國內飼育 원숭이의 血淸 CPK의 總活性値와 isoenzyme에 관한 硏究

윤상보,김덕환,서지민,신남식,현병화,박배근,송희종 한국임상수의학회 2001 한국임상수의학회지 Vol.18 No.4

CKP isoenzymes have a high level of efficaciousness as diagnostic and prognostic aids in various diseases. There is not any report on the total activity of CPK of non-human primates, let alone CPK isoenzyme patterns, in Korea. In this study, total activities and isoenzyme patterns of CPK were measured to obtain their reference values in domestically reared common marmosets, crab-eating macaques and Japanese macaques. We observed remarkable different values of serum total CPK from the primates used in this experiment. Serum CPK activities of Japanese macaques and crab-eating macaques were 275.8$\pm$158.1 IU/l and 396.7$\pm$697.4 IU/l, respectively, whereas those of common marmosets showed much higher value of 618.8$\pm$1,117.6 IU/l. In all common marmosets and crab-eating macaques, only CPK$_3$ ws observed. In five out of eight Japanese macaques, CPK$_3$ was the sole fraction but two animals showed CPK$_1$ and CPK$_3$ isoenzymes, and the remaining one had CPK$_2$ and CPK$_3$ fractions. There were some discrepancies in the pattern and ratio of isoenzyme fractions in Japanese macaques. In conclusion, values such as CPK and CPK isoenzyme patterns of investigated for the first time form non-human primates reared in Korea, could be reference values for the optimal diagnosis and therapy diseases of the corresponding animal species.

중증 기관지 천식 환아의 치료중 혈청 CPK - MB isoenzyme 활성도에 관한 연구

이은영(Eun Young Yi),송영호(Young Ho Song),이재욱(Jae Uk Yi),강임주(Im Ju Kang) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.2

N/A This study was performed to observe transient myocardial ischemia evaluated by ST-T wave change in ECG and CPK-MB isoenzyme activity during the treatment with intravenous corticosteroid and isoproterenol in severe childhood bronchial asthma. The children admitted to pediatric intensive care unit due to severe bronchial asthma from Jan, 1992 to Jun, 1993 were divided into 4 groups; Group A received nebulized albuterol and continuous intravenous infusion of theophylline, Group B received continuous intravenous infusion of both theophylline and terbutaline, Group C received intravenous methylprednisolone in addition to the therapy of Group A or B, and Group D received intravenous isoproterenol in addition to the therapy of Group C, Arterial blood gas analysis, serum CPK-MB isoenzyme activity, ECG, arterial O₂saturation (SpO₂) were compared. Resuts were as following : 1) The severity of asthma was considerably related to the past history of infantile eczema and family history of allergy. 2) The CPK-MB isoenzyme activity was highest in group D (58.9 IU/L) followed by group C (36. 7 IU/L), A (24.5 IU/L), B (22.4 IU/L), so the CPK-MB isoenzyme elevation was consistent with the severity of asthma. 3) Pulmonary index score (PIS) and SpO₂was unrelated with CPK-MB isoenzyme elevation, but PaCO₂, acidosis (pH< 7.2) was considerably associated with CPK-MB isoenzyme elevation. 4) Past history of corticosteroid therapy was considerably related to the CPK-MB isoenzyme elevation. In conclusion, we should consider transient myocardial ischemic injury during the treatment of severe bronchial asthma with intravenous methylprednisolone or isoproterenol and it is necessary to evaluate ECG and CPK-MB isoenzyme activity in patients with the history of previous therapy of corticosteroid and with severe acidosis or hypercapnia.

균형조절치료가 직업 관련성 근골격계 질환자의 통증 및 CPK에 미치는 영향

오영택 한국자료분석학회 2009 Journal of the Korean Data Analysis Society Vol.11 No.5

The purpose of this study is to know the effects which the balance control therapy for four weeks has on a cognition scale of pain (VAS) and the CPK of patients suffering from work-related musculoskeletal disorders. The subjects are ten workers manufacturing parts of automobiles and are divided into five workers of control group and five workers of experimental group. The experimental group has been given balance control therapy for four weeks while the control group has no treatment. VAS and CPK were measured in a pretest and a posttest four weeks later. The result were as follows; In the change of VAS and CPK, the VAS (p<0.05) of experimental group are significantly decreased within groups. In the variation differences of VAS and CPK, there is a significance in the VAS (p<0.05) of the experimental group between groups. In conclusion, two groups was no significant difference in the change of serum CPK. However, I think that balance control therapy will be efficient as a method to cope because it has a positive effect on VAS. 본 연구의 목적은 4주간의 균형조절치료가 직업 관련성 근골격계 질환자들의 통증(VAS)및 크레아틴 포스포 키나제(CPK)의 변화에 미치는 영향을 알아보는 것이다. 연구대상자는 직업 관련성 근골격계 질환을 호소하는 자동차부품제조업체 종사자 10명으로 4주간 균형조절치료를 적용하는 실험집단과 아무런 처치를 하지 않는 대조집단으로 나누어 통증(VAS) 및 근 손상 지표인 CPK의 변화를 분석하였으며, 그 결과는 다음과 같았다. VAS의 경우 실험 4주 후에 대조집단은 약간 증가하였고, 실험집단은 집단 내(p<0.05)와 두 집단간의 평균 변화량의 차이에 대한 유의성 검증에서 유의하게 감소하였다(p<0.05). CPK의 경우 실험집단에 감소가 있었으나 두 집단 모두 유의한 차이는 없었다.

