[P199] Epithelioid cell histiocytoma developed on palm

( Sang-myung Park ),( Min-jung Kang ),( Seung-hee Loh ),( Dong-woo Suh ),( Bark-lynn Lew ),( Woo-young Sim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Fibrous histiocytoma is the most common cutaneous soft tissue lesions mainly located on the limbs and present as small, hyperkeratotic, cutaneous nodules. Epithelioid cell histiocytoma is one of the several variants of fibrous histiocytoma. Histologically, it is characterized as a well demarcated lesion composed of large epithelioid cells in the papillary and superficial reticular dermis. A49-year-old male presented with slowly increased mass on the left palm during 3 months. The physical examination revealed a well demarcated 1 x 1 cm sized dark brownish to flesh colored protruded mass on the left palm. Histopathologic examination revealed an infiltration of the papillary dermis by polygonal epithelioid cells with abundant eosinophilic cytoplasm. Lesional tissue was enclosed by collarettes of surface epithelium. There were abundant small blood vessels and a few multinucleated giant cells. Immunohistochemical study revealed that epithelioid cells were positive for CD31, CD68 and negative for S-100, CK AE1/3, CD1, CD34. Based onthese findings, he was diagnosed with epithelioid cell histiocytoma. The lesion was completely excised. Epithelioid cell histiocytoma has a broad differential diagnosis. Therefore, we should consider the histological features with immunohistochemical studies to diagnose epithelioid cell histiocytoma. We report a rare epitheloid cell histiocytoma located in the left palm, which is occurred in unusual site.

Case Report : A Case of Primary Cutaneous Perivascular Epithelioid Cell Tumor

( You Jin Yang ),( Chong Won Choi ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.6

Perivascular epithelioid cell tumors (PEComas) are a rare, recently described group of mesenchymal tumors, which is composed of distinctive perivascular epithelioid cells. Primary cutaneous PEComas are composed of focally nested or trabecularly arranged groups of epithelioid cells with clear to eosinophilic cytoplasm and round to oval nuclei with obvious nucleoli. Here, we describe the case of a 27-year-old Korean man who was presented with a solitary, cutaneous nodule on his left popliteal fossa. Physical examination revealed a solitary, 1.2×1.0 cm-sized erythematous protruding nodule on his left popliteal fossa. Immunohistochemical evaluation showed that the epithelioid tumor cells were positive for HMB-45 and desmin. These clinical and histological findings were consistent with a diagnosis of primary cutaneous PEComa.

Cytotoxic Effect of Syringic Acid on Human Oral Epithelioid Carcinoma Cells

Lee Joo-Hyun,Han Du-Suk,Jekal Seung-Joo,Lee Jae-Hyung,Kim Chong-Ho,Yoo Min,Park Seung-Taeck 대한의생명과학회 2005 Biomedical Science Letters Vol.11 No.3

This study was undertaken to clerify the cytotoxic effect of syringic acid by colorimetric assay on human cancer cells. For the evaluation of cytotoxicity of syringic acid, the cell viability and cell adhesion activity of syringic acid on cancer cells, human oral epithelioid carcinoma cells were determined using by colorimetric assays such as MTT (3-[4,5­dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and XTT (2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]­2H-tetrazolium-5-caboxanilide) assay, respectively after human oral epithelioid carcinoma cells were treated with syringic acid for 48 hours. In this study, the cell viability of syringic acid on human oral epithelioid carcinoma cells showed a significant decrease by MTT assay compared with control, and also, the cell adhesion activity by XTT assay was decreased significantly in these cells after cells were treated with various concentrations of syringic acid for 48 hours. $MTT_{50}\;and\;XTT_{50}\;were\;282.3\;{\mu}M\;and\;418.8{\mu}M$ syringic acid, respectively. These results suggest that syringic acid shows midcytotoxic effect on human oral epithelioid carcinoma cells by the decreasement of the cell viability and the cell adehision activity assessed by colorimetric assay in these cultures.

A rare histopathological variant of Schwannoma with rosette-like arrangements and epithelioid cells: a case report from a histopathologist’s perspective

Mehendiratta Monica,Sant Vikas Kumar,Lakhanpal Manisha,Chauhan Keerti 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.4

Schwannomas exhibit histopathological variation that leads to diagnostic dilemmas, although less frequent in the oral cavity. We describe a case with unique histopathology and no relevant clinical history that adds to the breadth of literature on the diversity presented by Schwannoma. A 60-year-old female patient presented with a small dome-shaped, asymptomatic swelling on the alveolar ridge 6 years in duration. Histopathologically, it showed rich cellular pathology with a unique arrangement of tumor cells forming irregular rosettes. Each rosette presented with a central core of fibrincollagenous material and the tumor cells were arranged on the periphery, exhibiting epithelioid change with evidence of mild cellular and nuclear pleomorphism. On immunohistochemical evaluation, the cells were strongly and diffusely positive for S-100 and negative for Ki-67. A diagnosis of benign Schwannoma with a rosette-like arrangement with epithelioid change was made. The case report emphasizes the risk of misdiagnosis and the importance of awareness regarding rare histopathological variants of Schwannoma.

