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Kekilli, Kezban Esra,Abakay, Candan Demioz,Tezcan, Gulcin,Tunca, Berrin,Egeli, Unal,Saraydaroglu, Ozlem,Esbah, Onur,Ekinci, Ahmet Siyar,Arslan, Sonay,Uslu, Nuri,Ozkan, Lutfi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7
Purpose: To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cytokeratin 20 (CK20) and survinin gene expression on local control (LC) and overall survival (OS) in patients with locally advanced head and neck cancer (LAHNC) who were administered radiotherapy (RT). Materials and Methods: Twenty-six patients who were admitted to Uludag University Medical Faculty Department of Radiation Oncology with a diagnosis of LAHNC (GIII-GIV) were included in this study. Gene expression was evaluated in tumor tissues and peripheral blood. RNA isolation was performed on paraffinized tumor tissues and peripheral blood samples obtained before RT (BR). The densities of the obtained RNAs were analyzed at 260/280 nm. cDNA samples obtained from total RNA,EGFR, CK19, CK20 and survinin gene expression levels were assessed via the Sybr Green method and data were analyzed with the ${\Delta}{\Delta}Ct$ method. The same process was repeated for peripheral blood samples taken after RT (AR). Results: The female/male ratio was 3:23 and the mean age was 56.5 years (38-75years). After radiotherapy, CK19 and CK20 levels in the peripheral blood were found to be correlated according to Pearson correlation analysis(p=0.049). This result indicates a possibility of remaining positive for CK19 and CK20 in the peripheral blood even after RT in patients with CK19, CK20, and EGFR positive tumors before RT. There was a statistically significant correlation between survinin levels measured BR and AR (p=0.028). Conclusions: In this study, we found that patients with any EGFR, CK19, CK20 or survinin positivity in their peripheral blood obtain less benefit from radiotherapy. A wider patient population and advanced protein analyses are necessary in order to increase the reliability of our findings.
[P365] A case of CK20 negative Merkel cell carcinoma
( Osung Kwon ),( Yongwoo Choi ),( Hyungrok Kim ),( Hyunjung Kwon ),( Kyung Duck Park ),( Joonsoo Park ),( Hyun Chung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Merkel cell carcinoma is a rare neuroendocrine tumor that is highly aggressive in nature and indolent in progression. The common risk factors for Merkel cell carcinoma are senility, prolonged exposure to sunlight, immune deficient states and recently, Merkel cell polyomavirus has been characterized to be significantly associated with the pathogenesis of the disease including the expression of CK20. The diagnosis is often difficult since histopathological results require a number of differential diagnosis through immunohistochemical stains with other cutaneous malignancies. A 67-year-old male presented with a solitary dome-shaped erythematous round mass on left upper arm for two months. Initially the lesion was grain-sized but eventually enlarged over two months. Biopsy revealed sheets of lymphoid cells with grouped clusters of darkly stained nuclei and intermittently trabecular projections. immunohistochemical stains revealed positive findings to Ki-67, pan-cytokeratin, synaptophysin, chromogranin, CD 56 and negative results to CK 20, leukocyte common antigen, S-100, HMB45 and thyroid transcription factor-1 and CK 20 negative Merkel cell carcinoma was diagnosed based on the adjuvant immunohistochemical findings. Herein, we present a CK20 negative Merkel cell carcinoma in light of expanding the knowledge of unusally stained immunohistochemial results in Merkel cell carcinoma.
Alrashidy, Mohammed,Atef, Aliaa,Baky, Tarek Abdel Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Urothelial papilloma and non-invasive papillary carcinoma are common neoplasms of the urinary bladder. Distinguishing papillomas and papillary carcinomas, especially the low grade type, is often debatable on the basis of histological features alone. Materials and Methods: We investigated immunohistochemical expression of cytokeratin 20 (CK20), p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder. Whole tissue sections were examined. Results: Among the 30 carcinoma cases, 12 (40%) showed strong reactivity for the whole panel, 16 (53%) reacted positively for two markers, and 2 (7%) reacted just to one of them. Ki-67 was considered positive in 27 cases (90%) and p53 in 24 (80%), CK20 showed positive reactivity in 21 cases (70%). Only small percentages of papillomas were positive, and then only weakly. Conclusions: We concluded that the intense positivity of suspicious cells for at least one of these markers would confirm the presence of malignant changes and favours the diagnosis of carcinoma.
Primary merkel cell carcinoma on the finger
( Hyung-jin Park ),( Ye-jin Lee ),( Chan-yang Lee ),( Hye-jin Ahn ),( Min Kyung Shin ),( Ki-heon Jeong ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Merkel cell carcinomas are rare neuroendocrine cancer of the skin. It is a highly aggressive primary skin cancer and leading cause of death in non-melanoma skin cancer. Usual presentation of primary merkel cell carcinomas is solitary violet or blue dome-shaped nodules with non-tender intra-cutaneous swelling that has grown rapidly and may ulcerate. They are most often encountered in the head and neck (50%), the extremities (40%), and the trunk (10%). A 87-year-old female presented with a asymptomatic mass on the finger. Physical examination revealed a solitary 1.5x1cm sized erythematous nodule on the dorsal surface of the Lt.4th finger. The histopathological evaluation demonstrated intradermal coalescing sheets consisting of small blue cells with many atypical mitotic features. Immunohistochemical finding was positive for CK-20 and negative for TTF-1. Finally the patient was diagnosed as primary merkel cell carcinoma, and PET-CT showed no evidence of metastasis, so surgical mass excision was performed. Adjuvant radiotherapy was recommended, but the patient refused. To the best of our knowledge, merkel cell carcinoma on the finger has been reported in seven cases.