스포츠 생리학 : 철인3종경기의 Royale 과 King Course 시합 전 · 후 혈장 크레아틴인산효소, 젖산탈수소효소 활성도 및 젖산탈수소 동위효소의 변화

김학렬(HagLyeolKim),조현철(HyunChulCho) 한국체육학회 1997 한국체육학회지 Vol.36 No.2

수많은 연구자들이 철인3종경기의 생리적 특성을 파악하기 위해 높은 관심을 보이고 있다. 본 연구는 ‘93 CHFJU INTERNATIONAL TRIATHLON CHAMPIONSHIP, KOREA’에 참여하였던 철인3종경기 선수들의 Royale(수영 1.5km, 싸이클 40km, 달리기 10km)과 King(수영 3km, 싸이클 180km, 달리기 42.195km)Course 시합 전,후에 따른 혈장 크레아틴인산효소(CPK), 젖산탈수소효소(LDH) 및 젖산탈수소 동위효소(H/M- Specific type)의 변화를 확인하는 것이었다.21명의 남자 철인3종경기선수(Royale, n=9, King, n=11)들이 현재연구에 대한 피험자로 참여하였다.철인3종경기의 2가지 시합형태에 대한 혈정 CPK와 LDH 활성도는 안정시 수준에 비해 시합후 유의하게 증가된 수준을 나타내었다(Royale :CPK p<0.001, LDH p<0.001 ; King: CPK p<0.01, LDH p<0.001). 그러나 두가지 시합형태간(Royale vs. King Course) 유의한 차이는 발견되지 않았다. 또한 M-specific type의 유의한 증가(p<0.001)가 Royale Course 시합후에 관찰되었으며, 동시적으로 H-Specific type (p<0.001)과 H/M Subunit ratio(p<0.01)가 감소를 나타내었다. 그러나 King Course 시합 후에 유의한 차이는 관찰되지 않았다. 이러한 결과로서 두가지 시합형태간 통계적으로 유의한 차이를 나타내었다.결론적으로, 현재연구가 시사하는 바는 짧은거리로 구성된 Royale 철인3종경기는 긴거리로 구성된 King Course보다 더욱 큰 생리적 스트레스가 요구된다는 것을 의미하는 것이다. Numerous studies have been done m an attempt to characterize the triathlete.The purpose of this study was to identify a changes of plasma CPK, LDH and LDH isozymes(H-& M-specific type) before and after royale(Swim 1.5 km, Bike 40 km, Run 10 km) and king(Swim 3 km, Bike 180 km, Run 42.195km)course competition of triathletes participated to '‘93 CHHJU INTERNATIONAL TRIATHLON CHAMPIONSHIP KOREA’.Twenty male triathletes(royal, n=9; king, n=11) 》were volunteered as subjects of this study.Significant rises were noted in plasma CPK and LDH activities after both forms of triathlone competition, compared to rest vaiues(royale: CPK p<0,001, LDH p<0.001; king: CPK p<0.01, ,LDH p<0.00l). However, No significant changes was found between both triathlone competition types. Significant (p<0.001) increase in M- specific type were observed after royale course competition. Simultaneously H-specific type (p<0,001) decreased as well as the H/M subunit ratio (p<0.01). No significant was observed after king course competition.As this results, significant difference was observed between both competition types.This results suggests that royale triathlon competition was a much greater physiological stress than king course competition.

VDT작업자에서 어깨 근육장애와 혈청 CPK의 관련성

정해관,김수근 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

VDT workers are often exposed to static load in the shoulder stabilizing muscle due to repetitive work over long periods. Many investigations were reported the relationships between static load due to repetitive work and regional muscle disorder. However, diagnostic approach to work-related muscle disorder is difficult due to the absence of objective dignostic tools. This study was performed to investigate the relationship between the serum CPK(creatine phosphokinase) concentrations and the shoulder muscle disorders. Results are as follow. 1. Mean serum CPK in total VDT workers was 67.6±28.4 IU/l and workers with abnormal serum CPK were 35(21.5%). 2. Comparison between cases and controls did not show significant difference in the serum CPK level and the distribution of abnormal findings. 3. Sensitivity and sepcificity of the CPK test was 23.0% and 82.0%, respectively. Above results, in accordance with literatures, show that while serum CPK measurement can be useful for the diagnosis of acute muscle injury, it does not adequately reflect the muscle disorders developed by the repetitive work of low tension over long time, such as VDT works.