대장암으로 오인된 혈관주위상피모양세포종양 1예

조영환 ( Young Whan Cho ),김경조 ( Kyung Jo Kim ),예병덕 ( Byong Duk Ye ),변정식 ( Jeong Sik Byeon ),명승재 ( Seung Jae Myung ),양석균 ( Suk Kyun Yang ),김진호 ( Jin Ho Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.6

Perivascular epithelioid cell tumor (PEComa) is extremely rare, which originated from mesenchymal cells in the intestine, and composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. We report here on a case of PEComa in the sigmoid colon. A 62-year-old woman presented with hematochzia 10 days ago. Her abdominal computed tomography scan showed a 5 cm sized intraluminal fungating heterogeneously enhanced, high density mass, which infiltrated pericolic tissue surrounding the sigmoid colon. Colonoscopy showed a purple colored polypoid mass with lobulating contour in the sigmoid colon. She underwent laparoscopic anterior resection. On the histologic examination, the tumor consisted of polygonal epithelioid cells with sheet-like growth of nests, which looked like alveolar tissues in lung. The tumor cells were strongly positive stained with human melanoma black-45 (HMB-45). Pathologic examination was compatible with PEComa. Sixteen months after surgery, she did well without tumor recurrence after surgery. We review the literatures concerning PEComa of the intestine focusing on endoscopic findings.

A case of primary cutaneous perivascular epithelioid cell tumor (PEComa)

( Haneul Oh ),( Jae Yeong Jeong ),( Sook In Ryu ),( Bo Young Kim ),( Hye Rim Moon ),( Il-hwan Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Primary cutaneous perivascular epithelioid cell tumors (PEComa) are rare, recently described mesenchymal tumors composed of perivascular epithelioid cells. These rare tumors are characterized by the co-expression of melanocytic and muscle markers. A 66-year-old female was referred to our dermatology clinic because of a suspected clear cell neoplasm in excisional biopsy performed at local clinic. According to the patient, the lesion was a 1 cm-sized asymptomatic nodule on her right knee. On histopathological examination, the tumor was a dermal tumor composed of nests of epithelioid cells exhibiting clear cytoplasm and showed involvement of resection margins. In immunohistochemistry, tumor cells were positive for HMB-45, Vimentin and CD-10. These clinical and histological findings were consistent with a diagnosis of primary cutaneous PEComa. Because of the marginal positive lesion, additional excision was performed and no lesion remained in the pathologic report. After a complete excision, the patient has not experienced relapse until now. We herein reported a rare case of primary cutaneous PEComa in a 66-year-old female with diagnosis based on clinical and histologic findings. This case indicated primary cutaneous PEComa is rare but could occur and mimic other cutaneous tumors including clear cell fibrous histiocytoma, claear cell sarcoma and melanocytic neoplasms with balloon cell change.

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Tafrihi, Majid,Toosi, Samane,Minaei, Tayebeh,Gohari, Ahmad Reza,Niknam, Vahid,Arab Najafi, Seyed Mahmoud Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and ${\beta}$-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity.

단핵구성 탐식세포의 분화에 관한 연구

서재흥,임성철,최종범,이길선,기근흉 최신의학사 1990 最新醫學 Vol.33 No.7

안식향이 인체상피암종세포에 미치는 효과에 관한 연구

전주원,이병찬,한두석,서부일 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1

Objective : This study was done to examine the cytotoxicity of styrax benzoin (SB) on human oral epithelioid carcinoma cell line (KI3). Methods : The cytotoxic effect of SB was measured by MTT assay or XTT assay. The microscopic study was performed to observe the mophorlogical changes of KI3 cells. Results : The cytotoxic effect of SB on KI3 cells showed a significant increase at 50 uM or 100 uM SB by MTT assay or XTT assay compared with control after cells were treated with various concentrations of SB for 48 hours. MTT_(50) and XTTg were 419.9 uM and 375.5 uM, respectively. In microscopic study, KB cells exposed to SB showed both the decreased cell number and the morphological changes. Conclusion : From these results, SB has a midcytotoxicity by the showing the decrease of cell number and the morphological changes in KJ3 by MTT and XTT assays.

Cellular type of angiomatoid Spitz nevus

( Gi Hyun Seong ),( Myeong Jin Park ),( Minkee Park ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung Phil Hong ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Angiomatoid spitz nevus is rare and distinct variant of Spitz nevus which exhibits a spindle and/or epithelioid nevus placed among angioma-like densely arraged small blood vessels. A 1-year-old male patient presented with an one-month-history of a 0.3x0.3x0.3cm pinkish well circumscribed firm papule on the left mandible without specific symptom. Histopathologically, the lesion was symmetrical and sharply demarcated. There was epidermal hyperplasia with rete ridge clutching dermal tumor cell involving the full thickness of the dermis. Tumor nests were mostly composed of epithelioid cells containing abundant cytoplasm with sparse melanin granules. Even though some of bizarre atypical melanocytes with mitoses in superficial portion of lesion, cellular polymorphism was not observed. Kamino bodies at dermal-epidermal junction were also seen. The fibrous stroma contained numerous small and large blood vessels lined by plump endothelial cells. On immunohistochemical staining, S-100 was diffusely positive, HMB-45 was partialy positive within upper dermal nest and Ki-67 was mostly low. These findings allowed us to make the diagnosis of cellular type of angiomatoid spitz nevus. The tumor was removed by total excision. We report a case of rare histologic variant as an angiomatoid spitz nevus, cellular type.