis score of 6.0 ± 4.8, 25.6 ± 23.9 and 38.1 ± 28.3, respectively, while PBS-treated controls scored 10.4 ± 9.2, 27.2 ± 16.7, and 39.0 ± 22.8, respectively (p>0.4, Wilcoxon signed rank test). In a rabbit corneal pocket assay, CB2'-ph appears to be ineffective against bFGF-induced corneal angiogenesis in the model. (Journal of Korean Ophthalmology Society 40:657-661, 1999)
Inhibition of Corneal Angiogenesis by a Farnesyl Transferase Inhibitor
Chung, Sung-Kun,Lee, Ja-Young,Joo, Choun-Ki,Kim, Jae-Ho 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Farnesyl transferase inhibitor(FTI) disrupt farnesylation of ras protein and thus, suppress tumor growth in vivo. The ras oncogene is thought to contribute to tumor development directly by promoting tumor cell proliferation and indirectly by stimulating vascular endothelial growth from Cinnamomum Cassia Blume (CB2'-ph) interferes with angiogenesis, we studied the effect of CB2'-ph on rabbit corneal angiogenesis induced by VEGF. A hygrogel disk containing 250ng of VEGF was implanted intrastromally in the superior cornea of 16 NZW rabbit eyes. All eyes received a second intrastromal disk, randomized to contain either 40㎍ of CB2'-ph(n=8) or phosphate-buffered saline (PBS) (n=8). Both disks were positioned side-by-side, 1.2mm from the superior limbus. Each eye was examined daily by two masked observers and assigned an angiogenesis score based on number and length of new blood vessels. At 3, 5 and 7 days postimplantation of VEGF disks, eyes treated with CB2'-ph showed mean angiogenesis score of 2.0 ± 1.7, 13.4 ± 6.6 and 23.8 ± 11.3, respectively, while PBS- treated controls scored 8.6 ± 4.4, 30.3 ± 20.8 and 52.2 ± 26.9, respectively (p<0.05, Wilcoxon signed rank test). In a rabbit corneal pocket assay, CB2'-ph appears to be effective on VEGF-induced corneal angiogenesis in the model. (Journal of Korean Ophthamology Society 40:662-666, 1999)
비소세포성 폐암 세포주에서 Farnesyl Transferase Inhibitor SCH66336과 인슐린양 성장 인자 결합 단백-3의 병용처리에 의한 세포고사 상승 작용
김영 ( Young Kim ),김세규 ( Se Kyu Kim ),김형중 ( Hyung Jung Kim ),장준 ( Joon Chang ),안철민 ( Chul Min Ahn ),김성규 ( Sung Kyu Kim ),장윤수 ( Yoon Soo Chang ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
연구배경 : 인슐린 양 성장 인자 결합 단백질-3 (IGF binding protein-3, IGFBP-3)는 생체내와 실험관내에서 인슐린 양 성장인자 매개 신호전달 체계를 억제하여 비소세포성 폐암 세포의 증식을 조절하는 것으로 알려져 있다. 이에 본 연구에서는 비소세포성 폐암의 치료에 있어 IGFBP-3를 이용한 치료전략의 개발을 위하여 IGFBP-3(Ad5CMV-BP3)와 FTI SCH66336의 병용치료 상승작용을 분석하였다. 방법 : 비소세포성 Background : Insulin-like growth factor binding protein (IGFBP)-3 regulates non-small cell lung cancer(NSCLC) cell proliferation in vitro and in vivo by inhibiting IGF-mediated signaling pathways. To have better strategies for the treatment of lung cancer