걷기운동과 달리기운동이 염증지표에 미치는 영향

조재혁 한국스포츠학회 2021 한국스포츠학회지 Vol.19 No.1

본 연구에서는 12주 동안의 걷기운동과 달리기운동이 CRP, IL-6, CPK와 같은 염증지표에 어떠한 영향을 줄 수 있는지를 살펴보고자 S 대학교에 재학 중이며, 내과·외과적으로 특정 질환이 없고 실험 변인인 CRP, IL-6, CPK가 모두 정상범주에 있는 20대 남자 대학생 12명을 대상으로 하였다. 12명 중 6명은 걷기운동집단, 6명은 달리기운동집단으 로 나누어 운동프로그램을 진행하였으며, 걷기운동집단은 20~30% 운동강도, 달리기운동집단은 60~70% 운동강도를 적용하여 다음과 같은 결론을 도출했다. 12주간의 걷기운동과 달리기운동은 20대 남성의 CRP, IL-6, CPK 모든 항목에 서 운동전보다 통계적으로 유의하게 감소시켰으며, 달리기운동집단에서 보다 큰 유의한 감소가 나타났다. 결론적으로 12주간의 걷기운동과 달리기운동은 염증지표 개선에 긍정적인 효과를 줄 수 있는 것으로 나타났다. 추후 연구에서는 다른 연령대를 대상으로 염증지표 개선을 위한 유산소운동 강도와 운동시간 등에 대한 연구와 중년 이상의 대상자들에게 유산 소운동 실천을 높일 수 있는 다양한 형태의 운동프로그램개발이 필요할 것으로 생각한다. In this study, in order to examine how walking and running exercise for 12 weeks can affect inflammatory Markers such as CRP, IL-6, and CPK, he is currently attending S University. Twelve male college students in their twenties, whose variables CRP, IL-6, and CPK were all in the normal category, were targeted. 6 out of 12 people were divided into walking exercise group and 6 people were divided into running exercise group, and 20-30% exercise intensity was applied to the walking exercise group, and 60-70% exercise intensity was applied to the running exercise group. Derived. The 12-week walking and running exercise were statistically significantly reduced in all items of CRP, IL-6, and CPK in men in their twenties than before exercise, and significantly decreased in the running exercise group. In conclusion, it was found that walking and running exercise for 12 weeks can have a positive effect on improving inflammation index. In future studies, it is necessary to study the intensity of aerobic exercise and exercise time to improve inflammation indicators for other age groups, and to develop various types of exercise programs that can increase the practice of aerobic exercise for middle-aged and older subjects.

자연과학편 : 70~80%RM Weight Training에서 1RM 재설정 시기가 남고생의 최대근력과 Testosterone·CPK에 미치는 영향

김강훈(KangHunKim),양점홍(JumHongYang),최재현(JaeHyunChoi) 한국체육학회 2006 한국체육학회지 Vol.45 No.4

이 연구는 weight training시 보다 효율적인 1RM 재설정 시기를 제시하는데 목적이 있다. 남자고등학교 2학년 학생을 1RM 재설정 시기를 기준으로 A(1주), B(2주), C(3주), D(4주) 그룹, 각 10명씩 총 40명을 유의 추출하여 12주간, 주 3회 55~70분간 70~80%RM의 weight training을 실시하여 각 그룹내·간의 시기별 변화율을 비교한 결과, bench press, squat, dead lift는 모두 그룹 내 운동 전·후 향상되었으며, 그룹 간 비교에서는 2주, 3주, 4주마다 1RM 재설정 그룹이 1주마다 1RM 재설정 그룹보다 향상되었다. testosterone은 그룹 내·간, 운동 전·후 차이가 없었다. CPK는 그룹 내 운동 전·6주 후 2주, 4주마다 1RM 재설정 그룹에서 감소하였으며, 그룹 간에는 차이가 없었다. 따라서 남자고교생의 WT 프로그램에서 1RM 재설정 시기가 testosterone, CPK에는 영향을 미치지 않았으며, 최대근력 향상 면에서는 2~4주의 1RM 재설정 시기가 효과적인 것으로 본다. The purpose of this study was to investigate more effective 1RM resetting time in WT program after comparative analysis of 1RM, testosterone, and CPK variations in male high school students. Forty subjects participated in this study from P high school in B metropolitan city. The subjects were grouped according to A(1week), B(2weeks), C(3weeks), and D(4weeks) on 1RM resetting time respectively in weight training period. The application of WT program for 12weeks was performed according to 55~70minutes per day, 3times a week, 70~80%RM, 8~12 repetitions, and 3sets. The detailed results of this study were as follows; 1) 1RM of bench press, squat, and dead lift between pre-exercise and post-exercise were all significantly improved in intragroup. 1RM resetting group of 2weeks, 3weeks, and 4weeks each in intergroup comparison were significantly improved better than 1RM resetting group of each week. 2) There was no significant difference in testosterone between intragroup, and intergroup, pre-exercise, and post-exercise. 3) The group was controlled 1RM resetting in pre-exercise and 2weeks, 4weeks each after 6weeks was significantly decreased in CPK, and there was no significant difference among each group. In conclusion, these results indicated that 1RM resetting time in WT doesn't lead to testosterone and CPK variations in male high school students, but 1RM resetting time from 2 to 4 weeks is effective on improvement of maximal strength.

