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Moon, Heeyeon,Jeong, Kihoon,Kwak, Moo Jin,Choi, Siyoung Q.,Im, Sung Gap American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.38
<P>A new fabrication method for an ultrathin (500 nm thick) pressure-sensitive adhesive (PSA) was demonstrated by utilizing a series of in situ cross-linked viscoelastic copolymer films. Viscoelastic films composed of poly(2-hydroxyethyl acrylate-<I>co</I>-2-ethylhexyl acrylate) were synthesized successfully in a one-step manner by an initiated chemical vapor deposition (iCVD) process, where free-radical polymerization is triggered in the vapor phase either by heat or UV, or a combination of both. In particular, the photoinitiated chemical vapor deposition method generated a highly cross-linked polymer film, whereas cross-linking of the copolymer film was suppressed greatly in the conventional thermal iCVD method. A combination of thermal and photoinitiated chemical vapor deposition could regulate the cross-linking density of the copolymer films. We controlled the cross-linking density of the copolymer films to exhibit a viscoelastic property so that they would readily adhere to various kinds of substrates with only 500 nm thick copolymer PSA. The adhesion performance of the PSA was systematically optimized by tuning the copolymer composition as well as the cross-linking density, and consequently a high shear strength of more than 85.2 ± 5 N/cm<SUP>2</SUP> was achieved despite the 500 nm thickness. In addition, the PSA was completely transparent. We expect that the ultrathin PSAs developed in this work will be utilized widely for the realization of various soft electronic devices, which usually require strong adhesion, tunable viscoelastic properties, and optical transparency.</P> [FIG OMISSION]</BR>
( Magharla Dasaratha Dhanaraju ),( Sheela Elizabeth ),( Ganesan Poovi ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.5
The Dexamethasone (DEX) loaded chitosan microspheres were prepared by thermal denaturation and chemical cross-linking method using a dierent concentration of glutaraldehyde as chemical cross-linking agent. The prepared microspheres were evaluated for the percentage of Drug Loading (DL), Encapsulation Efficiency (EE) and surface morphology by Scanning Electron Microscopy (SEM). DL and EE were found to be maximum range of 10.0 to 10.79 % and 58.19 to 64.73 % respectively. The SEM Photographs of the resultant microspheres exhibited fairly smooth surfaces and predominantly spherical in appearance. In addition, Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) shown that there was no interaction between the drug and polymer. In vitro and in vivo release studies revealed that the release of dexamethasone was sustained and extended up to 63 days and effectively controlled by the extent of cross-linking agent. Non-clinical parameters such as paw volume, hematological parameters like Erythrocyte Sedimentation Rate (ESR), Paced Cell Volume (PCV), Total Leucocytes Count (TLC), Hemoglobin (Hb), Differential Cell Count (DCC) were investigated in Fruend``s Complete Adjuvant (FCA) induced arthritic rats. Radiology and histopathological studies were also performed in order to evaluate the therapeutic efficacy of the DEX-loaded microspheres in extenuating the rat arthritic model.
Chao Sheng,Yiming Zhou,Xinyu Zhang,Guoxin Xue 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10
Cross-linked hydrogels of chitosan/poly(vinyl alcohol) (PVA)/oxidized cellulose nanowhiskers (CNWs) were prepared by using oxidized CNWs as a cross-linker. The effects of the oxidation level of CNWs on the swelling behavior, thermal stability, viscoelastic properties and compressive strength of the hydrogels were studied. Chemical cross-links, hydrogen bonds, as well as nanofiller reinforcement between the three materials played a major role in determining the properties of the hydrogels. Swelling test results showed that the incorporation of oxidized CNWs decreased the water absorbability of the hydrogels due to the increase in cross-linking degree. Viscoelastic properties of the hydrogels with oxidized CNWs was increased by 537 % in storage modulus, from 4.65 kPa to 29.6 kPa. Compressive strength of 181.5 kPa at 50 % strain was observed from the cross-linked hydrogels, compared with 21.2 kPa of the non-cross-linked hydrogels. The thermal experiments showed that the chemical cross-linking slightly increase the resistance toward thermal degradation of the hydrogels.
박신아,김길수,구영순 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.49 No.-
Empty cross-linked albumin microcapsules were prepared by chemical denaturation method using glutaraldehyde(GA) or terephthaloyl chloride(TP) as a cross-linking agent. The binding efficiency of cross-linked albumin microcapsules was evaluated as a function of various conditions. Increasing of the concentrations of cross-linking agent, stirring time, the amount of microcapsules and the initial PropranololㆍHCl(PPHㆍHCl) concentration reduced the binding ability of these microcapsules. But the increasing of the mean particle diameter increase that of these microcapsules. The release rates of PPHㆍHCl from the ion-exchange albumin microcapsules were retarded compared with the powder. And the total amount of drug released was dependent on the nature, the concentration of ionic strength of the cations used.