굽 높이에 따른 걷기 운동 시 혈장 LDH, CPK와 코티졸에 미치는 영향

최인애(Choi, In-Ae),민은정(Min, Eun-Jung) 한국체육과학회 2012 한국체육과학회지 Vol.21 No.6

This study was examined the effects of walking exercise according to the height of heel(5cm, 7cm, 9cm) on plasma LDH, CPK and cortisol with 10 female college students who are in twenties, and following conclusions were obtained. First, the LDH of before and after 30 minutes walking exercise according to height of heel(5cm, 7cm, 9cm) was increased when heel was higher and also showed significant differences. Second, the CPK of before and after 30 minutes walking exercise according to height of heel(5cm, 7cm, 9cm) was increased when heel was higher and also showed significant differences. Third, the cortisol of before and after 30 minutes walking exercise according to height of heel(5cm, 7cm, 9cm) was increased when heel was higher and also showed significant differences. From the above results, higher heel showed significant increase in plasma enzyme such as LDH, CPK and cortisol, thus it caused high stress and inflammation index of body, and it has negative effects on the human body. Therefore, according to the report of higher heel walking excercise, walking on lower heels are suggested that it could limit the fatigue occurs and inflammatory index. In the future study, it will be needed to study on the response of material fatigue, immune system and the endocrine system and on various walking speeds, as well as LDH, CPK and cortisol.

태권도 경기시 젖산, LDH 및 CPK의 변화에 관한 연구

김우규,윤영학,성혜련 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the changes of blood lactate, LDH and CPK in Taekwondo competition. Subjects as a T group were seven well-trained Taekwondo players. Control group was composed of seven healthy male students who taking Taekwondo club in D university. With K4b^2 telemetry, VˇO_2max was determined for each subject by administering a treadmill exercise test(5% slope, start speed: 120m/min, increased 20m/min each 2min). Data were analyzed by ANOVA with post hoc-test The 0.05 level of significance was as critical level for the study In lactate concentration of rest, the Taekwondo group was lower than the control group, but there was no significance. In LDH and CPK activity of rest, the Taekwondo group were significantly(p<.05, p<.01) higher than the control group. In the Taekwondo competition, lactate concentration and LDH, CPK activity in both of the group were all more significantly (p<.05, p<.01, p<.01) after the 3rd round than in the 1st and 2nd round. Putting the above-mentioned together, we can assume tat CPK is related to ATP-PC system, while lactate and LDH are connected with lactate system. In the future, I think that it will be necessary to find how to classify the ratio of ATP-PC system which was brought about n the Taekwondo competition, that of lactate system and aerobic on the metabolism.

12주간 웨이트 트레이닝 시 아라키돈산 보충제 섭취가 골격근량, 최대근력, LDH 및 CPK에 미치는 영향

조민규,이상호,한상철 충북대학교 국가미래기술경영연구소 2020 기술경영 Vol.5 No.1

The purpose of this study was to identify the effects of taking arachidonic acid on maximum muscular strength, skeletal muscle mass, LDH and CPK in weight training for 12 weeks. 20 male subjects with no medical problem were selected from I sports center. The subjects were randomly alloted to two groups. The experiment group took arachidonic acid with exercise whereas the contrast group just conducted exercise. This study measured changes in maximum muscular strength, skeletal muscle mass, LDH and CPK. Arachidonic acid intake showed significant increase in skeletal muscle mass and CPK change, but no significant difference in maximal muscle strength and LDH change. However, long-term or high doses of arachidonic acid may cause various side effects such as phenomena, diarrhea or abdominal pain.