Cross-Linked Polymer Based OFET Chemical Sensors for Direct Detection of Organic Solvents
박종민,이무열,김윤기,김형준,정관영,한아름,곽상규,김범준,오준학 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Organic field-effect transistors (OFETs) chemical sensor has potential at various applications due to its advantages including easy fabrication, low cost, lightweight, processibility, and flexibility. Though organic field-effect transistors can easily fabricate by using the solution process, it can also easily be damaged by organic solvents. The poor chemical resistance of OFETs based chemical sensor limits commercialization. Herein, we study about OFET sensors which can directly detect organic solvent due to its cross-linkable azide functional group. Also, we improve the sensitivity of OFET sensors by depositing functional small molecules of calixarene derivatives. Various liquid-phase organic solvents have been detected successfully and reliable sensing responses have been obtained. Our research demonstrates a novel methodology for the fabrication of high-performance organic sensors.
이무열,김형준,정관영,한아름,박종민,곽상규,김범준,오준학 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
An organic field-effect transistor (OFET)-based sensors have been demonstrated for sensing various types of analytes including chemicals, biological species, light, and pressure. In general, however, conjugated polymers suffer from poor chemical resistance toward liquid-phase organic solvents, which limits their practical applications to commercial electronic devices. Herein, we demonstrate solvent-resistant OFETbased sensors using cross-linkable organic semiconductor. Calixarene derivatives have been adopted to increase the sensitivity and selectivity of the OFET-based sensors. Various liquid-phase organic solvents have been tested successfully, and reliable sensing responses have been obtained. Our findings demonstrate a novel methodology for the fabrication of high-performance organic sensors and extend the practical applications of OFET-based sensors.
박신아,김길수,구영순 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2
Empty cross-linked albumin microcapsules were prepared by chemical denaturation method using glutaraldehyde(GA) or terephthaloyl chloride(TP) as a cross-linking agent. The binding efficiency of cross-linked albumin microcapsules was evaluated as a function of various conditions. Increasing of the concentrations of croos-linking agent, stirring time, the amount of microcapsules and the initial Propranolol HCI(PPH, HCI) concentration reduced the binding ability of these microcapsules. But the increasing of the mean particle diameter increase that of these microcapsules. The release rates of PPH, HCI from the ion-exchange albumin microcapsules were retarded compared with the powder. And the total amount of drug released was dependent on the nature, the concentration of ionic strength of the cations used.
Thermally Fast-Curable, “Sticky” Nanoadhesive for Strong Adhesion on Arbitrary Substrates
Joo, Munkyu,Kwak, Moo Jin,Moon, Heeyeon,Lee, Eunjung,Choi, Siyoung Q.,Im, Sung Gap American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.46
<P>Demand of adhesives that are strong but ultrathin with high flexibility, optical transparency, and longterm stability has been rapidly growing recently. Here, we suggest a thermally curable, 'sticky' nanoadhesive with outstanding adhesion strength accomplished by single-side deposition of the nanoadhesive on arbitrary substrates. The sticky nanoadhesive is composed of an ionic copolymer film generated from two acrylate monomers with tertiary amine and alkyl halide functionalities, formed by a solvent-free method, initiated chemical vapor deposition (iCVD). Because of the low glass transition temperature (T-g) of the copolymer (-9 degrees C), the ionic copolymer shows a viscoelastic behavior that makes the adhesive attachable to various substrates, regardless of the substrate materials. Moreover, the copolymer film is thermally curable via a cross-linking reaction between the alkyl halide and tertiary amine functionalities, which substantially increased the adhesion strength of the 500 nm thick nanoadhesive greater than 25 N/25 mm within 5 min of curing at 120 degrees C. The adhesive thickness can further be reduced to 50 nm to achieve greater than 35 N/25 mm within 30 min at 120 degrees C. The nanoadhesive layer can form uniform adhesion in a large area substrate (up to 130 x 100 mm(2)) with the deposition of the adhesive only on one side of the substrates to be laminated. Because of its ultrathin nature, the nanoadhesive is also optically transparent as well as highly flexible, which will play a critical role in fabrication and the lamination of future flexible/wearable devices.</P>
A hydrogel-coated membrane for highly efficient separation of microalgal bio-lipid
신지혜,김호기,문희연,곽무진,Seula Oh,유영민,이은정,장용근,임성갑 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.6
A cross-linked hydrogel-coated membrane was fabricated to achieve simple but highly efficient separation of bio-lipids directly from an aqueous microalgal culture medium. The membrane is composed of a stainless steel membrane coated conformally with a cross-linked hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), synthesized by a photo-initiated chemical vapor deposition (piCVD) process. The pHEMA-coated membrane has hydrophilicity and underwater-oleophobicity for efficient separation of a bio-lipid-in-hexane/water mixture by gravity. The conformal pHEMA film-coated membrane enables extremely high oil rejection performance with intrusion pressure of 6.1 kPa and water permeation flux of 6.5×103 L m2 h1, with excellent separation efficiency greater than 98.0%.